TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1058.19 | Formula: C45H63N13O13S2
H donors: 14 H acceptors: 13 LogP: -6.34 Rotable bonds: 23
Rule of 5 violations (Lipinski): 4
SMILES: NC(=O)C[C@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@@H](NC1=O)C(=O)C(CC(=O)N[C@H](C(=O)NCC(=O)O)CCCN=C(N)N)C)N
InChi: 1S/C45H63N13O13S2/c1-23(16-36(62)53-28(8-5-15-51-45(49)50)40(67)52-20-37(63)64)38(65)33-22-73-72-21-27(46)39(66)55-30(18-25-9-11-26(59)12-10-25)43(70)56-31(17-24-6-3-2-4-7-24)42(69)54-29(13-14-34(47)60)41(68)57-32(19-35(48)61)44(71)58-33/h2-4,6-7,9-12,23,27-33,59H,5,8,13-22,46H2,1H3,(H2,47,60)(H2,48,61)(H,52,67)(H,53,62)(H,54,69)(H,55,66)(H,56,70)(H,57,68)(H,58,71)(H,63,64)(H4,49,50,51)/t23?,27-,28+,29-,30-,31+,32+,33+/m1/s1
InChiKey: BYEQNLMUPFNQAH-CSAICDOGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	orexin receptor type 2	0.0065	0.0209	0.0209
Onchocerca volvulus		0.0113	0.0439	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0146	0.06	0.1609
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0058	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0209	0.3483
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0146	0.06	0.1609
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0065	0.0209	0.0209
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0209	0.3483
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0065	0.0209	0.0209
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.2101	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.0209	0.3483
Trichomonas vaginalis	penicillin-binding protein, putative	0.0058	0.0177	0.255
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0056
Brugia malayi	G protein-coupled receptor F59B2.13	0.0065	0.0209	0.3119
Brugia malayi	larval opioid receptor	0.0065	0.0209	0.3119
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0198	0.3296
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Mycobacterium ulcerans	esterase/lipase LipP	0.0058	0.0177	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0064	0.0203	0.0172
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0033	0.0056	0.043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0158	0.2219
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0028	0.0032	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0065	0.0209	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0065	0.0209	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0065	0.0209	0.0209
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Brugia malayi	Peptidase family M1 containing protein	0.0033	0.0056	0.043
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	neuropeptides capa receptor	0.0065	0.0209	0.0209
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0065	0.0209	0.3119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus granulosus	allatostatin A receptor	0.0065	0.0209	0.0178
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	biogenic amine receptor	0.0065	0.0209	0.3483
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0065	0.0209	0.0209
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0065	0.0209	0.4349
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0146	0.06	0.06
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Onchocerca volvulus		0.0065	0.0209	0.4349
Entamoeba histolytica	protein kinase rad3, putative	0.0083	0.0293	0.4601
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	fmrfamide receptor	0.0065	0.0209	0.0209
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	Serotonin receptor	0.0065	0.0209	0.3119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0209	0.0178
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0146	0.06	1
Onchocerca volvulus		0.0065	0.0209	0.4349
Echinococcus multilocularis	g-protein coupled receptor	0.0065	0.0209	0.0209
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.0209	0.3483
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0056
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0083	0.0293	0.4601
Echinococcus multilocularis	neuropeptide Y receptor	0.0065	0.0209	0.0209
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0065	0.0209	0.0209
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0146	0.06	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0065	0.0209	0.3119
Toxoplasma gondii	FATC domain-containing protein	0.0083	0.0293	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Brugia malayi	follicle stimulating hormone receptor	0.0065	0.0209	0.3119
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0025
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0198	0.0198
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0028	0.0032	0.0093
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0028	0.0032	0.0093
Echinococcus granulosus	g protein coupled receptor	0.0065	0.0209	0.0178
Schistosoma mansoni	biogenic amine receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	neuropeptide f receptor 76f	0.0065	0.0209	0.3483
Trichomonas vaginalis	D-aminoacylase, putative	0.0058	0.0177	0.255
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0146	0.06	1
Brugia malayi	putative neuropeptide receptor	0.0065	0.0209	0.3119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0033	0.0056	0.0056
Schistosoma mansoni	amine GPCR	0.0065	0.0209	0.3483
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0146	0.06	0.175
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0032	0.0529
Mycobacterium tuberculosis	Probable esterase LipL	0.0058	0.0177	0.0875
