TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 340.418 | Formula: C23H20N2O
H donors: 1 H acceptors: 0 LogP: 5.04 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)c1ccc2c(c1)c(cc(c2)CCc1ccccc1)c1cocc1
InChi: 1S/C23H20N2O/c24-23(25)19-9-8-18-12-17(7-6-16-4-2-1-3-5-16)13-21(22(18)14-19)20-10-11-26-15-20/h1-5,8-15H,6-7H2,(H3,24,25)
InChiKey: SEMRDESNSNIQCH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	plasminogen activator, urokinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	Mastin	plasminogen activator, urokinase	414 aa	340 aa	24.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine repeat modular protein 1	0.0035	0.0267	0.0267
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0092	0.0911	0.5068
Mycobacterium ulcerans	DNA gyrase subunit B	0.008	0.0768	0.4721
Toxoplasma gondii	kringle domain-containing protein	0.0035	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0582	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0015	0.004	0.0066
Schistosoma mansoni	patched 1	0.0041	0.0333	0.0549
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0972	0.16
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.008	0.0768	0.1162
Trypanosoma brucei	unspecified product	0.0023	0.0124	0.0385
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0077	0.0739	0.1216
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0956	0.1573
Plasmodium vivax	lysine--tRNA ligase, putative	0.0047	0.0399	0.0399
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.004	0.0318	0.1957
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0129	0.133	0.4143
Schistosoma mansoni	sugar transporter	0.0077	0.0739	0.1216
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Onchocerca volvulus		0.0077	0.0739	0.3712
Brugia malayi	polk-prov protein	0.0036	0.0276	0.0454
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Echinococcus multilocularis	dna polymerase eta	0.0033	0.024	0.0394
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1187	0.1954
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0065	0.0597	0.0982
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0041	0.0126
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0041	0.0041
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0041	0.0041
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0137	0.1413	0.2137
Schistosoma mansoni	ap endonuclease	0.0018	0.0074	0.0122
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Echinococcus multilocularis	short transient receptor potential channel 6	0.0063	0.0576	0.0949
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0313	0.0974
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0074	0.023
Brugia malayi	Protein kinase domain containing protein	0.0035	0.0267	0.0439
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0145	0.0219
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0276	0.086
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0126	0.0208
Chlamydia trachomatis	lysine--tRNA ligase	0.0047	0.0399	0.5191
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0065	0.0597	0.0982
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0074	0.0701	0.2184
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0399	0.245
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Schistosoma mansoni	sugar transporter	0.0077	0.0739	0.1216
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.004	0.0066
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0145	0.0145
Entamoeba histolytica	hypothetical protein	0.0035	0.0264	0.0711
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0333	0.0549
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0597	0.0982
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0145	0.0451
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0077	0.0739	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0913	0.1502
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Trypanosoma brucei	THT1 - hexose transporter, putative	0.017	0.1792	0.5583
Chlamydia trachomatis	DNA gyrase subunit B	0.008	0.0768	1
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Chlamydia trachomatis	DNA gyrase subunit A	0.0029	0.0198	0.2584
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Trypanosoma brucei	THT1 - hexose transporter, putative	0.017	0.1792	0.5583
Schistosoma mansoni	transient receptor potential channel 4	0.0095	0.094	0.1547
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0065	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0041	0.0067
Trypanosoma brucei	THT1 - hexose transporter, putative	0.017	0.1792	0.5583
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0065	0.0597	0.0903
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Schistosoma mansoni	serine/threonine protein kinase	0.0065	0.0597	0.0982
Schistosoma mansoni	hypothetical protein	0.004	0.0317	0.0521
Mycobacterium ulcerans	DNA gyrase subunit A	0.0029	0.0198	0.122
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0074	0.0454
Trypanosoma cruzi	sugar transporter, putative	0.0077	0.0739	0.2302
Giardia lamblia	Flap structure-specific endonuclease	0.0025	0.0154	0.0415
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.008	0.0768	1
Brugia malayi	Major Facilitator Superfamily protein	0.0077	0.0739	0.1216
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0597	0.0982
Onchocerca volvulus		0.0077	0.0739	0.3712
