Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 295 aa | 23.4 % | |
Schistosoma mansoni | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 286 aa | 21.3 % |
Echinococcus granulosus | allatostatin A receptor | Adenosine A3 receptor | 320 aa | 320 aa | 24.4 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Adenosine A3 receptor | 320 aa | 324 aa | 20.7 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A3 receptor | 320 aa | 309 aa | 24.9 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 308 aa | 20.5 % | |
Schistosoma japonicum | Rhodopsin, putative | Adenosine A3 receptor | 320 aa | 320 aa | 23.8 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 320 aa | 24.4 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Adenosine A3 receptor | 320 aa | 304 aa | 24.3 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A3 receptor | 320 aa | 307 aa | 26.4 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Adenosine A3 receptor | 320 aa | 324 aa | 21.0 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 288 aa | 20.8 % | |
Echinococcus granulosus | tachykinin peptides receptor 99D | Adenosine A3 receptor | 320 aa | 297 aa | 26.6 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 311 aa | 23.5 % | |
Schistosoma mansoni | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 306 aa | 23.5 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Adenosine A3 receptor | 320 aa | 312 aa | 25.0 % |
Schistosoma japonicum | 5-hydroxytryptamine receptor 4, putative | Adenosine A3 receptor | 320 aa | 311 aa | 27.3 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Adenosine A3 receptor | 320 aa | 296 aa | 27.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Adenosine A3 receptor | 320 aa | 358 aa | 25.4 % |
Echinococcus multilocularis | allatostatin A receptor | Adenosine A3 receptor | 320 aa | 317 aa | 24.9 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 350 aa | 24.9 % | |
Loa Loa (eye worm) | neuropeptide F receptor | Adenosine A3 receptor | 320 aa | 321 aa | 24.0 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 276 aa | 22.5 % | |
Schistosoma japonicum | Alpha-1A adrenergic receptor, putative | Adenosine A3 receptor | 320 aa | 325 aa | 24.9 % |
Schistosoma mansoni | dro/myosuppressin receptor | Adenosine A1 receptor | 326 aa | 326 aa | 22.1 % |
Schistosoma japonicum | ko:K04255 opsin 4 (melanopsin), putative | Adenosine A3 receptor | 320 aa | 370 aa | 21.4 % |
Echinococcus multilocularis | tachykinin peptides receptor 99D | Adenosine A3 receptor | 320 aa | 297 aa | 26.6 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A3 receptor | 320 aa | 300 aa | 22.0 % |
Brugia malayi | hypothetical protein | Adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Schistosoma mansoni | adenoreceptor | Adenosine A3 receptor | 320 aa | 319 aa | 27.9 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Adenosine A3 receptor | 320 aa | 332 aa | 24.4 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 282 aa | 20.6 % | |
Loa Loa (eye worm) | hypothetical protein | Adenosine A1 receptor | 326 aa | 300 aa | 24.3 % |
Echinococcus multilocularis | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 282 aa | 24.1 % |
Echinococcus granulosus | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 290 aa | 23.4 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Adenosine A1 receptor | 326 aa | 286 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.85 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.02 | 1 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.02 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.018 | 0.85 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0145 | 0.5902 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.018 | 0.85 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.02 | 1 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.02 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.02 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.02 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0145 | 0.5902 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.02 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0191 | 0.9342 | 0.5 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0066 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.5096 | 0.4103 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.5096 | 0.4103 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.02 | 1 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0066 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0066 | 0 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.02 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.018 | 0.85 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.02 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0145 | 0.5902 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.85 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0109 | 0.3184 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.02 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0066 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 12 % | Binding affinity against Adenosine A2A receptor of rat striatal membranes using [3H]- CGS 21680 at 10E-4 | ChEMBL. | 9703463 |
Ki (binding) | = 75.1 nM | Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]-R-PIA. | ChEMBL. | 9703463 |
Ki (binding) | = 75.1 nM | Inhibition of [3H]-R-PIA binding to Adenosine A1 receptor from rat brain membrane | ChEMBL. | 15863334 |
Ki (binding) | = 324 nM | Displacement of [125I]AB-MECA from rat adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16356715 |
Ki (binding) | = 324 nM | Binding affinity against rat adenosine A3 receptor expressed in CHO cells using [125I]-. | ChEMBL. | 9703463 |
Ki (binding) | = 324 nM | Displacement of radioligand [125I]-AB-MECA binding at rat A3 receptor expressed in CHO cells | ChEMBL. | 15990306 |
Ki (binding) | = 324 nM | Displacement of [125I]AB-MECA from rat adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16356715 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.