Detailed information for compound 354283

Basic information

Technical information
  • TDR Targets ID: 354283
  • Name: N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfany lbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[ 2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]be nzamide
  • MW: 761.95 | Formula: C39H47N5O7S2
  • H donors: 2 H acceptors: 5 LogP: 7.24 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(CCCN2CCOCC2)ccc1c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])N[C@@H](CSc1ccccc1)CCN(C)C
  • InChi: 1S/C39H47N5O7S2/c1-42(2)21-19-32(28-52-33-9-5-4-6-10-33)40-36-18-16-34(27-37(36)44(46)47)53(48,49)41-39(45)31-14-12-30(13-15-31)35-17-11-29(26-38(35)50-3)8-7-20-43-22-24-51-25-23-43/h4-6,9-18,26-27,32,40H,7-8,19-25,28H2,1-3H3,(H,41,45)/t32-/m1/s1
  • InChiKey: ODNXRXAXPHKAQQ-JGCGQSQUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[[(1R)-3-(dimethylamino)-1-(phenylsulfanylmethyl)propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
  • N-[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
  • N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanyl-butan-2-yl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide
  • N-[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
  • N-[4-[[(2R)-4-dimethylamino-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide
  • N-[4-[[(1R)-3-dimethylamino-1-(phenylsulfanylmethyl)propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
  • N-[4-[[(1R)-3-dimethylamino-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
  • N-[4-[[(1R)-3-dimethylamino-1-[(phenylthio)methyl]propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
  • N-[4-[[(2R)-4-dimethylamino-1-phenylsulfanyl-butan-2-yl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-cell CLL/lymphoma 2 Starlite/ChEMBL References
Homo sapiens BCL2-like 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus EGFP:Bcl2 fusion protein Get druggable targets OG5_139665 All targets in OG5_139665
Echinococcus multilocularis EGFP:Bcl2 fusion protein Get druggable targets OG5_139665 All targets in OG5_139665
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0154 0.0939 0.1625
Echinococcus granulosus 7TM GPCR rhodopsin 0.0154 0.0939 0.1625
Loa Loa (eye worm) LGC-31 protein 0.0093 0.0503 0.1673
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0154 0.0939 0.1625
Brugia malayi excitatory GABA receptor EXP-1A 0.0093 0.0503 0.1673
Onchocerca volvulus 0.0154 0.0939 0.273
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0043 0.0146 0.0253
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0154 0.0939 0.1625
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0043 0.0146 0.0487
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0093 0.0503 0.1673
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0295 0.051
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Echinococcus multilocularis fmrfamide receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0915 0.1583
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0043 0.0146 0.0487
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0154 0.0939 0.8019
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0051 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0093 0.0503 0.4291
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Onchocerca volvulus 0.0093 0.0503 0.1461
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) independent phosphoglycerate mutase isoform 2 0.0113 0.0644 0.2144
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Echinococcus multilocularis g protein coupled receptor 0.0154 0.0939 0.1625
Entamoeba histolytica hypothetical protein 0.005 0.0198 0.2476
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0708 0.0708
Trichomonas vaginalis set domain proteins, putative 0.0506 0.344 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0089 0.0154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0292 0.0504
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0154 0.0939 0.1625
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0093 0.0503 0.1673
Schistosoma mansoni nAChR subunit 0.0093 0.0503 0.4291
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0805 0.0805
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0781 0.6665
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0003 0.001
Echinococcus granulosus neuropeptide receptor 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Schistosoma mansoni nAChR subunit 0.0043 0.0146 0.1249
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus multilocularis g protein coupled receptor 0.0154 0.0939 0.1625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0619 0.2062
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi phosphofructokinase 0.0109 0.0619 0.2062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) hypothetical protein 0.0319 0.2112 0.7031
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0221 0.0383
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0051 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0619 0.18