Echinococcus multilocularis		0.0028	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0177	0.2944
Mycobacterium ulcerans	lipase LipD	0.0058	0.0177	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0065	0.0209	0.3483
Mycobacterium tuberculosis	Probable lipase LipD	0.0058	0.0177	0.0875
Trypanosoma cruzi	hypothetical protein, conserved	0.0735	0.343	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	phosphatidylinositol 3	0.0028	0.0032	0.0529
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.0209	0.0209
Trypanosoma brucei	hypothetical protein, conserved	0.0058	0.0177	0.255
Schistosoma mansoni	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	neuropeptide F receptor	0.0065	0.0209	0.3119
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0146	0.06	0.175
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0028	0.0032	0.0529
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0056
Brugia malayi	neuropeptide F receptor	0.0065	0.0209	0.3119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Schistosoma mansoni	neuropeptide F-like receptor	0.0065	0.0209	0.3483
Echinococcus multilocularis	neuropeptide Y receptor	0.0065	0.0209	0.0209
Onchocerca volvulus		0.0065	0.0209	0.4349
Onchocerca volvulus		0.0065	0.0209	0.4349
Schistosoma mansoni	myosin xvIII	0.0065	0.0209	0.3483
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0028	0.0032	0.0529
Brugia malayi	hypothetical protein	0.0033	0.0056	0.043
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0056
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0209	0.0178
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0065	0.0209	0.0178
Brugia malayi	AKH receptor	0.0065	0.0209	0.3119
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0028	0.0032	0.0529
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0065	0.0209	0.0178
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0198	0.3296
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0058	0.0177	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0339	0.5399
Mycobacterium leprae	conserved hypothetical protein	0.0058	0.0177	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Entamoeba histolytica	aminopeptidase, putative	0.0033	0.0056	0.043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0198	0.3296
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0177	0.2944
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0065	0.0209	0.3483
Echinococcus granulosus	fmrfamide receptor	0.0065	0.0209	0.0178
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0028	0.0032	0.0093
Onchocerca volvulus		0.0065	0.0209	0.4349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Schistosoma mansoni	adenoreceptor	0.0065	0.0209	0.3483
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0083	0.0293	0.4601
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0065	0.0209	0.0178
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0146	0.06	0.1609
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus granulosus	sex peptide receptor	0.0065	0.0209	0.0178
Echinococcus multilocularis	allatostatin A receptor	0.0065	0.0209	0.0209
Loa Loa (eye worm)	TYRA-2 protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0028	0.0032	0.0032
Onchocerca volvulus		0.0065	0.0209	0.4349
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0033	0.0056	0.043
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.0209	0.0178
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0146	0.06	1
Mycobacterium tuberculosis	Conserved protein	0.0058	0.0177	0.0875
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Trypanosoma brucei	Aminopeptidase M1, putative	0.0033	0.0056	0.043
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0065	0.0209	0.3483
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0083	0.0293	0.4601
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0158	0.2631
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0065	0.0209	0.0209
Echinococcus granulosus	neuropeptide FF receptor 2	0.0065	0.0209	0.0178
Echinococcus granulosus	neuropeptides capa receptor	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	phosphatidylinositol 3	0.0146	0.06	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0083	0.0293	0.0855
Echinococcus multilocularis	Zinc finger, PHD finger	0.0028	0.0032	0.0032
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0033	0.0056	0.0936
Loa Loa (eye worm)	G-protein coupled receptor	0.0065	0.0209	0.3483
Trypanosoma cruzi	aminopeptidase, putative	0.0033	0.0056	0.0164
Trichomonas vaginalis	D-aminoacylase, putative	0.0058	0.0177	0.255
Echinococcus multilocularis	serotonin receptor	0.0065	0.0209	0.0209
Schistosoma mansoni	hypothetical protein	0.0064	0.0203	0.3386
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Leishmania major	hypothetical protein, conserved	0.0058	0.0177	0.041
Echinococcus multilocularis	serine protein kinase ATM	0.0083	0.0293	0.0293
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0092	0.0339	0.5399
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Onchocerca volvulus		0.0065	0.0209	0.4349
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0083	0.0293	0.4601
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0028	0.0032	0.0093
Brugia malayi	G-protein coupled receptor	0.0065	0.0209	0.3119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0092	0.0339	0.5399
Brugia malayi	TAR-binding protein	0.0063	0.0198	0.2921
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0064	0.0203	0.0203
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0025
