Detailed information for compound 410387

Basic information

Technical information
  • TDR Targets ID: 410387
  • Name: 2-[(4-chlorophenyl)methyl]-3-phenylmethoxy-7, 8,9,10-tetrahydrobenzo[h]quinoline-4-carboxyl ic acid
  • MW: 457.948 | Formula: C28H24ClNO3
  • H donors: 1 H acceptors: 3 LogP: 7.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cc1nc2c3CCCCc3ccc2c(c1OCc1ccccc1)C(=O)O
  • InChi: 1S/C28H24ClNO3/c29-21-13-10-18(11-14-21)16-24-27(33-17-19-6-2-1-3-7-19)25(28(31)32)23-15-12-20-8-4-5-9-22(20)26(23)30-24/h1-3,6-7,10-15H,4-5,8-9,16-17H2,(H,31,32)
  • InChiKey: QXZQACKNQKMNGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-benzyloxy-2-[(4-chlorophenyl)methyl]-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
  • 3-benzoxy-2-(4-chlorobenzyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
  • 2-[(4-chlorophenyl)methyl]-3-(phenylmethoxy)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
  • 3-(benzyloxy)-2-(4-chlorobenzyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nAChR subunit 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1373 1
Onchocerca volvulus 0.0156 0.2309 0.5111
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0607 0.1189
Loa Loa (eye worm) hypothetical protein 0.0036 0.0359 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0152 0.0279
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0441 0.7274
Trypanosoma brucei glucose transporter 2A 0.0036 0.0367 0.1176
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1373 1
Schistosoma mansoni glucose transport protein 0.0117 0.1666 0.3055
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Brugia malayi glutathione reductase 0.0039 0.041 0.0554
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0819 0.1502
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.029 0.4472 0.6044
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0367 0.6045
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0367 0.1176
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0359 0.0659
Echinococcus granulosus solute carrier family 22 0.0016 0.0047 0.0087
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.036 0.0463
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0203 0.0372
Loa Loa (eye worm) GABA receptor subunit 0.0156 0.2309 0.2297
Treponema pallidum NADH oxidase 0.0013 0 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.041 0.0527
Leishmania major trypanothione reductase 0.0039 0.041 0.6755
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.029 0.4472 0.8197
Entamoeba histolytica hypothetical protein 0.0156 0.2309 1
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.041 0.6755
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Brugia malayi Sugar transporter family protein 0.0016 0.0047 0.0064
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0367 0.2201
Schistosoma mansoni neurotransmitter gated ion channel 0.0134 0.1946 0.3567
Schistosoma mansoni sugar transporter 0.0016 0.0047 0.0087
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0367 0.1176
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0359 0.0659
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Schistosoma mansoni sodium/solute symporter 0.009 0.123 0.2255
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0367 0.6045
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.029 0.4472 0.8197
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0134 0.1946 0.263
Brugia malayi hypothetical protein 0.0051 0.0607 0.082
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0047 0.0087
Schistosoma mansoni nAChR subunit 0.029 0.4472 0.8197
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.1666 0.3055
Schistosoma mansoni nAChR subunit 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0362 0.0664
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0203 0.0261
Toxoplasma gondii thioredoxin reductase 0.0039 0.041 0.0803
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Schistosoma mansoni nAChR subunit 0.0134 0.1946 0.3567
Brugia malayi hypothetical protein 0.0134 0.1946 0.263
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.036 0.0705
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Brugia malayi TAR-binding protein 0.0064 0.0819 0.1107
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Schistosoma mansoni high-affinity choline transporter 0.009 0.123 0.2255
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0047 0.0087
Onchocerca volvulus Putative nachr subunit 0.029 0.4472 1
Toxoplasma gondii sugar transporter ST2 0.0016 0.0047 0.0093
Trypanosoma cruzi hexose transporter 0.0036 0.0367 0.6045
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0202 0.5818
Onchocerca volvulus 0.029 0.4472 1
Brugia malayi Sugar transporter family protein 0.0117 0.1666 0.2252
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0047 0.2338
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0047 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Onchocerca volvulus 0.0134 0.1946 0.429
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0188 0.2827 0.3634
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0441 0.7274
Loa Loa (eye worm) RNA binding protein 0.0064 0.0819 0.0806
Onchocerca volvulus 0.029 0.4472 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Loa Loa (eye worm) acetylcholine receptor protein 0.0134 0.1946 0.1934
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.036 0.0463
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0211 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Echinococcus granulosus nAChR subunit 0.0156 0.2309 0.4232
Trypanosoma cruzi hexose transporter, putative 0.002 0.0102 0.168
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0359 0.0486
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Onchocerca volvulus 0.029 0.4472 1
Leishmania major hypothetical protein, conserved 0.0016 0.0047 0.0783