Schistosoma mansoni	hypothetical protein	0.004	0.0317	0.0521
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0077	0.0739	0.9621
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1187	0.1954
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0066
Entamoeba histolytica	protein kinase, putative	0.0065	0.0597	0.1607
Echinococcus multilocularis	General substrate transporter	0.0472	0.5203	0.8563
Schistosoma mansoni	hypothetical protein	0.0549	0.6076	1
Entamoeba histolytica	hypothetical protein	0.0047	0.0399	0.1073
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Giardia lamblia	Lysyl-tRNA synthetase	0.0047	0.0399	0.1073
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0092	0.0911	0.5068
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0956	0.1573
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0041	0.0126
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0145	0.0451
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0065	0.0597	0.0982
Schistosoma mansoni	hypothetical protein	0.004	0.0317	0.0521
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0137	0.1413	0.2326
Leishmania major	lysyl-tRNA synthetase, putative	0.0047	0.0399	0.1242
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0041	0.0067
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.0313	0.0974
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0418	0.0687
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0074	0.0122
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0956	0.2573
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0074	0.023
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.1448	0.4512
Leishmania major	DNA topoisomerase ii	0.0129	0.133	0.4143
Schistosoma mansoni	transient receptor potential channel	0.0063	0.0576	0.0949
Chlamydia trachomatis	DNA gyrase subunit A	0.0029	0.0198	0.2584
Schistosoma mansoni	glucose transport protein	0.0549	0.6076	1
Loa Loa (eye worm)	sugar transporter	0.0549	0.6076	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0065	0.0597	0.0597
Echinococcus multilocularis	geminin	0.0166	0.1742	0.2866
Trichomonas vaginalis	glucose transporter, putative	0.017	0.1792	0.2949
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Echinococcus multilocularis	calcium dependent protein kinase	0.0061	0.0552	0.0908
Schistosoma mansoni	hypothetical protein	0.0035	0.0267	0.0439
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.024	0.0394
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0549	0.6076	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0041	0.0067
Mycobacterium ulcerans	DNA polymerase IV	0.0059	0.0534	0.3282
Schistosoma mansoni	sugar transporter	0.0077	0.0739	0.1216
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0333	0.0549
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0597	0.0982
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Leishmania major	mitochondrial DNA polymerase beta	0.0296	0.3209	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0418	0.0687
Schistosoma mansoni	hypothetical protein	0.0033	0.0243	0.04
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0041	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0035	0.0267	0.0267
Brugia malayi	major facilitator superfamily protein	0.0077	0.0739	0.1216
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0025	0.0154	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0333	0.0549
Onchocerca volvulus		0.0077	0.0739	0.3712
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0549	0.6076	1
Echinococcus multilocularis	protein patched	0.0041	0.0333	0.0549
Schistosoma mansoni	glucose transporter	0.0077	0.0739	0.1216
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0336	0.1046
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0074	0.0122
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0129	0.133	0.4143
Trypanosoma cruzi	hexose transporter, putative	0.017	0.1792	0.5583
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0041	0.0067
Echinococcus multilocularis	lysyl tRNA synthetase	0.0047	0.0399	0.0656
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0063	0.0582	0.1567
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.004	0.0066
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0549	0.6076	1
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0163	0.1706	0.2807
Trypanosoma cruzi	hexose transporter, putative	0.0093	0.0918	0.2862
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Leishmania major	DNA polymerase kappa, putative	0.004	0.0313	0.0974
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0041	0.0067
Schistosoma mansoni	sugar transporter	0.0077	0.0739	0.1216
Brugia malayi	Cam kinase protein 1	0.0065	0.0597	0.0982
Brugia malayi	hypothetical protein	0.0035	0.0264	0.0434
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0267	0.0832
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0035	0.0265	0.0437
Plasmodium falciparum	proline--tRNA ligase	0.0074	0.0701	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0077	0.0739	0.1216
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0418	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Plasmodium vivax	DNA topoisomerase II, putative	0.0137	0.1413	0.1413
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0065	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0041	0.0067
