TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 770.952 | Formula: C41H62N4O10
H donors: 1 H acceptors: 6 LogP: 4.39 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@@H]2[C@@H]1OC(=O)N2CCCCn1ccc2c1cccn2)C)C)(C)OC
InChi: 1S/C41H62N4O10/c1-11-31-36-32(45(40(50)54-36)19-13-12-18-44-20-16-28-29(44)15-14-17-42-28)25(4)33(46)23(2)22-41(7,51-10)37(26(5)34(47)27(6)38(49)53-31)55-39-35(48)30(43(8)9)21-24(3)52-39/h14-17,20,23-27,30-32,35-37,39,48H,11-13,18-19,21-22H2,1-10H3/t23-,24-,25-,26+,27-,30+,31-,32-,35-,36-,37-,39+,41-/m1/s1
InChiKey: OVDTWWMHNPJKME-WWKGQMFJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cyclins	0.0016	0.0188	0.0183
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.282	0.2817
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0188	0.0058
Entamoeba histolytica	cyclin family protein	0.0016	0.0188	0.0184
Echinococcus granulosus	cyclin B	0.0031	0.0701	0.0697
Trypanosoma brucei	protein kinase, putative	0.0169	0.5416	0.5414
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0302	0.9942	0.9942
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0153	0.4849	0.4781
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0014	0.013	0.0126
Giardia lamblia	Kinase, CAMK CAMKL	0.0014	0.013	0.013
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0016	0.0188	0.0183
Echinococcus multilocularis	cyclin b3	0.0016	0.0188	0.0183
Trypanosoma brucei	cdc2-related kinase 3	0.0153	0.4849	0.4847
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0304	1	1
Trichomonas vaginalis	cyclin B, putative	0.0016	0.0188	0.0058
Giardia lamblia	Hypothetical protein	0.0016	0.0188	0.0188
Echinococcus granulosus	cyclin dependent kinase	0.0153	0.4849	0.4847
Echinococcus granulosus	cyclins	0.0016	0.0188	0.0183
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0.282	0.2834
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0153	0.4849	0.4781
Echinococcus granulosus	dual specificity	0.0093	0.282	0.2817
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0153	0.4849	0.4847
Schistosoma mansoni	kinase	0.0044	0.115	0.1147
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0014	0.013	0.0126
Echinococcus multilocularis	dual specificity	0.0093	0.282	0.2817
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0701	0.0578
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0701	0.0578
Plasmodium vivax	serine/threonine kinase-1, putative	0.0304	1	1
Brugia malayi	intracellular kinase	0.0169	0.5416	0.5356
Trichomonas vaginalis	CMGC family protein kinase	0.0093	0.282	0.2725
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0169	0.5416	0.5414
Leishmania major	cyclin	0.0031	0.0701	0.0697
Schistosoma mansoni	serine/threonine protein kinase	0.0304	1	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0153	0.4849	0.4847
Echinococcus granulosus	dual specificity	0.0093	0.282	0.2817
Entamoeba histolytica	protein kinase, putative	0.0302	0.9942	1
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0044	0.115	0.1034
Entamoeba histolytica	cyclin, putative	0.0031	0.0701	0.0701
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0011	0.0004	0.5
Schistosoma mansoni	protein kinase	0.0014	0.013	0.0126
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0304	1	1
Trypanosoma cruzi	cyclin, putative	0.0031	0.0701	0.0697
Entamoeba histolytica	protein kinase, putative	0.0302	0.9942	1
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.115	0.1147
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0169	0.5416	0.5356
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0304	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0701	0.0578
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0031	0.0701	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0294	0.9672	0.9668
Loa Loa (eye worm)	hypothetical protein	0.0294	0.9672	0.9668
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0014	0.013	0.0126
Trichomonas vaginalis	CMGC family protein kinase	0.0093	0.282	0.2725
Schistosoma mansoni	serine/threonine protein kinase	0.0153	0.4849	0.4847
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0014	0.013	0.0126
Trypanosoma cruzi	cdc2-related kinase 1	0.0153	0.4849	0.4847
Brugia malayi	Protein kinase domain containing protein	0.0153	0.4849	0.4781