Trypanosoma brucei trypanothione reductase 0.0039 0.041 0.1314
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.1214 0.8706
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0203 0.1219
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1373 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0418 0.0767
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.029 0.4472 0.8197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.1946 0.263
Echinococcus granulosus glycine receptor subunit alpha 1 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Brugia malayi Thioredoxin reductase 0.0039 0.041 0.0554
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.036 0.0705
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.076
Mycobacterium ulcerans sugar transporter 0.0016 0.0047 0.2338
Schistosoma mansoni protein kinase 0.0036 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0607 0.078
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.029 0.4472 0.6044
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.029 0.4472 0.8197
Loa Loa (eye worm) sugar transporter 0.0117 0.1666 0.1654
Plasmodium vivax sugar transporter, putative 0.0016 0.0047 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0047 0.0285
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1373 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Brugia malayi hypothetical protein 0.0016 0.0047 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0819 0.1502
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0047 0.0285
Schistosoma mansoni protein kinase 0.0036 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.029 0.4472 0.4463
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0203 0.0372
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0047 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0359 0.0345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0819 0.0806
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.1666 0.3055
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) glutathione reductase 0.0039 0.041 0.0396
Leishmania major glucose transporter, lmgt2 0.0036 0.0367 0.6045
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0324 0.0594
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.029 0.4472 0.8197
Schistosoma mansoni inositol transporter 0.0351 0.5455 1
Schistosoma mansoni hypothetical protein 0.0207 0.3119 0.5718
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0047 0.0783
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0047 0.0087
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0441 0.7274
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.029 0.4472 0.8197
Echinococcus granulosus solute carrier family 22 0.0016 0.0047 0.0087
Schistosoma mansoni inositol transporter 0.0351 0.5455 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0495 0.7778 1
Schistosoma mansoni nAChR subunit 0.029 0.4472 0.8197
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0359 0.0345
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0047 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Schistosoma mansoni nAChR subunit 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.009 0.123 0.1217
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.009 0.123 0.2255
Leishmania major glucose transporter, lmgt1 0.0036 0.0367 0.6045
Echinococcus granulosus sodium:glucose cotransporter 2 0.0351 0.5455 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.029 0.4472 0.6044
Schistosoma mansoni hypothetical protein 0.0036 0.0362 0.0664
Loa Loa (eye worm) LGC-31 protein 0.029 0.4472 0.4463
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.029 0.4472 0.8197
Plasmodium falciparum glutathione reductase 0.0039 0.041 0.0527
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.1666 0.3055
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Brugia malayi hypothetical protein 0.0016 0.0047 0.0064
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0348 1
Plasmodium falciparum thioredoxin reductase 0.0039 0.041 0.0527
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0348 0.0638
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0607 0.078
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0819 0.1502
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0134 0.1946 0.3567
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0156 0.2309 0.312
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Schistosoma mansoni protein kinase 0.0036 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Echinococcus multilocularis solute carrier family 22 0.0016 0.0047 0.0087
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.1214 0.8837
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0134 0.1946 0.1934
Schistosoma mansoni sugar transporter 0.0016 0.0047 0.0087
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0047 0.0346
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.036 0.0463
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.0338 0.5235 0.5228
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.029 0.4472 0.4463
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0151 0.0908
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.041 0.2985
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0047 0.0783
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0203 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.029 0.4472 0.6044
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.014 0.1017
Schistosoma mansoni glucose transport protein 0.0117 0.1666 0.3055
Echinococcus granulosus glycine receptor subunit alpha 1 0.029 0.4472 0.8197
Echinococcus granulosus tar DNA binding protein 0.0064 0.0819 0.1502
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0047 0.0285
Onchocerca volvulus 0.0156 0.2309 0.5111