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0093 0.0503 0.1673
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0619 0.18
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Trypanosoma brucei 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0113 0.0644 0.1618
Echinococcus multilocularis g-protein coupled receptor 0.0154 0.0939 0.1625
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0093 0.0503 0.1673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Brugia malayi GnHR receptor homolog 0.0154 0.0939 0.3127
Echinococcus granulosus nAChR subunit 0.005 0.0198 0.0342
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0154 0.0939 0.1625
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0154 0.0939 0.8019
Schistosoma mansoni amine GPCR 0.0154 0.0939 0.8019
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0221 0.0172
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0051 0.015
Schistosoma mansoni hypothetical protein 0.0075 0.0376 0.3212
Trypanosoma brucei Polypeptide deformylase 1 0.0545 0.3718 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0077 0.0386 0.33
Schistosoma mansoni biogenic amine receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Mycobacterium ulcerans peptide deformylase 0.1428 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0154 0.0939 0.1625
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0278 0.0481
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0051 0.0001
Brugia malayi Dopamine receptor protein 1 0.0154 0.0939 0.3127
Loa Loa (eye worm) G-protein coupled receptor 0.0154 0.0939 0.3127
Schistosoma mansoni opsin-like receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0093 0.0503 0.1673
Loa Loa (eye worm) glutathione reductase 0.0053 0.0221 0.0737
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0295 0.2518
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Echinococcus multilocularis allatostatin A receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0093 0.0503 0.087
Loa Loa (eye worm) hypothetical protein 0.0238 0.1534 0.5106
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0093 0.0503 0.087
Brugia malayi Carboxylesterase family protein 0.0132 0.0781 0.2599
Brugia malayi Dopamine receptor 0.0154 0.0939 0.3127
Echinococcus multilocularis G protein coupled receptor 139 0.0154 0.0939 0.1625
Brugia malayi G protein-coupled receptor 0.0154 0.0939 0.3127
Loa Loa (eye worm) apoptosis regulator protein 0.0067 0.0315 0.105
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Giardia lamblia 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0113 0.0644 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Schistosoma mansoni histamine h1 receptor 0.0154 0.0939 0.8019
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0619 0.0616
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus tm gpcr rhodopsin 0.0154 0.0939 0.1625
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0093 0.0503 0.4291
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0087 0.0457 0.0457
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0093 0.0503 0.1673
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.1534 0.2654
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0113 0.0644 0.1618
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0154 0.0939 0.8019
Brugia malayi G-protein coupled receptor 0.0154 0.0939 0.3127
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0003 0.0003
Brugia malayi Heterochromatin protein 1 0.0079 0.0401 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0064 0.0185
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0154 0.0939 0.1625
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0292 0.2489
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0915 0.1583
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Echinococcus granulosus neuropeptides capa receptor 0.0154 0.0939 0.1625
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0043 0.0146 0.0253
Schistosoma mansoni amine GPCR 0.0154 0.0939 0.8019
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0154 0.0939 0.8019
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.1428 1 1
Onchocerca volvulus 0.0093 0.0503 0.1461
Brugia malayi Thioredoxin reductase 0.0053 0.0221 0.0737
Schistosoma mansoni flap endonuclease-1 0.0027 0.003 0.026
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Schistosoma mansoni nAChR subunit 0.0093 0.0503 0.4291
Brugia malayi neuropeptide F receptor 0.0154 0.0939 0.3127
Echinococcus multilocularis nAChR subunit 0.005 0.0198 0.0342
Echinococcus granulosus g protein coupled receptor 0.0154 0.0939 0.1625
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0708 0.0708
Schistosoma mansoni biogenic amine (5HT) receptor 0.0154 0.0939 0.8019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0805 0.0802
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0093 0.0503 0.087
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0179 0.052
Entamoeba histolytica 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0113 0.0644 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0087 0.0291
