Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0175 | 0.3356 | 0.4883 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0028 | 0.0137 | 0.0199 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0175 | 0.3356 | 0.3356 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0127 | 0.0127 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0175 | 0.3356 | 0.4883 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0175 | 0.3356 | 0.4883 |
Schistosoma mansoni | lamin | 0.0028 | 0.0127 | 0.0215 |
Schistosoma mansoni | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Schistosoma mansoni | nAChR subunit | 0.0081 | 0.129 | 0.2195 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0094 | 0.1587 | 0.2309 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0514 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0514 | 0.0875 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0081 | 0.129 | 0.1877 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0081 | 0.129 | 0.1877 |
Giardia lamblia | Kinase, putative | 0.0032 | 0.0234 | 0.0398 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0175 | 0.3356 | 0.4883 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0028 | 0.0137 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Brugia malayi | Cation transporter family protein | 0.0175 | 0.3356 | 0.4883 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0335 | 0.6874 | 1 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0094 | 0.1587 | 0.27 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0175 | 0.3356 | 0.5711 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0514 | 0.0875 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0081 | 0.129 | 0.2195 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0175 | 0.3356 | 0.5711 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0175 | 0.3356 | 0.5711 |
Onchocerca volvulus | 0.0028 | 0.0127 | 0.0377 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0094 | 0.1587 | 0.2309 |
Loa Loa (eye worm) | ACC-1 protein | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | hypothetical protein | 0.0081 | 0.129 | 0.1877 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0175 | 0.3356 | 0.3356 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0175 | 0.3356 | 0.4883 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0028 | 0.0137 | 0.0199 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Onchocerca volvulus | 0.0094 | 0.1587 | 0.4729 | |
Schistosoma mansoni | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0028 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0127 | 0.0215 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.1121 | 0.1631 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0073 | 0.1121 | 0.1907 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Echinococcus granulosus | FTZ F1 alpha | 0.0028 | 0.0137 | 0.0233 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0028 | 0.0137 | 0.0233 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0028 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0175 | 0.3356 | 0.5711 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0028 | 0.0137 | 0.0233 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0081 | 0.129 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0028 | 0.0137 | 0.0233 |
Schistosoma mansoni | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0127 | 0.0184 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0028 | 0.0137 | 0.0199 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0028 | 0.0137 | 0.0233 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.029 | 0.5877 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0408 | 0.0694 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0175 | 0.3356 | 0.5711 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0175 | 0.3356 | 0.5711 |
Onchocerca volvulus | 0.0032 | 0.0234 | 0.0697 | |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0175 | 0.3356 | 0.5711 |
Entamoeba histolytica | bromodomain-containing protein | 0.0032 | 0.0234 | 0.0398 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0175 | 0.3356 | 0.3356 |
Onchocerca volvulus | 0.0175 | 0.3356 | 1 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0028 | 0.0137 | 0.0233 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0028 | 0.0137 | 0.0199 |
Onchocerca volvulus | 0.0175 | 0.3356 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0028 | 0.0137 | 0.0199 |
Schistosoma mansoni | coup transcription factor | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0028 | 0.0137 | 0.0199 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0081 | 0.129 | 0.1877 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0081 | 0.129 | 0.1877 |
Mycobacterium ulcerans | proteasome PrcB | 0.029 | 0.5877 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.029 | 0.5877 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0028 | 0.0137 | 0.0137 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0175 | 0.3356 | 0.5711 |
Toxoplasma gondii | bromodomain-containing protein | 0.0032 | 0.0234 | 0.0398 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0175 | 0.3356 | 0.4883 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0514 | 0.0875 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Schistosoma mansoni | nAChR subunit | 0.0081 | 0.129 | 0.2195 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0028 | 0.0137 | 0.0233 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0028 | 0.0137 | 0.0233 |
Trichomonas vaginalis | bromodomain-containing protein 4, brd4, putative | 0.0032 | 0.0234 | 0.0398 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0028 | 0.0137 | 0.0233 |
Echinococcus granulosus | nAChR subunit | 0.0094 | 0.1587 | 0.27 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.1587 | 0.27 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0028 | 0.0137 | 0.0233 |
Schistosoma mansoni | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0175 | 0.3356 | 0.5711 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Onchocerca volvulus | 0.0081 | 0.129 | 0.3844 | |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0175 | 0.3356 | 0.5711 |
