TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 268.117 | Formula: C12H21BN2O4
H donors: 3 H acceptors: 4 LogP: 0.1 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OB([C@@H]1CCCN1C(=O)CNC(=O)C1CCCC1)O
InChi: 1S/C12H21BN2O4/c16-11(15-7-3-6-10(15)13(18)19)8-14-12(17)9-4-1-2-5-9/h9-10,18-19H,1-8H2,(H,14,17)/t10-/m0/s1
InChiKey: KXDXUFDMNMEQHZ-JTQLQIEISA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References
Homo sapiens	fibroblast activation protein, alpha	Starlite/ChEMBL	References
Homo sapiens	prolyl endopeptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma brucei gambiense	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania mexicana	prolyl oligopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma congolense	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Toxoplasma gondii	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	Prolyl endopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Onchocerca volvulus	Prolyl endopeptidase homolog	Get druggable targets OG5_129295	All targets in OG5_129295
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania donovani	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus granulosus	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129295	All targets in OG5_129295
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania infantum	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma cruzi	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	Get druggable targets OG5_129295	All targets in OG5_129295
Neospora caninum	Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related	Get druggable targets OG5_129295	All targets in OG5_129295
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	oligopeptidase b	prolyl endopeptidase	710 aa	630 aa	27.0 %
Echinococcus multilocularis	Dipeptidyl peptidase 9	fibroblast activation protein, alpha	735 aa	597 aa	24.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0174	0.0168	0.0494
Echinococcus multilocularis	endothelin converting enzyme 1	0.0097	0.002	0.0018
Trypanosoma brucei	prolyl endopeptidase	0.0191	0.0201	0.3143
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0419	0.0636	0.6047
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0108	0.0041	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0108	0.102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0595	0.9361
Brugia malayi	hypothetical protein	0.0108	0.004	0.0372
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0142	0.0106	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0089	0.0004	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0419	0.0636	1
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0157	0.0136	0.2195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0388	0.0577	0.9079
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0154	0.0129	0.2015
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0435	0.0667	1
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0157	0.0136	0.038
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.022	0.0256	0.4012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0407	0.0613	0.9645
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0419	0.0636	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0139	0.0101	0.0947
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0087	0.0001	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0242	0.0298	0.2831
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0388	0.0577	0.0576
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0635	0.1051	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.002	0.0176
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0157	0.0136	0.0134
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0143	0.0108	0.1703
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0419	0.0636	0.1796
Echinococcus granulosus	serine protein kinase ATM	0.022	0.0256	0.0255
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0407	0.0613	0.9645
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0254	0.0321	0.5044
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0263	0.0338	0.0336
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0108	0.0041	0.0639
Brugia malayi	Peptidase family M13 containing protein	0.0097	0.002	0.0176
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0174	0.0168	0.0494
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0388	0.0577	0.9079
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.022	0.0256	0.2426
Loa Loa (eye worm)	hypothetical protein	0.0348	0.0501	0.4765
Trypanosoma cruzi	target of rapamycin kinase 3	0.0409	0.0618	0.1821
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.022	0.0256	0.2426
Mycobacterium ulcerans	zinc metalloprotease	0.0097	0.002	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0108	0.0041	0.0589
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0407	0.0613	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0139	0.0101	0.0099
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0388	0.0577	0.163
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0157	0.0136	0.2116
Trypanosoma cruzi	hypothetical protein, conserved	0.1855	0.3386	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0263	0.0338	0.0336
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0435	0.0667	0.0666
Loa Loa (eye worm)	phosphatidylinositol 3	0.0388	0.0577	0.5488
Schistosoma mansoni	hypothetical protein	0.0168	0.0156	0.232
Giardia lamblia	GTOR	0.0419	0.0636	1
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0157	0.0136	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0303	0.2878
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0168	0.0156	0.0155
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0388	0.0577	0.0576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0407	0.0613	0.9645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0388	0.0577	0.9079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0595	0.9362
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.531	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0388	0.0577	0.1701
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0108	0.0041	0.0618
Trichomonas vaginalis	conserved hypothetical protein	0.0168	0.0156	0.2452
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0174	0.0168	0.2649
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0595	0.9362
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.022	0.0256	0.3821
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0096	0.0018	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0595	0.9361
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0174	0.0168	0.2649
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0143	0.0108	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0241	0.0296	0.4662
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0096	0.0018	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0388	0.0577	0.9079
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0419	0.0636	0.1796
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0251	0.0314	0.4946
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0108	0.0041	0.0639
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0388	0.0577	0.163
Brugia malayi	Angiotensin-converting enzyme family protein	0.0635	0.1051	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0419	0.0636	0.1874
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0409	0.0618	0.9716
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0201	0.19
Trichomonas vaginalis	conserved hypothetical protein	0.0143	0.0108	0.1705
Echinococcus multilocularis	prolyl endopeptidase	0.0191	0.0201	0.0199
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0407	0.0613	0.9645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0239	0.0292	0.4591
Trypanosoma cruzi	oligopeptidase b	0.0096	0.0018	0.005
Loa Loa (eye worm)	phosphatidylinositol 3	0.0419	0.0636	0.6047
Toxoplasma gondii	prolyl endopeptidase	0.0191	0.0201	0.3259
Entamoeba histolytica	hypothetical protein	0.022	0.0256	0.4012
