Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0022 | 0.0066 | 0.4509 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0028 | 0.0122 | 1 |
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.0028 | 0.0122 | 1 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0028 | 0.0122 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0022 | 0.0066 | 0.4509 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0022 | 0.0058 | 0.0683 |
Treponema pallidum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.102 | 1 | 1 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0022 | 0.0066 | 0.0046 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0022 | 0.0066 | 0.0772 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.102 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0022 | 0.0058 | 0.0038 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0028 | 0.0122 | 0.2137 |
Schistosoma mansoni | ATPase | 0.0028 | 0.0122 | 0.1897 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0063 | 0.0468 | 1 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0028 | 0.0122 | 0.2137 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0022 | 0.0058 | 0.0683 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0063 | 0.0468 | 0.8875 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0028 | 0.0122 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 1 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0063 | 0.0468 | 1 |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0028 | 0.0122 | 0.2137 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0068 | 0.0524 | 0.3898 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0022 | 0.0066 | 0.0772 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0028 | 0.0122 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0028 | 0.0739 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Mycobacterium ulcerans | beta-lactamase | 0.0026 | 0.0102 | 0.0075 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.0028 | 0.0122 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0026 | 0.0102 | 0.0123 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0102 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0333 | 0.2475 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0102 | 0.0123 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0026 | 0.0102 | 0.8066 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0026 | 0.0102 | 0.0535 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0178 | 0.1327 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.0028 | 0.0122 | 0.0094 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0026 | 0.0102 | 0.0535 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0028 | 0.0208 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0022 | 0.0066 | 0.0493 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0022 | 0.0058 | 0.0683 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0026 | 0.0102 | 0.0762 |
Leishmania major | calcium-transporting ATPase, putative | 0.0022 | 0.0066 | 0.4509 |
Trichomonas vaginalis | set domain proteins, putative | 0.0172 | 0.1552 | 1 |
Brugia malayi | beta-lactamase | 0.0026 | 0.0102 | 0.0762 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0068 | 0.0524 | 0.3898 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0028 | 0.0739 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS | 0.102 | 1 | 1 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras | 0.0625 | 0.6068 | 1 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.102 | 1 | 1 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.0028 | 0.0122 | 0.2137 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0028 | 0.0049 |
Plasmodium vivax | SET domain protein, putative | 0.0022 | 0.0058 | 0.003 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0102 | 0.0123 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0028 | 0.2288 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.0028 | 0.0122 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0102 | 0.0762 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0334 | 0.2483 |
Brugia malayi | E1-E2 ATPase family protein | 0.0018 | 0.002 | 0.0152 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0059 | 0.0435 | 0.3231 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0102 | 0.0762 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0178 | 0.3033 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.102 | 1 | 1 |
Trichomonas vaginalis | cation-transporting ATPase fungi, putative | 0.0028 | 0.0122 | 0.0664 |
Giardia lamblia | Plasma membrane calcium-transporting ATPase 2 | 0.0028 | 0.0122 | 0.2137 |
Wolbachia endosymbiont of Brugia malayi | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0178 | 0.1327 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0102 | 0.0762 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0028 | 0.0122 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0026 | 0.0102 | 0.0123 |
Brugia malayi | Pre-SET motif family protein | 0.0022 | 0.0058 | 0.0431 |
Onchocerca volvulus | 0.0172 | 0.1552 | 1 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0334 | 0.2483 |
Onchocerca volvulus | 0.0068 | 0.0524 | 0.312 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0028 | 0.0739 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0063 | 0.0468 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0021 | 0.005 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0102 | 0.0762 |
Echinococcus multilocularis | calcium transporting atpase | 0.0022 | 0.0066 | 0.087 |
Onchocerca volvulus | 0.0026 | 0.0102 | 0.0297 | |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 1 |
Leishmania major | P-type ATPase, putative | 0.0022 | 0.0066 | 0.4509 |
Onchocerca volvulus | 0.0026 | 0.0102 | 0.0297 | |
Mycobacterium tuberculosis | Possible metal cation transporting P-type ATPase CtpH | 0.0019 | 0.0032 | 0.0007 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0028 | 0.0049 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0059 | 0.0435 | 0.3231 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0026 | 0.0102 | 0.0075 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0151 | 0.1345 | 1 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0022 | 0.0066 | 0.4509 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0028 | 0.0008 |