Toxoplasma gondii protein kinase, putative 0.0329 0.5105 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0134 0.1946 0.3567
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0203 0.584
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1666 0.3055
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0359 0.0659
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0202 0.0371
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0607 1
Trypanosoma brucei RNA helicase, putative 0.0207 0.3119 1
Echinococcus multilocularis nAChR subunit 0.0156 0.2309 0.4232
Entamoeba histolytica protein kinase, putative 0.0036 0.0359 0.0746
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0156 0.2309 0.4232
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.029 0.4472 0.8197
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.029 0.4472 0.4463
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.076
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0359 0.0659
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.029 0.4472 0.6044
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.036 0.0463
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.041 0.0396
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.029 0.4472 0.8197
Echinococcus granulosus solute carrier family 5 0.0351 0.5455 1
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0242 0.0228
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0324 0.0594
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0367 0.2201
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0047 0.0152
Brugia malayi hypothetical protein 0.0134 0.1946 0.263
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0441 0.0568
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Giardia lamblia Sugar-proton symporter 0.0016 0.0047 0.1366
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Onchocerca volvulus 0.029 0.4472 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0156 0.2309 0.4232
Echinococcus granulosus solute carrier family 22 0.0016 0.0047 0.0087
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.029 0.4472 0.6044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.029 0.4472 0.6044
Brugia malayi excitatory GABA receptor EXP-1A 0.029 0.4472 0.6044
Onchocerca volvulus 0.029 0.4472 1
Onchocerca volvulus 0.029 0.4472 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0202 0.0649
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.029 0.4472 0.8197
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0202 0.3334
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0348 0.2087
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.029 0.4472 0.4463
Echinococcus multilocularis solute carrier family 22 0.0016 0.0047 0.0087
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0202 0.026
Loa Loa (eye worm) ACC-1 protein 0.029 0.4472 0.4463
Brugia malayi Cam kinase protein 1 0.0036 0.0359 0.0486
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Onchocerca volvulus 0.0134 0.1946 0.429
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0047 0.0285
Entamoeba histolytica hypothetical protein 0.0026 0.0203 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.1666 1
Leishmania major hypothetical protein, conserved 0.0051 0.0607 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.029 0.4472 0.6044
Mycobacterium tuberculosis Probable reductase 0.0089 0.1214 0.8837
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0348 0.0638
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.036 0.0705
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Echinococcus granulosus sodium:myo inositol cotransporter 0.0351 0.5455 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0607 0.078
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0047 0.2338
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0607 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.1214 0.8837
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0047 0.2338
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.029 0.4472 0.6044
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.009 0.123 0.2409
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Plasmodium falciparum protein kinase 6 0.0495 0.7778 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0134 0.1946 0.263
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Echinococcus granulosus glycine receptor subunit beta 0.029 0.4472 0.8197
Brugia malayi Cation transporter family protein 0.029 0.4472 0.6044
Schistosoma mansoni hypothetical protein 0.0023 0.0152 0.0279
Echinococcus multilocularis high affinity choline transporter 1 0.009 0.123 0.2255
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0348 0.0638
Plasmodium falciparum flap endonuclease 1 0.0026 0.0202 0.026
Echinococcus multilocularis solute carrier family 5 0.0351 0.5455 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0418 0.0767
Giardia lamblia Hexose transporter 0.0016 0.0047 0.1366
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0203 0.0275
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0441 0.0568
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0359 0.2157
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0441 0.7274
Brugia malayi GH02984p 0.009 0.123 0.1663
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0203 0.3347
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0047 0.0783
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.029 0.4472 0.6044
Brugia malayi hypothetical protein 0.0016 0.0047 0.0064
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0156 0.2309 0.312
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0819 0.1502
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.036 0.0463
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0203 0.0372
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0203 0.0514
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.1214 0.8837
