Detailed information for compound 329989

Basic information

Technical information
  • TDR Targets ID: 329989
  • Name: 4-(cyclobutylmethoxy)-3-ethyl-6-fluoro-1H-qui nolin-2-one
  • MW: 275.318 | Formula: C16H18FNO2
  • H donors: 1 H acceptors: 2 LogP: 4.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(O)nc2c(c1OCC1CCC1)cc(cc2)F
  • InChi: 1S/C16H18FNO2/c1-2-12-15(20-9-10-4-3-5-10)13-8-11(17)6-7-14(13)18-16(12)19/h6-8,10H,2-5,9H2,1H3,(H,18,19)
  • InChiKey: CERPSDUBSGDEHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(cyclobutylmethoxy)-3-ethyl-6-fluoro-carbostyril
  • AIDS222511
  • 2(1H)-Quinolinone, 4-(cyclobutylmethoxy)-6-fluoro-3-ethyl-
  • AIDS-222511

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1339 0.2634
Mycobacterium ulcerans hypothetical protein 0.0009 0.0027 0.0016
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0136 0.1592 0.3148
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0009 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0334
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0136 0.1592 0.3137
Onchocerca volvulus 0.0136 0.1592 0.8187
Plasmodium vivax alpha/beta hydrolase, putative 0.0009 0.0027 0.0012
Echinococcus granulosus cyclins 0.0089 0.1015 0.2003
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0027 0.0054
Echinococcus granulosus cyclin dependent kinase 5 0.0417 0.5039 1
Mycobacterium ulcerans haloalkane dehalogenase 0.0009 0.0027 0.0016
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0009 0.0027 0.0016
Echinococcus multilocularis G-protein coupled receptor, putative 0.0136 0.1592 0.1585
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Mycobacterium ulcerans oxidoreductase 0.0009 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0021 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0184 0.0364
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0009 0.0027 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0276 0.0518
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis Cyclin L1 0.0022 0.0184 0.0176
Trichomonas vaginalis cyclin B, putative 0.0022 0.0184 0.0364
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0009 0.0027 0.0012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0136 0.1592 0.3148
Giardia lamblia Hypothetical protein 0.0022 0.0184 0.0324
Echinococcus multilocularis cyclins 0.0089 0.1015 0.1008
Mycobacterium ulcerans lipase/esterase 0.0009 0.0027 0.0016
Schistosoma mansoni adenoreceptor 0.0136 0.1592 0.3148
Echinococcus granulosus cpg binding protein 0.0031 0.0296 0.0574
Mycobacterium ulcerans bromoperoxidase BpoC 0.0009 0.0027 0.0016
Giardia lamblia ENC6 protein 0.0009 0.0027 0.0012
Echinococcus multilocularis abhydrolase domain containing protein 0.0009 0.0027 0.002
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0025 0.0009
Trichomonas vaginalis cyclin B3, putative 0.0089 0.1015 0.2015
Brugia malayi neuropeptide F receptor 0.0136 0.1592 0.3137
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0136 0.1592 0.3148
Echinococcus granulosus cyclins 0.0089 0.1015 0.2003
Loa Loa (eye worm) hydrolase 0.0009 0.0027 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0184 0.0324
Mycobacterium ulcerans hydrolase 0.0009 0.0027 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.0027 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.1592 0.3148
Brugia malayi Dopamine receptor 0.0136 0.1592 0.3137
Echinococcus granulosus cyclin 0.0022 0.0184 0.035
Schistosoma mansoni apoferritin-2 0.0009 0.0025 0.0033
Mycobacterium ulcerans exported protease 0.0009 0.0027 0.0016
Mycobacterium ulcerans lignin peroxidase LipJ 0.0009 0.0027 0.0016
Giardia lamblia Cyclin A 0.0089 0.1015 0.1981
Echinococcus multilocularis orexin receptor type 2 0.0136 0.1592 0.1585
Trichomonas vaginalis cyclins, putative 0.0097 0.1108 0.2198
Brugia malayi putative neuropeptide receptor NPR1 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus cyclin B 0.0164 0.1939 0.3839
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0009 0.0027 0.0016
Brugia malayi Alpha/beta hydrolase 0.0009 0.0027 0.0023
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0009 0.0027 0.0012
Onchocerca volvulus 0.0136 0.1592 0.8187
Echinococcus granulosus abhydrolase domain containing protein 11 0.0009 0.0027 0.0039
Echinococcus multilocularis g protein coupled receptor 0.0136 0.1592 0.1585
Echinococcus granulosus G protein coupled receptor 139 0.0136 0.1592 0.3148
Schistosoma mansoni Smad4 0.0008 0.0016 0.0016
Echinococcus granulosus cyclin A3 4 0.0022 0.0184 0.035
Plasmodium vivax protein kinase Crk2 0.0417 0.5039 1
Trypanosoma brucei cyclin 9 0.0022 0.0184 0.0324
Loa Loa (eye worm) melatonin receptor type 1A 0.0136 0.1592 0.3137
Giardia lamblia G2/mitotic-specific cyclin B 0.0164 0.1939 0.3823
Echinococcus multilocularis cyclin dependent kinase 5 0.0417 0.5039 0.5035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.0023
Plasmodium falciparum cyclin 1 0.0022 0.0184 0.0324
Echinococcus granulosus neuropeptide Y receptor 0.0136 0.1592 0.3148
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0008 0.0021 0.0026
Echinococcus granulosus cyclin G2 0.0022 0.0184 0.035
Echinococcus granulosus cyclins 0.0089 0.1015 0.2003
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Echinococcus granulosus Smad4 0.0008 0.0016 0.0016