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0137	0.1413	0.2326
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0163	0.1706	0.2807
Onchocerca volvulus		0.0077	0.0739	0.3712
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0029	0.0198	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0739	0.1216
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Echinococcus granulosus	short transient receptor potential channel 6	0.0063	0.0576	0.0949
Echinococcus granulosus	solute carrier family 22	0.0077	0.0739	0.1216
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0333	0.0549
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0264	0.0434
Onchocerca volvulus		0.0077	0.0739	0.3712
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Giardia lamblia	Hexose transporter	0.0077	0.0739	0.1989
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0399	0.0656
Schistosoma mansoni	hypothetical protein	0.0084	0.0816	0.1343
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0033	0.024	0.0394
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Brugia malayi	hypothetical protein	0.0077	0.0739	0.1216
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0077	0.0739	0.0739
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0033	0.024	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0495	0.0815
Brugia malayi	Sugar transporter family protein	0.0077	0.0739	0.1216
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0358	0.3911	0.6438
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Plasmodium vivax	hexose transporter	0.0549	0.6076	0.6076
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0276	0.086
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0065	0.0597	0.0903
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0896	1	1
Entamoeba histolytica	Flap nuclease, putative	0.0025	0.0154	0.0415
Onchocerca volvulus		0.0077	0.0739	0.3712
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0333	0.0549
Chlamydia trachomatis	DNA gyrase subunit B	0.0063	0.0579	0.7533
Brugia malayi	Sugar transporter family protein	0.0549	0.6076	1
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0119	0.1546
Plasmodium vivax	sugar transporter, putative	0.0077	0.0739	0.0739
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0074	0.023
Brugia malayi	hypothetical protein	0.0148	0.1539	0.2532
Echinococcus multilocularis	dna polymerase kappa	0.0059	0.0534	0.0879
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0065	0.0597	0.0982
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0033	0.024	0.0645
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0077	0.0739	0.4542
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0197	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0739	0.1216
Trypanosoma brucei	DNA polymerase IV, putative	0.0053	0.0461	0.1436
Trichomonas vaginalis	glucose transporter, putative	0.0077	0.0739	0.1216
Entamoeba histolytica	hypothetical protein	0.0035	0.0264	0.0711
Echinococcus granulosus	solute carrier family 22	0.0077	0.0739	0.1216
Schistosoma mansoni	transient receptor potential channel	0.0063	0.0576	0.0949
Onchocerca volvulus		0.0148	0.1539	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0264	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0072	0.068	0.112
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0145	0.0451
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0065	0.0597	0.0982
Trypanosoma brucei	DNA polymerase IV, putative	0.0059	0.0534	0.1664
Echinococcus multilocularis	GPCR, family 2	0.0015	0.004	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0448	0.0737
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.004	0.0066
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trichomonas vaginalis	sugar transporter, putative	0.017	0.1792	0.2949
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0549	0.6076	1
Echinococcus multilocularis	solute carrier family 22	0.0077	0.0739	0.1216
Trypanosoma brucei	unspecified product	0.0023	0.0124	0.0385
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0399	0.0657
Trypanosoma brucei	DNA topoisomerase ii	0.0154	0.1602	0.4994
Toxoplasma gondii	sugar transporter ST1	0.0077	0.0739	0.1117
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.004	0.0066
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0079	0.0755	0.1243
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.3209	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0074	0.0701	0.2184
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.004	0.0066
Trypanosoma brucei	unspecified product	0.0053	0.0461	0.1436
Echinococcus granulosus	synaptic vesicle 2 protein	0.0077	0.0739	0.1216
Brugia malayi	Transient-receptor-potential like protein	0.0035	0.0265	0.0437
Onchocerca volvulus		0.0077	0.0739	0.3712
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0047	0.0399	0.1242
Leishmania major	glucose transporter/membrane transporter D2, putative	0.017	0.1792	0.5583
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.1792	0.2949
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0145	0.0145
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0092	0.0911	0.5068
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0265	0.0437
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0549	0.6076	1
Onchocerca volvulus	Putative transporter	0.0077	0.0739	0.3712
