Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.003 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0047 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.003 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | 0.003 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0047 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0047 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.003 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.003 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.003 | 0 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.003 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0047 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0047 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.21 uM | Inhibition of trypsin like activity of the proteasome purified from lymphoblastoid cell lines (in vitro) | ChEMBL. | 16033282 |
IC50 (binding) | = 0.86 uM | Inhibition of chymotrypsin like activity of the proteasome purified from lymphoblastoid cell lines (in vitro) | ChEMBL. | 16033282 |
IC50 (binding) | > 10 uM | Inhibition of post-acidic-like (PGPH) activity of the proteasome purified from lymphoblastoid cell lines (in vitro) | ChEMBL. | 16033282 |
T1/2 (ADMET) | > 360 min | Half-life of the compound was determined in human plasma by incubation at 370 C | ChEMBL. | 16033282 |
T1/2 (ADMET) | > 360 min | Half-life of the compound was determined in culturemedium (RPMI) in the presence of 10% foetal calf serum by incubation at 370 C | ChEMBL. | 16033282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.