Plasmodium vivax	protein kinase Crk2	0.0153	0.4849	0.4847
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0188	0.0058
Plasmodium falciparum	glycogen synthase kinase 3	0.0169	0.5416	0.5414
Echinococcus multilocularis	protein kinase shaggy	0.0169	0.5416	0.5414
Trichomonas vaginalis	cyclins, putative	0.0031	0.0701	0.0578
Onchocerca volvulus		0.0169	0.5416	1
Echinococcus multilocularis		0.0296	0.973	0.973
Brugia malayi	Protein kinase domain containing protein	0.0302	0.9942	0.9941
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0093	0.282	0.2817
Schistosoma mansoni	cyclin B3	0.0016	0.0188	0.0183
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0304	1	1
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0169	0.5416	0.5414
Trypanosoma cruzi	cyclin, putative	0.0031	0.0701	0.0697
Trypanosoma cruzi	cyclin 6, putative	0.0031	0.0701	0.0697
Plasmodium falciparum	cyclin	0.0016	0.0188	0.0183
Leishmania major	protein kinase, putative	0.0304	1	1
Trichomonas vaginalis	cyclins, putative	0.0031	0.0701	0.0578
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0304	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.3021	0.2929
Giardia lamblia	Kinase, CMGC CLK	0.0304	1	1
Echinococcus granulosus	cyclins	0.0016	0.0188	0.0183
Echinococcus multilocularis	dual specificity	0.0093	0.282	0.2817
Echinococcus multilocularis	cyclin B3 1	0.0016	0.0188	0.0183
Trichomonas vaginalis	cyclin D, putative	0.0016	0.0188	0.0058
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0701	0.0578
Echinococcus granulosus	protein kinase shaggy	0.0169	0.5416	0.5414
Plasmodium falciparum	protein serine/threonine kinase-1	0.0304	1	1
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0014	0.013	0.0126
Entamoeba histolytica	protein kinase domain containing protein	0.0169	0.5416	0.5446
Trichomonas vaginalis	cyclins, putative	0.0031	0.0701	0.0578
Entamoeba histolytica	cyclin family protein	0.0016	0.0188	0.0184
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0701	0.0578
Trichomonas vaginalis	CMGC family protein kinase	0.0093	0.282	0.2725
Trichomonas vaginalis	CMGC family protein kinase	0.0153	0.4849	0.4781
Schistosoma mansoni	serine/threonine kinase	0.0014	0.013	0.0126
Trichomonas vaginalis	CMGC family protein kinase	0.0153	0.4849	0.4781
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0093	0.282	0.2725
Echinococcus multilocularis	cyclins	0.0016	0.0188	0.0183
Echinococcus granulosus	mitogen activated protein kinase 15	0.0014	0.013	0.0126
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0169	0.5416	0.5414
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0153	0.4849	0.4847
Giardia lamblia	Kinase, CMGC GSK	0.0169	0.5416	0.5416
Entamoeba histolytica	cell division protein kinase 2, putative	0.0153	0.4849	0.4875
Leishmania major	serine/threonine kinase-like protein, putative	0.0014	0.013	0.0126
Echinococcus multilocularis	cyclin dependent kinase	0.0153	0.4849	0.4847
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0701	0.0578
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0302	0.9942	0.9941
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0014	0.013	0.0126
Leishmania major	protein kinase, putative	0.0304	1	1
Brugia malayi	cell division control protein 2 homolog	0.0153	0.4849	0.4781
Trichomonas vaginalis	CMGC family protein kinase	0.0093	0.282	0.2725
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0169	0.5416	0.5414
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0014	0.013	0.0126
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0302	0.9942	0.9942
Echinococcus granulosus	cyclin dependent kinase 1	0.0153	0.4849	0.4847
Echinococcus multilocularis	cyclin dependent kinase 9	0.0051	0.1367	0.1364
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0011	0.0004	0.5
Echinococcus granulosus	dual specificity	0.0302	0.9942	0.9942
Trichomonas vaginalis	cyclins, putative	0.0016	0.0188	0.0058
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0014	0.013	0.0126
Echinococcus granulosus	cyclin dependent kinase 9	0.0051	0.1367	0.1364
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0093	0.282	0.2817
Brugia malayi	hypothetical protein	0.0099	0.3021	0.2929
Echinococcus granulosus	hypothetical protein	0.0296	0.973	0.973