Onchocerca volvulus | 0.0028 | 0.0127 | 0.0377 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0028 | 0.0137 | 0.0137 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0127 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | hypothetical protein | 0.0081 | 0.129 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0028 | 0.0137 | 0.0137 |
Schistosoma mansoni | thyroid hormone receptor | 0.0028 | 0.0137 | 0.0233 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0175 | 0.3356 | 0.5711 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0081 | 0.129 | 0.2195 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0045 | 0.0514 | 0.0875 |
Brugia malayi | Cation transporter family protein | 0.0175 | 0.3356 | 0.4883 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0081 | 0.129 | 0.2195 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0094 | 0.1587 | 0.27 |
Brugia malayi | steroid hormone receptor | 0.0028 | 0.0137 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Onchocerca volvulus | 0.0081 | 0.129 | 0.3844 | |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0081 | 0.129 | 0.129 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0028 | 0.0137 | 0.0199 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0175 | 0.3356 | 0.3356 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.029 | 0.5877 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0073 | 0.1121 | 0.1907 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0175 | 0.3356 | 0.4883 |
Echinococcus granulosus | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0073 | 0.1121 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | Cation transporter family protein | 0.0175 | 0.3356 | 0.4883 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0028 | 0.0137 | 0.0408 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0175 | 0.3356 | 0.5711 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0081 | 0.129 | 0.129 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0081 | 0.129 | 0.2195 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0175 | 0.3356 | 0.4883 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0127 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Brugia malayi | ecdysteroid receptor | 0.0028 | 0.0137 | 0.0199 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.029 | 0.5877 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0094 | 0.1587 | 0.27 |
Loa Loa (eye worm) | LGC-31 protein | 0.0175 | 0.3356 | 0.3356 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0028 | 0.0137 | 0.0233 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0081 | 0.129 | 0.2195 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0028 | 0.0137 | 0.0137 |
Schistosoma mansoni | nuclear hormone receptor | 0.0028 | 0.0137 | 0.0233 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0234 | 0.0398 |
Echinococcus multilocularis | Bromodomain containing protein | 0.0032 | 0.0234 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0127 | 0.0185 |
Onchocerca volvulus | 0.0175 | 0.3356 | 1 | |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0175 | 0.3356 | 0.5711 |
Onchocerca volvulus | Putative nachr subunit | 0.0175 | 0.3356 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0175 | 0.3356 | 0.4883 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0028 | 0.0137 | 0.0137 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0127 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0175 | 0.3356 | 0.4883 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0127 | 0.0127 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0028 | 0.0137 | 0.0233 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.029 | 0.5877 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.029 | 0.5877 | 0.5877 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0028 | 0.0137 | 0.0233 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0081 | 0.129 | 0.2195 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0081 | 0.129 | 0.2195 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0175 | 0.3356 | 0.5711 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0028 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1121 | 0.1121 |
Brugia malayi | hypothetical protein | 0.0081 | 0.129 | 0.1877 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0094 | 0.1587 | 0.27 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.0032 | 0.0234 | 0.0398 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.1121 | 0.1631 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.6874 | 0.6874 |
Echinococcus granulosus | lamin | 0.0028 | 0.0127 | 0.0215 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0175 | 0.3356 | 0.4883 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0175 | 0.3356 | 0.4883 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0094 | 0.1587 | 0.2309 |
Brugia malayi | hypothetical protein | 0.0081 | 0.129 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0115 | 0.0115 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0127 | 0.0215 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0032 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0175 | 0.3356 | 0.5711 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0028 | 0.0137 | 0.0233 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0028 | 0.0137 | 0.0233 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0081 | 0.129 | 0.2195 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0094 | 0.1587 | 0.1587 |
Echinococcus multilocularis | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0028 | 0.0137 | 0.0199 |
Onchocerca volvulus | 0.0175 | 0.3356 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0028 | 0.0137 | 0.0199 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0028 | 0.0137 | 0.0199 |
Onchocerca volvulus | 0.0081 | 0.129 | 0.3844 | |
