Detailed information for compound 337638

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 224.152 | Formula: C6H13N2O5P--
  • H donors: 1 H acceptors: 5 LogP: -5.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: [NH3+]CCC(=O)N(CCCP(=O)([O-])[O-])[O-]
  • InChi: 1S/C6H14N2O5P/c7-3-2-6(9)8(10)4-1-5-14(11,12)13/h1-5,7H2,(H2,11,12,13)/q-1/p-1
  • InChiKey: YUYKHQIAKOQQNM-UHFFFAOYSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutathione reductase 0.0052 0.022 0.2231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Plasmodium vivax glutathione reductase, putative 0.0052 0.022 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0029 0.011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0019 0.0248
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0138 0.0119
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0068
Brugia malayi hypothetical protein 0.004 0.0148 0.144
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0612 0.8837
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0138 0.7003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.022 0.2985
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0039 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0138 0.0404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0029 0.0375
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0148 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0612 0.8837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Schistosoma mansoni hypothetical protein 0.0194 0.1054 0.2283
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.022 0.2663
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0152 0.7832
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0322 0.4513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0064 0.2534
Schistosoma mansoni hypothetical protein 0.004 0.0148 0.0285
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0853 0.1839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Plasmodium falciparum thioredoxin reductase 0.0052 0.022 0.068
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0152 0.0452
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Onchocerca volvulus 0.0038 0.0138 1
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.022 0.068
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0039 0.03
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0039 0.1183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.0224
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0138 0.0263
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0152 0.0452
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0138 0.0263
Leishmania major cysteine peptidase A (CPA) 0.0038 0.0138 0.1583
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0138 1
Onchocerca volvulus 0.0038 0.0138 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0019 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.0224
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0981
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0138 0.0263
Echinococcus multilocularis geminin 0.0194 0.1054 0.1037
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0039 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Loa Loa (eye worm) glutathione reductase 0.0052 0.022 0.2053
Plasmodium vivax vivapain-2 0.0038 0.0138 0.0404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0148 0.0285
Leishmania major DNA polymerase eta, putative 0.0022 0.0039 0.0267
Echinococcus multilocularis cysteine protease 0.0038 0.0138 0.0119
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus multilocularis cysteine protease 0.0038 0.0138 0.0119
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0166 1
Trypanosoma cruzi cruzipain precursor, putative 0.0146 0.0772 1
Onchocerca volvulus 0.0038 0.0138 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Echinococcus granulosus cathepsin L 0.002 0.0029 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0584 0.621
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0166 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0612 0.1709
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Trypanosoma cruzi major cysteine proteinase, putative 0.0115 0.0588 0.7558
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0138 0.1128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0138 0.1128
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0064 0.0098
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.2966 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0064 0.0497
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Giardia lamblia DINP protein human, muc B family 0.0022 0.0039 0.1368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.0917 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0019 0.0248
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0152 0.7832
Echinococcus granulosus dna polymerase kappa 0.0022 0.0039 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0584 0.6295
Echinococcus granulosus GPCR family 2 0.0036 0.0125 0.0234
Loa Loa (eye worm) acetyltransferase 0.016 0.0853 0.9266
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0138 0.0404
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0138 0.7963
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0322 0.0668
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0125 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0029 0.0375
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0853 0.9283
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0152 0.0452
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.0827 0.1781
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0029 0.0131
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0029 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0039 0.03
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0138 0.0263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0322 0.0668
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.022 0.2053
Brugia malayi Muscleblind-like protein 0.0171 0.0917 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0125 0.0234
Echinococcus granulosus dna polymerase eta 0.0022 0.0039 0.0044
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Brugia malayi Cathepsin L-like precursor 0.0026 0.0064 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0322 0.0668
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0125 0.0234
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0138 0.1583
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0125 0.0981
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Leishmania major trypanothione reductase 0.0052 0.022 0.2663
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0612 0.8837
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0612 0.8837
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0039 0.0267
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0134 0.0697 0.901
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0189 0.0578
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0019 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0064 0.2623
