Detailed information for compound 420323

Basic information

Technical information
  • TDR Targets ID: 420323
  • Name: 2-[(2Z)-2-[(2-methylphenyl)methylidene]hydraz inyl]-3-phenylquinazolin-4-one
  • MW: 354.405 | Formula: C22H18N4O
  • H donors: 1 H acceptors: 1 LogP: 4.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1/C=N\Nc1nc2ccccc2c(=O)n1c1ccccc1
  • InChi: 1S/C22H18N4O/c1-16-9-5-6-10-17(16)15-23-25-22-24-20-14-8-7-13-19(20)21(27)26(22)18-11-3-2-4-12-18/h2-15H,1H3,(H,24,25)/b23-15-
  • InChiKey: MDMNCKWKRCKWCE-HAHDFKILSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(N'Z)-N'-(o-tolylmethylene)hydrazino]-3-phenyl-quinazolin-4-one
  • 2-[(N'Z)-N'-(o-tolylmethylene)hydrazino]-3-phenyl-4-quinazolinone
  • 2-[(2Z)-2-[(2-methylphenyl)methylidene]hydrazinyl]-3-phenyl-quinazolin-4-one
  • 2-[(N'Z)-N'-(2-methylbenzylidene)hydrazino]-3-phenyl-quinazolin-4-one
  • 2-[(N'Z)-N'-[(2-methylphenyl)methylene]hydrazino]-3-phenyl-quinazolin-4-one
  • 2-[(N'Z)-N'-[(2-methylphenyl)methylene]hydrazino]-3-phenyl-4-quinazolinone
  • ZINC08306414

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum glutathione reductase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast glutathione reductase 500 aa 561 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0051 0.0692
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0153 0.0548
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0299 0.0249
Brugia malayi Animal haem peroxidase family protein 0.0216 0.1246 0.4468
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0051 0.0692
Brugia malayi EGF-like domain containing protein 0.0028 0.0061 0.0218
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0299 0.0249
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0299 0.0249
Brugia malayi Animal haem peroxidase family protein 0.0216 0.1246 0.4468
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0066 0.0299 0.0249
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0009
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0054 0.0226 0.3044
Brugia malayi larval opioid receptor 0.0066 0.0299 0.1071
Schistosoma mansoni laminin gamma-3 chain 0.0028 0.0061 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus granulosus hypothetical protein 0.0066 0.0299 0.0903
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0299 0.0903
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0153 0.0371
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0299 0.0903
Echinococcus multilocularis slit 2 protein 0.0028 0.0061 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Giardia lamblia High cysteine protein 0.0028 0.0061 0.0034
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0051 0.5
Echinococcus multilocularis notch 0.0028 0.0061 0.0034
Echinococcus granulosus sex peptide receptor 0.0066 0.0299 0.0903
Schistosoma mansoni microsomal glutathione s-transferase 0.0367 0.2203 0.2163
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0299 0.0903
Onchocerca volvulus Peroxidasin homolog 0.0216 0.1246 0.4345
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0066 0.0299 0.1071
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0066 0.0299 0.0903
Brugia malayi G protein-coupled receptor F59B2.13 0.0066 0.0299 0.1071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Brugia malayi Muscle positioning protein 4 0.0028 0.0061 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0299 0.0903
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Echinococcus multilocularis serotonin receptor 0.0066 0.0299 0.0903
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0153 0.0548
Leishmania major trypanothione reductase 0.0076 0.0366 0.4917
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0299 0.0903
Echinococcus granulosus prolyl endopeptidase 0.0136 0.0743 0.2528
Schistosoma mansoni peroxidasin 0.0216 0.1246 0.1201
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0066 0.0299 0.0903
Onchocerca volvulus 0.0066 0.0299 0.0872
Leishmania major oligopeptidase b 0.0054 0.0226 0.3044
Schistosoma mansoni septate junction protein 0.0028 0.0061 0.0009
Schistosoma mansoni notch 0.0028 0.0061 0.0009
Echinococcus granulosus glycogen phosphorylase 0.046 0.2789 1
Schistosoma mansoni notch 0.0028 0.0061 0.0009
Onchocerca volvulus 0.0066 0.0299 0.0872
Trypanosoma cruzi oligopeptidase b 0.0054 0.0226 0.3044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi EGF-like domain containing protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) animal heme peroxidase 0.0216 0.1246 0.4468
Echinococcus granulosus delta-like protein 1 0.0028 0.0061 0.0034
Trichomonas vaginalis glycogen phosphorylase, putative 0.046 0.2789 1