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Giardia lamblia	DNA topoisomerase II	0.013	0.1332	0.3587
Schistosoma mansoni	glucose transport protein	0.0549	0.6076	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0065	0.0597	0.0982
Giardia lamblia	DINP protein human, muc B family	0.004	0.0313	0.0842
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0041	0.0067
Schistosoma mansoni	protein kinase	0.0065	0.0597	0.0982
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0399	0.0656
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0074	0.0199
Brugia malayi	lysyl-tRNA synthetase	0.0047	0.0399	0.0656
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0047	0.0399	0.1242
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0333	0.0549
Trichomonas vaginalis	myo-inositol transporter, putative	0.0077	0.0739	0.1216
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0065	0.0597	0.186
Plasmodium vivax	DNA gyrase subunit B, putative	0.008	0.0768	0.0768
Echinococcus granulosus	dna polymerase kappa	0.0059	0.0534	0.0879
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0033	0.024	0.0394
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0154	0.1602	0.4994
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0047	0.0399	0.6849
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0074	0.0962
Plasmodium falciparum	DNA gyrase subunit A	0.0029	0.0198	0.0198
Trypanosoma brucei	DNA polymerase IV, putative	0.0059	0.0534	0.1664
Brugia malayi	Probable DNA topoisomerase II	0.0137	0.1413	0.2326
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0041	0.0126
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0074	0.023
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.016	0.0263
Giardia lamblia	Sugar-proton symporter	0.0077	0.0739	0.1989
Echinococcus granulosus	TRP transient receptor potential channel	0.0035	0.0265	0.0437
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0041	0.0249
Toxoplasma gondii	lysine-tRNA ligase	0.0047	0.0399	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Toxoplasma gondii	sugar transporter ST3	0.0077	0.0739	0.1117
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0267	0.0439
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0065	0.0597	0.0982
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0582	0.0958
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0025	0.0154	0.048
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.0313	0.1921
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0097	0.0961	0.2586
Echinococcus granulosus	dna polymerase eta	0.0033	0.024	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0597	0.0982
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0074	0.0962
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0145	0.0145
Plasmodium falciparum	flap endonuclease 1	0.0025	0.0154	0.0154
Brugia malayi	CHE-14 protein	0.0041	0.0333	0.0549
Schistosoma mansoni	protein kinase	0.0065	0.0597	0.0982
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0029	0.0198	0.2584
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.1448	0.4512
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0549	0.6076	1
Onchocerca volvulus		0.0077	0.0739	0.3712
Echinococcus multilocularis	solute carrier family 22	0.0077	0.0739	0.1216
Toxoplasma gondii	sugar transporter ST2	0.0077	0.0739	0.1117
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0077	0.0739	0.1216
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0063	0.0582	0.0958
Schistosoma mansoni	hypothetical protein	0.0166	0.1742	0.2866
Trypanosoma cruzi	hexose transporter, putative	0.0077	0.0739	0.2302
Leishmania major	myo-inositol/proton symporter (MIT)	0.0077	0.0739	0.2302
Brugia malayi	MH2 domain containing protein	0.0117	0.1187	0.1954
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0077	0.0739	0.1216
Mycobacterium ulcerans	integral membrane transport protein	0.0077	0.0739	0.4542
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0074	0.0122
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0022	0.0119	0.073
Echinococcus granulosus	calcium dependent protein kinase	0.0061	0.0552	0.0908
Echinococcus multilocularis	transient receptor potential ion channel A	0.0092	0.0904	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0078	0.0129
Echinococcus granulosus	expressed conserved protein	0.009	0.0889	0.1464
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0033	0.024	0.1473
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0065	0.0597	0.0597
Trichomonas vaginalis	glucose transporter, putative	0.017	0.1792	0.2949
Brugia malayi	Sugar transporter family protein	0.0077	0.0739	0.1216
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma cruzi	hexose transporter	0.017	0.1792	0.5583
Brugia malayi	Major Facilitator Superfamily protein	0.0077	0.0739	0.1216
Echinococcus granulosus	short transient receptor potential channel 6	0.0063	0.0576	0.0949
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.1627	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.094	0.1547
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.1423	0.2343
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Brugia malayi	hypothetical protein	0.0077	0.0739	0.1216
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Echinococcus granulosus	solute carrier family 22	0.0077	0.0739	0.1216
Onchocerca volvulus		0.0077	0.0739	0.3712