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0401 0.1166
Brugia malayi putative neuropeptide receptor 0.0154 0.0939 0.3127
Schistosoma mansoni nAChR subunit 0.0093 0.0503 0.4291
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0292 0.2489
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0619 0.2062
Echinococcus granulosus acetylcholinesterase 0.0132 0.0781 0.1351
Schistosoma mansoni chromobox protein 0.0079 0.0401 0.3426
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0154 0.0939 0.1625
Schistosoma mansoni hypothetical protein 0.0187 0.1171 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0708 0.0705
Brugia malayi Dopamine receptor protein 2 0.0154 0.0939 0.3127
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus multilocularis nAChR subunit 0.0093 0.0503 0.087
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0221 0.0466
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis neuropeptide s receptor 0.0154 0.0939 0.1625
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0154 0.0939 0.8019
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0093 0.0503 0.1673
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0805 0.0805
Onchocerca volvulus 0.0043 0.0146 0.0425
Brugia malayi Tachykinin-like peptides receptor 99D 0.0154 0.0939 0.3127
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0295 0.051
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0051 0.0001
Loa Loa (eye worm) hypothetical protein 0.0087 0.0457 0.1523
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0093 0.0503 0.087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Echinococcus granulosus peptide allatostatin:somatostatin 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0296
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus carboxylesterase 5A 0.0132 0.0781 0.1351
Brugia malayi Melatonin receptor type 1A 0.0154 0.0939 0.3127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0915 0.1583
Toxoplasma gondii melibiase subfamily protein 0.0116 0.0664 0.0617
Brugia malayi hypothetical protein 0.0043 0.0146 0.0487
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0154 0.0939 0.1625
Brugia malayi Cation transporter family protein 0.0093 0.0503 0.1673
Echinococcus multilocularis G-protein coupled receptor, putative 0.0154 0.0939 0.1625
Brugia malayi AKH receptor 0.0154 0.0939 0.3127
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0093 0.0503 0.4291
Brugia malayi G-protein coupled receptor 0.0154 0.0939 0.3127
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0292 0.2489
Schistosoma mansoni acetylcholine receptor-related 0.0043 0.0146 0.1249
Brugia malayi MH2 domain containing protein 0.0119 0.069 0.2297
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0067 0.0315 0.0546
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0401 0.1336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Schistosoma mansoni adenoreceptor 0.0154 0.0939 0.8019
Echinococcus multilocularis sex peptide receptor 0.0154 0.0939 0.1625
Echinococcus granulosus orexin receptor type 2 0.0154 0.0939 0.1625
Echinococcus multilocularis dro:myosuppressin receptor 0.0154 0.0939 0.1625
Loa Loa (eye worm) TYRA-2 protein 0.0154 0.0939 0.3127
Schistosoma mansoni hypothetical protein 0.0154 0.0939 0.8019
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0179 0.052
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Onchocerca volvulus 0.0506 0.344 1
Echinococcus multilocularis fmrfamide receptor 0.0154 0.0939 0.1625
Echinococcus granulosus glycine receptor subunit alpha 1 0.0093 0.0503 0.087
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0051 0.0015
Schistosoma mansoni neuropeptide receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0093 0.0503 0.087
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0064 0.0185
Schistosoma mansoni hypothetical protein 0.0067 0.0315 0.2693
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0292 0.0971
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0295 0.0246
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.005 0.0198 0.1687
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Loa Loa (eye worm) hypothetical protein 0.0064 0.0295 0.0982
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0619 0.1551
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0093 0.0503 0.087
Schistosoma mansoni neurotransmitter gated ion channel 0.005 0.0198 0.1687
Echinococcus multilocularis g protein coupled receptor 0.0154 0.0939 0.1625
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.0915 0.3046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0093 0.0503 0.1673
Echinococcus granulosus neuropeptides capa receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis chromobox protein 1 0.0079 0.0401 0.0694
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0154 0.0939 0.8019
Plasmodium vivax glutathione reductase, putative 0.0053 0.0221 0.0172
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0154 0.0939 0.273
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0093 0.0503 0.1673
