Detailed information for compound 321690

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.376 | Formula: C22H17NO2
  • H donors: 0 H acceptors: 2 LogP: 4.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1)Oc1cccc(c1)C#Cc1cccc(n1)C
  • InChi: 1S/C22H17NO2/c1-17-7-5-11-20(23-17)14-13-19-10-6-12-21(15-19)25-22(24)16-18-8-3-2-4-9-18/h2-12,15H,16H2,1H3
  • InChiKey: RJINFAHMSRSECM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0125 0.0104
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0117 0.0868
Loa Loa (eye worm) glutamate receptor 0.0049 0.0381 0.1047
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0279 0.0305
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0149 0.0151
Echinococcus granulosus snurportin 1 0.0303 0.3643 0.4275
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0149 0.0151
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0468 0.0527
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0032 0.0169 0.0175
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0149 0.0151
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0116 0.1239 0.1438
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0378 0.0421
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0149 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.013 0.0357
Echinococcus granulosus poly ADP ribose polymerase 1 0.0141 0.1569 0.1827
Plasmodium vivax JmjC domain containing protein 0.0031 0.0149 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.01 0.1035 0.3174
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1129 0.7161
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0021 0.0026 0.0005
Brugia malayi RNA, U transporter 1 0.0081 0.0789 0.2404
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.01 0.1035 0.3174
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0383 0.1133
Brugia malayi jmjC domain containing protein 0.0031 0.0149 0.0401
Mycobacterium ulcerans glutaminase 0.0269 0.3215 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0125 0.0325
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0116 0.0112
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0527 0.0597
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0116 0.1239 0.1438
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.013 0.0129
Entamoeba histolytica hypothetical protein 0.0022 0.0035 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1265 0.3472
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0383 0.1133
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0149 0.0409
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0527 0.0597
Loa Loa (eye worm) hypothetical protein 0.006 0.0527 0.1446
Brugia malayi glutaminase DH11.1 0.0269 0.3215 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0147 0.164 0.1622
Brugia malayi WGR domain containing protein 0.0078 0.075 0.2284
Loa Loa (eye worm) glutaminase 0.0269 0.3215 0.8826
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0078 0.075 0.6582
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0125 0.8093
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0117 0.0096
Loa Loa (eye worm) hypothetical protein 0.01 0.1035 0.2841
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1129 1
Schistosoma mansoni importin beta-1 0.0028 0.0117 0.0114
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0048 0.0085
Onchocerca volvulus 0.0049 0.0378 0.1294
Loa Loa (eye worm) hypothetical protein 0.0031 0.0149 0.0409
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0125 0.5
Onchocerca volvulus 0.01 0.1035 0.3709
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1129 0.7161
Onchocerca volvulus 0.0029 0.013 0.0383
Entamoeba histolytica hypothetical protein 0.0023 0.0048 0.0176
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0125 0.0325
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0149 0.0151
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0078 0.075 0.0861
Echinococcus granulosus lysine specific demethylase 5A 0.0116 0.1239 0.1438
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0125 0.0325
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.013 0.0129
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0149 0.1157
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0149 0.0151
Brugia malayi ShTK domain containing protein 0.01 0.1035 0.3174
Onchocerca volvulus 0.01 0.1035 0.3709
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0125 0.0325
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0383 0.1051
Leishmania major hypothetical protein, conserved 0.0031 0.0149 0.1157
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.0021 0.0026 0.0005
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0149 0.0128
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1129 1
Loa Loa (eye worm) ShTK domain-containing protein 0.01 0.1035 0.2841
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0125 0.8093
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0381 0.1129
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1129 0.3471
Brugia malayi jmjC domain containing protein 0.0031 0.0149 0.0401
Trichomonas vaginalis glutaminase, putative 0.0269 0.3215 1
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0141 0.1569 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0048 0.0085
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0125 0.0325
Echinococcus granulosus importin subunit beta 1 0.0028 0.0117 0.0114
Loa Loa (eye worm) hypothetical protein 0.0049 0.0378 0.1037
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.052 0.0589
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0035 0.0016
Echinococcus granulosus tumor protein p63 0.0332 0.4023 0.4724
Schistosoma mansoni glutaminase 0.0269 0.3215 0.377
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.052 0.0589
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0048 0.0246
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0125 0.5
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1129 0.1308
Loa Loa (eye worm) hypothetical protein 0.0031 0.0149 0.0409
Brugia malayi prolyl 4-hydroxylase 0.0021 0.0026 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0149 0.0409
Loa Loa (eye worm) hypothetical protein 0.0049 0.0383 0.1051
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1265 0.3472
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0149 0.0151
Brugia malayi Common central domain of tyrosinase family protein 0.01 0.1035 0.3174
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.0021 0.0026 0.0005
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0021 0.0026 0.0044
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0048 0.0085
Onchocerca volvulus 0.01 0.1035 0.3709
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1129 0.7161
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1129 0.1308
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0321
Loa Loa (eye worm) jmjC domain-containing protein 0.0116 0.1239 0.3402
Loa Loa (eye worm) ShTK domain-containing protein 0.01 0.1035 0.2841
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0117 0.0868
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0149 0.0151
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0078 0.075 0.0861
Plasmodium vivax SET domain protein, putative 0.0029 0.013 0.8506
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0149 0.0151
Loa Loa (eye worm) hypothetical protein 0.01 0.1035 0.2841
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0056 0.0468 0.1286
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1129 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1129 0.3471
