Detailed information for compound 347563

Basic information

Technical information
  • TDR Targets ID: 347563
  • Name: N-[2-[4-(4-chloro-3-hydroxyphenyl)-5-pyridin- 4-yl-1H-imidazol-2-yl]-2-methylpropyl]methane sulfonamide
  • MW: 420.913 | Formula: C19H21ClN4O3S
  • H donors: 3 H acceptors: 5 LogP: 2.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(ccc1Cl)c1nc([nH]c1c1ccncc1)C(CNS(=O)(=O)C)(C)C
  • InChi: 1S/C19H21ClN4O3S/c1-19(2,11-22-28(3,26)27)18-23-16(12-6-8-21-9-7-12)17(24-18)13-4-5-14(20)15(25)10-13/h4-10,22,25H,11H2,1-3H3,(H,23,24)
  • InChiKey: CMKGLLDJHXJPIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[4-(4-chloro-3-hydroxy-phenyl)-5-(4-pyridyl)-1H-imidazol-2-yl]-2-methyl-propyl]methanesulfonamide
  • N-[2-[4-(4-chloro-3-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazol-2-yl]-2-methylpropyl]methanesulfonamide
  • N-[2-[4-(4-chloro-3-hydroxy-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-2-methyl-propyl]methanesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta LACTamase domain containing family member 0.0046 0.0713 0.1453
Echinococcus granulosus Protein kinase C brain isozyme 0.0009 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0046 0.0713 0.2639
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0713 0.0659
Loa Loa (eye worm) hypothetical protein 0.0046 0.0713 0.1452
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0086 0.0115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0452 0.0917
Brugia malayi beta-lactamase family protein 0.0046 0.0713 0.1499
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Echinococcus multilocularis myotubularin protein 13 0.0009 0.0005 0.0009
Plasmodium vivax importin-beta 2, putative 0.0018 0.0179 0.1484
Echinococcus granulosus jumonji domain containing protein 0.0026 0.0334 0.0681
Brugia malayi beta-lactamase family protein 0.0046 0.0713 0.1499
Brugia malayi PHD-finger family protein 0.0019 0.0192 0.0396
Brugia malayi jmjC domain containing protein 0.0061 0.102 0.215
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Echinococcus granulosus protein kinase c iota type 0.0009 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0012 0.0058 0.0053
Trypanosoma brucei ingi protein (ORF1) 0.0152 0.2771 0.2728
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Toxoplasma gondii ABC1 family protein 0.0046 0.0713 0.2794
Mycobacterium tuberculosis Conserved protein 0.0046 0.0713 0.1207
Schistosoma mansoni cpg binding protein 0.0036 0.0522 0.0518
Loa Loa (eye worm) raf kinase 0.026 0.4882 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Onchocerca volvulus Ribonuclease H1 homolog 0.014 0.254 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0179 0.0122
Schistosoma mansoni cpg binding protein 0.0038 0.0562 0.0558
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0058 0.0118
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0159 0.0326
Schistosoma mansoni hypothetical protein 0.0019 0.0192 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.0046 0.0713 0.2639
Echinococcus granulosus Diacylglycerol kinase theta 0.0009 0.0005 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0255 0.4776 0.9734
Brugia malayi Zinc knuckle family protein 0.0012 0.0058 0.0113
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0306 0.0301
Echinococcus granulosus protein kinase c eta type 0.0009 0.0005 0.0009
Schistosoma mansoni phosphoglucomutase 0.014 0.254 0.2537
Treponema pallidum ribonuclease H (rnhA) 0.014 0.254 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0046 0.0713 0.1453
Schistosoma mansoni importin beta-1 0.0018 0.0179 0.0175
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0009 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0046 0.0713 0.2639
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0009 0.0005 0.0009
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0113 0.0222
Echinococcus multilocularis N chimaerin 0.0009 0.0005 0.0009
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0086 0.0115
Loa Loa (eye worm) hypothetical protein 0.0036 0.053 0.1078
Echinococcus granulosus Rac GTPase activating protein 1 0.0009 0.0005 0.0009
Brugia malayi hypothetical protein 0.0012 0.0058 0.0113