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0011
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0051 0.0168
Echinococcus granulosus allatostatin A receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0093 0.0503 0.087
Onchocerca volvulus 0.0035 0.0087 0.0254
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0051 0.015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Schistosoma mansoni hypothetical protein 0.0154 0.0939 0.8019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus multilocularis neuropeptide receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Leishmania major polypeptide deformylase-like protein, putative 0.0545 0.3718 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0154 0.0939 0.8019
Echinococcus granulosus tar DNA binding protein 0.0063 0.0292 0.0504
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Onchocerca volvulus 0.0093 0.0503 0.1461
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Schistosoma mansoni neuropeptide F-like receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.0781 0.2599
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus granulosus biogenic amine 5HT receptor 0.0154 0.0939 0.1625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0915 0.7812
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0093 0.0503 0.087
Brugia malayi Serotonin receptor 0.0154 0.0939 0.3127
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0051 0.0147
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0089 0.0296
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0781 0.1351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Schistosoma mansoni amine GPCR 0.0154 0.0939 0.8019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0093 0.0503 0.1673
Echinococcus granulosus acetylcholinesterase 0.0132 0.0781 0.1351
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0093 0.0503 0.1673
Echinococcus granulosus sex peptide receptor 0.0154 0.0939 0.1625
Toxoplasma gondii thioredoxin reductase 0.0053 0.0221 0.0172
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0093 0.0503 0.087
Loa Loa (eye worm) GABA receptor subunit 0.005 0.0198 0.0658
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Schistosoma mansoni nAChR subunit 0.0093 0.0503 0.4291
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Schistosoma mansoni hypothetical protein 0.0067 0.0315 0.2693
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0154 0.0939 0.1625
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0198 0.0658
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0051 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0198 0.0658
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0093 0.0503 0.1673
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) melatonin receptor type 1A 0.0154 0.0939 0.3127
Echinococcus granulosus serotonin receptor 0.0154 0.0939 0.1625
Toxoplasma gondii hypothetical protein 0.1428 1 1
Onchocerca volvulus 0.0154 0.0939 0.273
Treponema pallidum polypeptide deformylase (def) 0.1428 1 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus glycine receptor subunit alpha 1 0.0093 0.0503 0.087
Onchocerca volvulus 0.0154 0.0939 0.273
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0087 0.0457 0.1523
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0154 0.0939 0.3127
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus neuropeptide Y receptor 0.0154 0.0939 0.1625
Echinococcus granulosus tm gpcr rhodopsin 0.0154 0.0939 0.1625
Schistosoma mansoni amine GPCR 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0093 0.0503 0.087
Onchocerca volvulus Neuropeptide F receptor homolog 0.0154 0.0939 0.273
Loa Loa (eye worm) hypothetical protein 0.0077 0.039 0.1299
Echinococcus multilocularis neuropeptide Y receptor 0.0154 0.0939 0.1625
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0089 0.0296
Echinococcus multilocularis orexin receptor type 2 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0781 0.1351
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0186 0.0621
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Echinococcus granulosus g protein coupled receptor 0.0154 0.0939 0.1625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0915 0.7812
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0093 0.0503 0.087
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0619 0.5287
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0154 0.0939 0.1625
Schistosoma mansoni acetylcholine receptor subunit beta 0.0043 0.0146 0.1249
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Trypanosoma cruzi Peptide deformylase 2, putative 0.0545 0.3718 1
Leishmania major trypanothione reductase 0.0053 0.0221 0.0466
Echinococcus multilocularis serotonin receptor 0.0154 0.0939 0.1625
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.1592
Echinococcus granulosus neuropeptide s receptor 0.0154 0.0939 0.1625
Brugia malayi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0069 0.0333 0.1109
Loa Loa (eye worm) hypothetical protein 0.0132 0.0781 0.2599