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.0209	0.0178
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Echinococcus multilocularis	fmrfamide receptor	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0033	0.0056	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0028	0.0032	0.0093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0383	0.6385
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0198	0.3296
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0209	0.3483
Trichomonas vaginalis	penicillin-binding protein, putative	0.0058	0.0177	0.255
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0058	0.0177	0.2944
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0065	0.0209	0.0209
Loa Loa (eye worm)	neuropeptide F receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0065	0.0209	0.3483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Onchocerca volvulus		0.0065	0.0209	0.4349
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0028	0.0032	0.0093
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0028	0.0032	0.0529
Onchocerca volvulus		0.0058	0.0177	0.3556
Brugia malayi	Dopamine receptor protein 1	0.0065	0.0209	0.3119
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0028	0.0032	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	G protein coupled receptor 139	0.0065	0.0209	0.0209
Echinococcus multilocularis	sex peptide receptor	0.0065	0.0209	0.0209
Echinococcus granulosus	neuropeptide receptor	0.0065	0.0209	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Echinococcus granulosus	neuropeptide s receptor	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Trypanosoma cruzi	target of rapamycin kinase 3	0.0146	0.06	0.175
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0293	0.4887
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0198	0.3296
Schistosoma mansoni	hypothetical protein	0.0028	0.0032	0.0529
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0372	0.1688	1
Trichomonas vaginalis	esterase, putative	0.0058	0.0177	0.255
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Echinococcus granulosus	serine protein kinase ATM	0.0083	0.0293	0.0262
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0177	0.0515
Onchocerca volvulus		0.0065	0.0209	0.4349
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0065	0.0209	0.3119
Loa Loa (eye worm)	phosphatidylinositol 3	0.0028	0.0032	0.0529
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0092	0.0339	0.5399
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0209	0.0178
Toxoplasma gondii	ABC1 family protein	0.0058	0.0177	0.255
Brugia malayi	Serotonin receptor	0.0065	0.0209	0.3119
Brugia malayi	RNA binding protein	0.0063	0.0198	0.2921
Onchocerca volvulus		0.0065	0.0209	0.4349
Echinococcus multilocularis	neuropeptide receptor	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Loa Loa (eye worm)	phosphatidylinositol 3	0.0028	0.0032	0.0529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0083	0.0293	0.4887
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0146	0.06	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0146	0.06	0.057
Schistosoma mansoni	amine GPCR	0.0065	0.0209	0.3483
Echinococcus granulosus	beta LACTamase domain containing family member	0.0058	0.0177	0.0145
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0065	0.0209	0.3483
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0065	0.0209	0.0209
Loa Loa (eye worm)	phosphatidylinositol 3	0.0146	0.06	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0146	0.06	0.1609
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.0209	0.0209
Echinococcus multilocularis	neuropeptide receptor A26	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0198	0.3296
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	Dopamine receptor	0.0065	0.0209	0.3119
Echinococcus granulosus	neuropeptides capa receptor	0.0065	0.0209	0.0178
Loa Loa (eye worm)	beta-lactamase	0.0058	0.0177	0.2944
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0065	0.0209	0.0209
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0146	0.06	0.175
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0177	0.2944
Entamoeba histolytica	hypothetical protein	0.0083	0.0293	0.4601
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0065	0.0209	0.3483
Schistosoma mansoni	biogenic amine receptor	0.0065	0.0209	0.3483
Onchocerca volvulus		0.0033	0.0056	0.06
Schistosoma mansoni	amine GPCR	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus granulosus	G protein coupled receptor 139	0.0065	0.0209	0.0178
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0054	0.0158	0.046
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0028	0.0032	0.0093
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0028	0.0032	0.0032
Onchocerca volvulus		0.0065	0.0209	0.4349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0146	0.06	0.06
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0065	0.0209	0.0178
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	growth hormone secretagogue receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0146	0.06	0.1609
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0033	0.0056	0.0164
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0146	0.06	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0065	0.0209	0.0178
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0146	0.06	0.057
Schistosoma mansoni	opsin-like receptor	0.0065	0.0209	0.3483
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0091	0.0336	0.5594