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0136 0.1592 0.3137
Echinococcus multilocularis neuropeptides capa receptor 0.0136 0.1592 0.1585
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Mycobacterium leprae Probable exported protease 0.0009 0.0027 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0184 0.0334
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0136 0.1592 0.1585
Plasmodium vivax cyclin 4, putative 0.0022 0.0184 0.0324
Trypanosoma cruzi hydrolase-like protein 0.0009 0.0027 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0676 0.1329
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0027 0.0054
Schistosoma mansoni ferritin 0.0009 0.0025 0.0033
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0022 0.0184 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.1015 0.2015
Schistosoma mansoni cpg binding protein 0.0031 0.0296 0.0574
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0009 0.0027 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0164 0.1939 0.3823
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0417 0.5039 1
Entamoeba histolytica cyclin C, putative 0.0022 0.0184 0.0324
Echinococcus granulosus tm gpcr rhodopsin 0.0136 0.1592 0.3148
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0136 0.1592 0.3148
Schistosoma mansoni cyclin B3 0.0312 0.3747 0.7432
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Mycobacterium ulcerans hydrolase 0.0009 0.0027 0.0016
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0136 0.1592 0.3148
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0417 0.5039 1
Schistosoma mansoni amine GPCR 0.0136 0.1592 0.3148
Entamoeba histolytica cyclin family protein 0.0089 0.1015 0.1981
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0136 0.1592 0.1585
Entamoeba histolytica hypothetical protein 0.0022 0.0184 0.0324
Schistosoma mansoni Cyclin fold protein 0.0022 0.0184 0.035
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0136 0.1592 0.3148
Echinococcus multilocularis g protein coupled receptor 0.0136 0.1592 0.1585
Trichomonas vaginalis cyclin A, putative 0.0022 0.0184 0.0364
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus tm gpcr rhodopsin 0.0136 0.1592 0.3148
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0136 0.1592 0.1585
Onchocerca volvulus 0.0136 0.1592 0.8187
Schistosoma mansoni biogenic amine (5HT) receptor 0.0136 0.1592 0.3148
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0136 0.1592 0.1585
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0009 0.0027 0.0012
Brugia malayi cyclin fold protein 1 variant b 0.0022 0.0184 0.0334
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0022 0.0184 0.0312
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0022
Onchocerca volvulus 0.0136 0.1592 0.8187
Schistosoma mansoni ferritin light chain 0.0009 0.0025 0.0033
Leishmania major cyclin 9, putative 0.0022 0.0184 0.0312
Schistosoma mansoni neuropeptide F-like receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) TYRA-2 protein 0.0136 0.1592 0.3137
Schistosoma mansoni neuropeptide receptor 0.0136 0.1592 0.3148
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0136 0.1592 0.3148
Schistosoma mansoni hypothetical protein 0.0136 0.1592 0.3148
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0184 0.0334
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Brugia malayi follicle stimulating hormone receptor 0.0136 0.1592 0.3137
Brugia malayi CXXC zinc finger family protein 0.0029 0.0276 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0184 0.0364
Echinococcus granulosus biogenic amine 5HT receptor 0.0136 0.1592 0.3148
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0027 0.0054
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis cyclin A3 4 0.0022 0.0184 0.0176
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0164 0.1939 0.3829
Echinococcus granulosus cyclin y 0.0022 0.0184 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0027 0.0012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0184 0.0334
Plasmodium falciparum cyclin 0.0089 0.1015 0.1981
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0008 0.0021 0.0026
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0021 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Echinococcus multilocularis cyclin y 0.0022 0.0184 0.0176
Echinococcus multilocularis cyclins 0.0089 0.1015 0.1008
Trichomonas vaginalis cyclins, putative 0.0089 0.1015 0.2015
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0025 0.5444
Mycobacterium ulcerans hypothetical protein 0.0009 0.0027 0.0016
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0009 0.0027 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0027 0.0012
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Schistosoma mansoni cyclin k 0.0022 0.0184 0.035
Loa Loa (eye worm) hypothetical protein 0.0412 0.4985 0.9891
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0009 0.0027 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.5039 1
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.5039 1
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0009 0.0027 0.0032
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.0184 0.0324
Echinococcus granulosus neuropeptide Y receptor 0.0136 0.1592 0.3148
Schistosoma mansoni smad 0.0008 0.0016 0.0016
Schistosoma mansoni biogenic amine receptor 0.0136 0.1592 0.3148