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Onchocerca volvulus 0.0093 0.0503 0.1461
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0619 0.9582
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0664 0.5674
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Plasmodium falciparum thioredoxin reductase 0.0053 0.0221 0.0172
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.0457 0.0409
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0051 0.015
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) neuropeptide F receptor 0.0154 0.0939 0.3127
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.0457 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0116 0.0664 0.115
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0051 0.015
Schistosoma mansoni growth hormone secretagogue receptor 0.0154 0.0939 0.8019
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0154 0.0939 0.1625
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0051 0.0001
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0386 0.2585 0.8608
Schistosoma mansoni biogenic amine (5HT) receptor 0.0154 0.0939 0.8019
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0664 0.5674
Echinococcus multilocularis geminin 0.0187 0.1171 0.2026
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0545 0.3718 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0154 0.0939 0.3127
Mycobacterium ulcerans hypothetical protein 0.0023 0.0003 0.0003
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0093 0.0503 0.4291
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0093 0.0503 0.1673
Echinococcus multilocularis chromobox protein 1 0.0079 0.0401 0.0694
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.039 0.3332
Trichomonas vaginalis 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0113 0.0644 0.1872
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0093 0.0503 0.087
Schistosoma mansoni myosin xvIII 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi hypothetical protein 0.0043 0.0146 0.0487
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.039 0.3332
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0708 0.0708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Echinococcus granulosus flap endonuclease 1 0.0029 0.0051 0.0088
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0051 0.0001
Schistosoma mansoni opsin-like receptor 0.0154 0.0939 0.8019
Schistosoma mansoni chromobox protein 0.0079 0.0401 0.3426
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0154 0.0939 0.1625
Schistosoma mansoni hypothetical protein 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.069 0.2297
Loa Loa (eye worm) hypothetical protein 0.0075 0.0376 0.1252
Brugia malayi ORL1-like opioid receptor 0.0154 0.0939 0.3127
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0051 0.0015
Onchocerca volvulus 0.005 0.0198 0.0574
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.005 0.0198 0.0658
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0179 0.052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0093 0.0503 0.1673
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0043 0.0146 0.0487
Brugia malayi hypothetical protein 0.0043 0.0146 0.0487
Echinococcus granulosus hypothetical protein 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi Pre-SET motif family protein 0.0445 0.3003 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0089 0.0154
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0154 0.0939 0.8019
Mycobacterium ulcerans epimerase 0.0023 0.0003 0.0003
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0835 0.578 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0154 0.0939 0.3127
Onchocerca volvulus 0.0043 0.0146 0.0425
Schistosoma mansoni neuropeptide receptor 0.0154 0.0939 0.8019
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0067 0.0315 0.0546
Brugia malayi hypothetical protein 0.0238 0.1534 0.5106
Echinococcus granulosus 7tm_1 domain containing protein 0.0154 0.0939 0.1625
Echinococcus multilocularis neuropeptide receptor A26 0.0154 0.0939 0.1625
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0619 0.0571
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0089 0.0154
Brugia malayi 6-phosphofructokinase 0.0109 0.0619 0.2062
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0077 0.039 0.1134
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0154 0.0939 0.3127
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0113 0.0644 0.1618
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus chromobox protein 1 0.0079 0.0401 0.0694
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Schistosoma mansoni nAChR subunit 0.0093 0.0503 0.4291
Brugia malayi hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0445 0.3003 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0003 0.0003
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0043 0.0146 0.0487
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0292 0.0971
Onchocerca volvulus 0.0049 0.0186 0.0542
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0835 0.578 1
Echinococcus granulosus chromobox protein 1 0.0079 0.0401 0.0694
