TDR Targets

Basic information

Technical information

TDR Targets ID: 369684
Name: N-(3-cyanophenyl)-2-phenylacetamide
MW: 236.269 | Formula: C15H12N2O
H donors: 1 H acceptors: 2 LogP: 2.41 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cccc(c1)NC(=O)Cc1ccccc1
InChi: 1S/C15H12N2O/c16-11-13-7-4-8-14(9-13)17-15(18)10-12-5-2-1-3-6-12/h1-9H,10H2,(H,17,18)
InChiKey: AFBIVMWJUFLUNW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-cyanophenyl)-2-phenyl-acetamide
N-(3-cyanophenyl)-2-phenyl-ethanamide
ARONIS000870
Oprea1_051374
MLS000684027
ST039765
SMR000291660
Oprea1_357948
AN-329/40892422
ZINC00142250

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	ctsf protein	0.0313	0.1712	1
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0058	0.0157	0.0213
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Brugia malayi	Cathepsin L-like precursor	0.021	0.1082	0.1495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0313	0.1712	1
Echinococcus granulosus	cathepsin l1	0.021	0.1082	0.6311
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0058	0.0157	0.0919
Plasmodium vivax	unspecified product	0.0104	0.0436	0.1145
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1712	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0313	0.1712	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Brugia malayi	Cathepsin L-like precursor	0.0313	0.1712	0.2369
Echinococcus multilocularis	cysteine protease	0.0313	0.1712	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Schistosoma mansoni	cathepsin B (C01 family)	0.0058	0.0157	0.09
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0788	0.4054
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0458	0.259	1
Brugia malayi	Cathepsin L-like precursor	0.0313	0.1712	0.2369
Brugia malayi	Papain family cysteine protease containing protein	0.0313	0.1712	0.2369
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Echinococcus granulosus	cathepsin l1	0.0313	0.1712	1
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0458	0.259	0.3519
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0161	0.0788	0.0912
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Schistosoma mansoni	cathepsin F (C01 family)	0.021	0.1082	0.6311
Trypanosoma cruzi	cysteine peptidase, putative	0.1194	0.707	1
Echinococcus multilocularis	cathepsin b	0.0058	0.0157	0.09
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Brugia malayi	Papain family cysteine protease containing protein	0.0161	0.0788	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0436	0.2546
Trypanosoma cruzi	cysteine proteinase, putative	0.0161	0.0788	0.0912
Leishmania major	cathepsin L-like protease	0.1194	0.707	1
Leishmania major	cathepsin L-like protease	0.0313	0.1712	0.2249
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0313	0.1712	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0104	0.0436	0.0599
Onchocerca volvulus		0.0058	0.0157	0.0154
Trypanosoma cruzi	cysteine peptidase, putative	0.1194	0.707	1
Schistosoma mansoni	cathepsin C	0.0058	0.0157	0.09
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0313	0.1712	1
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Brugia malayi	Cathepsin L-like precursor	0.021	0.1082	0.1495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0313	0.1712	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1082	0.6319
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0458	0.259	0.3519
Trypanosoma cruzi	cysteine proteinase, putative	0.0161	0.0788	0.0912
Trypanosoma cruzi	cruzipain precursor, putative	0.1194	0.707	1
Onchocerca volvulus	Cathepsin L homolog	0.0313	0.1712	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0919
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0058	0.0157	0.09
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0161	0.0788	0.2591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0161	0.0788	0.4054
Toxoplasma gondii	RNA-directed DNA polymerase	0.0458	0.259	1
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Leishmania major	cathepsin L-like protease	0.1194	0.707	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0161	0.0788	0.0912
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Entamoeba histolytica	cysteine proteinase, putative	0.0313	0.1712	1
Leishmania major	cathepsin L-like protease	0.0313	0.1712	0.2249
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0919
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0919
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Leishmania major	cathepsin L-like protease	0.0313	0.1712	0.2249
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0058	0.0157	0.0213
Loa Loa (eye worm)	cysteine protease	0.0313	0.1712	1
Onchocerca volvulus	Cathepsin F homolog	0.0313	0.1712	0.1709
Brugia malayi	Cathepsin L-like precursor	0.0313	0.1712	0.2369
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0436	0.2546
Echinococcus granulosus	cathepsin L	0.0161	0.0788	0.4589
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Brugia malayi	cathepsin L-like cysteine proteinase	0.0058	0.0157	0.0213
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0058	0.0157	0.0919
Trypanosoma cruzi	major cysteine proteinase, putative	0.0939	0.5515	0.7751
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Brugia malayi	Cathepsin L-like precursor	0.0313	0.1712	0.2369
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Onchocerca volvulus		0.0313	0.1712	0.1709
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0157	0.0213
Schistosoma mansoni	cathepsin s	0.0104	0.0436	0.253
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0058	0.0157	0.09
Onchocerca volvulus	Cathepsin L homolog	0.0058	0.0157	0.0154
Onchocerca volvulus		0.021	0.1082	0.1079
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Echinococcus multilocularis	cathepsin L	0.0161	0.0788	0.4589
Toxoplasma gondii	cathepsin CPL	0.0313	0.1712	0.6392
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0058	0.0157	0.09
Brugia malayi	Cathepsin L-like precursor	0.0313	0.1712	0.2369
Loa Loa (eye worm)	hypothetical protein	0.021	0.1082	0.6319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Entamoeba histolytica	cysteine proteinase 2	0.0161	0.0788	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.021	0.1082	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Plasmodium vivax	vivapain-1	0.0161	0.0788	0.2591
Brugia malayi	cathepsin F-like cysteine proteinase	0.0058	0.0157	0.0213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0157	0.0213
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0313	0.1712	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0313	0.1712	0.6392