Schistosoma mansoni cpg binding protein 0.0029 0.0276 0.0533
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0136 0.1592 0.1585
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0184 0.0334
Echinococcus granulosus neuropeptide receptor 0.0136 0.1592 0.3148
Echinococcus granulosus orexin receptor type 2 0.0136 0.1592 0.3148
Echinococcus multilocularis neuropeptide Y receptor 0.0136 0.1592 0.1585
Echinococcus multilocularis allatostatin A receptor 0.0136 0.1592 0.1585
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Mycobacterium ulcerans hypothetical protein 0.0009 0.0027 0.0016
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0136 0.1592 0.1585
Trypanosoma cruzi cyclin, putative 0.0164 0.1939 0.3823
Echinococcus granulosus 7tm_1 domain containing protein 0.0136 0.1592 0.3148
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0136 0.1592 0.3148
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0312 0.3747 0.3742
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0321 0.3861 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0136 0.1592 0.3137
Echinococcus multilocularis fmrfamide receptor 0.0136 0.1592 0.1585
Echinococcus granulosus cyclin B3 1 0.0089 0.1015 0.2003
Schistosoma mansoni biogenic amine receptor 0.0136 0.1592 0.3148
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0009 0.0027 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0027 0.0012
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0136 0.1592 0.3148
Echinococcus multilocularis cyclins 0.0089 0.1015 0.1008
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0009 0.0027 0.0016
Brugia malayi Cyclin, N-terminal domain containing protein 0.0164 0.1939 0.3829
Brugia malayi Dopamine receptor protein 1 0.0136 0.1592 0.3137
Giardia lamblia Cyclin fold protein 1, putative 0.0022 0.0184 0.0324
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0136 0.1592 0.3148
Onchocerca volvulus Cyclin L homolog 0.0022 0.0184 0.0847
Trichomonas vaginalis hydrolase, putative 0.0009 0.0027 0.0054
Echinococcus multilocularis dro:myosuppressin receptor 0.0136 0.1592 0.1585
Entamoeba histolytica cell division protein kinase 2, putative 0.0417 0.5039 1
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0009 0.0027 0.0023
Echinococcus granulosus cyclins 0.0089 0.1015 0.2003
Mycobacterium ulcerans epoxide hydrolase EphF 0.0009 0.0027 0.0016
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0021 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.0027 0.0016
Echinococcus granulosus serotonin receptor 0.0136 0.1592 0.3148
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0136 0.1592 0.1585
Mycobacterium ulcerans proline iminopeptidase PIP 0.0009 0.0027 0.0016
Echinococcus multilocularis cyclin dependent kinase 1 0.0417 0.5039 0.5035
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0008 0.0021 0.001
Echinococcus multilocularis cyclins 0.0089 0.1015 0.1008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Schistosoma mansoni neuropeptide receptor 0.0136 0.1592 0.3148
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.0184 0.0324
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0027 0.002
Schistosoma mansoni neuropeptide f receptor 76f 0.0136 0.1592 0.3148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.0024
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis Smad4 0.0008 0.0016 0.0008
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0184 0.0334
Onchocerca volvulus 0.0136 0.1592 0.8187
Schistosoma mansoni choline dehydrogenase 0.0008 0.0021 0.0026
Echinococcus multilocularis somatostatin receptor 0.0136 0.1592 0.1585
Plasmodium falciparum protein kinase 5 0.0417 0.5039 1
Mycobacterium tuberculosis Probable exported protease 0.0009 0.0027 0.0016
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0009 0.0027 0.0016
Brugia malayi Dopamine receptor protein 2 0.0136 0.1592 0.3137
Giardia lamblia Kinase, CMGC CDK 0.0417 0.5039 1
Echinococcus granulosus cyclins 0.0089 0.1015 0.2003
Loa Loa (eye worm) hypothetical protein 0.0343 0.4133 0.8196
Onchocerca volvulus Lipase homolog 0.0009 0.0027 0.0032
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Brugia malayi alpha/beta hydrolase 0.0009 0.0027 0.0023
Entamoeba histolytica cyclin family protein 0.0089 0.1015 0.1981
Echinococcus multilocularis fmrfamide receptor 0.0136 0.1592 0.1585
Mycobacterium ulcerans exported protease 0.0009 0.0027 0.0016
Echinococcus multilocularis abhydrolase domain containing 3 0.0009 0.0027 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0136 0.1592 0.3148
Brugia malayi larval opioid receptor 0.0136 0.1592 0.3137
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0136 0.1592 0.3137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Trichomonas vaginalis ferritin, putative 0.0009 0.0025 0.0049
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0027 0.0054
Loa Loa (eye worm) neuropeptide F receptor 0.0136 0.1592 0.3137
Echinococcus granulosus hypothetical protein 0.0136 0.1592 0.3148
Loa Loa (eye worm) CYL-1 protein 0.0022 0.0184 0.0334
Onchocerca volvulus 0.0136 0.1592 0.8187
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0136 0.1592 0.3148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Toxoplasma gondii cyclin dependent kinase binding protein 0.0022 0.0184 0.0312