Trichomonas vaginalis	D-aminoacylase, putative	0.0058	0.0177	0.255
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.0209	0.0209
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0058	0.0177	0.2944
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0065	0.0209	0.3483
Schistosoma mansoni	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	serotonin receptor	0.0065	0.0209	0.0209
Echinococcus multilocularis	neuropeptide s receptor	0.0065	0.0209	0.0209
Echinococcus multilocularis	g protein coupled receptor	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0203	0.3386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0177	0.0515
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Giardia lamblia	GTOR	0.0146	0.06	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0065	0.0209	0.0209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Brugia malayi	beta-lactamase family protein	0.0058	0.0177	0.255
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0028	0.0032	0.0093
Echinococcus granulosus	7tm_1 domain containing protein	0.0065	0.0209	0.0178
Onchocerca volvulus		0.0065	0.0209	0.4349
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0065	0.0209	0.0209
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0058	0.0177	0.0875
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0033	0.0056	0.0069
Brugia malayi	G-protein coupled receptor	0.0065	0.0209	0.3119
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0177	0.2944
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0058	0.0177	0.2944
Echinococcus granulosus	7TM GPCR rhodopsin	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0177	0.2944
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0065	0.0209	0.3119
Echinococcus granulosus	neuropeptide Y receptor	0.0065	0.0209	0.0178
Mycobacterium ulcerans	hypothetical protein	0.0058	0.0177	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0198	0.3296
Brugia malayi	FAT domain containing protein	0.0064	0.0203	0.3017
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0065	0.0209	0.0178
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0028	0.0032	0.0032
Mycobacterium tuberculosis	Probable lipase LipE	0.0058	0.0177	0.0875
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0146	0.06	0.175
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Mycobacterium tuberculosis	Conserved protein	0.0058	0.0177	0.0875
Brugia malayi	Peptidase family M1 containing protein	0.0113	0.0439	0.7172
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	Melatonin receptor type 1A	0.0065	0.0209	0.3119
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0065	0.0209	0.0209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0083	0.0293	0.4601
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0339	0.5642
Echinococcus granulosus	neuropeptide receptor A26	0.0065	0.0209	0.0178
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Onchocerca volvulus		0.0065	0.0209	0.4349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Schistosoma mansoni	opsin-like receptor	0.0065	0.0209	0.3483
Brugia malayi	GnHR receptor homolog	0.0065	0.0209	0.3119
Echinococcus granulosus	aminopeptidase N	0.0113	0.0439	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0065	0.0209	0.0178
Mycobacterium ulcerans	beta-lactamase	0.0058	0.0177	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0177	0.2944
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0033	0.0056	0.0069
Echinococcus granulosus	g-protein coupled receptor	0.0065	0.0209	0.0178
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0065	0.0209	0.4349
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0028	0.0032	0.0529
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0065	0.0209	0.3483
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0028	0.0032	0.0032
Brugia malayi	Dopamine receptor protein 2	0.0065	0.0209	0.3119
Mycobacterium tuberculosis	Conserved protein	0.0058	0.0177	0.0875
Brugia malayi	hypothetical protein	0.0065	0.0209	0.3119
Echinococcus granulosus	biogenic amine 5HT receptor	0.0065	0.0209	0.0178
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0065	0.0209	0.3483
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.0209	0.0209
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0146	0.06	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0146	0.06	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Brugia malayi	RE15519p	0.0065	0.0209	0.3119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Loa Loa (eye worm)	phosphatidylinositol 3	0.0028	0.0032	0.0529
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0065	0.0209	0.3119
Leishmania major	hypothetical protein, conserved	0.0763	0.3566	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Onchocerca volvulus		0.0058	0.0177	0.3556
Mycobacterium leprae	Probable lipase LipE	0.0058	0.0177	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0083	0.0293	0.0293
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0025
Schistosoma mansoni	amine GPCR	0.0065	0.0209	0.3483
Echinococcus multilocularis	aminopeptidase N	0.0113	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0198	0.2921
Schistosoma mansoni	opsin-like receptor	0.0065	0.0209	0.3483
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0065	0.0209	0.3119
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0177	1
Echinococcus granulosus	hypothetical protein	0.0065	0.0209	0.0178
Onchocerca volvulus		0.0065	0.0209	0.4349