Echinococcus granulosus | bromodomain containing 2 | 0.0073 | 0.1121 | 0.1907 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.029 | 0.5877 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | nuclear hormone receptor | 0.0028 | 0.0137 | 0.0199 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0175 | 0.3356 | 0.5711 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.029 | 0.5877 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.029 | 0.5877 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0028 | 0.0137 | 0.0199 |
Entamoeba histolytica | bromodomain-containing protein | 0.0032 | 0.0234 | 0.0398 |
Entamoeba histolytica | bromodomain-containing protein | 0.0032 | 0.0234 | 0.0398 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0175 | 0.3356 | 0.4883 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0028 | 0.0137 | 0.0199 |
Onchocerca volvulus | 0.0175 | 0.3356 | 1 | |
Echinococcus granulosus | proteasome prosome macropain | 0.029 | 0.5877 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0073 | 0.1121 | 0.1907 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0094 | 0.1587 | 0.2309 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0175 | 0.3356 | 0.4883 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0081 | 0.129 | 0.129 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0028 | 0.0137 | 0.0199 |
Onchocerca volvulus | 0.0175 | 0.3356 | 1 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0175 | 0.3356 | 0.5711 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0127 | 0.0215 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0081 | 0.129 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.129 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0028 | 0.0137 | 0.0199 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.5104 | 0.5104 |
Schistosoma mansoni | thyroid hormone receptor | 0.0028 | 0.0137 | 0.0233 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0127 | 0.0215 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0175 | 0.3356 | 0.5711 |
Schistosoma mansoni | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Leishmania major | proteasome beta 5 subunit, putative | 0.029 | 0.5877 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.029 | 0.5877 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0175 | 0.3356 | 0.4883 |
Onchocerca volvulus | 0.0028 | 0.0137 | 0.0408 | |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.029 | 0.5877 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.029 | 0.5877 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0028 | 0.0137 | 0.0233 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0028 | 0.0137 | 0.0233 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.029 | 0.5877 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0028 | 0.0137 | 0.0199 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.029 | 0.5877 | 0.8551 |
Schistosoma mansoni | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0175 | 0.3356 | 0.5711 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1587 | 0.1587 |
Schistosoma mansoni | lamin | 0.0028 | 0.0127 | 0.0215 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0127 | 0.0127 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0081 | 0.129 | 0.2195 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | hypothetical protein | 0.0081 | 0.129 | 0.1877 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0175 | 0.3356 | 0.5711 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.029 | 0.5877 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0028 | 0.0137 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0137 | 0.0137 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0028 | 0.0137 | 0.0233 |
Loa Loa (eye worm) | ACC-1 protein | 0.0175 | 0.3356 | 0.3356 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0028 | 0.0137 | 0.0233 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0032 | 0.0234 | 0.0398 |
Schistosoma mansoni | nAChR subunit | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0028 | 0.0137 | 0.0199 |
Onchocerca volvulus | 0.0094 | 0.1587 | 0.4729 | |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.3356 | 0.3356 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0175 | 0.3356 | 0.5711 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0175 | 0.3356 | 0.4883 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0175 | 0.3356 | 0.3356 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0028 | 0.0137 | 0.0199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MST (functional) | ND 0 day | Antimalarial effect measured against trophozoite induced P. berghei in mice at dosage of 640 mg/kg after sc administration | ChEMBL. | 7009867 |
MST (functional) | ND 0 day | Antimalarial effect measured in trophozoite induced P. berghei mice at dose of 320 mg/kg after sc administration. | ChEMBL. | 7009867 |
MST (functional) | 0 day | Antimalarial effect measured against trophozoite induced Plasmodium berghei in mice at dosage of 80 mg/kg after sc administration; no data | ChEMBL. | 7009867 |
MST (functional) | 0 day | Antimalarial effect measured against trophozoite induced P. berghei in mice at dosage of 20 mg/kg after sc administration; no data | ChEMBL. | 7009867 |
MST (functional) | = 0.6 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | = 0.6 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | = 0.8 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice at dosage of 160 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 0.8 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice at dosage of 160 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
No. of toxic deaths (ADMET) | = 5 | Number of toxic deaths at a dose of 640 mg/kg | ChEMBL. | 7009867 |
No. of toxic deaths (ADMET) | = 5 | Number of toxic deaths at a dose of 640 mg/kg | ChEMBL. | 7009867 |
Ratio (functional) | < 2.5 | The ratio of SD90 of the quinine hydrocloride, to the SD90 of the test substance for the Dose of >30 mg/kg | ChEMBL. | 7009867 |
SD90 (functional) | > 30 mg kg-1 day-1 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice. | ChEMBL. | 7009867 |
SD90 (functional) | > 30 mg kg-1 day-1 | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice. | ChEMBL. | 7009867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.