Brugia malayi Raf kinase 0.0253 0.4729 1
Brugia malayi CXXC zinc finger family protein 0.0036 0.0522 0.1096
Echinococcus granulosus dnaJ subfamily B 0.0255 0.4776 0.9734
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0192 0.168
Echinococcus granulosus raf serine:threonine protein kinase 0.0262 0.4906 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0013 0.0086 0.0168
Loa Loa (eye worm) hypothetical protein 0.0046 0.0713 0.1452
Loa Loa (eye worm) hypothetical protein 0.0019 0.0192 0.0384
Schistosoma mansoni phosphoglucomutase 0.014 0.254 0.2537
Leishmania major importin beta-1 subunit, putative 0.0015 0.0113 0.0107
Trypanosoma brucei unspecified product 0.0152 0.2771 0.2728
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Brugia malayi hypothetical protein 0.0012 0.0058 0.0113
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0113 0.0222
Echinococcus multilocularis PHD finger protein rhinoceros 0.0019 0.0192 0.0391
Echinococcus granulosus metabotropic glutamate receptor 2 0.0025 0.0306 0.0623
Echinococcus multilocularis protein kinase c iota type 0.0009 0.0005 0.0009
Brugia malayi RNase H family protein 0.014 0.254 0.5367
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0046 0.0713 0.1452
Echinococcus multilocularis snurportin 1 0.0194 0.3585 0.7307
Entamoeba histolytica hypothetical protein 0.0015 0.0113 1
Trichomonas vaginalis esterase, putative 0.0046 0.0713 0.2639
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.0334 0.0681
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.102 0.208
Loa Loa (eye worm) hypothetical protein 0.0046 0.0713 0.1452
Trichomonas vaginalis penicillin-binding protein, putative 0.0046 0.0713 0.2639
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.058 0.1179
Trichomonas vaginalis ran, putative 0.0013 0.0086 0.0115
Echinococcus multilocularis protein kinase c eta type 0.0009 0.0005 0.0009
Mycobacterium ulcerans esterase/lipase LipP 0.0046 0.0713 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0713 0.1452
Onchocerca volvulus 0.0046 0.0713 0.2794
Echinococcus granulosus RNA directed DNA polymerase 0.0012 0.0058 0.0118
Onchocerca volvulus 0.0036 0.0522 0.2042
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0058 0.0118
Trypanosoma cruzi ribonuclease H1, putative 0.014 0.254 1
Echinococcus granulosus ribonuclease H1 0.014 0.254 0.5177
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0113 0.0222
Schistosoma mansoni hypothetical protein 0.0255 0.4776 0.4773
Brugia malayi Importin beta-1 subunit 0.0018 0.0179 0.037
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0012 0.0058 0.0118
Loa Loa (eye worm) hypothetical protein 0.0046 0.0713 0.1452
Schistosoma mansoni hypothetical protein 0.0194 0.3585 0.3582
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0013 0.0086 0.0173
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Mycobacterium ulcerans beta-lactamase 0.0046 0.0713 0.5
Toxoplasma gondii ribonuclease HI protein 0.014 0.254 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0046 0.0713 0.2639
Entamoeba histolytica Ran family GTPase 0.0013 0.0086 0.7566
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0119 0.0115
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0308 0.0304
Schistosoma mansoni ran 0.0013 0.0086 0.0082
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0194 0.3585 0.7342
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0019 0.0192 0.0187
Echinococcus granulosus peregrin 0.0019 0.0192 0.0391
Brugia malayi Metabotropic glutamate receptor precursor. 0.0029 0.0398 0.0834
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0192 0.0738
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0009 0.0005 0.0009
Mycobacterium tuberculosis Probable lipase LipD 0.0046 0.0713 0.1207
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0058 0.0118
Brugia malayi jmjC domain containing protein 0.0025 0.0308 0.0642
Onchocerca volvulus 0.0046 0.0713 0.2794
Loa Loa (eye worm) glutamate receptor 0.0029 0.0398 0.0808
Onchocerca volvulus 0.0012 0.0058 0.021
Echinococcus granulosus unc 13 munc13 0.0009 0.0005 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0046 0.0713 0.1207
