Detailed information for compound 325840

Basic information

Technical information
  • TDR Targets ID: 325840
  • Name: (5Z)-5-[(5-chloro-2-phenylmethoxyphenyl)methy lidene]-1,3-thiazolidine-2,4-dione
  • MW: 345.8 | Formula: C17H12ClNO3S
  • H donors: 1 H acceptors: 2 LogP: 4.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)/C(=C/c2cc(Cl)ccc2OCc2ccccc2)/S1
  • InChi: 1S/C17H12ClNO3S/c18-13-6-7-14(22-10-11-4-2-1-3-5-11)12(8-13)9-15-16(20)19-17(21)23-15/h1-9H,10H2,(H,19,20,21)/b15-9-
  • InChiKey: OVELZDQGMGPZBH-DHDCSXOGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[(2-benzyloxy-5-chloro-phenyl)methylene]thiazolidine-2,4-dione
  • (5Z)-5-[(2-benzyloxy-5-chlorophenyl)methylene]thiazolidine-2,4-dione
  • (5Z)-5-[(5-chloro-2-phenylmethoxy-phenyl)methylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-5-(2-benzoxy-5-chloro-benzylidene)thiazolidine-2,4-quinone
  • (5Z)-5-[[5-chloro-2-(phenylmethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-5-[[5-chloro-2-(phenylmethoxy)phenyl]methylene]thiazolidine-2,4-dione
  • (5Z)-5-[2-(benzyloxy)-5-chloro-benzylidene]thiazolidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0894 0.1328
Echinococcus granulosus serine:threonine protein kinase Nek1 0.0035 0.0387 0.0387
Schistosoma mansoni serine/threonine protein kinase 0.024 0.5377 0.5377
Schistosoma mansoni serine/threonine protein kinase 0.0362 0.8326 0.8326
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1893 0.1893
Brugia malayi Protein kinase c protein 2 0.0021 0.0049 0.0051
Brugia malayi Protein kinase domain containing protein 0.0082 0.153 0.1587
Loa Loa (eye worm) AGC/PKN protein kinase 0.0082 0.153 0.1544
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0894 0.0761
Brugia malayi Hr1 repeat family protein 0.0082 0.153 0.1587
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0894 0.0894
Giardia lamblia Kinase, STE STE20 0.0152 0.3234 0.6086
Brugia malayi Raf kinase 0.0416 0.9637 1
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0431 1 1
Brugia malayi map kinase activated protein kinase protein 2 0.0362 0.8326 0.864
Echinococcus multilocularis rac serine:threonine kinase 0.0159 0.34 0.34
Trypanosoma cruzi SNF1-related protein kinase regulatory subunit beta, putative 0.0112 0.2258 0.6209
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0231 0.5145 0.5193
Trichomonas vaginalis AGC family protein kinase 0.0235 0.5244 1
Loa Loa (eye worm) raf kinase 0.0427 0.9908 1
Schistosoma mansoni protein kinase subunit beta 0.0112 0.2258 0.2258
Trichomonas vaginalis AGC family protein kinase 0.0235 0.5244 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0894 0.0761
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0152 0.3234 0.3264
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0894 0.168
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0152 0.3234 0.3356
Echinococcus granulosus neuroglian 0.0023 0.01 0.01
Echinococcus multilocularis protein kinase c iota type 0.0097 0.1893 0.1893
Brugia malayi putative serine/threonine kinase SADA gamma 0.0051 0.0766 0.0795
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0112 0.2258 0.2343
Brugia malayi loechrig isoform VII 0.0224 0.497 0.5158
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0159 0.34 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0362 0.8326 0.8403
Brugia malayi C1-like domain containing protein 0.0021 0.0049 0.0051
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0894 0.0894
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.024 0.5377 0.5377
Entamoeba histolytica protein kinase, putative 0.0235 0.5244 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0302 0.6862 0.7121
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0021 0.0049 0.0049
Giardia lamblia Kinase, CAMK CAMKL 0.0051 0.0766 0.052
Echinococcus multilocularis carboxylesterase 5A 0.0078 0.1434 0.1434
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.153 0.153
Giardia lamblia 5-AMP-activated protein kinase, beta-1 subunit 0.0112 0.2258 0.3884
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.34 0.6083
Trichomonas vaginalis AGC family protein kinase 0.0235 0.5244 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0894 0.0761
Onchocerca volvulus Alicorn homolog 0.0098 0.1914 0.2998
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0766 0.0766
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0041 0.0535 0.0491
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0082 0.153 0.153
