TDR Targets

Basic information

Technical information

TDR Targets ID: 374284
Name: 1-[(8R)-8-ethyl-5-oxo-4-propyl-7,8-dihydro-1H -imidazo[2,1-f]purin-2-yl]bicyclo[2.2.2]octan e-4-carboxylic acid
MW: 399.487 | Formula: C21H29N5O3
H donors: 2 H acceptors: 4 LogP: 2.26 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCn1c2nc([nH]c2c2=N[C@@H](Cn2c1=O)CC)C12CCC(CC1)(CC2)C(=O)O
InChi: 1S/C21H29N5O3/c1-3-11-25-16-14(15-22-13(4-2)12-26(15)19(25)29)23-17(24-16)20-5-8-21(9-6-20,10-7-20)18(27)28/h13H,3-12H2,1-2H3,(H,23,24)(H,27,28)/t13-,20?,21?/m1/s1
InChiKey: OPYSBGBVQBZGHC-ZJDGCUJOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(8R)-8-ethyl-5-oxo-4-propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-2-yl]-4-bicyclo[2.2.2]octanecarboxylic acid
1-[(8R)-8-ethyl-5-keto-4-propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-2-yl]bicyclo[2.2.2]octane-4-carboxylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Adenosine A1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	22.7 %
Echinococcus granulosus	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Adenosine A1 receptor	326 aa	327 aa	24.8 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	317 aa	24.6 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	274 aa	22.6 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	323 aa	20.7 %
Brugia malayi	hypothetical protein	Adenosine A1 receptor	326 aa	305 aa	21.0 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Adenosine A1 receptor	326 aa	286 aa	26.9 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	311 aa	21.2 %
Loa Loa (eye worm)	hypothetical protein	Adenosine A1 receptor	326 aa	300 aa	24.3 %
Echinococcus multilocularis	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	315 aa	21.6 %
Schistosoma mansoni	dro/myosuppressin receptor	Adenosine A1 receptor	326 aa	326 aa	22.1 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Adenosine A1 receptor	326 aa	295 aa	28.1 %
Echinococcus multilocularis	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Adenosine A1 receptor	326 aa	286 aa	22.7 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	306 aa	21.2 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	23.1 %
Echinococcus granulosus	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	304 aa	21.1 %
Loa Loa (eye worm)	neuropeptide F receptor	Adenosine A1 receptor	326 aa	316 aa	19.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0069	0.008	0.0076
Schistosoma mansoni	growth hormone secretagogue receptor	0.037	0.0776	0.0763
Echinococcus granulosus	rhodopsin orphan GPCR	0.037	0.0776	0.077
Schistosoma mansoni	adenoreceptor	0.037	0.0776	0.0763
Schistosoma mansoni	amine GPCR	0.037	0.0776	0.0763
Echinococcus granulosus	somatostatin receptor	0.037	0.0776	0.077
Echinococcus granulosus	carboxylesterase 5A	0.0067	0.0076	0.0071
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0076	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Echinococcus granulosus	single minded 2	0.0039	0.0011	0.0006
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0196	0.0193
Loa Loa (eye worm)	TYRA-2 protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	ACC-1 protein	0.0119	0.0196	0.0191
Loa Loa (eye worm)	melatonin receptor type 1A	0.037	0.0776	0.0771
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0069	0.008	0.0067
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.005	0.0038	0.0034
Onchocerca volvulus		0.0119	0.0196	0.0193
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.037	0.0776	0.0772
Trypanosoma brucei	C-8 sterol isomerase, putative	0.2622	0.5974	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0146	0.0259	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Onchocerca volvulus		0.0119	0.0196	0.0193
Brugia malayi	G-protein coupled receptor	0.037	0.0776	0.0772
Brugia malayi	sulfakinin receptor protein	0.037	0.0776	0.0772
Brugia malayi	hypothetical protein	0.005	0.0038	0.0034
Echinococcus granulosus	neuropeptides capa receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Schistosoma mansoni	nAChR subunit	0.0119	0.0196	0.0183
Echinococcus granulosus	nAChR subunit	0.0119	0.0196	0.0191
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.0038	0.0034
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0119	0.0196	0.0193
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.0244	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Echinococcus multilocularis	neuropeptide receptor	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Brugia malayi	putative neuropeptide receptor	0.037	0.0776	0.0772
Echinococcus multilocularis	g protein coupled receptor	0.037	0.0776	0.0772
Onchocerca volvulus		0.037	0.0776	0.0772
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0019	0.0013