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0009 0.0005 0.0009
Echinococcus multilocularis Diacylglycerol kinase theta 0.0009 0.0005 0.0009
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Brugia malayi reverse transcriptase 0.0012 0.0058 0.0113
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0113 0.0222
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0179 0.069
Onchocerca volvulus 0.0046 0.0713 0.2794
Echinococcus multilocularis importin subunit beta 1 0.0018 0.0179 0.0366
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0152 0.2771 0.2728
Echinococcus multilocularis lysine specific demethylase 5A 0.0023 0.0268 0.0547
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0713 0.2639
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0046 0.0713 0.5
Giardia lamblia PHD finger protein 15 0.0019 0.0192 0.0539
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0046 0.0713 0.0709
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0013 0.0086 0.0029
Brugia malayi metabotropic glutamate receptor type 2 0.0014 0.0106 0.0214
Echinococcus multilocularis ribonuclease H1 0.014 0.254 0.5177
Echinococcus granulosus GTP binding nuclear protein Ran 0.0013 0.0086 0.0176
Trypanosoma cruzi ribonuclease H1, putative 0.014 0.254 1
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0012 0.0058 0.0053
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0027 0.0345 0.072
Loa Loa (eye worm) hypothetical protein 0.0046 0.0713 0.1452
Leishmania major hypothetical protein, conserved 0.0046 0.0713 0.2553
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0042 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0713 0.2639
Mycobacterium tuberculosis Conserved protein 0.0046 0.0713 0.1207
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0179 0.0122
Brugia malayi Zinc knuckle family protein 0.0012 0.0058 0.0113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0046 0.0713 0.1207
Trypanosoma brucei RNA helicase, putative 0.0524 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0009 0.0005 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0042 0.0086
Schistosoma mansoni protein kinase 0.0012 0.0058 0.0053
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0291 0.5484 1
Schistosoma mansoni phosphoglucomutase 0.014 0.254 0.2537
Trypanosoma brucei ingi protein (ORF1) 0.0152 0.2771 0.2728
Echinococcus multilocularis unc 13 (munc13) 0.0009 0.0005 0.0009
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Echinococcus granulosus KRAB A domain containing protein 0.0012 0.0058 0.0118
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0235 0.0231
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0308 0.0622
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Schistosoma mansoni jumonji domain containing protein 0.0049 0.0775 0.0771
Brugia malayi RNase H family protein 0.014 0.254 0.5367
Schistosoma mansoni cpg binding protein 0.0038 0.0562 0.0558
Loa Loa (eye worm) hypothetical protein 0.0018 0.0179 0.0359
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.014 0.254 0.5
Brugia malayi Bromodomain containing protein 0.0019 0.0192 0.0396
Plasmodium falciparum importin beta, putative 0.0018 0.0179 0.8833
Schistosoma mansoni ran 0.0013 0.0086 0.0082
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0148 0.2707 0.5541
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0009 0.0005 0.0009
Echinococcus granulosus metabotropic glutamate receptor 5 0.0036 0.053 0.1081
Plasmodium falciparum phd finger protein, putative 0.0019 0.0192 1
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.4906 0.4904
Echinococcus multilocularis raf serine:threonine protein kinase 0.0262 0.4906 1
Echinococcus granulosus importin subunit beta 1 0.0018 0.0179 0.0366
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0013 0.0086 0.0323
Brugia malayi reverse transcriptase 0.0012 0.0058 0.0113
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0013 0.0086 0.0115
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0013 0.0086 0.0176
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0046 0.0713 0.1499
Echinococcus multilocularis Rac GTPase activating protein 1 0.0009 0.0005 0.0009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0042 0.0086
