Detailed information for compound 39637

Basic information

Technical information
  • TDR Targets ID: 39637
  • Name: 2-(2-pentoxyphenyl)-1H-imidazo[4,5-b]pyridine
  • MW: 281.352 | Formula: C17H19N3O
  • H donors: 1 H acceptors: 2 LogP: 3.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOc1ccccc1c1nc2c(n1)ccc[nH]2
  • InChi: 1S/C17H19N3O/c1-2-3-6-12-21-15-10-5-4-8-13(15)16-19-14-9-7-11-18-17(14)20-16/h4-5,7-11H,2-3,6,12H2,1H3,(H,18,19,20)
  • InChiKey: HQTPMVMZBPJOEV-UHFFFAOYSA-N  


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Synonyms

  • 2-(2-amoxyphenyl)-1H-imidazo[4,5-b]pyridine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4C, cAMP-specific References
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4B, cAMP-specific References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0073 0.0282 0.0358
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.0494 0.0494
Toxoplasma gondii hypothetical protein 0.0065 0.0178 0.0309
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0329 0.3354 0.4267
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.015 0.1204 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0344 0.3529 0.6141
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0344 0.3529 0.449
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0529 0.5747 0.7426
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0775 0.1349
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Brugia malayi Tyrosine-protein kinase abl-1 0.0427 0.453 0.7883
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0529 0.5747 0.5
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0091 0.0494 0.0859
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0114 0.0775 0.0775
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 0.5747
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Schistosoma mansoni tyrosine kinase 0.0695 0.7739 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0529 0.5747 0.5
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0114 0.0775 0.0987
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0344 0.3529 0.456
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0091 0.0494 0.0859
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0179 0.1552 0.1552
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0179 0.1552 0.1552
Brugia malayi Tyrosine-protein kinase abl-1 0.0287 0.285 0.4959
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0282 0.049
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0529 0.5747 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0344 0.3529 0.449
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0073 0.0282 0.0364
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0883 1 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0114 0.0775 0.0987
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0344 0.3529 0.449
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0179 0.1552 0.2701
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0199 0.1795 0.3124
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0114 0.0775 0.0775
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0073 0.0282 0.049
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0329 0.3354 0.5836
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 0.5747
Loa Loa (eye worm) hypothetical protein 0.0073 0.0282 0.0358
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0114 0.0775 0.1002
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0529 0.5747 0.5747
Loa Loa (eye worm) hypothetical protein 0.0344 0.3529 0.449
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0529 0.5747 0.5
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0529 0.5747 1
Loa Loa (eye worm) hypothetical protein 0.0329 0.3354 0.4267
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0294 0.2931 0.3729
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0529 0.5747 0.5747
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.035 0.3597 0.4577
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0529 0.5747 0.5
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0329 0.3354 0.4267
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0883 1 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0529 0.5747 0.5747
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0529 0.5747 0.5747
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0114 0.0775 0.1349
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0114 0.0775 0.0775
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0705 0.786 1
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.015 0.1204 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0529 0.5747 0.7426
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0529 0.5747 0.5747
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 0.5747
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0529 0.5747 0.7312
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0329 0.3354 0.4267
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0282 0.049
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0529 0.5747 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0529 0.5747 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0294 0.2931 0.3729
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 0.5747
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0529 0.5747 0.5747
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0529 0.5747 0.7426
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0178 0.0309
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0114 0.0775 0.1349
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0329 0.3354 0.5836
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0883 1 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.035 0.3597 0.4577
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0178 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0178 0.0309
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0529 0.5747 0.7312
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0282 0.049
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0282 0.049
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0179 0.1552 0.1552
Echinococcus granulosus tyrosine protein kinase ABL1 0.0705 0.786 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0379 0.3945 0.6865
Loa Loa (eye worm) TK/ABL protein kinase 0.0705 0.786 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0294 0.2931 0.5101
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0073 0.0282 0.0358
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0529 0.5747 0.5747
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0529 0.5747 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0529 0.5747 0.5747
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0529 0.5747 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0344 0.3529 0.449
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.0775 0.1349
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0529 0.5747 0.5
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0529 0.5747 0.7312
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0344 0.3529 0.6141
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0114 0.0775 0.0775
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0179 0.1552 0.1552
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0529 0.5747 1
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0529 0.5747 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0287 0.285 0.3626
Loa Loa (eye worm) hypothetical protein 0.0267 0.2611 0.3322
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0199 0.1795 0.3124
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0529 0.5747 0.7312
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0114 0.0775 0.0775
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0294 0.2931 0.3729
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0529 0.5747 0.7426
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0329 0.3354 0.4267
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0179 0.1552 0.1552
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0114 0.0775 0.1349
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0529 0.5747 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 uM In vitro inhibition of PDE-V isolated from porcine pulmonary artery. ChEMBL. 8388468
IC50 (binding) = 1 uM In vitro inhibition of PDE-V isolated from porcine pulmonary artery. ChEMBL. 8388468
IC50 (binding) = 6 uM In vitro inhibition of PDE-IV isolated from guinea pig ventricle. ChEMBL. 8388468
IC50 (binding) = 6 uM In vitro inhibition of PDE-IV isolated from guinea pig ventricle. ChEMBL. 8388468
Inhibition (binding) = 0 % Percentage inhibition against PDE-III (phosphodiesterase III) in guinea pig ventricle at 10 microM ChEMBL. 8388468
Inhibition (binding) = 0 % Percentage inhibition against PDE-III (phosphodiesterase III) in guinea pig ventricle at 10 microM ChEMBL. 8388468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.