Schistosoma mansoni hypothetical protein 0.0035 0.0089 0.0759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0154 0.0939 0.1625
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis neuropeptide receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0043 0.0146 0.0253
Plasmodium falciparum peptide deformylase 0.1428 1 1
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0089 0.0296
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0093 0.0503 0.087
Loa Loa (eye worm) acetylcholine receptor protein 0.0043 0.0146 0.0487
Echinococcus multilocularis neuropeptide FF receptor 2 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus somatostatin receptor 0.0154 0.0939 0.1625
Plasmodium falciparum glutathione reductase 0.0053 0.0221 0.0172
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0154 0.0939 0.1625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0624 0.2077
Chlamydia trachomatis endonuclease IV 0.0087 0.0457 0.0408
Loa Loa (eye worm) RNA binding protein 0.0063 0.0292 0.0971
Echinococcus multilocularis GPCR, family 2 0.0035 0.0089 0.0154
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0154 0.0939 0.3127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0093 0.0503 0.1673
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0376 0.1252
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0154 0.0939 0.8019
Echinococcus granulosus geminin 0.0187 0.1171 0.2026
Echinococcus granulosus neuropeptide receptor 0.0154 0.0939 0.1625
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0221 0.0737
Schistosoma mansoni neuropeptide F-like receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0155 0.0451
Brugia malayi Pre-SET motif family protein 0.0064 0.0295 0.0982
Mycobacterium tuberculosis Probable reductase 0.0122 0.0708 0.0708
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0198 0.1687
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0295 0.051
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.0517
Schistosoma mansoni hypothetical protein 0.0154 0.0939 0.8019
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0619 0.18
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0093 0.0503 0.1673
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0619 0.18
Echinococcus multilocularis neuropeptide Y receptor 0.0154 0.0939 0.1625
Schistosoma mansoni nAChR subunit 0.0093 0.0503 0.4291
Brugia malayi hypothetical protein 0.0122 0.0712 0.2372
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0292 0.2489
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0619 0.1551
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0221 0.0383
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Plasmodium vivax peptide deformylase, putative 0.1428 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0093 0.0503 0.087
Mycobacterium ulcerans endonuclease IV 0.0087 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0035 0.0089 0.0759
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Onchocerca volvulus 0.0154 0.0939 0.273
Loa Loa (eye worm) G-protein coupled receptor 0.0154 0.0939 0.3127
Trypanosoma cruzi Peptide deformylase 2, putative 0.0545 0.3718 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0093 0.0503 0.087
Schistosoma mansoni neurotransmitter gated ion channel 0.0043 0.0146 0.1249
Toxoplasma gondii endonuclease IV APN 0.0087 0.0457 0.0409
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0093 0.0503 0.1673
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0154 0.0939 0.1625
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0093 0.0503 0.087
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0664 0.5674
Brugia malayi RNA binding protein 0.0063 0.0292 0.0971
Plasmodium vivax SET domain protein, putative 0.0064 0.0295 0.0246
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0116 0.0664 0.115
Brugia malayi Melibiase family protein 0.0077 0.039 0.1299
Brugia malayi 6-phosphofructokinase 0.0109 0.0619 0.2062
Echinococcus granulosus glycine receptor subunit beta 0.0093 0.0503 0.087
Trypanosoma brucei Peptide deformylase 2 0.0545 0.3718 1
Brugia malayi follicle stimulating hormone receptor 0.0386 0.2585 0.8608
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Schistosoma mansoni opsin-like receptor 0.0154 0.0939 0.8019
Schistosoma mansoni hypothetical protein 0.0187 0.1171 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.2077
Onchocerca volvulus 0.0154 0.0939 0.273
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0093 0.0503 0.1673
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.1428 1 1
Onchocerca volvulus 0.005 0.0198 0.0574
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0043 0.0146 0.0253
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0154 0.0939 0.8019
Onchocerca volvulus 0.0093 0.0503 0.1461
Brugia malayi sulfakinin receptor protein 0.0154 0.0939 0.3127
Echinococcus multilocularis glycine receptor subunit beta 0.0093 0.0503 0.087
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0146 0.0487
