TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 290.359 | Formula: C19H18N2O
H donors: 0 H acceptors: 1 LogP: 3.21 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: CN1Cc2c(C1=O)c1CCCc1c1c2c2ccccc2n1C
InChi: 1S/C19H18N2O/c1-20-10-14-16-13-6-3-4-9-15(13)21(2)18(16)12-8-5-7-11(12)17(14)19(20)22/h3-4,6,9H,5,7-8,10H2,1-2H3
InChiKey: ULXJZPSNENAHKN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	poly (ADP-ribose) polymerase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly adp ribose polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei gambiense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei	poly(adp-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (adp ribose) polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma congolense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2-A, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly ADP ribose polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Neospora caninum	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative	Get druggable targets OG5_128423	All targets in OG5_128423

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0235	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0422	0.1477
Brugia malayi	hypothetical protein	0.0014	0.0035	0.0084
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0245	0.064
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0422	0.1096
Schistosoma mansoni	protein kinase	0.0031	0.0437	0.1135
Entamoeba histolytica	protein kinase, putative	0.0031	0.0437	0.0561
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0422	0.1102
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0245	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0235	0.0201
Schistosoma mansoni	glucose transport protein	0.0102	0.2122	0.554
Onchocerca volvulus		0.0014	0.0035	0.1421
Schistosoma mansoni	glucose transporter	0.0014	0.0035	0.0084
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Trypanosoma brucei	DNA repair protein, putative	0.0023	0.0233	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0285	0.0995
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2122	0.5543
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0245	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0014	0.003	0.0097
Trypanosoma cruzi	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0023	0.0233	0.1028
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0245	0.0633
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0543	0.051
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0035	0.0113
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0245	0.064
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.004	0.0642	0.1677
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0245	0.0633
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0437	0.0404
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0245	0.0633
Echinococcus granulosus	solute carrier family 22	0.0014	0.0035	0.0091
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0437	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0437	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0245	0.064
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0235	0.3046
Brugia malayi	steroid hormone receptor	0.0023	0.0245	0.0633
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0447	0.1973
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0422	0.1096
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0433	1	1
Onchocerca volvulus	DNA ligase 3 homolog	0.0023	0.0233	0.9514
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0235	0.0608
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0245	0.064
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2122	0.5543
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0165	0.3617	0.5495
Schistosoma mansoni	sugar transporter	0.0014	0.0035	0.0084
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0245	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0447	0.1973
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2122	0.5543
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0245	0.0633
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0035	0.0084
Onchocerca volvulus		0.0014	0.0035	0.1421
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0235	0.0308
Brugia malayi	major facilitator superfamily protein	0.0014	0.0035	0.0084
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0035	0.0091
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0165	0.3617	0.3595
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0437	0.0404
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0422	0.1855
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0245	0.0633
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0245	0.0633
Brugia malayi	nuclear hormone receptor	0.0023	0.0245	0.0633
Loa Loa (eye worm)	sugar transporter	0.0014	0.0035	0.0113
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0245	0.0633
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0245	0.064
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0245	0.0854
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0174	0.3828	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0245	0.0633
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0035	0.0091
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0447	0.2133
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0447	0.2133
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0422	0.1096
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0027	0.0064
Echinococcus granulosus	Ankyrin	0.0014	0.003	0.0079
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0447	0.2133
Brugia malayi	Death domain containing protein	0.0014	0.0027	0.0064
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0235	0.1039
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0105	0.0364
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0035	0.0091
Loa Loa (eye worm)	sugar transporter	0.0102	0.2122	0.7467
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0245	0.064
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0027	0.0064
Onchocerca volvulus		0.0014	0.0035	0.1421
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0245	0.0854
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0245	0.064
Trypanosoma cruzi	hexose transporter	0.0032	0.0447	0.2133
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.018	0.399	0.6066
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0245	0.0633
Schistosoma mansoni	protein kinase	0.0031	0.0437	0.1135
Echinococcus granulosus	General substrate transporter	0.0088	0.178	0.4651
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0543	0.2631
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2122	0.5543
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0035	0.0091
Brugia malayi	major facilitator superfamily protein	0.0014	0.0035	0.0084