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.037	0.0776	0.0772
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Echinococcus granulosus	acetylcholinesterase	0.0067	0.0076	0.0071
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0011	0.5
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0019	0.5
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0119	0.0196	0.0193
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0119	0.0196	0.0193
Schistosoma mansoni	acetylcholine receptor-related	0.005	0.0038	0.0024
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.037	0.0776	0.0772
Echinococcus multilocularis	neuropeptides capa receptor	0.037	0.0776	0.0772
Echinococcus granulosus	geminin	0.0167	0.0306	0.0301
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0069	0.008	0.0076
Entamoeba histolytica	hypothetical protein	0.0069	0.008	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Loa Loa (eye worm)	acetylcholine receptor protein	0.005	0.0038	0.0032
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.037	0.0776	0.0772
Schistosoma mansoni	sodium/chloride dependent transporter	0.0146	0.0259	0.0246
Echinococcus granulosus	sex peptide receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Echinococcus granulosus	acetylcholinesterase	0.0067	0.0076	0.0071
Onchocerca volvulus		0.037	0.0776	0.0772
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.005	0.0038	0.0034
Schistosoma mansoni	hypothetical protein	0.037	0.0776	0.0763
Echinococcus multilocularis	neuropeptide Y receptor	0.037	0.0776	0.0772
Onchocerca volvulus		0.037	0.0776	0.0772
Onchocerca volvulus		0.0146	0.0259	0.0256
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0196	0.0193
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	G-protein coupled receptor	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus granulosus	hypothetical protein	0.1039	0.2321	0.2317
Brugia malayi	G protein-coupled receptor	0.037	0.0776	0.0772
Schistosoma mansoni	hypothetical protein	0.0167	0.0306	0.0293
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0149	0.0266	0.0261
Echinococcus multilocularis	fmrfamide receptor	0.037	0.0776	0.0772
Brugia malayi	putative neuropeptide receptor NPR1	0.037	0.0776	0.0772
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.005	0.0038	0.0034
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.4365	1	1
Onchocerca volvulus		0.005	0.0038	0.0034
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.005	0.0038	0.0034
Echinococcus granulosus	tachykinin peptides receptor 99D	0.037	0.0776	0.077
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.0196	0.0193
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.2622	0.5974	0.5
Brugia malayi	larval opioid receptor	0.037	0.0776	0.0772
Schistosoma mansoni	amine GPCR	0.0691	0.1517	0.1506
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.037	0.0776	0.077
Schistosoma mansoni	myosin xvIII	0.037	0.0776	0.0763
Schistosoma mansoni	amine GPCR	0.037	0.0776	0.0763
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Echinococcus granulosus	fmrfamide receptor	0.037	0.0776	0.077
Echinococcus multilocularis	geminin	0.0167	0.0306	0.0303
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0006	0.0002
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0491	0.1055	0.1043
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.037	0.0776	0.0772
Echinococcus granulosus	biogenic amine 5HT receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.037	0.0776	0.0772
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.037	0.0776	0.0772
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0119	0.0196	0.0193
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.037	0.0776	0.0772
Onchocerca volvulus	Putative nachr subunit	0.0119	0.0196	0.0193
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0119	0.0196	0.0191
Echinococcus multilocularis	acetylcholinesterase	0.0067	0.0076	0.0073
Onchocerca volvulus	Neuropeptide F receptor homolog	0.037	0.0776	0.0772
Schistosoma mansoni	hypothetical protein	0.037	0.0776	0.0763
Schistosoma mansoni	biogenic amine receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.134	0.3015	0.3011
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0119	0.0196	0.0191
Echinococcus granulosus	neuropeptide receptor	0.037	0.0776	0.077
Echinococcus granulosus	neuropeptide receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0146	0.0259	0.0246
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.0196	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0253	0.024
Brugia malayi	hypoxia-induced factor 1	0.0149	0.0266	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0259	0.0254