Schistosoma mansoni neuropeptide f receptor 76f 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0295 0.2518
Schistosoma mansoni neuropeptide receptor 0.0154 0.0939 0.8019
Onchocerca volvulus 0.0154 0.0939 0.273
Echinococcus granulosus neuropeptide receptor A26 0.0154 0.0939 0.1625
Brugia malayi glutathione reductase 0.0053 0.0221 0.0737
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi Cation transporter family protein 0.0093 0.0503 0.1673
Echinococcus multilocularis somatostatin receptor 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus dro:myosuppressin receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0116 0.0664 0.115
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0708 0.0708
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0545 0.3718 1
Brugia malayi putative neuropeptide receptor NPR1 0.0154 0.0939 0.3127
Echinococcus granulosus neuropeptide FF receptor 2 0.0154 0.0939 0.1625
Echinococcus granulosus g-protein coupled receptor 0.0154 0.0939 0.1625
Echinococcus granulosus g protein coupled receptor 0.0154 0.0939 0.1625
Schistosoma mansoni alpha-1 adrenergic receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) carboxylesterase 0.0132 0.0781 0.2599
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0093 0.0503 0.1673
Echinococcus granulosus G protein coupled receptor 139 0.0154 0.0939 0.1625
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0619 0.1551
Brugia malayi Serotonin receptor 0.0154 0.0939 0.3127
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0292 0.0971
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0154 0.0939 0.1625
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0067 0.0315 0.105
Onchocerca volvulus Putative nachr subunit 0.0093 0.0503 0.1461
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.069 0.2297
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0089 0.0154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0939 0.1625
Schistosoma mansoni hypothetical protein 0.0035 0.0089 0.0759
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0805 0.0805
Schistosoma mansoni nAChR subunit 0.0043 0.0146 0.1249
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0619 0.0619
Echinococcus multilocularis neuropeptides capa receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis serotonin receptor 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0619 0.2062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0915 0.7812
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.1534 0.2654
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0155 0.0451
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Echinococcus granulosus GPCR family 2 0.0035 0.0089 0.0154
Onchocerca volvulus 0.0154 0.0939 0.273
Brugia malayi neuropeptide F receptor 0.0154 0.0939 0.3127
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Echinococcus granulosus tachykinin peptides receptor 99D 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) ACC-1 protein 0.0093 0.0503 0.1673
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0619 0.9582
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Schistosoma mansoni apoptosis regulator bax 0.0067 0.0315 0.2693
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0624 0.2077
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.0781 0.1351
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0154 0.0939 0.1625
Onchocerca volvulus 0.0154 0.0939 0.273
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0093 0.0503 0.087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0939 0.8019
Schistosoma mansoni amine GPCR 0.0154 0.0939 0.8019
Loa Loa (eye worm) neuropeptide F receptor 0.0154 0.0939 0.3127
Schistosoma mansoni survival motor neuron protein 0.0049 0.0186 0.1592
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0051 0.015
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0292 0.2489
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0154 0.0939 0.8019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Onchocerca volvulus 0.0154 0.0939 0.273
Loa Loa (eye worm) hypothetical protein 0.0093 0.0503 0.1673
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0708 0.0708
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0295 0.2518
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0051 0.015
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0619 0.5287
Loa Loa (eye worm) hypothetical protein 0.0132 0.0781 0.2599
Echinococcus granulosus fmrfamide receptor 0.0154 0.0939 0.1625
Brugia malayi hypothetical protein 0.0043 0.0146 0.0487
Schistosoma mansoni neuropeptide receptor 0.0154 0.0939 0.8019
Trypanosoma brucei trypanothione reductase 0.0053 0.0221 0.0466
Schistosoma mansoni neurotransmitter gated ion channel 0.0043 0.0146 0.1249
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Loa Loa (eye worm) hypothetical protein 0.0043 0.0146 0.0487
Schistosoma mansoni hypothetical protein 0.0067 0.0315 0.2693
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0401 0.1166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0915 0.1583
Brugia malayi G protein-coupled receptor F59B2.13 0.0154 0.0939 0.3127