Brugia malayi Tachykinin-like peptides receptor 99D 0.0136 0.1592 0.3137
Schistosoma mansoni ferritin light chain 0.0009 0.0025 0.0033
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Schistosoma mansoni cyclin l 0.0022 0.0184 0.035
Echinococcus multilocularis neuropeptide Y receptor 0.0136 0.1592 0.1585
Schistosoma mansoni biogenic amine receptor 0.0136 0.1592 0.3148
Onchocerca volvulus 0.0136 0.1592 0.8187
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0009 0.0027 0.0023
Echinococcus granulosus cyclin dependent kinase 1 0.0417 0.5039 1
Brugia malayi Melatonin receptor type 1A 0.0136 0.1592 0.3137
Giardia lamblia Cyclin B-like protein 0.0022 0.0184 0.0324
Entamoeba histolytica cell division protein kinase 2, putative 0.0417 0.5039 1
Echinococcus multilocularis smad 0.0008 0.0016 0.0008
Echinococcus multilocularis sex peptide receptor 0.0136 0.1592 0.1585
Echinococcus multilocularis cyclin G2 0.0022 0.0184 0.0176
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0027 0.0012
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0021 0.001
Entamoeba histolytica cyclin, domain containing protein 0.0022 0.0184 0.0324
Echinococcus granulosus cyclin b3 0.0089 0.1015 0.2003
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0027 0.0023
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Echinococcus multilocularis cyclin dependent kinase 0.0417 0.5039 0.5035
Schistosoma mansoni hypothetical protein 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0075 0.0843 0.1647
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Schistosoma mansoni histamine h1 receptor 0.0136 0.1592 0.3148
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Echinococcus granulosus g protein coupled receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0022 0.0184 0.0334
Echinococcus multilocularis ferritin 0.0009 0.0025 0.0017
Echinococcus multilocularis neuropeptide receptor 0.0136 0.1592 0.1585
Toxoplasma gondii hypothetical protein 0.0022 0.0184 0.0312
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0136 0.1592 0.3148
Onchocerca volvulus 0.0164 0.1939 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Brugia malayi Cyclin C 0.0022 0.0184 0.0334
Brugia malayi putative neuropeptide receptor 0.0136 0.1592 0.3137
Trichomonas vaginalis cyclin B, putative 0.0164 0.1939 0.3849
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0022 0.0184 0.035
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0184 0.0334
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0027 0.0016
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0016 0.0008
Echinococcus multilocularis cyclin y 0.0022 0.0184 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0027 0.0012
Trypanosoma brucei cdc2-related kinase 1 0.0417 0.5039 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0136 0.1592 0.1585
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0016 0.0008
Trichomonas vaginalis cyclin D, putative 0.0089 0.1015 0.2015
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0136 0.1592 0.3148
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Trichomonas vaginalis cyclin B, putative 0.0089 0.1015 0.2015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) G-protein coupled receptor 0.0136 0.1592 0.3137
Echinococcus multilocularis neuropeptide receptor A26 0.0136 0.1592 0.1585
Onchocerca volvulus 0.0136 0.1592 0.8187
Loa Loa (eye worm) neuropeptide F receptor 0.0136 0.1592 0.3137
Echinococcus multilocularis cyclins 0.0089 0.1015 0.1008
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0008 0.0021 0.001
Schistosoma mansoni cyclins 0.0089 0.1015 0.2003
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Echinococcus granulosus somatostatin receptor 0.0136 0.1592 0.3148
Brugia malayi GnHR receptor homolog 0.0136 0.1592 0.3137
Trypanosoma cruzi cyclin, putative 0.0164 0.1939 0.3823
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0022 0.0184 0.0324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0016 0.0016
Echinococcus granulosus g protein coupled receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trypanosoma brucei cdc2-related kinase 3 0.0417 0.5039 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Leishmania major mitotic cyclin, putative 0.0022 0.0184 0.0312
Giardia lamblia Kinase, CMGC CDK 0.0417 0.5039 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0164 0.1939 0.3815
Schistosoma mansoni amine GPCR 0.0136 0.1592 0.3148
Schistosoma mansoni cyclin B 0.0164 0.1939 0.3839
Echinococcus multilocularis cyclin 0.0022 0.0184 0.0176
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Trichomonas vaginalis cyclin B3, putative 0.0022 0.0184 0.0364
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0016 0.0016
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.1592 0.3148
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0136 0.1592 0.1585
Trichomonas vaginalis cyclin B, putative 0.0164 0.1939 0.3849
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Entamoeba histolytica cyclin, putative 0.0089 0.1015 0.1981
Plasmodium vivax cyclin homologue, putative 0.0022 0.0184 0.0324
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus abhydrolase domain containing protein 3 0.0009 0.0027 0.0039
Onchocerca volvulus 0.0029 0.0276 0.1329
Echinococcus granulosus cyclin t1 0.0022 0.0184 0.035
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0009 0.0027 0.002