Echinococcus multilocularis	cyclin dependent kinase 5	0.0153	0.4849	0.4847
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0016	0.0188	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0145	0.4579	0.4507
Loa Loa (eye worm)	hypothetical protein	0.0099	0.3021	0.2929
Giardia lamblia	Kinase, CMGC CDK	0.0153	0.4849	0.4849
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0169	0.5416	0.5414
Trypanosoma brucei	protein kinase, putative	0.0014	0.013	0.0126
Entamoeba histolytica	protein kinase domain containing protein	0.0014	0.013	0.0127
Entamoeba histolytica	cell division protein kinase 2, putative	0.0159	0.5066	0.5093
Echinococcus granulosus	cyclin dependent kinase 5	0.0153	0.4849	0.4847
Trichomonas vaginalis	CMGC family protein kinase	0.0093	0.282	0.2725
Brugia malayi	cyclin-dependent kinase 9	0.0044	0.115	0.1034
Plasmodium falciparum	MO15-related protein kinase	0.0014	0.013	0.0126
Echinococcus multilocularis	cyclin dependent kinase 1	0.0153	0.4849	0.4847
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.0207	0.6699	0.6697
Trichomonas vaginalis	cyclin D, putative	0.0016	0.0188	0.0058
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.0207	0.6699	0.6697
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0169	0.5416	0.5356
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0093	0.282	0.2817
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0157	0.0027
Trichomonas vaginalis	CMGC family protein kinase	0.0304	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0169	0.5416	0.5356
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0153	0.4849	0.4781
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0188	0.0058
Entamoeba histolytica	cyclin, putative	0.0016	0.0188	0.0184
Echinococcus multilocularis	cyclins	0.0016	0.0188	0.0183
Giardia lamblia	Kinase, CAMK CAMKL	0.0014	0.013	0.013
Echinococcus multilocularis	cyclins	0.0016	0.0188	0.0183
Echinococcus multilocularis	dual specificity	0.0093	0.282	0.2817
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0302	0.9942	0.9942
Trichomonas vaginalis	CMGC family protein kinase	0.0153	0.4849	0.4781
Giardia lamblia	Kinase, CMGC CDK	0.0153	0.4849	0.4849
Giardia lamblia	Kinase, CMGC GSK	0.0169	0.5416	0.5416
Echinococcus granulosus	dual specificity protein kinase clk2	0.0304	1	1
Plasmodium falciparum	protein kinase 5	0.0153	0.4849	0.4847
Loa Loa (eye worm)	hypothetical protein	0.0296	0.973	0.9726
Echinococcus granulosus	cyclins	0.0016	0.0188	0.0183
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0011	0.0004	0.5
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0031	0.0701	0.0697
Echinococcus granulosus	cyclin dependent kinase 9	0.0044	0.115	0.1147
Echinococcus granulosus	cyclin B3 1	0.0016	0.0188	0.0183
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0014	0.013	0.0126
Echinococcus granulosus	dual specificity	0.0093	0.282	0.2817
Loa Loa (eye worm)	hypothetical protein	0.0207	0.6699	0.6655
Entamoeba histolytica	protein kinase, putative	0.0169	0.5416	0.5446
Echinococcus granulosus	cyclins	0.0016	0.0188	0.0183
Trichomonas vaginalis	CMGC family protein kinase	0.0093	0.282	0.2725
Giardia lamblia	Kinase, CAMK CAMKL	0.0014	0.013	0.013
Echinococcus granulosus	cyclin b3	0.0016	0.0188	0.0183
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0304	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0302	0.9942	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0304	1	1
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0014	0.013	0.0126
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0701	0.0578
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0304	1	1
Schistosoma mansoni	cyclins	0.0016	0.0188	0.0183
Trypanosoma cruzi	cdc2-related kinase 3	0.0153	0.4849	0.4847
Schistosoma mansoni	serine/threonine protein kinase	0.0153	0.4849	0.4847
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0701	0.0578
Schistosoma mansoni	serine/threonine protein kinase	0.0304	1	1
Schistosoma mansoni	cyclin B	0.0031	0.0701	0.0697
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0304	1	1
Giardia lamblia	Kinase, CMGC DYRK	0.0093	0.282	0.282
Echinococcus multilocularis	dual specificity	0.0302	0.9942	0.9942
Echinococcus multilocularis	cyclins	0.0016	0.0188	0.0183
Trichomonas vaginalis	cyclin A, putative	0.0031	0.0701	0.0578