Schistosoma mansoni acetylcholine receptor-related 0.0134 0.1946 0.3567
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0134 0.1946 0.3567
Brugia malayi hypothetical protein 0.0036 0.0362 0.049
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) hypothetical protein 0.009 0.123 0.1217
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0203 0.0261
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0047 0.0064
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0819 0.0806
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0351 0.5455 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0047 0.0033
Schistosoma mansoni acetylcholine receptor subunit beta 0.0134 0.1946 0.3567
Toxoplasma gondii sugar transporter ST1 0.0016 0.0047 0.0093
Schistosoma mansoni neurotransmitter gated ion channel 0.0134 0.1946 0.3567
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.036 0.0463
Echinococcus multilocularis glycine receptor subunit beta 0.029 0.4472 0.8197
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.036 0.0463
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0334
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.029 0.4472 0.8197
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0441 0.0865
Echinococcus multilocularis solute carrier family 22 0.0016 0.0047 0.0087
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.029 0.4472 0.8197
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0203 0.0651
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.076
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1666 0.3055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0362 0.0664
Plasmodium falciparum protein kinase 7 0.0329 0.5105 0.6563
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0607 0.1946
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.1214 0.8837
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0188 0.2827 0.5537
Echinococcus multilocularis glycine receptor subunit alpha 1 0.029 0.4472 0.8197
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.029 0.4472 0.8197
Trypanosoma brucei glucose transporter 1E 0.0036 0.0367 0.1176
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1666 0.3055
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0047 0.0346
Plasmodium falciparum hexose transporter 0.0117 0.1666 0.2142
Echinococcus multilocularis glycine receptor subunit alpha 1 0.029 0.4472 0.8197
Schistosoma mansoni sugar transporter 0.0016 0.0047 0.0087
Brugia malayi hypothetical protein 0.0134 0.1946 0.263
Loa Loa (eye worm) hypothetical protein 0.0051 0.0607 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0367 0.2201
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0367 0.2201
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.029 0.4472 0.6044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.1214 0.8837
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.029 0.4472 0.8197
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.1666 0.3264
Echinococcus granulosus flap endonuclease 1 0.0026 0.0202 0.0371
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0047 0.0285
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.029 0.4472 0.4463
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0134 0.1946 0.263
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.029 0.4472 0.8197
Schistosoma mansoni nAChR subunit 0.029 0.4472 0.8197
Onchocerca volvulus 0.0134 0.1946 0.429
Schistosoma mansoni hypothetical protein 0.0117 0.1666 0.3055
Echinococcus granulosus glycine receptor subunit beta 0.029 0.4472 0.8197
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0202 0.1214
Schistosoma mansoni glucose transport protein 0.0117 0.1666 0.3055
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0367 0.6045
Entamoeba histolytica protein kinase, putative 0.0036 0.0359 0.0746
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0348 0.1687
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0819 0.1502
Echinococcus granulosus General substrate transporter 0.01 0.1402 0.2569
Schistosoma mansoni neurotransmitter gated ion channel 0.0156 0.2309 0.4232
Loa Loa (eye worm) sugar transporter 0.0016 0.0047 0.0033
Schistosoma mansoni nAChR subunit 0.0134 0.1946 0.3567
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0047 0.0093
Brugia malayi hypothetical protein 0.0033 0.0315 0.0425
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0203 0.0372
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0047 0.0087
Schistosoma mansoni flap endonuclease-1 0.0023 0.0162 0.0297
Trypanosoma brucei glucose transporter, putative 0.0036 0.0367 0.1176
Plasmodium falciparum mitogen-activated protein kinase 2 0.0188 0.2827 0.3634
Echinococcus multilocularis glycine receptor subunit alpha 1 0.029 0.4472 0.8197
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Echinococcus granulosus glycine receptor subunit alpha 1 0.029 0.4472 0.8197
Echinococcus multilocularis solute carrier family 22 0.0016 0.0047 0.0087
Brugia malayi hypothetical protein 0.0134 0.1946 0.263
Echinococcus multilocularis General substrate transporter 0.01 0.1402 0.2569
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0047 0.0064
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0819 0.1107
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0367 0.6045
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.014 0.1017
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Echinococcus granulosus high affinity choline transporter 1 0.009 0.123 0.2255
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Echinococcus granulosus solute carrier family 22 0.0016 0.0047 0.0087
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Brugia malayi Cytochrome P450 family protein 0.0026 0.0211 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0367 0.2201