Mycobacterium leprae Probable lipase LipE 0.0046 0.0713 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.2771 0.2728
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0012 0.0058 0.021
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0025 0.0306 0.0623
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Loa Loa (eye worm) beta-lactamase 0.0046 0.0713 0.1452
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.102 0.208
Echinococcus granulosus lysine specific demethylase 5A 0.0025 0.0308 0.0628
Echinococcus granulosus N chimaerin 0.0009 0.0005 0.0009
Brugia malayi hypothetical protein 0.0012 0.0058 0.0113
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Echinococcus granulosus PHD finger protein rhinoceros 0.0019 0.0192 0.0391
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0192 0.0738
Schistosoma mansoni hypothetical protein 0.0012 0.0058 0.0053
Onchocerca volvulus 0.0012 0.0058 0.021
Giardia lamblia Ribonuclease H 0.014 0.254 1
Mycobacterium ulcerans lipase LipD 0.0046 0.0713 0.5
Echinococcus granulosus snurportin 1 0.0194 0.3585 0.7307
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0046 0.0713 0.0709
Mycobacterium tuberculosis Conserved protein 0.0046 0.0713 0.1207
Trichomonas vaginalis ribonuclease H1, putative 0.014 0.254 1
Mycobacterium ulcerans hypothetical protein 0.0046 0.0713 0.5
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0033 0.0477 0.0472
Mycobacterium tuberculosis Probable esterase LipL 0.0046 0.0713 0.1207
Echinococcus granulosus myotubularin protein 13 0.0009 0.0005 0.0009
Echinococcus granulosus protein kinase c epsilon type 0.0009 0.0005 0.0009
Leishmania major ribonuclease H1, putative 0.014 0.254 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0036 0.0522 0.1062
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0009 0.0005 0.0009
Echinococcus multilocularis protein kinase c epsilon type 0.0009 0.0005 0.0009
Brugia malayi reverse transcriptase 0.0012 0.0058 0.0113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0308 0.0304
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0192 0.0384
Loa Loa (eye worm) glutamate receptor 0.0012 0.0052 0.0097
Trypanosoma brucei ribonuclease H1 0.014 0.254 0.2497
Echinococcus multilocularis RNA directed DNA polymerase 0.0012 0.0058 0.0118
Brugia malayi hypothetical protein 0.0012 0.0058 0.0113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0046 0.0713 0.1207
Echinococcus multilocularis peregrin 0.0019 0.0192 0.0391
Brugia malayi RNase H family protein 0.014 0.254 0.5367
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0713 0.5
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0058 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.1301 0.1297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.1144 0.4494
Mycobacterium tuberculosis Probable lipase LipE 0.0046 0.0713 0.1207
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Onchocerca volvulus Alhambra homolog 0.0019 0.0192 0.0738
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0036 0.053 0.1081
Mycobacterium tuberculosis Probable hydrolase 0.0046 0.0713 0.1207
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0713 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0058 0.0113
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0058 0.0118
Brugia malayi RNA, U transporter 1 0.0052 0.0828 0.1744
Echinococcus multilocularis cpg binding protein 0.0038 0.0562 0.1145
Brugia malayi beta-lactamase 0.0046 0.0713 0.1499
Echinococcus granulosus cpg binding protein 0.0038 0.0562 0.1145
Schistosoma mansoni metabotropic glutamate receptor 0.0014 0.0106 0.0101

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 14 nM Inhibition bRaf kinase activity ChEMBL. 16260133
IC50 (binding) = 14 nM Inhibition bRaf kinase activity ChEMBL. 16260133
Kd (binding) = 10 nM Binding affinity at bRaf kinase in fluorescent ligand displacement assay ChEMBL. 16260133
Kd (binding) = 10 nM Binding affinity at bRaf kinase in fluorescent ligand displacement assay ChEMBL. 16260133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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