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0253	0.025
Echinococcus multilocularis	neuropeptides capa receptor	0.037	0.0776	0.0772
Echinococcus granulosus	rhodopsin orphan GPCR	0.037	0.0776	0.077
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0069	0.008	0.0076
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Leishmania major	C-8 sterol isomerase-like protein	0.2622	0.5974	0.5
Schistosoma mansoni	opsin-like receptor	0.037	0.0776	0.0763
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0119	0.0196	0.0183
Onchocerca volvulus		0.0119	0.0196	0.0193
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.037	0.0776	0.077
Schistosoma mansoni	nAChR subunit	0.0119	0.0196	0.0183
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0295	0.029
Brugia malayi	RE15519p	0.037	0.0776	0.0772
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.2622	0.5974	0.5972
Brugia malayi	Serotonin receptor	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	excitatory GABA receptor EXP-1A	0.0119	0.0196	0.0193
Echinococcus granulosus	g protein coupled receptor	0.037	0.0776	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.037	0.0776	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Echinococcus granulosus	neuropeptide Y receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Brugia malayi	hypothetical protein	0.005	0.0038	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0119	0.0196	0.0193
Echinococcus granulosus	biogenic amine 5HT receptor	0.0491	0.1055	0.105
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Brugia malayi	ORL1-like opioid receptor	0.037	0.0776	0.0772
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0011	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0119	0.0196	0.0191
Echinococcus multilocularis	neuropeptide s receptor	0.037	0.0776	0.0772
Onchocerca volvulus		0.037	0.0776	0.0772
Echinococcus multilocularis	orexin receptor type 2	0.037	0.0776	0.0772
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.2622	0.5974	0.5972
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0119	0.0196	0.0193
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.037	0.0776	0.0771
Echinococcus multilocularis	glycine receptor subunit beta	0.0119	0.0196	0.0193
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0196	0.0193
Echinococcus granulosus	rhodopsin orphan GPCR	0.037	0.0776	0.077
Echinococcus granulosus	dro:myosuppressin receptor	0.037	0.0776	0.077
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Schistosoma mansoni	biogenic amine receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.037	0.0776	0.0763
Onchocerca volvulus		0.037	0.0776	0.0772
Echinococcus multilocularis	conserved hypothetical protein	0.0669	0.1467	0.1464
Brugia malayi	Carboxylesterase family protein	0.0067	0.0076	0.0073
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0119	0.0196	0.0183
Echinococcus multilocularis	dro:myosuppressin receptor	0.037	0.0776	0.0772
Schistosoma mansoni	neuropeptide F-like receptor	0.037	0.0776	0.0763
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0196	0.0193
Loa Loa (eye worm)	G-protein coupled receptor	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	norepinephrine transporter	0.0146	0.0259	0.0254
Brugia malayi	Tachykinin-like peptides receptor 99D	0.037	0.0776	0.0772
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.005	0.0038	0.0032
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Onchocerca volvulus		0.037	0.0776	0.0772
Schistosoma mansoni	biogenic amine (5HT) receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Echinococcus granulosus	G protein coupled receptor 139	0.037	0.0776	0.077
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.037	0.0776	0.0763
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Schistosoma mansoni	nAChR subunit	0.0119	0.0196	0.0183
Brugia malayi	G protein-coupled receptor F59B2.13	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Onchocerca volvulus		0.037	0.0776	0.0772
Echinococcus multilocularis	nAChR subunit	0.0119	0.0196	0.0193
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.037	0.0776	0.0763
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.037	0.0776	0.0772
Onchocerca volvulus		0.0069	0.008	0.0076
Brugia malayi	hypothetical protein	0.005	0.0038	0.0034
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0259	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Onchocerca volvulus		0.037	0.0776	0.0772
Brugia malayi	neuropeptide F receptor	0.037	0.0776	0.0772
Schistosoma mansoni	vesicular acetylcholine transporter	0.4365	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.037	0.0776	0.077
Echinococcus multilocularis	neuropeptide Y receptor	0.037	0.0776	0.0772