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0136 0.1592 0.3148
Echinococcus multilocularis neuropeptide s receptor 0.0136 0.1592 0.1585
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0022 0.0184 0.0312
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trichomonas vaginalis cyclin D, putative 0.0022 0.0184 0.0364
Echinococcus granulosus tachykinin peptides receptor 99D 0.0136 0.1592 0.3148
Trypanosoma cruzi cdc2-related kinase 3 0.0417 0.5039 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0417 0.5039 0.5035
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0184 0.0324
Trypanosoma cruzi mitotic cyclin, putative 0.0022 0.0184 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Brugia malayi G-protein coupled receptor 0.0136 0.1592 0.3137
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0016
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0022 0.0184 0.035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trichomonas vaginalis cyclins, putative 0.0022 0.0184 0.0364
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Onchocerca volvulus 0.0136 0.1592 0.8187
Schistosoma mansoni hydrolase 0.0009 0.0027 0.0039
Brugia malayi hypothetical protein 0.0343 0.4133 0.8196
Brugia malayi hydrolase, alpha/beta fold family protein 0.0009 0.0027 0.0023
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0136 0.1592 0.3137
Echinococcus granulosus G1:S specific cyclin D1 0.0022 0.0184 0.035
Schistosoma mansoni amine GPCR 0.0136 0.1592 0.3148
Leishmania major cyclin 0.0164 0.1939 0.3815
Schistosoma mansoni cyclin d 0.0022 0.0184 0.035
Onchocerca volvulus 0.0136 0.1592 0.8187
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Schistosoma mansoni amine GPCR 0.0136 0.1592 0.3148
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0136 0.1592 0.3137
Entamoeba histolytica hypothetical protein 0.0009 0.0027 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0136 0.1592 0.3148
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.1592 0.3148
Echinococcus multilocularis cyclin G2 0.0022 0.0184 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0417 0.5039 1
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0009 0.0027 0.002
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0009 0.0027 1
Brugia malayi Serotonin receptor 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0008 0.0021 0.001
Mycobacterium ulcerans epoxide hydrolase EphA 0.0321 0.3861 1
Onchocerca volvulus 0.0136 0.1592 0.8187
Echinococcus granulosus neuropeptide FF receptor 2 0.0136 0.1592 0.3148
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0417 0.5039 1
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0022 0.0184 0.035
Schistosoma mansoni opsin-like receptor 0.0136 0.1592 0.3148
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0417 0.5039 1
Echinococcus multilocularis serotonin receptor 0.0136 0.1592 0.1585
Echinococcus granulosus fmrfamide receptor 0.0136 0.1592 0.3148
Brugia malayi cell division control protein 2 homolog 0.0417 0.5039 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0184 0.0364
Loa Loa (eye worm) G-protein coupled receptor 0.0136 0.1592 0.3137
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0021 0.0042
Toxoplasma gondii cyclin 4, putative 0.0022 0.0184 0.0312
Mycobacterium ulcerans epoxide hydrolase EphB 0.0009 0.0027 0.0016
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0136 0.1592 0.1585
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0027 0.0054
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0136 0.1592 0.3137
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0184 0.0334
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0184 0.0324
Brugia malayi hypothetical protein 0.0022 0.0184 0.0334
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.5039 1
Mycobacterium ulcerans epoxide hydrolase EphE 0.0009 0.0027 0.0016
Trichomonas vaginalis cyclins, putative 0.0164 0.1939 0.3849
Echinococcus multilocularis cpg binding protein 0.0031 0.0296 0.0289
Onchocerca volvulus Cyclin L homolog 0.0022 0.0184 0.0847
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis cyclin k 0.0022 0.0184 0.0176
Echinococcus multilocularis cyclins 0.0089 0.1015 0.1008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0136 0.1592 0.3148
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0136 0.1592 0.1585
Trichomonas vaginalis cyclin B, putative 0.0022 0.0184 0.0364
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0009 0.0027 0.0012
Echinococcus multilocularis G1:S specific cyclin D1 0.0022 0.0184 0.0176
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0184 0.0334
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0009 0.0027 0.0023
Schistosoma mansoni cyclin G2 0.0022 0.0184 0.035
Echinococcus multilocularis neuropeptide FF receptor 2 0.0136 0.1592 0.1585
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0417 0.5039 1
Echinococcus multilocularis cyclin B3 1 0.0089 0.1015 0.1008
Echinococcus granulosus neuropeptide receptor 0.0136 0.1592 0.3148
Echinococcus granulosus 7TM GPCR rhodopsin 0.0136 0.1592 0.3148
Schistosoma mansoni neuropeptide F-like receptor 0.0136 0.1592 0.3148
Echinococcus granulosus allatostatin A receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0021 0.001
Echinococcus granulosus abhydrolase domain containing protein 0.0009 0.0027 0.0039