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0243	0.04
Trypanosoma cruzi	hexose transporter, putative	0.017	0.1792	0.5583
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0358	0.3911	0.6438
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0418	0.0687
Brugia malayi	hypothetical protein	0.0025	0.0145	0.0238
Brugia malayi	Cache domain containing protein	0.0072	0.068	0.112
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Trichomonas vaginalis	sugar transporter, putative	0.017	0.1792	0.2949
Brugia malayi	ImpB/MucB/SamB family protein	0.0033	0.024	0.0394
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Trypanosoma cruzi	glucose transporter, putative	0.0077	0.0739	0.2302
Plasmodium vivax	proline--tRNA ligase, putative	0.0074	0.0701	0.0701
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0739	0.1216
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0029	0.0198	0.122
Schistosoma mansoni	ap endonuclease	0.0018	0.0074	0.0122
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0041	0.0067
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0077	0.0739	0.4542
Chlamydia trachomatis	proline--tRNA ligase	0.0022	0.0119	0.1546
Trichomonas vaginalis	DNA polymerase eta, putative	0.0059	0.0534	0.0879
Leishmania major	hypothetical protein, conserved	0.0025	0.0145	0.0451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Leishmania major	glucose transporter, lmgt3	0.017	0.1792	0.5583
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0549	0.6076	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0913	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Trypanosoma brucei	glucose transporter 2A	0.017	0.1792	0.5583
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0582	0.0958
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0065	0.0597	0.0597
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0065	0.0597	0.0597
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0063	0.0582	0.0958
Leishmania major	hypothetical protein, conserved	0.0035	0.0267	0.0832
Brugia malayi	hypothetical protein	0.0077	0.0739	0.1216
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0074	0.0701	0.2184
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0077	0.0739	0.4542
Echinococcus multilocularis	solute carrier family 22	0.0077	0.0739	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0495	0.0815
Entamoeba histolytica	hypothetical protein	0.0035	0.0264	0.0711
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	0.3209	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Plasmodium falciparum	DNA topoisomerase 2	0.0137	0.1413	0.1413
Echinococcus granulosus	General substrate transporter	0.0472	0.5203	0.8563
Mycobacterium ulcerans	hypothetical protein	0.0156	0.1627	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0582	0.0958
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0129	0.133	0.4143
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0129	0.133	0.4143
Echinococcus granulosus	lysyl tRNA synthetase	0.0047	0.0399	0.0656
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0582	0.0958
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0264	0.0434
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0296	0.3209	1
Echinococcus granulosus	geminin	0.0166	0.1742	0.2866
Echinococcus granulosus	transient receptor potential gamma protein	0.0095	0.094	0.1547
Trypanosoma brucei	DNA polymerase eta, putative	0.0033	0.024	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Brugia malayi	major facilitator superfamily protein	0.0077	0.0739	0.1216
Leishmania major	glucose transporter, lmgt1	0.017	0.1792	0.5583
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0077	0.0739	0.2302
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0243	0.04
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Trypanosoma cruzi	hexose transporter, putative	0.017	0.1792	0.5583
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Trichomonas vaginalis	conserved hypothetical protein	0.0549	0.6076	1
Plasmodium falciparum	protein kinase 7	0.0596	0.6612	0.6612
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Loa Loa (eye worm)	hypothetical protein	0.006	0.0541	0.089
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0956	0.1573
Plasmodium vivax	DNA gyrase subunit A, putative	0.0029	0.0198	0.0198
Schistosoma mansoni	hypothetical protein	0.0166	0.1742	0.2866
Echinococcus multilocularis	solute carrier family 22	0.0077	0.0739	0.1216
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0063	0.0582	0.0958
Echinococcus granulosus	flap endonuclease 1	0.0025	0.0154	0.0253
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0041	0.0126
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Loa Loa (eye worm)	sugar transporter	0.0077	0.0739	0.1216
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0156	0.1631	0.2684
Trichomonas vaginalis	flap endonuclease-1, putative	0.0025	0.0154	0.0253
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.008	0.0768	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0197	0.0612
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0074	0.0074
Loa Loa (eye worm)	TK/ROR protein kinase	0.0035	0.0267	0.0439
Echinococcus granulosus	GPCR family 2	0.0015	0.004	0.0066
Onchocerca volvulus		0.0077	0.0739	0.3712
Echinococcus granulosus	tissue type plasminogen activator	0.0035	0.0267	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0276	0.0454
