Detailed information for compound 337638

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 224.152 | Formula: C6H13N2O5P--
  • H donors: 1 H acceptors: 5 LogP: -5.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: [NH3+]CCC(=O)N(CCCP(=O)([O-])[O-])[O-]
  • InChi: 1S/C6H14N2O5P/c7-3-2-6(9)8(10)4-1-5-14(11,12)13/h1-5,7H2,(H2,11,12,13)/q-1/p-1
  • InChiKey: YUYKHQIAKOQQNM-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0039 0.1183
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Toxoplasma gondii thioredoxin reductase 0.0052 0.022 0.068
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.022 0.2053
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0039 0.0267
Echinococcus multilocularis cathepsin L 0.002 0.0029 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0029 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0029 0.0131
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0148 0.0285
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0138 0.0119
Leishmania major DNA polymerase eta, putative 0.0022 0.0039 0.0267
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0138 0.0119
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0039 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0152 0.7832
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Schistosoma mansoni DNA polymerase eta 0.0022 0.0039 0.0044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.1128
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0019 0.0248
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Brugia malayi Muscleblind-like protein 0.0171 0.0917 1
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.2966 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0584 0.621
Schistosoma mansoni microtubule-associated protein tau 0.079 0.4553 1
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.2966 1
Trypanosoma brucei unspecified product 0.0022 0.0039 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0029 0.0579
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0853 0.0835
Echinococcus multilocularis microtubule associated protein 2 0.079 0.4553 0.4543
Trypanosoma brucei trypanothione reductase 0.0052 0.022 0.2844
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0134 0.0697 0.901
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Onchocerca volvulus 0.0038 0.0138 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0166 1
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0064 0.2534
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0029 0.0033
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0152 0.899
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0064 0.0497
Echinococcus granulosus dna polymerase eta 0.0022 0.0039 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0148 0.013
Mycobacterium tuberculosis Probable reductase 0.0119 0.0612 0.8837
Loa Loa (eye worm) hypothetical protein 0.0114 0.0584 0.621
Schistosoma mansoni hypothetical protein 0.0078 0.0372 0.0778
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.002
Echinococcus granulosus cysteine protease 0.002 0.0029 0.0022
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0138 0.0263
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0039 0.03
Trypanosoma cruzi major cysteine proteinase, putative 0.0115 0.0588 0.7558
Plasmodium vivax vivapain-1 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0171 0.0917 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0125 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0322 0.0668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0372 0.3929
Loa Loa (eye worm) hypothetical protein 0.0171 0.0917 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0064 0.0497
Onchocerca volvulus 0.0038 0.0138 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.069 1
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0029 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0189 0.0578
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0152 0.0134
Loa Loa (eye worm) glutathione reductase 0.0052 0.022 0.2053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Plasmodium vivax unspecified product 0.002 0.0029 0.0033
Loa Loa (eye worm) inositol-1 0.0041 0.0152 0.1289
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.0044
Loa Loa (eye worm) fibroinase 0.0038 0.0138 0.1128
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0612 0.8837
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0127 0.1611
Echinococcus granulosus muscleblind protein 0.0171 0.0917 0.1981
Brugia malayi Cathepsin L-like precursor 0.0026 0.0064 0.0497
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0138 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0612 0.8837
Echinococcus granulosus cathepsin l1 0.0026 0.0064 0.0098
Echinococcus granulosus geminin 0.0194 0.1054 0.2283
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Echinococcus multilocularis cysteine protease 0.0038 0.0138 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0138 0.1128
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0322 0.1028
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0138 0.7963
Plasmodium vivax vivapain-2 0.0038 0.0138 0.0404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0189 0.0578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0322 0.4513
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus granulosus GPCR family 2 0.0036 0.0125 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Toxoplasma gondii cathepsin CPL 0.0038 0.0138 0.0404
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0189 0.0578
Leishmania major trypanothione reductase 0.0052 0.022 0.2663
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0039 0.03
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.022 0.068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0125 0.0234
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0189 1
Plasmodium vivax glutathione reductase, putative 0.0052 0.022 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Plasmodium falciparum glutathione reductase 0.0052 0.022 0.068
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0612 0.8837
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.022 0.2985
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Echinococcus multilocularis cysteine protease 0.0038 0.0138 0.0119
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0152 0.0452
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0039 0.0508
Echinococcus multilocularis GPCR, family 2 0.0036 0.0125 0.0106
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0138 0.7963
Echinococcus multilocularis muscleblind protein 1 0.0171 0.0917 0.09
Echinococcus multilocularis muscleblind protein 0.0171 0.0917 0.09
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0029 0.0375
Loa Loa (eye worm) cysteine protease 0.0038 0.0138 0.1128