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0025 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Echinococcus granulosus ferritin 0.0009 0.0025 0.0033
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trypanosoma brucei mitotic cyclin 0.0022 0.0184 0.0324
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0184 0.0334
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus neuropeptide receptor A26 0.0136 0.1592 0.3148
Onchocerca volvulus Protein CNPPD1 homolog 0.0022 0.0184 0.0847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Brugia malayi MH2 domain containing protein 0.0116 0.1339 0.2634
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0008 0.0021 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.1592 0.3148
Loa Loa (eye worm) cyclin domain-containing protein 0.0312 0.3747 0.7428
Brugia malayi UPF0017 protein CG3488 0.0009 0.0027 0.0023
Schistosoma mansoni neuropeptide receptor 0.0136 0.1592 0.3148
Schistosoma mansoni hypothetical protein 0.0022 0.0184 0.035
Schistosoma mansoni neuropeptide receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.5039 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0016 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0596 0.1134
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0009 0.0027 0.0016
Echinococcus granulosus smad 0.0008 0.0016 0.0016
Echinococcus multilocularis cyclins 0.0089 0.1015 0.1008
Trypanosoma cruzi cyclin 9, putative 0.0022 0.0184 0.0324
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Brugia malayi ORL1-like opioid receptor 0.0136 0.1592 0.3137
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0009 0.0027 0.0016
Brugia malayi G protein-coupled receptor F59B2.13 0.0136 0.1592 0.3137
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0009 0.0027 0.0039
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0184 0.0334
Trichomonas vaginalis cyclin B, putative 0.0164 0.1939 0.3849
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0025 0.0009
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0009 0.0027 0.0016
Trypanosoma cruzi cyclin 6, putative 0.0164 0.1939 0.3823
Trichomonas vaginalis cyclins, putative 0.0022 0.0184 0.0364
Brugia malayi hypothetical protein 0.0022 0.0184 0.0334
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Brugia malayi Cyclin, N-terminal domain containing protein 0.0312 0.3747 0.7428
Echinococcus granulosus tm gpcr rhodopsin 0.0136 0.1592 0.3148
Onchocerca volvulus 0.0136 0.1592 0.8187
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0009 0.0027 0.0016
Brugia malayi AKH receptor 0.0136 0.1592 0.3137
Trypanosoma cruzi hydrolase-like protein, putative 0.0009 0.0027 0.0012
Giardia lamblia Hypothetical protein 0.0022 0.0184 0.0324
Mycobacterium ulcerans hypothetical protein 0.0009 0.0027 0.0016
Toxoplasma gondii hypothetical protein 0.0068 0.0751 0.1444
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0043
Trichomonas vaginalis cyclin D, putative 0.0089 0.1015 0.2015
Onchocerca volvulus 0.0136 0.1592 0.8187
Brugia malayi Serotonin receptor 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus sex peptide receptor 0.0136 0.1592 0.3148
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0312 0.3747 0.7432
Schistosoma mansoni ferritin 0.0009 0.0025 0.0033
Trichomonas vaginalis cyclins, putative 0.0164 0.1939 0.3849
Mycobacterium ulcerans lipase/esterase 0.0009 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus cyclin k 0.0022 0.0184 0.035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Onchocerca volvulus 0.0136 0.1592 0.8187
Echinococcus granulosus cyclin dependent kinase 0.0417 0.5039 1
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0008 0.0021 0.001
Schistosoma mansoni ferritin 0.0009 0.0025 0.0033
Brugia malayi RE15519p 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis cyclin b3 0.0089 0.1015 0.1008
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus neuropeptide s receptor 0.0136 0.1592 0.3148
Echinococcus granulosus alpha 1A adrenergic receptor 0.0136 0.1592 0.3148
Brugia malayi neuropeptide F receptor 0.0136 0.1592 0.3137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.0023
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0022 0.0184 0.0324
Schistosoma mansoni cpg binding protein 0.0031 0.0296 0.0574
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0136 0.1592 0.1585
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0009 0.0027 0.002
Echinococcus granulosus expressed protein 0.0009 0.0025 0.0033
Trichomonas vaginalis cyclins, putative 0.0164 0.1939 0.3849
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0022 0.0184 0.0176
Loa Loa (eye worm) cyclin C 0.0022 0.0184 0.0334
Schistosoma mansoni opsin-like receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus cyclins 0.0022 0.0184 0.035
Onchocerca volvulus 0.0022 0.0184 0.0847
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Chlamydia trachomatis phosphoglycolate phosphatase 0.0008 0.0021 0.5
Schistosoma mansoni cyclin G 0.0022 0.0184 0.035
Onchocerca volvulus Lipase homolog 0.0009 0.0027 0.0032
Echinococcus multilocularis g-protein coupled receptor 0.0136 0.1592 0.1585
Echinococcus granulosus peptide allatostatin:somatostatin 0.0136 0.1592 0.3148
Echinococcus multilocularis cyclin t1 0.0022 0.0184 0.0176