Echinococcus multilocularis serine threonine protein kinase 0.0082 0.153 0.153
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0894 0.0761
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Loa Loa (eye worm) hypothetical protein 0.0044 0.0618 0.0624
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0021 0.0049 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Brugia malayi protein kinase C II. 0.0097 0.1893 0.1965
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Entamoeba histolytica protein kinase, putative 0.0235 0.5244 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0894 0.168
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0894 0.168
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0041 0.0535 0.0491
Echinococcus granulosus serine threonine protein kinase nrc 0.0155 0.3301 0.3301
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0155 0.3301 0.3301
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Schistosoma mansoni protein kinase 0.0152 0.3234 0.3234
Trichomonas vaginalis STE family protein kinase 0.0152 0.3234 0.5733
Trichomonas vaginalis STE family protein kinase 0.0152 0.3234 0.5733
Echinococcus multilocularis serine:threonine protein kinase 38 0.0082 0.153 0.153
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0766 0.0766
Echinococcus multilocularis acetylcholinesterase 0.0078 0.1434 0.1434
Brugia malayi protein kinase C3,putative 0.0021 0.0049 0.0051
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0894 0.0894
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0362 0.8326 0.8326
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0021 0.0049 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.153 0.153
Echinococcus granulosus serine:threonine protein kinase N2 0.0082 0.153 0.153
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.021 0.4634 0.4634
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.1434 0.1434
Brugia malayi hypothetical protein 0.0044 0.0618 0.0641
Trichomonas vaginalis AGC family protein kinase 0.0235 0.5244 1
Trichomonas vaginalis AGC family protein kinase 0.0235 0.5244 1
Trichomonas vaginalis STE family protein kinase 0.0152 0.3234 0.5733
Loa Loa (eye worm) hypothetical protein 0.0029 0.0246 0.0248
Schistosoma mansoni protein kinase subunit gamma 0.0224 0.497 0.497
Echinococcus multilocularis raf serine:threonine protein kinase 0.0431 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0894 0.0902
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0155 0.3301 0.3301
Schistosoma mansoni protein kinase subunit beta 0.006 0.0997 0.0997
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.024 0.5377 0.5426
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0535 0.0535
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0894 0.0777
Echinococcus granulosus serine/threonine protein kinase 0.0159 0.34 0.34
Trichomonas vaginalis AGC family protein kinase 0.0235 0.5244 1
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0152 0.3234 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.34 0.6083
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0152 0.3234 0.5733
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0131 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0051 0.0766 0.1256
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0149 0.3153 0.3153
Echinococcus granulosus Protein kinase C brain isozyme 0.0097 0.1893 0.1893
Trypanosoma cruzi Protein kinase B 0.0159 0.34 1
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0112 0.2258 0.2343
Trichomonas vaginalis AGC family protein kinase 0.0235 0.5244 1
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0051 0.0766 0.1256
Schistosoma mansoni serine/threonine kinase 0.0082 0.153 0.153
Schistosoma mansoni cell adhesion molecule 0.0024 0.0131 0.0131
Echinococcus multilocularis roundabout 2 0.0029 0.0246 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.153 0.153
Entamoeba histolytica protein kinase, putative 0.0231 0.5145 0.979
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.153 0.153
Trichomonas vaginalis AGC family protein kinase 0.0086 0.1628 0.2322
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0082 0.153 0.153
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Loa Loa (eye worm) hypothetical protein 0.0024 0.0131 0.0133
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0894 0.0808
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0082 0.153 0.153
