Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAR-related orphan receptor C | Starlite/ChEMBL | No references |
Agaricus bisporus | Tyrosinase | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | No references |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Curated by TDR Targets | References |
Mycobacterium leprae | Probable transcriptional regulatory repressor protein (TetR-family) EthR | Curated by TDR Targets | References |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Mycobacterium leprae | possible TetR-family transcriptional regulatory protein | Probable transcriptional regulatory repressor protein (TetR-family) EthR | 214 aa | 192 aa | 57.3 % |
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | oxidoreductase-like protein | 0.003 | 0.0219 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0407 | 0.4775 | 0.524 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0447 | 0.5263 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0447 | 0.5263 | 0.5188 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0447 | 0.5263 | 1 |
Leishmania major | oxidoreductase-like protein | 0.003 | 0.0219 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.003 | 0.0219 | 0.024 |
Onchocerca volvulus | 0.0111 | 0.1197 | 1 | |
Onchocerca volvulus | 0.003 | 0.0219 | 0.1826 | |
Schistosoma mansoni | tyrosine kinase | 0.0244 | 0.2811 | 0.3085 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0064 | 0.007 |
Onchocerca volvulus | 0.0111 | 0.1197 | 1 | |
Echinococcus multilocularis | insulin receptor | 0.0244 | 0.2811 | 0.3085 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.0062 | 0.0069 |
Mycobacterium ulcerans | TetR family transcriptional regulator | 0.0838 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0447 | 0.5263 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.0062 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1197 | 0.1314 |
Schistosoma mansoni | tyrosinase precursor | 0.0111 | 0.1197 | 0.1314 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0064 | 0.007 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.003 | 0.0219 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0765 | 0.9113 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0111 | 0.1197 | 0.1314 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0111 | 0.1197 | 0.1314 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.003 | 0.0219 | 0.024 |
Mycobacterium ulcerans | AcrR family transcriptional regulator | 0.0838 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.0062 | 0.0069 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.1197 | 0.1314 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1598 | 0.1753 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0447 | 0.5263 | 0.5157 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0244 | 0.2811 | 0.3085 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0244 | 0.2811 | 0.3085 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0111 | 0.1197 | 0.1314 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.0062 | 0.0069 |
Onchocerca volvulus | 0.0111 | 0.1197 | 1 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.003 | 0.0219 | 0.024 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.1197 | 0.1314 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0411 | 0.4828 | 0.5298 |
Schistosoma mansoni | tyrosine kinase | 0.0407 | 0.4775 | 0.524 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.0062 | 0.0069 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.003 | 0.0219 | 0.5 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0064 | 0.007 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.1197 | 0.1314 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.003 | 0.0219 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.003 | 0.0219 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0411 | 0.4828 | 0.5298 |
Echinococcus multilocularis | 0.0237 | 0.2719 | 0.2983 | |
Brugia malayi | ShTK domain containing protein | 0.0111 | 0.1197 | 0.1314 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.0929 | 0.1019 |
Onchocerca volvulus | 0.003 | 0.0219 | 0.1826 | |
Schistosoma mansoni | tyrosine kinase | 0.0244 | 0.2811 | 0.3085 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0219 | 0.024 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0244 | 0.2811 | 0.3085 |
Onchocerca volvulus | 0.0111 | 0.1197 | 1 | |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.0062 | 0.0069 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0447 | 0.5263 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.003 | 0.0219 | 0.024 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.003 | 0.0219 | 0.5 |
Echinococcus granulosus | death domain containing protein | 0.0017 | 0.0062 | 0.0069 |
Brugia malayi | Protein kinase domain containing protein | 0.0244 | 0.2811 | 0.3085 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0017 | 0.0062 | 0.0069 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.003 | 0.0219 | 0.024 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0111 | 0.1197 | 0.1314 |
Schistosoma mansoni | tyrosinase precursor | 0.0111 | 0.1197 | 0.1314 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0447 | 0.5263 | 0.5157 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.003 | 0.0219 | 0.024 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.003 | 0.0219 | 0.5 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0017 | 0.0062 | 0.0069 |
Onchocerca volvulus | Netrin receptor homolog | 0.0017 | 0.0062 | 0.0521 |
Schistosoma mansoni | tyrosine kinase | 0.0411 | 0.4828 | 0.5298 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1598 | 0.1753 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.003 | 0.0219 | 0.5 |
Schistosoma mansoni | netrin receptor unc5 | 0.0017 | 0.0062 | 0.0069 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.0929 | 0.1019 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0765 | 0.9113 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0765 | 0.9113 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0765 | 0.9113 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0765 | 0.9113 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory repressor protein (TetR-family) EthR | 0.0833 | 0.9941 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0407 | 0.4775 | 0.524 |
Echinococcus granulosus | insulin receptor | 0.0244 | 0.2811 | 0.3085 |
Schistosoma mansoni | dihydropteridine reductase | 0.003 | 0.0219 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0062 | 0.0069 |
Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.0062 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0062 | 0.0069 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.003 | 0.0219 | 0.5 |
Brugia malayi | Death domain containing protein | 0.0017 | 0.0062 | 0.0069 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0447 | 0.5263 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.003 | 0.0219 | 0.024 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.003 | 0.0219 | 0.024 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0411 | 0.4828 | 0.5298 |