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0447	0.2133
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0245	0.0633
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0437	0.0617
Brugia malayi	Cam kinase protein 1	0.0031	0.0437	0.1135
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0095	0.1965	1
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0095	0.1965	0.5133
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0027	0.0336	0.0877
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0035	0.0084
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0245	0.0633
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0245	0.064
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0245	0.0633
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0437	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1965	0.6914
Onchocerca volvulus	Putative transporter	0.0014	0.0035	0.1421
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0235	0.0961
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0437	0.2084
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0245	0.064
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0437	0.0404
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0035	0.0091
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0245	0.0633
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2122	0.5543
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0245	0.0854
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0245	0.064
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0027	0.0087
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0422	0.0519
Leishmania major	glucose transporter, lmgt3	0.0032	0.0447	0.8107
Plasmodium vivax	hexose transporter	0.0102	0.2122	0.2094
Brugia malayi	WGR domain containing protein	0.0174	0.3828	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0035	0.0091
Onchocerca volvulus		0.0014	0.0035	0.1421
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0235	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2122	0.5543
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0235	0.082
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0235	0.0608
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0027	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0233	0.0812
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0165	0.3617	0.3595
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0095	0.1965	0.5129
Leishmania major	DNA repair protein, putative	0.0023	0.0233	0.3907
Brugia malayi	hypothetical protein	0.0014	0.0035	0.0084
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0235	0.5182
Leishmania major	glucose transporter, lmgt1	0.0032	0.0447	0.8107
Plasmodium falciparum	protein kinase 7	0.0288	0.6554	0.6542
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Onchocerca volvulus		0.0014	0.0035	0.1421
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0235	0.0201
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0447	0.2133
Leishmania major	hypothetical protein, conserved	0.0023	0.0233	0.3907
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0437	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0422	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Brugia malayi	ecdysteroid receptor	0.0023	0.0245	0.0633
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0437	0.1135
Echinococcus granulosus	death domain containing protein	0.0014	0.0027	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0027	0.0336	0.0877
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0245	0.0633
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0437	0.1142
Brugia malayi	Sugar transporter family protein	0.0014	0.0035	0.0084
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0027	0.0336	0.0877
Leishmania major	protein kinase, putative	0.0031	0.0437	0.7919
Trypanosoma cruzi	DNA repair protein, putative	0.0023	0.0233	0.1028
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0245	0.0633
Onchocerca volvulus		0.0014	0.0035	0.1421
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0437	0.1142
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0235	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Schistosoma mansoni	sugar transporter	0.0014	0.0035	0.0084
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0245	0.064
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.1405	0.3669
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.003	0.0072
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0437	0.1142
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0447	0.1973
Brugia malayi	Sugar transporter family protein	0.0102	0.2122	0.554
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0245	0.0854
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0169	0.0641
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0035	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0437	0.1927
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0235	0.0615
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0245	0.0633
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0245	0.0633
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0245	0.0633
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0235	0.0615
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0437	0.0404
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0245	0.064
Leishmania major	glucose transporter, lmgt2	0.0032	0.0447	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0245	0.064
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0245	0.064
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0082	0.1658	0.4328
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0422	0.1096
Onchocerca volvulus		0.0014	0.0035	0.1421
Onchocerca volvulus		0.0014	0.0035	0.1421
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0027	0.0087
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0095	0.1965	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0245	0.0633
Onchocerca volvulus		0.0014	0.0035	0.1421
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0437	0.1135
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0027	0.0072
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0422	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Onchocerca volvulus		0.0014	0.0035	0.1421
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0245	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0035	0.0084
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0391	0.1021
Echinococcus granulosus	solute carrier family 22	0.0014	0.0035	0.0091
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0027	0.0072
Onchocerca volvulus		0.0014	0.0035	0.1421
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0543	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0154	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0543	0.2631
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0245	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0035	0.0113