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.037	0.0776	0.0772
Echinococcus granulosus	tm gpcr rhodopsin	0.037	0.0776	0.077
Schistosoma mansoni	opsin-like receptor	0.037	0.0776	0.0763
Schistosoma mansoni	biogenic amine receptor	0.037	0.0776	0.0763
Brugia malayi	Melatonin receptor type 1A	0.037	0.0776	0.0772
Brugia malayi	hypothetical protein	0.005	0.0038	0.0034
Schistosoma mansoni	neuropeptide receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.005	0.0038	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0076	0.0071
Schistosoma mansoni	nAChR subunit	0.0119	0.0196	0.0183
Brugia malayi	Cation transporter family protein	0.0119	0.0196	0.0193
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Echinococcus granulosus	tm gpcr rhodopsin	0.037	0.0776	0.077
Onchocerca volvulus		0.037	0.0776	0.0772
Echinococcus multilocularis	allatostatin A receptor	0.037	0.0776	0.0772
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0119	0.0196	0.0191
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.037	0.0776	0.0772
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Onchocerca volvulus		0.005	0.0038	0.0034
Loa Loa (eye worm)	neuropeptide F receptor	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.037	0.0776	0.0763
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0119	0.0196	0.0193
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus granulosus	7tm_1 domain containing protein	0.037	0.0776	0.077
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.0038	0.0034
Echinococcus granulosus	glycine receptor subunit beta	0.0119	0.0196	0.0191
Echinococcus multilocularis	g protein coupled receptor	0.037	0.0776	0.0772
Echinococcus granulosus	neuropeptide receptor A26	0.037	0.0776	0.077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Loa Loa (eye worm)	neuropeptide F receptor	0.037	0.0776	0.0771
Echinococcus granulosus	serotonin transporter	0.0146	0.0259	0.0254
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.037	0.0776	0.0763
Onchocerca volvulus		0.037	0.0776	0.0772
Echinococcus granulosus	glycine receptor subunit beta	0.0119	0.0196	0.0191
Schistosoma mansoni	neuropeptide F-like receptor	0.037	0.0776	0.0763
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.005	0.0038	0.0034
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus multilocularis	neuropeptide receptor A26	0.037	0.0776	0.0772
Echinococcus multilocularis	somatostatin receptor	0.037	0.0776	0.0772
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.037	0.0776	0.0772
Brugia malayi	hypothetical protein	0.0162	0.0295	0.0292
Schistosoma mansoni	hypothetical protein	0.037	0.0776	0.0763
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.037	0.0776	0.0763
Schistosoma mansoni	hypothetical protein	0.037	0.0776	0.0763
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Echinococcus multilocularis	serotonin receptor	0.0491	0.1055	0.1051
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Onchocerca volvulus		0.037	0.0776	0.0772
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0119	0.0196	0.0191
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0196	0.0193
Schistosoma mansoni	neurotransmitter gated ion channel	0.005	0.0038	0.0024
Schistosoma mansoni	nAChR subunit	0.005	0.0038	0.0024
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Echinococcus multilocularis	g-protein coupled receptor	0.037	0.0776	0.0772
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.037	0.0776	0.077
Echinococcus granulosus	g protein coupled receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.037	0.0776	0.0771
Brugia malayi	Cation transporter family protein	0.0119	0.0196	0.0193
Schistosoma mansoni	neurotransmitter gated ion channel	0.005	0.0038	0.0024
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus granulosus	g protein coupled receptor	0.037	0.0776	0.077
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.005	0.0038	0.0034
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Schistosoma mansoni	nAChR subunit	0.005	0.0038	0.0024
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0069	0.008	0.0076
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus granulosus	tm gpcr rhodopsin	0.037	0.0776	0.077
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0119	0.0196	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.037	0.0776	0.0763
Brugia malayi	Dopamine receptor protein 2	0.037	0.0776	0.0772
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0119	0.0196	0.0191
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0196	0.0193
Onchocerca volvulus		0.037	0.0776	0.0772
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Brugia malayi	neuropeptide F receptor	0.037	0.0776	0.0772
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.037	0.0776	0.0772