Mycobacterium ulcerans | lipase LipD | 0.0026 | 0.0102 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0122 | 0.0908 |
Brugia malayi | beta-lactamase family protein | 0.0026 | 0.0102 | 0.0762 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0026 | 0.0102 | 0.1691 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0022 | 0.0058 | 0.0606 |
Plasmodium vivax | hypothetical protein, conserved | 0.0026 | 0.0102 | 0.0075 |
Plasmodium vivax | calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0094 |
Echinococcus granulosus | Ca2 transporting ATPase plasma membrane | 0.0022 | 0.0066 | 0.087 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0022 | 0.0066 | 0.4509 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0028 | 0.0122 | 0.2137 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0026 | 0.0102 | 0.0535 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0026 | 0.0102 | 0.0535 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0022 | 0.0066 | 0.0299 |
Mycobacterium ulcerans | cation-transporter ATPase I CtpI | 0.0019 | 0.0032 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0346 | 0.2575 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0026 | 0.0102 | 0.0123 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0026 | 0.0102 | 0.1501 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0167 | 0.1503 | 0.2442 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0022 | 0.0066 | 0.4509 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0022 | 0.0066 | 0.0493 |
Brugia malayi | beta-lactamase family protein | 0.0026 | 0.0102 | 0.0762 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.0028 | 0.0122 | 1 |
Plasmodium falciparum | calcium-transporting ATPase | 0.0022 | 0.0066 | 0.0038 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Schistosoma mansoni | calcium-transporting atpase 2 (atpase 2) | 0.0022 | 0.0066 | 0.0772 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0026 | 0.0102 | 0.1501 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0026 | 0.0102 | 0.0123 |
Brugia malayi | Pre-SET motif family protein | 0.0151 | 0.1345 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0026 | 0.0102 | 0.0762 |
Loa Loa (eye worm) | beta-lactamase | 0.0026 | 0.0102 | 0.0762 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0028 | 0.0122 | 0.0102 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0026 | 0.0102 | 0.1691 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0334 | 0.2483 |
Mycobacterium leprae | PROBABLE CATION-TRANSPORTER ATPASE I CTPI | 0.0059 | 0.0435 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0524 | 0.3898 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0026 | 0.0102 | 0.0075 |
Echinococcus multilocularis | Ca2+ transporting ATPase plasma membrane | 0.0022 | 0.0066 | 0.087 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0102 | 0.0075 |
Echinococcus granulosus | calcium transporting atpase | 0.0022 | 0.0066 | 0.087 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0068 | 0.0524 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0026 | 0.0102 | 0.0123 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Toxoplasma gondii | ABC1 family protein | 0.0026 | 0.0102 | 0.0082 |
Loa Loa (eye worm) | E1-E2 ATPase | 0.0018 | 0.002 | 0.0152 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0334 | 0.2483 |
Giardia lamblia | Plasma membrane calcium-transporting ATPase 2 | 0.0022 | 0.0066 | 0.087 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0028 | 0.0122 | 0.0102 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.0028 | 0.0122 | 1 |
Echinococcus multilocularis | plasma membrane calcium transporting ATPase | 0.0022 | 0.0066 | 0.087 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0058 | 0.0431 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0026 | 0.0102 | 0.8066 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0022 | 0.0058 | 0.0606 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0026 | 0.0102 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0102 | 0.0762 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0028 | 0.0208 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0028 | 0.0122 | 0.0664 |
Onchocerca volvulus | 0.0026 | 0.0102 | 0.0297 | |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0102 | 0.8066 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0022 | 0.0066 | 0.0772 |
Trichomonas vaginalis | esterase, putative | 0.0026 | 0.0102 | 0.0535 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0028 | 0.0739 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.0028 | 0.0122 | 0.0102 |
Plasmodium vivax | P-type ATPase4, putative | 0.0028 | 0.0122 | 0.0094 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0022 | 0.0066 | 0.0772 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0026 | 0.0102 | 0.0123 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0022 | 0.0058 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0245 | 0.1819 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0026 | 0.0102 | 0.8066 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0022 | 0.0058 | 0.0606 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0028 | 0.0122 | 1 |
Leishmania major | calcium-translocating P-type ATPase | 0.0028 | 0.0122 | 1 |
Schistosoma mansoni | ATPase | 0.0028 | 0.0122 | 0.1897 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0026 | 0.0102 | 0.0535 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0068 | 0.0524 | 0.0498 |
Toxoplasma gondii | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0102 | 0.0762 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase | 0.0022 | 0.0066 | 0.087 |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.0028 | 0.0122 | 0.2137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log IC50 (binding) | = 7 | Inhibitory concentration against DOXP reductoisomerase | ChEMBL. | 15887963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.