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0245	0.0633
Onchocerca volvulus		0.0014	0.0035	0.1421
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2122	0.5543
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.1405	0.3669
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0543	0.0779
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0437	0.0404
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0035	0.0091
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0543	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0235	1
Schistosoma mansoni	coup transcription factor	0.0023	0.0245	0.0633
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Entamoeba histolytica	hypothetical protein	0.0027	0.0336	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0027	0.112
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Trypanosoma brucei	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0023	0.0233	0.1028
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0437	0.0617
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0422	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0027	0.0064
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0235	0.1039
Onchocerca volvulus		0.0014	0.0035	0.1421
Echinococcus granulosus	solute carrier family 22	0.0014	0.0035	0.0091
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0035	0.5
Plasmodium falciparum	hexose transporter	0.0102	0.2122	0.2094
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0035	0.0091
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2122	0.3201
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0437	0.0404
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0245	0.0633
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0543	0.051
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0437	0.1142
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0068	0.1323	0.4651
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0174	0.3828	1
Onchocerca volvulus		0.0014	0.0035	0.1421
Echinococcus multilocularis	Ankyrin	0.0014	0.003	0.0079
Onchocerca volvulus		0.0023	0.0245	1
Brugia malayi	hypothetical protein	0.0014	0.0035	0.0084
Schistosoma mansoni	hypothetical protein	0.0102	0.2122	0.554
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0447	0.2133
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0422	0.1102
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0447	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0437	0.0404
Echinococcus granulosus	solute carrier family 22	0.0014	0.0035	0.0091
Entamoeba histolytica	protein kinase, putative	0.0031	0.0437	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0437	0.153
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0437	0.0404
Schistosoma mansoni	glucose transport protein	0.0102	0.2122	0.554
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0447	0.1973
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0437	0.153
Schistosoma mansoni	protein kinase	0.0031	0.0437	0.1135
Brugia malayi	WGR domain containing protein	0.0095	0.1965	0.5129
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0245	0.0633
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0027	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0245	0.0854
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0154	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0245	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Schistosoma mansoni	sugar transporter	0.0014	0.0035	0.0084
Schistosoma mansoni	sugar transporter	0.0014	0.0035	0.0084
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0245	0.064
Echinococcus granulosus	poly adp ribose polymerase 2	0.0095	0.1965	0.5133
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0245	0.0854
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0027	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0132	0.2841	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0437	0.153
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0447	0.2133
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0245	0.064
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0245	0.064
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0054	0.0978	0.2554
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0543	0.2631
Echinococcus granulosus	WGR domain containing protein	0.0054	0.0978	0.2554
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0174	0.3828	1
Toxoplasma gondii	protein kinase, putative	0.0288	0.6554	1
Onchocerca volvulus		0.0014	0.0035	0.1421
Onchocerca volvulus		0.0014	0.0035	0.1421
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0245	0.064
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0095	0.1965	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2122	1
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0174	0.3828	1
Brugia malayi	Sugar transporter family protein	0.0014	0.0035	0.0084
Echinococcus multilocularis	General substrate transporter	0.0088	0.178	0.4651
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0245	0.0633
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0245	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0113
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0447	0.2133
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0437	0.0617
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0074	0.0186
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0245	0.0633
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0245	0.0633
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2122	0.5543
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0447	0.1973
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0447	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0437	0.1142
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0447	0.2133
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0245	0.0633
Brugia malayi	Uncoordinated protein 44	0.0014	0.0027	0.0064
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0245	0.0854
Schistosoma mansoni	glucose transport protein	0.0102	0.2122	0.554
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0235	0.395
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0447	0.1973
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0245	0.0633
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0391	0.1021

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Potency in PC12 cells assessed by recovery of NAD+ at 1 uM	ChEMBL.	16359865
Efficacy (functional)	0	Efficacy in PC12 cells assessed by recovery of NAD+ at 30 uM	ChEMBL.	16359865
IC50 (binding)	= 10000 nM	Inhibition of recombinant human PARP1	ChEMBL.	16359865
IC50 (binding)	= 10000 nM	Inhibition of recombinant human PARP1	ChEMBL.	16359865

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL382430

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 353402