Echinococcus granulosus neuropeptide receptor 0.0066 0.0299 0.0903
Schistosoma mansoni amine GPCR 0.0066 0.0299 0.0249
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0009
Echinococcus multilocularis glycogen phosphorylase 0.046 0.2789 1
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0061 0.0034
Echinococcus granulosus neuropeptide receptor 0.0066 0.0299 0.0903
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0299 0.0903
Echinococcus multilocularis dro:myosuppressin receptor 0.0066 0.0299 0.0903
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0299 0.0903
Brugia malayi Blistered cuticle protein 3 0.0216 0.1246 0.4468
Onchocerca volvulus Peroxidase homolog 0.0216 0.1246 0.4345
Brugia malayi hypothetical protein 0.0216 0.1246 0.4468
Onchocerca volvulus 0.0066 0.0299 0.0872
Brugia malayi Serotonin receptor 0.0066 0.0299 0.1071
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0028 0.0061 0.0009
Echinococcus granulosus 7TM GPCR rhodopsin 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis protein jagged 1 0.0028 0.0061 0.0034
Toxoplasma gondii MAPEG family protein 0.0367 0.2203 1
Onchocerca volvulus 0.0216 0.1246 0.4345
Onchocerca volvulus 0.0066 0.0299 0.0872
Brugia malayi Serotonin receptor 0.0066 0.0299 0.1071
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0051 0.0692
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0299 0.0903
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Trypanosoma brucei trypanothione reductase 0.0076 0.0366 0.4917
Echinococcus granulosus g protein coupled receptor 0.0066 0.0299 0.0903
Onchocerca volvulus 0.0066 0.0299 0.0872
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0051 0.0451
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0076 0.0366 0.2884
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Schistosoma mansoni neuropeptide receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0066 0.0299 0.1071
Echinococcus multilocularis protein jagged 1 0.0028 0.0061 0.0034
Echinococcus granulosus alpha 1A adrenergic receptor 0.0066 0.0299 0.0903
Schistosoma mansoni hypothetical protein 0.0066 0.0299 0.0249
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0299 0.0903
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Trypanosoma brucei prolyl oligopeptidase, putative 0.0054 0.0226 0.3044
Echinococcus granulosus g protein coupled receptor 0.0066 0.0299 0.0903
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0299 0.0249
Onchocerca volvulus 0.0066 0.0299 0.0872
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0066 0.0299 0.0903
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0299 0.0903
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0007 0.0026
Echinococcus multilocularis fibropellin Ia 0.0028 0.0061 0.0034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus multilocularis somatostatin receptor 0.0066 0.0299 0.0903
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0299 0.1071
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0009
Schistosoma mansoni notch 0.0028 0.0061 0.0009
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0061 0.0218
Echinococcus granulosus neural cadherin 0.0028 0.0061 0.0034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0051 0.0692
Echinococcus multilocularis allatostatin A receptor 0.0066 0.0299 0.0903
Echinococcus multilocularis glycogen phosphorylase 0.046 0.2789 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0054 0.0226 1
Echinococcus granulosus somatostatin receptor 0.0066 0.0299 0.0903
Echinococcus granulosus g protein coupled receptor 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus multilocularis neuropeptide receptor A26 0.0066 0.0299 0.0903
Loa Loa (eye worm) glutathione reductase 0.0076 0.0366 0.1311
Loa Loa (eye worm) animal heme peroxidase 0.0216 0.1246 0.4468
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni amine GPCR 0.0066 0.0299 0.0249
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0299 0.0903
Schistosoma mansoni slit 0.0028 0.0061 0.0009
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0075 0.0269
Entamoeba histolytica glycogen phosphorylase, putative 0.046 0.2789 1
Plasmodium falciparum glutathione reductase 0.0076 0.0366 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Onchocerca volvulus Peroxidase homolog 0.0216 0.1246 0.4345
Brugia malayi Animal haem peroxidase family protein 0.0216 0.1246 0.4468
Echinococcus granulosus protein jagged 1 0.0028 0.0061 0.0034
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0061 0.0034
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni amine GPCR 0.0066 0.0299 0.0249
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0153 0.0371