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.115	0.1153
Echinococcus granulosus	cyclin dependent kinase 5 activator 1	0.0207	0.6699	0.6697
Echinococcus multilocularis	cyclin dependent kinase 1	0.0153	0.4849	0.4847
Entamoeba histolytica	protein kinase domain containing protein	0.0169	0.5416	0.5446
Trypanosoma brucei	mitotic cyclin 6	0.0031	0.0701	0.0697
Schistosoma mansoni	serine/threonine protein kinase	0.0302	0.9942	0.9942
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0093	0.282	0.2725
Trichomonas vaginalis	cyclin B3, putative	0.0016	0.0188	0.0058
Echinococcus granulosus	cyclins	0.0016	0.0188	0.0183
Trichomonas vaginalis	CMGC family protein kinase	0.0169	0.5416	0.5356
Giardia lamblia	Cyclin A	0.0016	0.0188	0.0188
Echinococcus multilocularis	cyclin dependent kinase 9	0.0044	0.115	0.1147
Trypanosoma brucei	cdc2-related kinase 1	0.0153	0.4849	0.4847
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0169	0.5416	0.5414
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0302	0.9942	0.9942
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0093	0.282	0.2817
Giardia lamblia	G2/mitotic-specific cyclin B	0.0031	0.0701	0.0701
Trichomonas vaginalis	cyclins, putative	0.0031	0.0701	0.0578
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0153	0.4849	0.4847
Echinococcus multilocularis	cyclin B	0.0031	0.0701	0.0697
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0014	0.013	0.0126
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0153	0.4849	0.4847
Trypanosoma cruzi	cdc2-related kinase 3	0.0153	0.4849	0.4847
Entamoeba histolytica	protein kinase, putative	0.0093	0.282	0.2834
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0169	0.5416	0.5414
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.013	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0209	0.6766	0.6724
Echinococcus multilocularis	cyclins	0.0016	0.0188	0.0183
Entamoeba histolytica	hypothetical protein	0.0302	0.9942	1
Trichomonas vaginalis	cyclins, putative	0.0023	0.0422	0.0296
Echinococcus multilocularis	cyclins	0.0016	0.0188	0.0183

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	<= 0.05 ug ml-1	Antibacterial activity against Streptococcus pyogenes 8668 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	<= 0.05 ug ml-1	Antibacterial activity against Streptococcus pneumoniae 49619 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	<= 0.05 ug ml-1	Antibacterial activity against Streptococcus pneumoniae 297-749 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	<= 0.05 ug ml-1	Antibacterial activity against Streptococcus pneumoniae 280-962 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	<= 0.05 ug ml-1	Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae mef S 3427 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 0.1 ug ml-1	Antibacterial activity against Enterococcus faecalis 29212 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 0.2 ug ml-1	Antibacterial activity against Staphylococcus aureus 29213 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 0.2 ug ml-1	Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae erm 6849 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 0.2 ug ml-1	Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae mef 5654 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 0.4 ug ml-1	Antibacterial activity against Staphylococcus epidermidis 14990 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 0.4 ug ml-1	Antibacterial activity against Staphylococcus epidermidis f50654 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 0.78 ug ml-1	Antibacterial activity against Haemophilus influenzae 2762 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 1.56 ug ml-1	Antibacterial activity against Haemophilus influenzae 49247 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	= 6.25 ug ml-1	Antibacterial activity against Enterococcus faecalis bc11148-2 by broth microdilution method	ChEMBL.	16784845
MIC (functional)	> 50 ug ml-1	Antibacterial activity against Staphylococcus aureus 33591 by broth microdilution method	ChEMBL.	16784845

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL437684

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 369317