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.069 1
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0138 0.0263
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0125 0.0106
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Loa Loa (eye worm) acetyltransferase 0.016 0.0853 0.9266
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0612 0.8837
Trypanosoma cruzi cysteine protease, putative 0.002 0.0029 0.0131
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0189 1
Brugia malayi hypothetical protein 0.004 0.0148 0.144
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0064 0.2623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0029 0.0579
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0125 0.0981
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0029 0.011
Schistosoma mansoni hypothetical protein 0.004 0.0148 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Brugia malayi Thioredoxin reductase 0.0052 0.022 0.2231
Onchocerca volvulus 0.0038 0.0138 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0584 0.6295
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0039 0.0267
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.022 0.0442
Loa Loa (eye worm) hypothetical protein 0.0078 0.0372 0.3789
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0152 0.7832
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0019 0.0248
Echinococcus granulosus cathepsin l1 0.0038 0.0138 0.0263
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Brugia malayi glutathione reductase 0.0052 0.022 0.2231
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1974
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0029 0.0375
Leishmania major cysteine peptidase A (CPA) 0.0038 0.0138 0.1583
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.022 0.2663
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0322 0.4025
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0064 0.2623
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0138 0.0119
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0322 0.0668
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0125 0.1183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0138 0.1128
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0138 0.1327
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0029 0.0131
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0029 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus granulosus microtubule associated protein 2 0.079 0.4553 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Giardia lamblia DINP protein human, muc B family 0.0022 0.0039 0.1368
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0853 0.9283
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0039 0.0748
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0064 0.0098
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0029 0.011
Echinococcus multilocularis dna polymerase eta 0.0022 0.0039 0.002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0853 0.1839
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.069 0.1984
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0322 0.0668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Onchocerca volvulus 0.0038 0.0138 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0322 0.0304
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0138 0.0263
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Plasmodium falciparum thioredoxin reductase 0.0052 0.022 0.068
Brugia malayi cathepsin L-like precursor 0.0026 0.0064 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0125 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0138 0.1583
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.069 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0152 0.7832
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0166 0.0499
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0039 0.002
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.0647 0.9353
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0125 0.1183
Trypanosoma cruzi cruzipain precursor, putative 0.0146 0.0772 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0138 0.0404
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0612 0.8837
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0138 0.0404
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0068
Entamoeba histolytica cysteine protease, putative 0.0038 0.0138 0.7963
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0152 0.0294
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.022 0.0201
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0138 0.0404
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Echinococcus granulosus dna polymerase kappa 0.0022 0.0039 0.0044
Echinococcus granulosus cathepsin L 0.002 0.0029 0.0022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0612 0.1709
Onchocerca volvulus 0.0038 0.0138 1
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0152 0.0452
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0019 0.0248
Schistosoma mansoni hypothetical protein 0.0194 0.1054 0.2283
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0138 0.0119
Onchocerca volvulus 0.0038 0.0138 1
Leishmania major DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0584 0.6295
Schistosoma mansoni inositol monophosphatase 0.0041 0.0152 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0166 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.0827 0.1781
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0189 0.0375
Schistosoma mansoni hypothetical protein 0.0194 0.1054 0.2283
Plasmodium vivax vivapain-2 0.0038 0.0138 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus multilocularis geminin 0.0194 0.1054 0.1037
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0138 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Onchocerca volvulus 0.0038 0.0138 1
Plasmodium vivax vivapain-3 0.002 0.0029 0.0033
Brugia malayi Inositol-1 0.0041 0.0152 0.1484
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Schistosoma mansoni inositol monophosphatase 0.0041 0.0152 0.0294
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0148 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0019 0.0248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0138 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0152 0.0452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0039 0.0044
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0039 0.1183
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.2966 1
Loa Loa (eye worm) ctsf protein 0.0038 0.0138 0.1128

Activities

Activity type Activity value Assay description Source Reference
Log IC50 (binding) = 4.8 Inhibitory concentration against DOXP reductoisomerase ChEMBL. 15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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