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Brugia malayi G-protein coupled receptor 0.0066 0.0299 0.1071
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0066 0.0299 0.0903
Toxoplasma gondii EGF family domain-containing protein 0.0028 0.0061 0.0044
Onchocerca volvulus 0.0066 0.0299 0.0872
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0299 0.0249
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0054 0.0226 0.3044
Brugia malayi Delta serrate ligand family protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0061 0.0034
Brugia malayi GCC2 and GCC3 family protein 0.0028 0.0061 0.0218
Echinococcus granulosus allatostatin A receptor 0.0066 0.0299 0.0903
Schistosoma mansoni neuropeptide receptor 0.0066 0.0299 0.0249
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0178 0.0127
Plasmodium falciparum thioredoxin reductase 0.0076 0.0366 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0054 0.0226 0.1606
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus multilocularis sex peptide receptor 0.0066 0.0299 0.0903
Trypanosoma brucei prolyl endopeptidase 0.0136 0.0743 1
Echinococcus granulosus fmrfamide receptor 0.0066 0.0299 0.0903
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0028 0.0061 0.0218
Brugia malayi Peroxidasin 0.0216 0.1246 0.4468
Schistosoma mansoni hypothetical protein 0.0066 0.0299 0.0249
Brugia malayi EGF-like domain containing protein 0.0028 0.0061 0.0218
Trypanosoma brucei oligopeptidase b 0.0054 0.0226 0.3044
Onchocerca volvulus Glycogen phosphorylase homolog 0.046 0.2789 1
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0299 0.0903
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0061 0.0034
Schistosoma mansoni opsin-like receptor 0.0066 0.0299 0.0249
Echinococcus granulosus dro:myosuppressin receptor 0.0066 0.0299 0.0903
Schistosoma mansoni notch 0.0028 0.0061 0.0009
Echinococcus granulosus protein jagged 2 0.0028 0.0061 0.0034
Onchocerca volvulus 0.0066 0.0299 0.0872
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus granulosus orexin receptor type 2 0.0066 0.0299 0.0903
Brugia malayi Cadherin domain containing protein 0.0028 0.0061 0.0218
Echinococcus granulosus 7tm_1 domain containing protein 0.0066 0.0299 0.0903
Onchocerca volvulus 0.0066 0.0299 0.0872
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0136 0.0743 0.0696
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus granulosus neurogenic locus protein delta 0.0028 0.0061 0.0034
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni peroxidasin 0.0216 0.1246 0.1201
Echinococcus granulosus neuropeptide FF receptor 2 0.0066 0.0299 0.0903
Brugia malayi ORL1-like opioid receptor 0.0066 0.0299 0.1071
Brugia malayi Dopamine receptor 0.0066 0.0299 0.1071
Echinococcus granulosus peptide allatostatin:somatostatin 0.0066 0.0299 0.0903
Onchocerca volvulus Peroxidasin homolog 0.0216 0.1246 0.4345
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0066 0.0299 0.0249
Brugia malayi putative neuropeptide receptor 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Treponema pallidum NADH oxidase 0.0026 0.0051 0.5
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0051 0.0692
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi RE15519p 0.0066 0.0299 0.1071
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0299 0.0903
Schistosoma mansoni neuropeptide f receptor 76f 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni cell polarity protein 0.0028 0.0061 0.0009
Schistosoma mansoni neuropeptide receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) notch protein 0.0028 0.0061 0.0218
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0135 0.0306
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Brugia malayi putative neuropeptide receptor NPR1 0.0066 0.0299 0.1071
Echinococcus granulosus serotonin receptor 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0054 0.0226 0.3044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni growth hormone secretagogue receptor 0.0066 0.0299 0.0249
Echinococcus multilocularis prolyl endopeptidase 0.0136 0.0743 0.2528
Schistosoma mansoni myosin xvIII 0.0066 0.0299 0.0249
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0054 0.0226 0.1984
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0051 0.0451
Echinococcus multilocularis orexin receptor type 2 0.0066 0.0299 0.0903
Plasmodium vivax glutathione reductase, putative 0.0076 0.0366 1
Onchocerca volvulus 0.0066 0.0299 0.0872
Mycobacterium tuberculosis Probable peptidase 0.0054 0.0226 0.1606
Brugia malayi sulfakinin receptor protein 0.0066 0.0299 0.1071
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0299 0.0903