Trichomonas vaginalis | hypothetical protein | 0.0447 | 0.5263 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.003 | 0.0219 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1598 | 0.1753 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0111 | 0.1197 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1197 | 0.1314 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0411 | 0.4828 | 0.5298 |
Mycobacterium ulcerans | transcriptional regulator | 0.0838 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.003 | 0.0219 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0064 | 0.007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 12.58925412 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Activity (binding) | Inhibition of human liver MAOB | ChEMBL. | 18834112 | |
Activity (binding) | Inhibition of human recombinant MAOB at 100 uM by fluorimetric method | ChEMBL. | 18834112 | |
Activity (functional) | 0 | Inhibition of mycolic acid synthesis in Mycobacterium bovis BCG NCTC 5692 with ethR-knockout mutant assessed as incorporation of [2-14C]acetate | ChEMBL. | 17220416 |
FC (functional) | = 8 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv over-expressing InhA cells assessed as upshift of MIC relative to wild type | ChEMBL. | 24967731 |
IC50 (functional) | Antimicrobial activity against Leishmania infantum | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Leishmania donovani | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Leishmania mexicana | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Trypanosoma brucei brucei | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Leishmania major | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Trypanosoma brucei rhodesiense | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Toxoplasma gondii | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Trichomonas vaginalis | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Plasmodium falciparum | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Entamoeba histolytica | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Cryptosporidium parvum | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Trypanosoma cruzi | ChEMBL. | 20185316 | |
IC50 (functional) | Antimicrobial activity against Trypanosoma brucei | ChEMBL. | 20185316 | |
IC50 (binding) | = 4 uM | Inhibition of mushroom tyrosinase using L-tyrosine as substrate | ChEMBL. | 26544630 |
Inhibition (ADMET) | = 66.20331844 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (binding) | = 88 % | Inhibition of tyrosinase in mouse B16F10 cell lysates using DOPA as substrate relative to control | ChEMBL. | 26544630 |
Inhibition (functional) | = 90 % | Antimycobacterial activity of compound against Mycobacterium tuberculosis H37Rv at 2.50 ug/mL | ChEMBL. | 15225698 |
Inhibition (functional) | = 90 % | Antimycobacterial activity of compound against Mycobacterium tuberculosis H37Rv at 2.50 ug/mL | ChEMBL. | 15225698 |
Inhibition (ADMET) | = 90.87743958 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (binding) | = 104 % | Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 20 uM relative to control | ChEMBL. | 26544630 |
Inhibition (binding) | = 104 % | Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 50 uM relative to control | ChEMBL. | 26544630 |
Inhibition (binding) | = 107 % | Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 10 uM relative to control | ChEMBL. | 26544630 |
Kic (binding) | = 1.9 uM | Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysis | ChEMBL. | 26544630 |
KSV (binding) | = 9.5 10'3/M | Binding affinity to mushroom tyrosinase assessed as fluorescence quenching | ChEMBL. | 26544630 |
MIC (functional) | = 0.25 ug ml-1 | Antimycobacterial activity against Mycobacterium bovis BCG str. Pasteur 1173P2 overexpressing ethA gene | ChEMBL. | 17220416 |
MIC (functional) | = 0.5 ug ml-1 | Antimycobacterial activity against Mycobacterium bovis BCG NCTC 5692 with ethR-knockout mutant | ChEMBL. | 17220416 |
MIC (functional) | = 1 ug ml-1 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 761 horboring rpoB S531L/Q510P, katG S315T/R463L, gyrA D94N/S95T, rrs G1484T by CLSI method | ChEMBL. | 20713679 |
MIC (functional) | = 2 ug ml-1 | Antimycobacterial activity against Mycobacterium bovis BCG Pasteur with pMV261 vector | ChEMBL. | 17220416 |
MIC (functional) | = 2 ug ml-1 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2301 horboring rpoB S531L, katG R463L/E217G, gyrA D94N/S95T, rrs A1401G by CLSI method | ChEMBL. | 20713679 |
MIC (functional) | = 4 ug ml-1 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2911 horboring rpoB D516V, katG S315T/R463L, gyrA D94G/S95T/R128S/Y129C, rrs A1401G by CLSI method | ChEMBL. | 20713679 |
MIC (functional) | = 4 ug ml-1 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 625 horboring rpoB S531L/G566R/I569L, katG S315T/R463L, gyrA A90V/S95T, rrs A1401G by CLSI method | ChEMBL. | 20713679 |
MIC (functional) | = 5 ug ml-1 | Antimycobacterial activity against Mycobacterium bovis BCG NCTC 5692 | ChEMBL. | 17220416 |
MIC (functional) | = 5 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 21 days by broth microdilution method | ChEMBL. | 9428161 |
MIC (functional) | = 5 ug ml-1 | Antimycobacterial activity against wild-type Mycobacterium tuberculosis H37Rv expressing VV16 plasmid by agar dilution method | ChEMBL. | 17785510 |
MIC (functional) | = 5 ug ml-1 | Antimycobacterial activity against wild-type Mycobacterium tuberculosis Mt103 expressing VV16 plasmid by agar dilution method | ChEMBL. | 17785510 |
MIC (functional) | = 10 ug ml-1 | Antimycobacterial activity against Mycobacterium bovis BCG str. Pasteur 1173P2 overexpressing ethR gene | ChEMBL. | 17220416 |
MIC (functional) | > 10 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis MT1K ISO-22 mutant expressing VV16 plasmid by agar dilution method | ChEMBL. | 17785510 |
MIC (functional) | > 10 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis MT1K ISO-33 mutant expressing VV16 plasmid by agar dilution method | ChEMBL. | 17785510 |
MIC (functional) | > 16 ug ml-1 | Antimycobacterial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 2474 horboring rpoB H526Y, katG D329A/R463L, gyrA D94G/S95T, rrs A1401G by CLSI method | ChEMBL. | 20713679 |
MIC (functional) | = 9 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by MTT assay | ChEMBL. | 22361273 |
MIC (functional) | = 18 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 22280816 |
Potency (functional) | 0.0977 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 1.1883 uM | PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 24.3282 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of glucocorticoid receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 27.0563 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 68.5896 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
922 literature references were collected for this gene.