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0006	0.0002
Echinococcus granulosus	vesicular acetylcholine transporter	0.4365	1	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0067	0.0076	0.0071
Schistosoma mansoni	hypothetical protein	0.0167	0.0306	0.0293
Schistosoma mansoni	neuropeptide receptor	0.037	0.0776	0.0763
Echinococcus granulosus	g-protein coupled receptor	0.037	0.0776	0.077
Brugia malayi	Carboxylesterase family protein	0.0067	0.0076	0.0073
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0119	0.0196	0.0193
Schistosoma mansoni	nAChR subunit	0.0119	0.0196	0.0183
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.0196	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Brugia malayi	follicle stimulating hormone receptor	0.037	0.0776	0.0772
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Echinococcus multilocularis	acetylcholinesterase	0.0067	0.0076	0.0073
Mycobacterium ulcerans	putative regulatory protein	0.0036	0.0004	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Schistosoma mansoni	neuropeptide receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	ACC-1 protein	0.0119	0.0196	0.0191
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.005	0.0038	0.0032
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0019	1
Echinococcus multilocularis	vesicular acetylcholine transporter	0.4365	1	1
Onchocerca volvulus		0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0119	0.0196	0.0193
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.037	0.0776	0.0763
Brugia malayi	Cation transporter family protein	0.0119	0.0196	0.0193
Brugia malayi	G-protein coupled receptor	0.037	0.0776	0.0772
Brugia malayi	hypothetical protein	0.005	0.0038	0.0034
Echinococcus granulosus	orexin receptor type 2	0.037	0.0776	0.077
Loa Loa (eye worm)	LGC-31 protein	0.0119	0.0196	0.0191
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.0196	0.0183
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	serotonin transporter b	0.0146	0.0259	0.0254
Echinococcus granulosus	neuropeptide FF receptor 2	0.037	0.0776	0.077
Treponema pallidum	sodium- and chloride- dependent transporter	0.0146	0.0259	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0119	0.0196	0.0191
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0119	0.0196	0.0193
Schistosoma mansoni	amine GPCR	0.037	0.0776	0.0763
Echinococcus multilocularis	fmrfamide receptor	0.037	0.0776	0.0772
Schistosoma mansoni	neuropeptide receptor	0.037	0.0776	0.0763
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Echinococcus granulosus	rhodopsin orphan GPCR	0.037	0.0776	0.077
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0033	0.0019
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.037	0.0776	0.0772
Echinococcus granulosus	serotonin receptor	0.037	0.0776	0.077
Echinococcus granulosus	neuropeptide s receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0076	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Onchocerca volvulus		0.005	0.0038	0.0034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Echinococcus granulosus	nAChR subunit	0.0069	0.008	0.0074
Brugia malayi	PAS domain containing protein	0.0048	0.0033	0.0029
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.037	0.0776	0.0763
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0119	0.0196	0.0193
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.0196	0.0193
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0253	0.0248
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Onchocerca volvulus		0.0119	0.0196	0.0193
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0146	0.0259	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0259	0.0254
Echinococcus multilocularis	neuropeptide receptor	0.037	0.0776	0.0772
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0119	0.0196	0.0193
Brugia malayi	Cytochrome P450 family protein	0.0036	0.0005	0.0002
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.005	0.0038	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.037	0.0776	0.0771
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Schistosoma mansoni	amine GPCR	0.037	0.0776	0.0763
Schistosoma mansoni	opsin-like receptor	0.037	0.0776	0.0763
Brugia malayi	AKH receptor	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0491	0.1055	0.105
Echinococcus multilocularis	serotonin receptor	0.0491	0.1055	0.1051
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.0196	0.0193
Echinococcus multilocularis	sex peptide receptor	0.037	0.0776	0.0772
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0019	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0119	0.0196	0.0191
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0119	0.0196	0.0191