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0178 0.0127
Echinococcus granulosus notch 0.0028 0.0061 0.0034
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis neural cadherin 0.0028 0.0061 0.0034
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0136 0.0743 0.2666
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0299 0.0903
Schistosoma mansoni glycogen phosphorylase 0.0199 0.1141 0.1095
Brugia malayi Tachykinin-like peptides receptor 99D 0.0066 0.0299 0.1071
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0136 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0066 0.0299 0.0249
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0299 0.0903
Onchocerca volvulus Chorion peroxidase homolog 0.0216 0.1246 0.4345
Brugia malayi Animal haem peroxidase family protein 0.0216 0.1246 0.4468
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0299 0.1071
Brugia malayi glutathione reductase 0.0076 0.0366 0.1311
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0051 0.0451
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0054 0.0226 0.3044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0299 0.0903
Onchocerca volvulus Neuropeptide F receptor homolog 0.0066 0.0299 0.0872
Schistosoma mansoni opsin-like receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) melatonin receptor type 1A 0.0066 0.0299 0.1071
Echinococcus granulosus glycogen phosphorylase 0.046 0.2789 1
Brugia malayi Animal haem peroxidase family protein 0.0216 0.1246 0.4468
Loa Loa (eye worm) animal heme peroxidase 0.0216 0.1246 0.4468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi prolyl oligopeptidase family protein 0.0136 0.0743 0.2666
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0051 0.0692
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0135 0.0306
Brugia malayi follicle stimulating hormone receptor 0.0066 0.0299 0.1071
Echinococcus multilocularis g-protein coupled receptor 0.0066 0.0299 0.0903
Brugia malayi Cadherin domain containing protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0066 0.0299 0.0903
Brugia malayi Dopamine receptor protein 2 0.0066 0.0299 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Echinococcus granulosus fibropellin Ia 0.0028 0.0061 0.0034
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0299 0.0903
Schistosoma mansoni hypothetical protein 0.0066 0.0299 0.0249
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0299 0.0903
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0051 0.0692
Echinococcus multilocularis G-protein coupled receptor, putative 0.0066 0.0299 0.0903
Echinococcus granulosus slit 2 protein 0.0028 0.0061 0.0034
Toxoplasma gondii thioredoxin reductase 0.0076 0.0366 0.146
Giardia lamblia Glycogen phosphorylase 0.046 0.2789 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0122 0.0653 0.5527
Echinococcus multilocularis serotonin receptor 0.0066 0.0299 0.0903
Entamoeba histolytica glycogen phosphorylase, putative 0.046 0.2789 1
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis fat cadherin tumor suppressor 0.0028 0.0061 0.0034
Brugia malayi hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni adenoreceptor 0.0066 0.0299 0.0249
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0299 0.0249
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0009
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0007 0.0026
Schistosoma mansoni opsin-like receptor 0.0066 0.0299 0.0249
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0066 0.0299 0.1071
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0051 0.0692
Brugia malayi notch-like transmembrane receptor 0.0028 0.0061 0.0218
Onchocerca volvulus 0.0066 0.0299 0.0872
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Brugia malayi Melatonin receptor type 1A 0.0066 0.0299 0.1071
Schistosoma mansoni biogenic amine receptor 0.0066 0.0299 0.0249
Echinococcus granulosus neuropeptide receptor A26 0.0066 0.0299 0.0903
Echinococcus granulosus protein jagged 1 0.0028 0.0061 0.0034
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Echinococcus multilocularis G protein coupled receptor 139 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Onchocerca volvulus 0.0066 0.0299 0.0872
Echinococcus granulosus microsomal glutathione S transferase 3 0.0367 0.2203 0.7859
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Onchocerca volvulus Dual oxidase homolog 0.0216 0.1246 0.4345
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.0366 0.1147
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0061 0.0218
Echinococcus multilocularis peroxidasin 0.0216 0.1246 0.4365