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0049 0.0049
Echinococcus granulosus roundabout 2 0.0029 0.0246 0.0246
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0152 0.3234 0.9452
Echinococcus multilocularis Glutaredoxin protein 5 0.0149 0.3153 0.3153
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0021 0.0049 0.005
Trypanosoma brucei protein kinase, putative 0.0056 0.0894 0.0761
Loa Loa (eye worm) AGC/AKT protein kinase 0.0235 0.5244 0.5292
Trypanosoma brucei SNF1-related protein kinases, putative 0.0051 0.0766 0.0489
Entamoeba histolytica protein kinase, putative 0.0082 0.153 0.2112
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.024 0.5377 0.5579
Loa Loa (eye worm) carboxylesterase 0.0078 0.1434 0.1447
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.153 0.153
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.34 0.34
Echinococcus multilocularis nervana 2 0.0149 0.3153 0.3153
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0894 0.0761
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0155 0.3301 0.9672
Loa Loa (eye worm) hypothetical protein 0.0078 0.1434 0.1447
Loa Loa (eye worm) hypothetical protein 0.0078 0.1434 0.1447
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0766 0.0766
Trichomonas vaginalis AGC family protein kinase 0.0082 0.153 0.2112
Echinococcus granulosus nervana 2 0.0149 0.3153 0.3153
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0041 0.0535 0.0491
Echinococcus granulosus protein kinase C gamma type 0.0082 0.153 0.153
Brugia malayi Carboxylesterase family protein 0.0078 0.1434 0.1488
Echinococcus multilocularis dual specificity mitogen activated protein 0.0152 0.3234 0.3234
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0224 0.497 0.497
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0894 0.168
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0051 0.0766 0.0766
Schistosoma mansoni atypical protein kinase C 0.0097 0.1893 0.1893
Toxoplasma gondii 5'-AMP-activated protein kinase subunit beta-1 family protein, putative 0.0066 0.1143 0.1318
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0894 0.1328
Echinococcus granulosus protein kinase c iota type 0.0097 0.1893 0.1893
Echinococcus granulosus AMPK beta subunit 0.0112 0.2258 0.2258
Echinococcus granulosus NDR protein kinase 0.0082 0.153 0.153
Echinococcus granulosus acetylcholinesterase 0.0078 0.1434 0.1434
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0224 0.497 0.497
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Echinococcus granulosus Glutaredoxin protein 5 0.0149 0.3153 0.3153
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0051 0.0766 0.0489
Schistosoma mansoni protein kinase C mu 0.0021 0.0049 0.0049
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.34 0.34
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Echinococcus granulosus nervana 2 0.0149 0.3153 0.3153
Giardia lamblia Kinase, AGC PKA 0.0155 0.3301 0.6236
Trichomonas vaginalis AGC family protein kinase 0.0082 0.153 0.2112
Brugia malayi Carboxylesterase family protein 0.0078 0.1434 0.1488
Trypanosoma cruzi NIMA-related kinase, putative 0.0041 0.0535 0.0491
Echinococcus multilocularis serine:threonine protein kinase Nek1 0.0035 0.0387 0.0387
Trypanosoma cruzi 5'-AMP-activated protein kinase subunit beta, putative 0.0112 0.2258 0.6209
Echinococcus granulosus 5' AMP activated protein kinase subunit beta 1 0.006 0.0997 0.0997
Brugia malayi Protein kinase domain containing protein 0.0021 0.0049 0.0051
Brugia malayi p70 ribosomal S6 kinase beta 0.0231 0.5145 0.5339
Echinococcus granulosus carboxylesterase 5A 0.0078 0.1434 0.1434
Loa Loa (eye worm) hypothetical protein 0.0029 0.0246 0.0248
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0155 0.3301 1
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0051 0.0766 0.0854
Echinococcus granulosus twitchin 0.0029 0.0248 0.0248
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0362 0.8326 0.8326
Loa Loa (eye worm) hypothetical protein 0.0051 0.0766 0.0773
Echinococcus granulosus protein kinase c epsilon type 0.0097 0.1893 0.1893
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0097 0.1893 0.1893
Entamoeba histolytica serine/threonine protein kinase, putative 0.0051 0.0766 0.0489
Schistosoma mansoni nephrin 0.0023 0.01 0.01
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.024 0.5377 0.5377
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1893 0.1893
Loa Loa (eye worm) loechrig isoform VII 0.0224 0.497 0.5016