Schistosoma mansoni	nAChR subunit	0.0119	0.0196	0.0183
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0076	0.0063
Echinococcus multilocularis	nAChR subunit	0.0069	0.008	0.0076
Echinococcus multilocularis	serotonin transporter	0.0146	0.0259	0.0256
Echinococcus granulosus	7TM GPCR rhodopsin	0.037	0.0776	0.077
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.037	0.0776	0.0771
Schistosoma mansoni	acetylcholine receptor subunit beta	0.005	0.0038	0.0024
Schistosoma mansoni	nAChR subunit	0.0119	0.0196	0.0183
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0019	0.5
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.0196	0.0191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.037	0.0776	0.077
Brugia malayi	GnHR receptor homolog	0.037	0.0776	0.0772
Echinococcus granulosus	rhodopsin orphan GPCR	0.037	0.0776	0.077
Schistosoma mansoni	single-minded	0.0048	0.0033	0.0019
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Schistosoma mansoni	neurotransmitter gated ion channel	0.0069	0.008	0.0067
Brugia malayi	Serotonin receptor	0.0816	0.1806	0.1803
Echinococcus multilocularis	G protein coupled receptor 139	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Brugia malayi	Dopamine receptor	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0196	0.0191
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.037	0.0776	0.077
Echinococcus multilocularis	glycine receptor subunit beta	0.0119	0.0196	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0491	0.1055	0.105
Echinococcus multilocularis	rhodopsin orphan GPCR	0.037	0.0776	0.0772
Onchocerca volvulus		0.037	0.0776	0.0772
Onchocerca volvulus		0.037	0.0776	0.0772
Brugia malayi	Dopamine receptor protein 1	0.037	0.0776	0.0772
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0019	1
Echinococcus granulosus	allatostatin A receptor	0.037	0.0776	0.077
Schistosoma mansoni	neuropeptide f receptor 76f	0.037	0.0776	0.0763
Onchocerca volvulus		0.0069	0.008	0.0076
Onchocerca volvulus		0.037	0.0776	0.0772
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.037	0.0776	0.0763
Onchocerca volvulus		0.0119	0.0196	0.0193
Echinococcus multilocularis	carboxylesterase 5A	0.0067	0.0076	0.0073
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0119	0.0196	0.0183
Echinococcus granulosus	alpha 1A adrenergic receptor	0.037	0.0776	0.077
Loa Loa (eye worm)	GABA receptor subunit	0.0069	0.008	0.0075
Schistosoma mansoni	histamine h1 receptor	0.037	0.0776	0.0763
Echinococcus multilocularis	G-protein coupled receptor, putative	0.037	0.0776	0.0772
Echinococcus multilocularis	neuropeptide FF receptor 2	0.037	0.0776	0.0772
Onchocerca volvulus		0.037	0.0776	0.0772
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.037	0.0776	0.0772
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0253	0.025
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.0196	0.0193
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus granulosus	neuropeptides capa receptor	0.037	0.0776	0.077
Onchocerca volvulus		0.0119	0.0196	0.0193
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.0196	0.0193
Echinococcus multilocularis	g protein coupled receptor	0.037	0.0776	0.0772
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0119	0.0196	0.0193
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0069	0.008	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0069	0.008	0.0075
Brugia malayi	hypothetical protein	0.037	0.0776	0.0772
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.0196	0.0183
Loa Loa (eye worm)	hypothetical protein	0.037	0.0776	0.0771
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0119	0.0196	0.0193
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.4365	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.037	0.0776	0.077
Schistosoma mansoni	alpha-1 adrenergic receptor	0.037	0.0776	0.0763
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.005	0.0038	0.0034
Loa Loa (eye worm)	hypothetical protein	0.005	0.0038	0.0032

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 48 %	Displacement of [3H]ZM241385 from adenosine A2A receptor in rat striatal membrane at 10 uM relative to control	ChEMBL.	17125265
Activity (binding)	= 48 %	Displacement of [3H]ZM241385 from adenosine A2A receptor in rat striatal membrane at 10 uM relative to control	ChEMBL.	17125265
Ki (binding)	= 40 nM	Displacement of [3H]DPCPX from adenosine A1 receptor in rat cerebral cortex	ChEMBL.	17125265
Ki (binding)	= 40 nM	Displacement of [3H]DPCPX from adenosine A1 receptor in rat cerebral cortex	ChEMBL.	17125265

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL217806
PubChem: 11994148

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 374284