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.004	0.0066
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.024	0.0746
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0154	0.1602	0.4994
Toxoplasma gondii	transporter, major facilitator family protein	0.0077	0.0739	0.1117
Onchocerca volvulus		0.0077	0.0739	0.3712
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0074	0.0074
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0078	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1539	0.2532
Plasmodium falciparum	DNA gyrase subunit B	0.008	0.0768	0.0768
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0341	0.3724	0.3724
Brugia malayi	Major Facilitator Superfamily protein	0.0077	0.0739	0.1216
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.1423	0.2343
Leishmania major	DNA polymerase eta, putative	0.0033	0.024	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0137	0.1413	0.2326
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0065	0.0597	0.0597
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0341	0.3724	0.3724
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0137	0.1413	0.2326
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0956	0.1573
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0318	0.5469
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0145	0.0238
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0074	0.0199
Echinococcus multilocularis	expressed conserved protein	0.009	0.0889	0.1464
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0264	0.0434
Schistosoma mansoni	hypothetical protein	0.0035	0.0264	0.0434
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0041	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0036	0.0268	0.46
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0065	0.0597	0.0597
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0041	0.0333	0.0548
Schistosoma mansoni	transient receptor potential channel	0.0095	0.094	0.1547
Entamoeba histolytica	DNA topoisomerase II, putative	0.0137	0.1413	0.3804
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0059	0.0534	0.0879
Echinococcus multilocularis	transient receptor potential gamma protein	0.0095	0.094	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Mycobacterium ulcerans	DNA polymerase IV	0.0059	0.0534	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0399	0.0656
Schistosoma mansoni	DNA polymerase eta	0.0033	0.024	0.0394
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0065	0.0597	0.0597
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.004	0.0066
Leishmania major	protein kinase, putative	0.0065	0.0597	0.186
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.1792	0.2949
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0336	0.1046
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0029	0.0198	0.2584
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0041	0.0061
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0025	0.0154	0.048
Entamoeba histolytica	hypothetical protein	0.0097	0.0961	0.2586
Toxoplasma gondii	facilitative glucose transporter GT1	0.0549	0.6076	0.9189
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0399	0.245
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0074	0.0701	0.106
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0739	0.1216
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0197	0.0612
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0336	0.1046
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0077	0.0739	0.1216
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0025	0.0154	0.048
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.034	0.3714	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0739	0.1216
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0063	0.0582	1
Toxoplasma gondii	exonuclease III APE	0.0018	0.0074	0.0112
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0065	0.0597	0.0903
Schistosoma mansoni	protein kinase	0.0065	0.0597	0.0982
Onchocerca volvulus		0.0077	0.0739	0.3712
Trypanosoma brucei	glucose transporter 1E	0.017	0.1792	0.5583
Schistosoma mansoni	hypothetical protein	0.004	0.0317	0.0521
Leishmania major	hypothetical protein, conserved	0.0077	0.0739	0.2302
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0047	0.0399	0.0656
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.1448	0.4512
Loa Loa (eye worm)	TOPoisomerase family member	0.0137	0.1413	0.2326
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Schistosoma mansoni	glucose transport protein	0.0549	0.6076	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0074	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0439	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0033	0.024	0.0394
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0439	0.1367
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0318	0.1957
Trypanosoma brucei	sugar transporter, putative	0.0077	0.0739	0.2302
Onchocerca volvulus		0.0077	0.0739	0.3712
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0229	0.0378
Plasmodium vivax	flap endonuclease 1, putative	0.0025	0.0154	0.0154
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Mycobacterium ulcerans	sugar transporter	0.0077	0.0739	0.4542
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0549	0.6076	1