Brugia malayi MAP kinase sur-1 0.0056 0.0894 0.0927
Toxoplasma gondii histone kinase SNF1, putative 0.0051 0.0766 0.05
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0082 0.153 0.1544
Onchocerca volvulus 0.0273 0.6177 0.9678
Echinococcus multilocularis neuroglian 0.0023 0.01 0.01
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Loa Loa (eye worm) 5'-AMP-activated protein kinase 0.0112 0.2258 0.2279
Loa Loa (eye worm) hypothetical protein 0.0082 0.153 0.1544
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0149 0.3153 0.3153
Brugia malayi Protein kinase domain containing protein 0.0235 0.5244 0.5442
Echinococcus multilocularis acetylcholinesterase 0.0078 0.1434 0.1434
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0894 0.0894
Entamoeba histolytica protein kinase 2, putative 0.0155 0.3301 0.5874
Loa Loa (eye worm) hypothetical protein 0.0044 0.0618 0.0624
Leishmania major hypothetical protein, conserved 0.0112 0.2258 0.6382
Loa Loa (eye worm) acetylcholinesterase 1 0.0078 0.1434 0.1447
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0224 0.497 1
Trichomonas vaginalis AGC family protein kinase 0.0082 0.153 0.2112
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.153 0.153
Echinococcus multilocularis 5' AMP activated protein kinase subunit beta 1 0.006 0.0997 0.0997
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0894 0.0894
Brugia malayi Protein kinase domain containing protein 0.0082 0.153 0.1587
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0021 0.0049 0.0049
Loa Loa (eye worm) AGC/NDR protein kinase 0.0082 0.153 0.1544
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0302 0.6862 0.6925
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0082 0.153 0.153
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0766 0.0766
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0082 0.153 0.153
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0155 0.3301 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0076 0.1382 0.1798
Giardia lamblia Kinase, CAMK CAMKL 0.0051 0.0766 0.052
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0051 0.0766 0.0833
Plasmodium falciparum serine/threonine protein kinase KIN 0.0051 0.0766 0.0833
Echinococcus multilocularis nervana 2 0.0149 0.3153 0.3153
Echinococcus granulosus serine:threonine kinase SAD 1 0.0051 0.0766 0.0766
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0049 0.0049
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0051 0.0766 0.0773
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Echinococcus granulosus acetylcholinesterase 0.0078 0.1434 0.1434
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0082 0.153 0.153
Echinococcus granulosus dual specificity mitogen activated protein 0.0152 0.3234 0.3234
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1893 0.1893
Onchocerca volvulus Tyrosine kinase homolog 0.0282 0.6383 1
Trypanosoma brucei 5'-AMP-activated protein kinase subunit beta 0.0112 0.2258 0.3658
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Echinococcus multilocularis AMPK beta subunit 0.0112 0.2258 0.2258
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0051 0.0766 0.0854
Echinococcus multilocularis protein kinase c epsilon type 0.0097 0.1893 0.1893
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0082 0.153 0.1544
Trypanosoma brucei rac serine-threonine kinase, putative 0.0235 0.5244 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0097 0.1893 0.1911
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0245 0.5487 0.5538
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0766 0.0489
Toxoplasma gondii AGC kinase 0.0231 0.5145 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0082 0.153 0.1544

Activities

Activity type Activity value Assay description Source Reference
Calcium release (functional) 0 Ability of compound to release intracellular calcium from Fluo-4 loaded 3T3 cells; + = Release ChEMBL. 15454234
GI50 (functional) = 5 uM Inhibition of human lung cancer cell line (A549) growth by 50% in sulforhodamineB assay ChEMBL. 15454234
GI50 (functional) = 5 uM Inhibition of human lung cancer cell line (A549) growth by 50% in sulforhodamineB assay ChEMBL. 15454234
Ratio (functional) = 4.52 Ratio of intensity of phosphorylation of phosphorylated eIF2a to the intensity of the total eIF2a was determined ChEMBL. 15454234

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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