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0047 0.0087
Brugia malayi RNA binding protein 0.0064 0.0819 0.1107
Loa Loa (eye worm) hypothetical protein 0.0026 0.0203 0.0189
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0202 0.0396
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0203 0.0398
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.009 0.123 0.2255
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.029 0.4472 0.6044
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0367 0.2201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.1666 0.3055
Echinococcus multilocularis glycine receptor subunit beta 0.029 0.4472 0.8197
Echinococcus granulosus sodium:glucose cotransporter 0.0351 0.5455 1
Brugia malayi Cation transporter family protein 0.029 0.4472 0.6044
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.036 0.0463
Loa Loa (eye worm) ACC-1 protein 0.029 0.4472 0.4463
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.1666 0.3055
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0351 0.5455 1
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.076
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0134 0.1946 0.3567
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0047 0.0285
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0134 0.1946 0.1934
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.029 0.4472 0.6044
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0047 0.0285
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0441 0.1415
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Plasmodium vivax hexose transporter 0.0117 0.1666 0.2142
Toxoplasma gondii sugar transporter ST3 0.0016 0.0047 0.0093
Brugia malayi Cation transporter family protein 0.029 0.4472 0.6044
Schistosoma mansoni glucose transporter 0.0016 0.0047 0.0087
Brugia malayi Sugar transporter family protein 0.0016 0.0047 0.0064
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0348 0.047
Loa Loa (eye worm) hypothetical protein 0.0471 0.7398 0.7395
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0334
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0348 0.0638
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0359 0.0659
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0348 0.047
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.029 0.4472 0.8197
Schistosoma mansoni sugar transporter 0.0016 0.0047 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0203 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0359 0.0659
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.1946 0.263
Echinococcus multilocularis nAChR subunit 0.029 0.4472 0.8197
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0203 1
Brugia malayi hypothetical protein 0.0134 0.1946 0.263
Trypanosoma brucei sugar transporter, putative 0.0016 0.0047 0.0152
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Plasmodium vivax glutathione reductase, putative 0.0039 0.041 0.0527
Brugia malayi Sodium:solute symporter family protein 0.009 0.123 0.1663
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.029 0.4472 0.6044
Schistosoma mansoni nAChR subunit 0.029 0.4472 0.8197
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.029 0.4472 0.8197
Leishmania major glucose transporter, lmgt3 0.0036 0.0367 0.6045
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0471 0.7398 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1946 0.1934
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0348 0.0691
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.029 0.4472 0.4463
Brugia malayi Flap endonuclease-1 0.0026 0.0202 0.0273
Leishmania major protein kinase, putative 0.0036 0.0359 0.5923
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0819 0.1502
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0033
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0047 0.0783
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0359 0.1152
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0359 0.0659
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0367 0.1176
Brugia malayi major facilitator superfamily protein 0.0016 0.0047 0.0064
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0047 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0362 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0047 0.0285
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0202 0.3334
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0156 0.2309 0.312
Loa Loa (eye worm) hypothetical protein 0.0156 0.2309 0.2297
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.036 0.0463
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.029 0.4472 0.6044
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0156 0.2309 0.312
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Brugia malayi major facilitator superfamily protein 0.0016 0.0047 0.0064
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0134 0.1946 0.3567
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0047 0.0285
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0203 0.3347
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0134 0.1946 0.263
Onchocerca volvulus 0.009 0.123 0.2673
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0359 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0367 0.2201
Schistosoma mansoni nAChR subunit 0.029 0.4472 0.8197
Loa Loa (eye worm) hypothetical protein 0.029 0.4472 0.4463
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0202 0.0188
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0152 0.0279

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 390 uM Inhibition of P-Selectin by Biacore assay ChEMBL. 17201409
IC50 (binding) = 390 uM Inhibition of P-Selectin by Biacore assay ChEMBL. 17201409

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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