Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0136 | 0.8055 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0136 | 0.8055 | 0.7587 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.8055 | 0.7587 |
Trypanosoma cruzi | p450 reductase, putative | 0.0136 | 0.8055 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0153 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0136 | 0.8055 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0136 | 0.8055 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0084 | 0.1939 | 0.1939 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0136 | 0.8055 | 0.7587 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0136 | 0.8055 | 0.7587 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0068 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0136 | 0.8055 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0136 | 0.8055 | 1 |
Leishmania major | p450 reductase, putative | 0.0136 | 0.8055 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0069 | 0.0122 | 0.0122 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0136 | 0.8055 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0136 | 0.8055 | 0.7587 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0136 | 0.8055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0136 | 0.8055 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0136 | 0.8055 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0136 | 0.8055 | 1 |
Giardia lamblia | Hypothetical protein | 0.0121 | 0.6237 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0136 | 0.8055 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0136 | 0.8055 | 0.7587 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0136 | 0.8055 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0084 | 0.1939 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0121 | 0.6237 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0136 | 0.8055 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0136 | 0.8055 | 0.8055 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0136 | 0.8055 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0068 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.11 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Ki (binding) | = 7.7 nM | Displacement of radioligand [3H]-2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate | ChEMBL. | 8410989 |
Ki (binding) | = 7.7 nM | Binding affinity to displace [3H]-2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogenates | ChEMBL. | 8064803 |
Ki (binding) | = 7.7 nM | Displacement of radioligand [3H]-2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate | ChEMBL. | 8410989 |
Ki (binding) | = 7.7 nM | Binding affinity to displace [3H]-2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogenates | ChEMBL. | 8064803 |
Log Ki (binding) | = 8.11 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.