Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Torpedo californica | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0368 | 0.8785 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0368 | 0.8785 | 0.8785 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.8785 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.8785 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0062 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0368 | 0.8785 | 0.8785 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0368 | 0.8785 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0411 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0368 | 0.8785 | 0.8785 |
Loa Loa (eye worm) | carboxylesterase | 0.0368 | 0.8785 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0368 | 0.8785 | 0.8785 |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0368 | 0.8785 | 1 |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Onchocerca volvulus | 0.0062 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.8469 | 0.964 |
Echinococcus granulosus | acetylcholinesterase | 0.0368 | 0.8785 | 0.8785 |
Echinococcus granulosus | carboxylesterase 5A | 0.0368 | 0.8785 | 0.8785 |
Brugia malayi | Carboxylesterase family protein | 0.0368 | 0.8785 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.13 nM | Inhibition of human plasma BChE | ChEMBL. | 17149883 |
IC50 (binding) | = 7.13 nM | Inhibition of human plasma BChE | ChEMBL. | 17149883 |
IC50 (binding) | = 26.3 nM | Inhibition of Torpedo californica AChE | ChEMBL. | 17149883 |
IC50 (binding) | = 26.3 nM | Inhibition of Torpedo californica AChE | ChEMBL. | 17149883 |
IC50 (binding) | = 60.5 nM | Inhibition of Electrophorus electricus AChE | ChEMBL. | 17149883 |
IC50 (binding) | = 60.5 nM | Inhibition of Electrophorus electricus AChE | ChEMBL. | 17149883 |
IC50 (binding) | = 241 nM | Inhibition of human AChE | ChEMBL. | 17149883 |
IC50 (binding) | = 241 nM | Inhibition of human AChE | ChEMBL. | 17149883 |
Ratio IC50 (binding) | = 33.8 | Selectivity for human BChE over human AChE | ChEMBL. | 17149883 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.