Brugia malayi	sulfakinin receptor protein	0.0065	0.0209	0.3119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0028	0.0032	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0028	0.0032	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus granulosus	dro:myosuppressin receptor	0.0065	0.0209	0.0178
Echinococcus multilocularis	somatostatin receptor	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0158	0.2219
Brugia malayi	G protein-coupled receptor	0.0065	0.0209	0.3119
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0058	0.0177	0.0875
Brugia malayi	beta-lactamase	0.0058	0.0177	0.255
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0033	0.0056	0.043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0065	0.0209	0.0178
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0028	0.0032	0.0529
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0028	0.0032	0.0529
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0065	0.0209	0.0209
Echinococcus granulosus	g protein coupled receptor	0.0065	0.0209	0.0178
Brugia malayi	ORL1-like opioid receptor	0.0065	0.0209	0.3119
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0065	0.0209	0.0209
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0203	0.3017
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0146	0.06	1
Onchocerca volvulus		0.0058	0.0177	0.3556
Brugia malayi	beta-lactamase family protein	0.0058	0.0177	0.255
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0033	0.0056	0.0164
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0083	0.0293	0.0855
Schistosoma mansoni	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus granulosus	somatostatin receptor	0.0065	0.0209	0.0178
Schistosoma mansoni	neuropeptide F-like receptor	0.0065	0.0209	0.3483
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0058	0.0177	0.255
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0065	0.0209	0.0209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0065	0.0209	0.3483
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0058	0.0177	0.0875
Loa Loa (eye worm)	aminopeptidase N	0.0033	0.0056	0.0936
Echinococcus granulosus	serotonin receptor	0.0065	0.0209	0.0178
Schistosoma mansoni	histamine h1 receptor	0.0065	0.0209	0.3483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0198	0.0167
Echinococcus granulosus	orexin receptor type 2	0.0065	0.0209	0.0178
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0146	0.06	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0065	0.0209	0.3119
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0028	0.0032	0.5
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0028	0.0032	0.0093
Echinococcus granulosus	tm gpcr rhodopsin	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0065	0.0209	0.3483
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0065	0.0209	0.0209
Trypanosoma brucei	Aminopeptidase M1, putative	0.0033	0.0056	0.043
Schistosoma mansoni	neuropeptide receptor	0.0065	0.0209	0.3483
Echinococcus multilocularis	neuropeptide receptor	0.0065	0.0209	0.0209
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0033	0.0056	0.0056
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0028	0.0032	0.0032
Schistosoma mansoni	amine GPCR	0.0065	0.0209	0.3483
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0083	0.0293	0.4887
Onchocerca volvulus		0.0065	0.0209	0.4349
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0028	0.0032	0.0529
Loa Loa (eye worm)	hypothetical protein	0.008	0.028	0.4658
Echinococcus granulosus	neuropeptide Y receptor	0.0065	0.0209	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0032	0.0529
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Mycobacterium tuberculosis	Probable hydrolase	0.0058	0.0177	0.0875
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0065	0.0209	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0209	0.3483
Echinococcus granulosus	g protein coupled receptor	0.0065	0.0209	0.0178
Echinococcus granulosus	neuropeptide receptor	0.0065	0.0209	0.0178
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0198	0.3296
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0146	0.06	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Onchocerca volvulus		0.0065	0.0209	0.4349
Loa Loa (eye worm)	melatonin receptor type 1A	0.0065	0.0209	0.3483
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0146	0.06	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0083	0.0293	0.0262
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0065	0.0209	0.3483
Loa Loa (eye worm)	phosphatidylinositol 3	0.0028	0.0032	0.0529
Onchocerca volvulus		0.0065	0.0209	0.4349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0146	0.06	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0065	0.0209	0.0209
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0065	0.0209	0.0178

Activities

Activity type	Activity value	Assay description	Source	Reference
Antidiuretic activity (functional)	= 580 mg	Antidiuretic activity on water loaded, ethanol-anesthetized rat.	ChEMBL.	3612693
Pressor activity (functional)	= 1 mg	Pressor activity on urethane-anesthetized, phenoxybenzamine-treated rat.	ChEMBL.	3612693
Uterine activity (functional)	= 38 mg	Uterine activity was meseared in isolated rat uterus in solutions in the absence No Mg2+ 0.5 mM in vitro	ChEMBL.	3612693
Uterine activity (functional)	= 49 mg	Uterine activity was meseared in isolated rat uterus in solutions in the presense Mg2+ 0.5 mM in vitro	ChEMBL.	3612693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 153779

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 377692