Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 230 nM | Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane | ChEMBL. | 15566292 |
Ki (binding) | > 500 nM | Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane | ChEMBL. | 15566292 |
Ki (binding) | > 500 nM | Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane | ChEMBL. | 15566292 |
Stabilty (ADMET) | = 51 % | Metabolic stability in rat liver microsome at 2 uM after 60 mins | ChEMBL. | 15566292 |
Stabilty (ADMET) | = 81 % | Metabolic stability in rat liver microsome at 2 uM after 30 mins | ChEMBL. | 15566292 |
Stabilty (ADMET) | = 97 % | Metabolic stability in rat liver microsomes at 2 uM after 15 mins | ChEMBL. | 15566292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.