Entamoeba histolytica	protein kinase, putative	0.0065	0.0597	0.1607
Schistosoma mansoni	DNA topoisomerase II	0.0137	0.1413	0.2326
Leishmania major	glucose transporter, lmgt2	0.017	0.1792	0.5583
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0066
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0065	0.0597	0.0982
Brugia malayi	hypothetical protein	0.0016	0.0046	0.0075
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0336	0.1046
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0137	0.1413	0.2326
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0074	0.0122
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0739	0.1216
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.008	0.0768	0.4721
Trichomonas vaginalis	CAMK family protein kinase	0.0065	0.0597	0.0982
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0074	0.0122
Brugia malayi	Flap endonuclease-1	0.0025	0.0154	0.0253
Trichomonas vaginalis	sugar transporter, putative	0.017	0.1792	0.2949
Echinococcus multilocularis	short transient receptor potential channel 6	0.0063	0.0576	0.0949
Schistosoma mansoni	serine-rich repeat protein	0.0084	0.0816	0.1343
Toxoplasma gondii	hypothetical protein	0.0048	0.0405	0.0612
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0066
Trichomonas vaginalis	sugar transport protein, putative	0.0077	0.0739	0.1216
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0341	0.3724	0.5632
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0078	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0582	0.0958
Echinococcus granulosus	solute carrier family 22	0.0077	0.0739	0.1216
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0074	0.0701	0.2184
Leishmania major	mitochondrial DNA topoisomerase II	0.0154	0.1602	0.4994
Giardia lamblia	DNA repair protein RAD52	0.034	0.3714	1
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Plasmodium falciparum	lysine--tRNA ligase	0.0047	0.0399	0.0399
Plasmodium falciparum	hexose transporter	0.0549	0.6076	0.6076
Onchocerca volvulus		0.0077	0.0739	0.3712
Echinococcus multilocularis	tissue type plasminogen activator	0.0035	0.0267	0.0439
Echinococcus granulosus	transient receptor potential ion channel A	0.0092	0.0904	0.1488
Onchocerca volvulus		0.0077	0.0739	0.3712
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0033	0.024	0.0394
Echinococcus multilocularis	flap endonuclease 1	0.0025	0.0154	0.0253
Schistosoma mansoni	hypothetical protein	0.0015	0.004	0.0066
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0074	0.0701	0.2184
Onchocerca volvulus		0.0077	0.0739	0.3712
Trypanosoma brucei	DNA polymerase kappa, putative	0.0059	0.0534	0.1664
Loa Loa (eye worm)	flap endonuclease-1	0.0025	0.0154	0.0253
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0017	0.0055	0.0083
Giardia lamblia	Prolyl-tRNA synthetase	0.0063	0.0582	0.1567
Toxoplasma gondii	protein kinase, putative	0.0596	0.6612	1
Trichomonas vaginalis	sugar transporter, putative	0.0077	0.0739	0.1216
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0077	0.0739	0.4542
Brugia malayi	Kringle domain containing protein	0.0035	0.0267	0.0439
Trypanosoma brucei	glucose transporter, putative	0.017	0.1792	0.5583
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0041	0.0067
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0074	0.0454
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0033	0.024	0.0394

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	= 17.6 uM h	Area under the curve time curve value of the compound in sprague dawley rat was determined at a dosage of 3 mg/kg	ChEMBL.	15582418
CI (ADMET)	= 3.31 l hr-1 kg-1	Clearance value of the compound in sprague dawley rat was determined at a dosage of 3 mg/kg	ChEMBL.	15582418
F (ADMET)	= 18 %	Bioavailability in rat (Sprague-Dawley) (dose 10 mg/kg)	ChEMBL.	15582418
Ki (binding)	uM	Binding affinity value against Tissue plasminogen activator; NT means not tested	ChEMBL.	15582418
Ki (binding)	uM	Binding affinity value against trypsin; NT means not tested	ChEMBL.	15582418
Ki (binding)	uM	Binding affinity value against kallikrein; NT means not tested	ChEMBL.	15582418
Ki (binding)	uM	Binding affinity value against plasmin; NT means not tested	ChEMBL.	15582418
Ki (binding)	0 uM	Binding affinity value against Tissue plasminogen activator; NT means not tested	ChEMBL.	15582418
Ki (binding)	0 uM	Binding affinity value against thrombin; NT means not tested	ChEMBL.	15582418
Ki (binding)	0 uM	Binding affinity value against plasmin; NT means not tested	ChEMBL.	15582418
Ki (binding)	0 uM	Binding affinity value against kallikrein; NT means not tested	ChEMBL.	15582418
Ki (binding)	0 uM	Binding affinity value against trypsin; NT means not tested	ChEMBL.	15582418
Ki (binding)	= 0.731 uM	Binding affinity value against urokinase plasminogen activator	ChEMBL.	15582418
Ki (binding)	= 0.731 uM	Binding affinity value against urokinase plasminogen activator	ChEMBL.	15582418
T1/2 (ADMET)	0 hr	Terminal half life value of the compound in sprague dawley rat was determined at a dosage of 3 mg/kg; NT means not tested	ChEMBL.	15582418
Vd (ADMET)	= 1.53 l kg-1	Volume distribution value of the compound in sprague dawley rat was determined at a dosage of 3 mg/kg	ChEMBL.	15582418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL182546

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 321200