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0788	0.4054
Loa Loa (eye worm)	cathepsin B	0.0058	0.0157	0.0919
Echinococcus granulosus	cysteine protease	0.0161	0.0788	0.4589
Plasmodium vivax	unspecified product	0.0161	0.0788	0.2591
Onchocerca volvulus	Cathepsin L homolog	0.0313	0.1712	0.1709
Onchocerca volvulus		0.0313	0.1712	0.1709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.021	0.1082	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Onchocerca volvulus		0.0313	0.1712	0.1709
Brugia malayi	Cathepsin L-like precursor	0.0104	0.0436	0.0599
Echinococcus granulosus	cathepsin L	0.0058	0.0157	0.09
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0313	0.1712	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0104	0.0436	0.0403
Giardia lamblia	Telomerase catalytic subunit	0.0458	0.259	1
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0157	0.0213
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0161	0.0788	0.4589
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0157	0.09
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0058	0.0157	0.09
Trypanosoma cruzi	cysteine peptidase, putative	0.1194	0.707	1
Plasmodium falciparum	telomerase reverse transcriptase	0.0458	0.259	1
Brugia malayi	Telomerase reverse transcriptase	0.1218	0.7215	1
Onchocerca volvulus		0.0313	0.1712	0.1709
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0058	0.0157	0.0919
Onchocerca volvulus		0.0313	0.1712	0.1709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0788	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0788	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0104	0.0436	0.0599
Echinococcus granulosus	cathepsin L cysteine protease	0.0161	0.0788	0.4589
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.021	0.1082	0.5946
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.109	0.644	0.9088
Brugia malayi	fibroinase precursor	0.0058	0.0157	0.0213
Brugia malayi	Cathepsin L-like cysteine proteinase	0.021	0.1082	0.1495
Plasmodium vivax	vivapain-2	0.0313	0.1712	0.6392
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0161	0.0788	0.4589
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0788	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0313	0.1712	1
Leishmania major	telomerase reverse transcriptase, putative	0.0458	0.259	0.3519
Leishmania major	cathepsin L-like protease	0.0313	0.1712	0.2249
Leishmania major	cathepsin L-like protease	0.1194	0.707	1
Echinococcus multilocularis	cathepsin L	0.0058	0.0157	0.09
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0004	0.0021
Trypanosoma cruzi	cysteine peptidase, putative	0.0161	0.0788	0.0912
Echinococcus multilocularis	cathepsin b	0.0058	0.0157	0.09
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0104	0.0436	0.2546
Trypanosoma cruzi	cruzipain precursor, putative	0.0104	0.0436	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0919
Brugia malayi	Cathepsin L-like precursor	0.0313	0.1712	0.2369
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0436	0.2546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Brugia malayi	cathepsin L-like precursor	0.021	0.1082	0.1495
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0313	0.1712	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1194	0.707	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0313	0.1712	0.2249
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0788	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0161	0.0788	0.0912
Brugia malayi	cathepsin B-like cysteine proteinase	0.0058	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0004	0.0021
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0313	0.1712	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1082	0.6319
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0919
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0058	0.0157	0.09
Trypanosoma brucei	telomerase reverse transcriptase	0.0458	0.259	0.3519
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0161	0.0788	0.4589
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Brugia malayi	cathepsin L precursor	0.0058	0.0157	0.0213
Schistosoma mansoni	cathepsin F (C01 family)	0.0313	0.1712	1
Echinococcus granulosus	cathepsin b	0.0058	0.0157	0.09
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0919
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0004	0.0021
Trypanosoma cruzi	cysteine protease, putative	0.0161	0.0788	0.0912
Brugia malayi	Papain family cysteine protease containing protein	0.0161	0.0788	0.1087
Onchocerca volvulus		0.0313	0.1712	0.1709
Onchocerca volvulus		0.0313	0.1712	0.1709
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0313	0.1712	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0313	0.1712	1
Loa Loa (eye worm)	fibroinase	0.0313	0.1712	1
Leishmania major	cysteine peptidase A (CPA)	0.0313	0.1712	0.2249
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0313	0.1712	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0788	0.4054
Leishmania major	cathepsin L-like protease	0.0313	0.1712	0.2249
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0313	0.1712	0.6392
Plasmodium vivax	vivapain-3	0.0161	0.0788	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0919
Echinococcus granulosus	cathepsin b	0.0058	0.0157	0.09
Entamoeba histolytica	cysteine proteinase, putative	0.0313	0.1712	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0058	0.0157	0.09
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0313	0.1712	0.6392
Plasmodium vivax	vivapain-2	0.0313	0.1712	0.6392
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0058	0.0157	0.0213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1712	1
Echinococcus multilocularis	cysteine protease	0.0313	0.1712	1

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	> 600 uM	Cytotoxicity against Vero-CD150w cells	ChEMBL.	16913698
IC50 (functional)	= 6.5 uM	Antiviral activity against wild type Measles virus Edmonston in Vero-CD150w cells by cytopathicity assay	ChEMBL.	16913698
IC50 (functional)	> 150 uM	Antiviral activity against Measles virus variant in Vero-CD150w cells by cytopathicity assay	ChEMBL.	16913698
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Selectivity index (functional)	> 92	Selectivity index, CC50 for Vero-CD150w cells/IC50 for Measles virus Edmonston	ChEMBL.	16913698

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL215684
PubChem: 729975
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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 369684