Brugia malayi	FAT domain containing protein	0.0168	0.0156	0.1473
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0096	0.0018	0.005
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0096	0.0018	0.0048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0239	0.0292	0.4591
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0419	0.0636	1
Echinococcus granulosus	prolyl endopeptidase	0.0191	0.0201	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0108	0.004	0.0372
Schistosoma mansoni	fkbp-rapamycin associated protein	0.022	0.0256	0.3821
Trichomonas vaginalis	PIKK family atypical protein kinase	0.022	0.0256	0.4025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0407	0.0613	0.9645
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0143	0.0108	0.1703
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.022	0.0256	0.0255
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0191	0.0201	0.2993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.04	0.06	0.9434
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0087	0.0001	0.0022
Echinococcus granulosus	endothelin converting enzyme 1	0.0097	0.002	0.0018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0407	0.0613	0.9645
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0157	0.0136	0.0397
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0419	0.0636	0.9525
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0435	0.0667	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0174	0.0168	0.2633
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0108	0.0041	0.0639
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0168	0.0156	0.0155
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0097	0.002	0.0176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0266	0.0344	0.5409
Leishmania major	oligopeptidase b	0.0096	0.0018	0.0048
Trypanosoma cruzi	prolyl endopeptidase	0.0191	0.0201	0.0589
Mycobacterium leprae	probable zinc metalloprotease	0.0097	0.002	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.022	0.0256	0.0752
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0087	0.0001	0.0022
Loa Loa (eye worm)	prolyl oligopeptidase	0.0435	0.0667	0.6348
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0388	0.0577	0.9077
Trichomonas vaginalis	PIKK family atypical protein kinase	0.022	0.0256	0.4025
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0409	0.0618	0.1745
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0409	0.0618	0.9716
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0088	0.0004	0.0023
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.022	0.0256	0.4012
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0419	0.0636	0.1874
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0419	0.0636	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0595	0.9362
Brugia malayi	prolyl oligopeptidase family protein	0.0157	0.0136	0.128
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0108	0.0041	0.0618
Entamoeba histolytica	protein kinase rad3, putative	0.022	0.0256	0.4012
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0419	0.0636	0.0635
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0157	0.0136	0.2016
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0097	0.002	0.0277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0419	0.0636	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0087	0.0001	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0119	0.0062	0.0948
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0143	0.0108	0.1705
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0409	0.0618	0.9716
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0096	0.0018	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0595	0.9362
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0108	0.0041	0.0116
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0409	0.0618	0.9716
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0409	0.0618	0.9716
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0388	0.0577	0.9077
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0419	0.0636	0.0635
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0435	0.0667	0.0666
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0191	0.0201	0.0564
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0263	0.0338	0.5049
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0191	0.0201	0.2993
Echinococcus multilocularis	serine protein kinase ATM	0.022	0.0256	0.0255
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0097	0.0021	0.0309
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0122	0.0069	0.0778
Leishmania major	hypothetical protein, conserved	0.1932	0.3533	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.0041	0.0374
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0157	0.0136	0.2116
Trichomonas vaginalis	PIKK family atypical protein kinase	0.022	0.0256	0.4025
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0139	0.0101	0.0099
Brugia malayi	SH2 domain containing protein	0.0348	0.0501	0.4765
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0388	0.0577	0.9079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.0595	0.9361
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0174	0.0168	0.2649
Loa Loa (eye worm)	hypothetical protein	0.0097	0.002	0.0176
Toxoplasma gondii	peptidase family M13 protein	0.0097	0.002	0.0301
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0157	0.0136	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0097	0.002	0.0176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0419	0.0636	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0388	0.0577	0.1701
Loa Loa (eye worm)	hypothetical protein	0.022	0.0256	0.2426
Entamoeba histolytica	hypothetical protein	0.0154	0.0129	0.2015
Toxoplasma gondii	FATC domain-containing protein	0.022	0.0256	0.416
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.022	0.0256	0.0752
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0409	0.0618	0.9717
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0101	0.0947
Brugia malayi	prolyl oligopeptidase family protein	0.0191	0.0201	0.19
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0156	0.1473
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0174	0.0168	0.1592
Trichomonas vaginalis	conserved hypothetical protein	0.0245	0.0303	0.4771
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0407	0.0613	0.9645
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0419	0.0636	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0089	0.0004	0.0003
Trypanosoma cruzi	oligopeptidase b	0.0096	0.0018	0.005
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.022	0.0256	0.0255
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0097	0.002	0.0156
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0096	0.0018	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.04	0.06	0.9434
Brugia malayi	prolyl oligopeptidase family protein	0.0435	0.0667	0.6348
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0388	0.0577	0.8646
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0239	0.0292	0.4591
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0087	0.0001	0.0022
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0245	0.0303	0.4936
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0388	0.0577	0.5488
Trypanosoma brucei	oligopeptidase b	0.0096	0.0018	0.0269

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 2.3 nM	Inhibitory constant against POP	ChEMBL.	17174090
Ki (binding)	= 2.3 nM	Inhibitory constant against POP	ChEMBL.	17174090
Ki (binding)	= 20 nM	Inhibitiory constant against FAP	ChEMBL.	17174090
Ki (binding)	= 20 nM	Inhibitiory constant against FAP	ChEMBL.	17174090
Ki (binding)	= 9080 nM	Inhibition constant against DPP-4	ChEMBL.	17174090
Ki (binding)	= 9080 nM	Inhibition constant against DPP-4	ChEMBL.	17174090

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL217244

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 376306