Brugia malayi larval opioid receptor 0.0154 0.0939 0.3127
Onchocerca volvulus 0.0154 0.0939 0.273
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0664 0.5674
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0043 0.0146 0.0487
Brugia malayi RE15519p 0.0154 0.0939 0.3127
Echinococcus granulosus alpha 1A adrenergic receptor 0.0154 0.0939 0.1625
Schistosoma mansoni biogenic amine receptor 0.0154 0.0939 0.8019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0154 0.0939 0.3127
Echinococcus granulosus glycine receptor subunit beta 0.0093 0.0503 0.087
Brugia malayi Cation transporter family protein 0.0093 0.0503 0.1673
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0093 0.0503 0.4291
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0154 0.0939 0.3127
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.1428 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0155 0.0451
Schistosoma mansoni biogenic amine receptor 0.0154 0.0939 0.8019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0093 0.0503 0.087
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0093 0.0503 0.1673
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0154 0.0939 0.3127
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0093 0.0503 0.4291
Echinococcus multilocularis glycine receptor subunit beta 0.0093 0.0503 0.087
Entamoeba histolytica 2,3-bisphosphoglycerate-independentphosphoglycerate mutase, putative 0.0062 0.0283 0.3924
Echinococcus granulosus biogenic amine 5HT receptor 0.0154 0.0939 0.1625
Onchocerca volvulus 0.0077 0.0386 0.1123
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0051 0.015
Schistosoma mansoni hypothetical protein 0.0035 0.0089 0.0759
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0154 0.0939 0.1625
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi Carboxylesterase family protein 0.0132 0.0781 0.2599
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Schistosoma mansoni nAChR subunit 0.0093 0.0503 0.4291
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0154 0.0939 0.3127
Brugia malayi TAR-binding protein 0.0063 0.0292 0.0971
Loa Loa (eye worm) ACC-1 protein 0.0093 0.0503 0.1673
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0043 0.0146 0.0253
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0619 0.1071
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0619 0.1071
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0093 0.0503 0.1673
Brugia malayi hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi chromobox protein homolog 3 0.0044 0.0155 0.0517
Onchocerca volvulus 0.0043 0.0146 0.0425
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0093 0.0503 0.1673
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0658
Onchocerca volvulus 0.0093 0.0503 0.1461
Echinococcus granulosus neuropeptide Y receptor 0.0154 0.0939 0.1625
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0067 0.0315 0.2693
Loa Loa (eye worm) hypothetical protein 0.0067 0.0315 0.105
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0624 0.2077
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0051 0.0088
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0619 0.9582
Loa Loa (eye worm) hypothetical protein 0.0154 0.0939 0.3127
Echinococcus multilocularis neuropeptides capa receptor 0.0154 0.0939 0.1625
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0093 0.0503 0.087
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0087 0.0457 0.0454
Brugia malayi Flap endonuclease-1 0.0029 0.0051 0.0168
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.005 0.0198 0.0658
Echinococcus granulosus nAChR subunit 0.0093 0.0503 0.087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.0915 0.3046

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.399 uM Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatin ChEMBL. 16451081
EC50 (functional) = 0.399 uM Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatin ChEMBL. 16451081
EC50 (functional) = 2.08 uM Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serum ChEMBL. 16451081
EC50 (functional) = 2.08 uM Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serum ChEMBL. 16451081
Kd (binding) = 94 uM Binding affinity for human serum albumin domain III ChEMBL. 16451081
Kd (binding) = 94 uM Binding affinity for human serum albumin domain III ChEMBL. 16451081
Ki (binding) < 0.0005 uM Binding affinity to Bcl-XL by fluorescence polarization assay ChEMBL. 16451081
Ki (binding) < 0.0005 uM Binding affinity to Bcl-XL by fluorescence polarization assay ChEMBL. 16451081
Ki (binding) = 0.116 uM Binding affinity to Bcl2 by fluorescence polarization assay ChEMBL. 16451081
Ki (binding) = 0.116 uM Binding affinity to Bcl2 by fluorescence polarization assay ChEMBL. 16451081
Ki (binding) = 0.148 uM Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay ChEMBL. 16451081
Ki (binding) = 0.148 uM Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay ChEMBL. 16451081

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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