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.013 0.0129
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0149 0.0151
Onchocerca volvulus 0.0233 0.2746 1
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.0021 0.0026 0.0044
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1129 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1129 0.3471
Echinococcus granulosus geminin 0.0167 0.1899 0.2217
Echinococcus granulosus phd:f box containing protein 0.0031 0.0149 0.0151
Echinococcus multilocularis microtubule associated protein 2 0.068 0.8493 1
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1129 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0149 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.1239 0.1438
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2383 0.6541
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0057
Schistosoma mansoni hypothetical protein 0.0167 0.1899 0.2217
Brugia malayi jmjC domain containing protein 0.0116 0.1239 0.3814
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.0021 0.0026 0.0006
Brugia malayi phosphofructokinase 0.0107 0.1129 0.3471
Echinococcus multilocularis tumor protein p63 0.0332 0.4023 0.4724
Brugia malayi jmjC domain containing protein 0.0031 0.0149 0.0401
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0149 0.0151
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0125 0.8093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0149 0.1157
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0149 0.0151
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1129 0.2261
Schistosoma mansoni hypothetical protein 0.0033 0.0183 0.0192
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1129 0.3101
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1129 0.3101
Brugia malayi 6-phosphofructokinase 0.0107 0.1129 0.3471
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.0021 0.0026 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0183 0.0503
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.013 0.0129
Leishmania major hypothetical protein, unknown function 0.0021 0.0026 0.0044
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1129 1
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.01 0.1035 0.3174
Leishmania major hypothetical protein, conserved 0.0021 0.0026 0.0044
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0059 0.0045
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0149 0.1157
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0183 0.0509
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.052 0.05
Brugia malayi MH2 domain containing protein 0.0118 0.1265 0.3894
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0071
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0322 0.0944
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.01 0.1035 0.3174
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0141 0.1569 0.1827
Echinococcus granulosus WGR domain containing protein 0.0044 0.0317 0.0349
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0125 0.0325
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.1239 0.1438
Onchocerca volvulus 0.01 0.1035 0.3709
Plasmodium vivax importin-beta 2, putative 0.0028 0.0117 0.7504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.013 0.0129
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.052 0.0589
Echinococcus granulosus poly adp ribose polymerase 2 0.0078 0.075 0.0861
Schistosoma mansoni tyrosinase precursor 0.0474 0.5842 0.6871
Brugia malayi jmjC domain containing protein 0.0116 0.1239 0.3814
Loa Loa (eye worm) hypothetical protein 0.0108 0.1135 0.3116
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.052 0.4503
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1129 0.1308
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0125 0.0325
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.013 0.0129
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0141 0.1569 0.1827
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0078 0.075 0.6582
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0125 0.0104
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1129 0.3101
Echinococcus multilocularis lysine specific demethylase 5A 0.0116 0.1239 0.1438
Echinococcus granulosus microtubule associated protein 2 0.068 0.8493 1
Schistosoma mansoni hypothetical protein 0.0167 0.1899 0.2217
Schistosoma mansoni jumonji domain containing protein 0.0116 0.1239 0.1438
Trypanosoma brucei poly(adp-ribose) polymerase 0.0078 0.075 0.6582
Brugia malayi 6-phosphofructokinase 0.0107 0.1129 0.3471
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.013 0.0129
Schistosoma mansoni tyrosinase precursor 0.0474 0.5842 0.6871
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0035 0.0016
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.3643 1
Schistosoma mansoni microtubule-associated protein tau 0.068 0.8493 1
Echinococcus granulosus poly (ADP ribose) polymerase 0.0044 0.0317 0.0349
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0149 0.0151
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0035 0.0016
Echinococcus multilocularis snurportin 1 0.0303 0.3643 0.4275
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.052 0.0589
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0279 0.0305
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0149 0.0409
Loa Loa (eye worm) glutaminase 2 0.0269 0.3215 0.8826
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0125 0.0104
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.0021 0.0026 0.0006
Plasmodium falciparum importin beta, putative 0.0028 0.0117 0.7504
Echinococcus multilocularis geminin 0.0167 0.1899 0.2217
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1129 0.1308
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0021 0.0026 0.0044
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0125 0.8093
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0125 0.067
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0059 0.012
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0117 0.0114
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0067 0.0616 0.0702
Brugia malayi Importin beta-1 subunit 0.0028 0.0117 0.0301
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0021 0.0026 0.0005
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.0021 0.0026 0.0006
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0125 1
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0279 0.0305
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.013 0.0109
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0149 0.0128
Loa Loa (eye worm) hypothetical protein 0.0078 0.075 0.206
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0149 0.0151
Brugia malayi Pre-SET motif family protein 0.0205 0.2383 0.7394
Loa Loa (eye worm) tyrosinase 1 0.01 0.1035 0.2841
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1129 0.3471
Loa Loa (eye worm) hypothetical protein 0.0031 0.0149 0.0409
Schistosoma mansoni hypothetical protein 0.0303 0.3643 0.4275
Brugia malayi WGR domain containing protein 0.0141 0.1569 0.4846
Brugia malayi jmjC domain containing protein 0.0031 0.0149 0.0401
Leishmania major importin beta-1 subunit, putative 0.0023 0.0048 0.0246
Brugia malayi Pre-SET motif family protein 0.0029 0.013 0.0341
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2746 0.8532

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.74 uM Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay ChEMBL. 15686891
IC50 (binding) = 0.74 uM Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay ChEMBL. 15686891

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.