Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | zinc metalloprotease | 0.3208 | 0.2656 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2371 | 0.1718 | 0.0956 |
Mycobacterium leprae | probable zinc metalloprotease | 0.3208 | 0.2656 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3208 | 0.2656 | 0.198 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.3208 | 0.2656 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.1619 | 0.0875 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.2427 | 0.178 | 0.1024 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.3208 | 0.2656 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.3208 | 0.2656 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2427 | 0.178 | 0.1024 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.2371 | 0.1718 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.2427 | 0.178 | 0.1024 |
Onchocerca volvulus | 0.1589 | 0.0842 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2427 | 0.178 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.3208 | 0.2656 | 0.198 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1619 | 0.0875 | 0.3296 |
Toxoplasma gondii | peptidase family M13 protein | 0.3208 | 0.2656 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.3208 | 0.2656 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2427 | 0.178 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.2371 | 0.1718 | 0.0956 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.1619 | 0.0875 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.2371 | 0.1718 | 0.0956 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.9765 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2427 | 0.178 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.3208 | 0.2656 | 0.198 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.1619 | 0.0875 | 0.3296 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.2371 | 0.1718 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.2371 | 0.1718 | 0.0956 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1619 | 0.0875 | 0.3296 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 120 nM | Binding affinity to Angiotensin II receptor, type 1 as displacement of 125I-Sar, Ile-AII from rat adrenal cortex membranes | ChEMBL. | No reference |
IC50 (binding) | = 120 nM | Binding affinity to Angiotensin II receptor, type 1 as displacement of 125I-Sar, Ile-AII from rat adrenal cortex membranes | ChEMBL. | No reference |
IC50 (functional) | > 100000 nM | Compound was evaluated for inhibitory activity against PAF (platelet activating factor) induced platelet aggregation | ChEMBL. | No reference |
IC50 (functional) | > 100000 nM | Calcium channel blocking activity (CCB) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.