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0009 0.0027 1
Schistosoma mansoni opsin-like receptor 0.0136 0.1592 0.3148
Schistosoma mansoni amine GPCR 0.0136 0.1592 0.3148
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0136 0.1592 0.8187
Plasmodium falciparum alpha/beta hydrolase, putative 0.0009 0.0027 0.0012
Schistosoma mansoni g1/s-specific cyclin C 0.0022 0.0184 0.035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0184 0.0334
Echinococcus multilocularis neuropeptide receptor 0.0136 0.1592 0.1585
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0016
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0009 0.0027 0.0016
Echinococcus granulosus g-protein coupled receptor 0.0136 0.1592 0.3148
Mycobacterium ulcerans peroxidase BpoB 0.0009 0.0027 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.1592 0.3148
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0016
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0008 0.0021 0.001
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0184 0.0334
Brugia malayi sulfakinin receptor protein 0.0343 0.4133 0.8196
Brugia malayi hypothetical protein 0.0136 0.1592 0.3137
Plasmodium falciparum epoxide hydrolase 1 0.0009 0.0027 0.0012
Echinococcus granulosus Cyclin L1 0.0022 0.0184 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.5039 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0022 0.0184 0.0334
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0136 0.1592 0.3148
Echinococcus granulosus cyclin y 0.0022 0.0184 0.035
Brugia malayi Cyclin, N-terminal domain containing protein 0.0164 0.1939 0.3829
Echinococcus multilocularis cyclin B 0.0164 0.1939 0.1933
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Onchocerca volvulus 0.0136 0.1592 0.8187
Schistosoma mansoni hypothetical protein 0.0136 0.1592 0.3148
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0025 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus g protein coupled receptor 0.0136 0.1592 0.3148
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0009 0.0027 0.0012
Echinococcus multilocularis G protein coupled receptor 139 0.0136 0.1592 0.1585
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0009 0.0027 0.0016
Brugia malayi Protein kinase domain containing protein 0.0417 0.5039 1
Trypanosoma brucei mitotic cyclin 6 0.0164 0.1939 0.3823
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.1592 0.3148
Trypanosoma brucei cyclin 3 0.0022 0.0184 0.0324
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0136 0.1592 0.1585
Entamoeba histolytica cyclin, putative 0.0164 0.1939 0.3823
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Schistosoma mansoni hypothetical protein 0.0136 0.1592 0.3148
Brugia malayi G protein-coupled receptor 0.0136 0.1592 0.3137
Schistosoma mansoni myosin xvIII 0.0136 0.1592 0.3148
Loa Loa (eye worm) cyclin domain-containing protein 0.0022 0.0184 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0184 0.0364
Mycobacterium tuberculosis Conserved protein 0.0009 0.0027 0.0016
Echinococcus multilocularis neuropeptides capa receptor 0.0136 0.1592 0.1585
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0009 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0164 0.1939 0.3829
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0136 0.1592 0.1585
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Trypanosoma cruzi cdc2-related kinase 1 0.0417 0.5039 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0136 0.1592 0.3148
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0008 0.0021 0.0013
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0136 0.1592 0.1585
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.0027
Mycobacterium leprae Probable exported protease 0.0009 0.0027 1
Giardia lamblia Hypothetical protein 0.0089 0.1015 0.1981
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Trichomonas vaginalis cyclin B, putative 0.0164 0.1939 0.3849
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1339 0.2634
Mycobacterium ulcerans haloalkane dehalogenase 0.0009 0.0027 0.0016
Schistosoma mansoni hypothetical protein 0.0022 0.0184 0.035
Trichomonas vaginalis cyclin B3, putative 0.0022 0.0184 0.0364
Echinococcus granulosus cyclin G2 0.0022 0.0184 0.035
Echinococcus granulosus dro:myosuppressin receptor 0.0136 0.1592 0.3148
Echinococcus multilocularis serotonin receptor 0.0136 0.1592 0.1585
Brugia malayi G-protein coupled receptor 0.0136 0.1592 0.3137
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0417 0.5039 1
Leishmania major mitotic cyclin, putative 0.0022 0.0184 0.0312
Onchocerca volvulus Neuropeptide F receptor homolog 0.0136 0.1592 0.8187
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Echinococcus granulosus neuropeptides capa receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0136 0.1592 0.3137
Schistosoma mansoni apoferritin-2 0.0009 0.0025 0.0033
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0009 0.0027 0.0054
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0008 0.0021 0.0026
Onchocerca volvulus 0.0136 0.1592 0.8187
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0136 0.1592 0.3148
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0136 0.1592 0.3137
Echinococcus granulosus biogenic amine 5HT receptor 0.0136 0.1592 0.3148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0136 0.1592 0.3148