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0138 0.1327
Echinococcus multilocularis cathepsin L 0.002 0.0029 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus multilocularis dna polymerase eta 0.0022 0.0039 0.002
Schistosoma mansoni hypothetical protein 0.0194 0.1054 0.2283
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Plasmodium vivax unspecified product 0.002 0.0029 0.0033
Trypanosoma cruzi cysteine protease, putative 0.002 0.0029 0.0131
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0322 0.1028
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0322 0.0304
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0138 0.0119
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.0647 0.9353
Schistosoma mansoni microtubule-associated protein tau 0.079 0.4553 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.1128
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0152 0.899
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0138 0.7003
Loa Loa (eye worm) hypothetical protein 0.0114 0.0584 0.621
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1974
Echinococcus multilocularis muscleblind protein 1 0.0171 0.0917 0.09
Schistosoma mansoni inositol monophosphatase 0.0041 0.0152 0.0294
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0039 0.1183
Mycobacterium tuberculosis Probable reductase 0.0119 0.0612 0.8837
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0612 0.8837
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0138 1
Echinococcus granulosus geminin 0.0194 0.1054 0.2283
Loa Loa (eye worm) fibroinase 0.0038 0.0138 0.1128
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.069 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0039 0.0267
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0152 0.7832
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0039 0.0748
Plasmodium vivax vivapain-1 0.002 0.0029 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.069 1
Echinococcus granulosus cathepsin l1 0.0026 0.0064 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0029 0.0579
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Echinococcus multilocularis microtubule associated protein 2 0.079 0.4553 0.4543
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0584 0.6295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0029 0.0579
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0029 0.011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0189 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0064 0.0497
Echinococcus multilocularis GPCR, family 2 0.0036 0.0125 0.0106
Brugia malayi cathepsin L-like precursor 0.0026 0.0064 0.0497
Toxoplasma gondii thioredoxin reductase 0.0052 0.022 0.068
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0029 0.0131
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0189 0.0375
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0125 0.1183
Schistosoma mansoni hypothetical protein 0.0078 0.0372 0.0778
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.022 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni inositol monophosphatase 0.0041 0.0152 0.0294
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0189 0.0578
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0372 0.3929
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.2966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0152 0.0134
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0853 0.0835
Loa Loa (eye worm) cysteine protease 0.0038 0.0138 0.1128
Leishmania major DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Brugia malayi Inositol-1 0.0041 0.0152 0.1484
Plasmodium vivax vivapain-3 0.002 0.0029 0.0033
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0127 0.1611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trypanosoma brucei unspecified product 0.0022 0.0039 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0064 0.2623
Entamoeba histolytica cysteine protease, putative 0.0038 0.0138 0.7963
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.022 0.0201
Loa Loa (eye worm) ctsf protein 0.0038 0.0138 0.1128
Onchocerca volvulus 0.0038 0.0138 1
Plasmodium vivax vivapain-2 0.0038 0.0138 0.0404
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0148 0.013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.069 1
Echinococcus granulosus microtubule associated protein 2 0.079 0.4553 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0125 0.0106
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.069 0.1984
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.2966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma brucei trypanothione reductase 0.0052 0.022 0.2844
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0138 0.7963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0152 0.0294
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0029 0.0033
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0138 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0029 0.0131
Echinococcus granulosus cathepsin l1 0.0038 0.0138 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0039 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0322 0.4025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Loa Loa (eye worm) hypothetical protein 0.0171 0.0917 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0372 0.3789
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0138 0.0404
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Schistosoma mansoni DNA polymerase eta 0.0022 0.0039 0.0044
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0125 0.1183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0189 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0068
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0039 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0029 0.0131
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Echinococcus granulosus cysteine protease 0.002 0.0029 0.0022
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Toxoplasma gondii cathepsin CPL 0.0038 0.0138 0.0404
Onchocerca volvulus 0.0038 0.0138 1
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Loa Loa (eye worm) inositol-1 0.0041 0.0152 0.1289
Echinococcus multilocularis muscleblind protein 0.0171 0.0917 0.09
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0189 0.0578
Brugia malayi Thioredoxin reductase 0.0052 0.022 0.2231
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Echinococcus granulosus muscleblind protein 0.0171 0.0917 0.1981
Onchocerca volvulus 0.0038 0.0138 1
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0166 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0138 0.0119
Onchocerca volvulus 0.0038 0.0138 1
Plasmodium falciparum glutathione reductase 0.0052 0.022 0.068

Activities

Activity type Activity value Assay description Source Reference
Log IC50 (binding) = 4.8 Inhibitory concentration against DOXP reductoisomerase ChEMBL. 15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.