Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neural cadherin | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0144 | 0.1295 | 0.1295 |
Brugia malayi | EGF-like domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0203 | 0.2389 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.2246 | 0.2246 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Echinococcus multilocularis | calpain A | 0.0207 | 0.2469 | 0.2469 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Onchocerca volvulus | 0.032 | 0.4542 | 1 | |
Echinococcus multilocularis | peroxidasin | 0.032 | 0.4542 | 0.4542 |
Brugia malayi | EGF-like domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0195 | 0.2246 | 0.2246 |
Onchocerca volvulus | 0.0122 | 0.0886 | 0.0849 | |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Onchocerca volvulus | 0.032 | 0.4542 | 1 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | septate junction protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.4542 | 0.4542 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0103 | 0.0546 | 0.0546 |
Onchocerca volvulus | Peroxidase homolog | 0.032 | 0.4542 | 1 |
Echinococcus granulosus | calpain A | 0.0207 | 0.2469 | 0.2469 |
Brugia malayi | calpain family protein 1 | 0.0195 | 0.2246 | 0.2246 |
Echinococcus multilocularis | protein jagged 2 | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.4542 | 0.4542 |
Toxoplasma gondii | cathepsin B | 0.0203 | 0.2389 | 1 |
Schistosoma mansoni | notch | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.4542 | 0.4542 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0207 | 0.2469 | 0.2469 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | EGF-like domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | peroxidasin | 0.032 | 0.4542 | 0.4542 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0207 | 0.2469 | 0.2469 |
Schistosoma mansoni | cell polarity protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | slit 2 protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | protein jagged 1 | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0615 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0615 | 1 | 1 |
Echinococcus granulosus | delta-like protein 1 | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | notch | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Cadherin domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Echinococcus granulosus | neural cadherin | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.032 | 0.4542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | integrin alpha | 0.0092 | 0.0336 | 0.0336 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | peroxidasin | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Schistosoma mansoni | notch | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | fibropellin Ia | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | cathepsin b | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0144 | 0.1295 | 0.1295 |
Echinococcus multilocularis | cathepsin b | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0207 | 0.2469 | 0.2469 |
Brugia malayi | Muscle positioning protein 4 | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0092 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | notch | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.4542 | 0.4542 |
Onchocerca volvulus | 0.032 | 0.4542 | 1 | |
Echinococcus multilocularis | protein jagged 1 | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203 | 0.2389 | 0.2389 |
Schistosoma mansoni | notch | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | notch-like transmembrane receptor | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | protein jagged 2 | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | calpain family protein 1 | 0.0195 | 0.2246 | 0.2246 |
Brugia malayi | EGF-like domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | EGF-like domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1295 | 0.1295 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0103 | 0.0546 | 0.0546 |
Onchocerca volvulus | Peroxidasin homolog | 0.032 | 0.4542 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0103 | 0.0546 | 0.0546 |
Plasmodium vivax | calpain, putative | 0.0074 | 0 | 0.5 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0092 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0103 | 0.0546 | 0.0546 |
Onchocerca volvulus | Peroxidasin homolog | 0.032 | 0.4542 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 1 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0103 | 0.0546 | 0.0546 |
Giardia lamblia | Cathepsin B precursor | 0.0203 | 0.2389 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0092 | 0.0336 | 0.0336 |
Echinococcus multilocularis | slit 2 protein | 0.0103 | 0.0546 | 0.0546 |
Onchocerca volvulus | Peroxidase homolog | 0.032 | 0.4542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | notch | 0.0103 | 0.0546 | 0.0546 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0203 | 0.2389 | 1 |
Schistosoma mansoni | peroxidasin | 0.032 | 0.4542 | 0.4542 |
Schistosoma mansoni | notch | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | integrin alpha-4 | 0.0393 | 0.5897 | 0.5897 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Peroxidasin | 0.032 | 0.4542 | 0.4542 |
Giardia lamblia | Cathepsin B precursor | 0.0203 | 0.2389 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Cadherin domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | cathepsin b | 0.0615 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0103 | 0.0546 | 0.0546 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0203 | 0.2389 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | fibropellin Ia | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | integrin alpha ps | 0.0092 | 0.0336 | 0.0336 |
Echinococcus multilocularis | cathepsin b | 0.0615 | 1 | 1 |
Schistosoma mansoni | notch | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0103 | 0.0546 | 0.0546 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0203 | 0.2389 | 0.2389 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Giardia lamblia | Cathepsin B precursor | 0.0203 | 0.2389 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0103 | 0.0546 | 0.0546 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.032 | 0.4542 | 0.4542 |
Echinococcus multilocularis | protein jagged 1 | 0.0103 | 0.0546 | 0.0546 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0207 | 0.2469 | 0.2469 |
Loa Loa (eye worm) | Notch2 | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0886 | 0.0886 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0203 | 0.2389 | 0.2389 |
Loa Loa (eye worm) | notch protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus granulosus | protein jagged 1 | 0.0103 | 0.0546 | 0.0546 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0195 | 0.2246 | 0.2246 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.4542 | 0.4542 |
Schistosoma mansoni | slit | 0.0103 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.4542 | 0.4542 |
Onchocerca volvulus | Dual oxidase homolog | 0.032 | 0.4542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.1837 | 0.1837 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0546 | 0.0546 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.4542 | 0.4542 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of Toxoplasma gondii 2F1 invasion in HFF cells assessed as beta-galactosidase activity at 10 uM | ChEMBL. | 17145790 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.