Schistosoma mansoni ferritin 0.0009 0.0025 0.0033
Trichomonas vaginalis cyclin A, putative 0.0164 0.1939 0.3849
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0009 0.0027 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0027 0.0012
Trypanosoma cruzi cdc2-related kinase 3 0.0417 0.5039 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0136 0.1592 0.3148
Echinococcus multilocularis expressed protein 0.0009 0.0025 0.0017
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0022 0.0184 0.0324
Loa Loa (eye worm) hypothetical protein 0.0136 0.1592 0.3137
Schistosoma mansoni alpha-1 adrenergic receptor 0.0136 0.1592 0.3148
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0008 0.0021 0.0042
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0025 0.0009
Trypanosoma cruzi cdc2-related kinase 1 0.0417 0.5039 1
Trichomonas vaginalis cyclins, putative 0.0164 0.1939 0.3849
Echinococcus multilocularis g protein coupled receptor 0.0136 0.1592 0.1585
Onchocerca volvulus 0.0136 0.1592 0.8187
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0025 0.0009
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0021 0.001
Trypanosoma cruzi hydrolase-like protein, putative 0.0009 0.0027 0.0012
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0008 0.0021 0.001

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 39 nM Inhibitory concentration against wild type human immunodeficiency virus type 1 was determined by MT-4 assay ChEMBL. 15537347
IC50 (functional) = 39 nM Inhibitory concentration against wild type human immunodeficiency virus type 1 was determined by MT-4 assay ChEMBL. 15537347
IC50 (functional) = 89 nM Inhibitory concentration against wild type human immunodeficiency virus type 1 was determined by recombinant virus assay ChEMBL. 15537347
IC50 (functional) = 110 nM Inhibitory concentration against human immunodeficiency virus type 1 (with G190A resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 110 nM Inhibitory concentration against human immunodeficiency virus type 1 (with G190A resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 130 nM Inhibitory concentration against human immunodeficiency virus type 1 (with Y188C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 130 nM Inhibitory concentration against human immunodeficiency virus type 1 (with Y188C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 230 nM Inhibitory concentration against nevirapine resistant strain (with Y181C mutation in HIV-1 RT gene) of human immunodeficiency virus type 1 was determined by MT-4 assay ChEMBL. 15537347
IC50 (functional) = 230 nM Inhibitory concentration against nevirapine resistant strain (with Y181C mutation in HIV-1 RT gene) of human immunodeficiency virus type 1 was determined by MT-4 assay ChEMBL. 15537347
IC50 (functional) = 250 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V108I resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 250 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V108I resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 270 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 270 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 390 nM Inhibitory concentration against human immunodeficiency virus type 1 (with Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 390 nM Inhibitory concentration against human immunodeficiency virus type 1 (with Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 870 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V108I/Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 870 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V108I/Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 1100 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N/G190A resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 1100 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N/G190A resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 1700 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V106A resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) = 1700 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V106A resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 2000 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V106A/Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 2000 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N/V108I resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 2000 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N/Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 2000 nM Inhibitory concentration against human immunodeficiency virus type 1 (with V106A/Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 2000 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N/V108I resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
IC50 (functional) > 2000 nM Inhibitory concentration against human immunodeficiency virus type 1 (with K103N/Y181C resistant mutation) was determined in HeLa-CD4 MAGI assay ChEMBL. 15537347
Ratio (functional) > 8000 Ratio of cytotoxic concentration to that of inhibitory concentration as selectivity index was determined by MT-4 assay ChEMBL. 15537347

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15537347

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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