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0299 0.0903
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0066 0.0299 0.0249
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0051 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0066 0.0299 0.1071
Trypanosoma cruzi trypanothione reductase, putative 0.0076 0.0366 0.4917
Brugia malayi carbohydrate phosphorylase 0.046 0.2789 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Brugia malayi neuropeptide F receptor 0.0066 0.0299 0.1071
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0367 0.2203 0.7859
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0299 0.1071
Loa Loa (eye worm) thioredoxin reductase 0.0076 0.0366 0.1311
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus granulosus neuropeptide s receptor 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0061 0.0034
Trypanosoma cruzi prolyl endopeptidase 0.0136 0.0743 1
Brugia malayi neuropeptide F receptor 0.0066 0.0299 0.1071
Loa Loa (eye worm) TYRA-2 protein 0.0066 0.0299 0.1071
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0066 0.0299 0.0249
Brugia malayi GnHR receptor homolog 0.0066 0.0299 0.1071
Brugia malayi AKH receptor 0.0066 0.0299 0.1071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) Notch2 0.0028 0.0061 0.0218
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Brugia malayi EGF-like domain containing protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0136 0.0743 0.0696
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Brugia malayi Cytochrome P450 family protein 0.003 0.0075 0.0269
Echinococcus multilocularis neuropeptide FF receptor 2 0.0066 0.0299 0.0903
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Echinococcus granulosus G protein coupled receptor 139 0.0066 0.0299 0.0903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Schistosoma mansoni hypothetical protein 0.0066 0.0299 0.0249
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0061 0.0034
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0066 0.0299 0.0903
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0199 0.1141 1
Echinococcus granulosus Glycosyl transferase family 35 0.046 0.2789 1
Onchocerca volvulus 0.0066 0.0299 0.0872
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni alpha-1 adrenergic receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Brugia malayi Dopamine receptor protein 1 0.0066 0.0299 0.1071
Schistosoma mansoni notch 0.0028 0.0061 0.0009
Loa Loa (eye worm) glycogen phosphorylase 0.046 0.2789 1
Echinococcus multilocularis neuropeptide s receptor 0.0066 0.0299 0.0903
Schistosoma mansoni neuropeptide receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Schistosoma mansoni biogenic amine receptor 0.0066 0.0299 0.0249
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0299 0.0903
Echinococcus granulosus peroxidasin 0.0216 0.1246 0.4365
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Plasmodium vivax thioredoxin reductase, putative 0.0076 0.0366 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0066 0.0299 0.1071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0051 0.0692
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0299 0.0249
Schistosoma mansoni amine GPCR 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0199 0.1141 1
Echinococcus multilocularis protein jagged 2 0.0028 0.0061 0.0034
Onchocerca volvulus 0.0066 0.0299 0.0872
Onchocerca volvulus 0.0216 0.1246 0.4345
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Trichomonas vaginalis glycogen phosphorylase, putative 0.046 0.2789 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0299 0.0903
Chlamydia trachomatis glycogen phosphorylase 0.046 0.2789 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Echinococcus granulosus g-protein coupled receptor 0.0066 0.0299 0.0903
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0299 0.0903
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0299 0.0249
Brugia malayi G protein-coupled receptor 0.0066 0.0299 0.1071
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0299 0.0903
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0216 0.1246 0.4468
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0066 0.0299 0.1071
Brugia malayi EGF-like domain containing protein 0.0028 0.0061 0.0218
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0299 0.0903
Schistosoma mansoni biogenic amine receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0066 0.0299 0.0903
Schistosoma mansoni glycogen phosphorylase 0.046 0.2789 0.2752
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.1071
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0299 0.0903
Toxoplasma gondii prolyl endopeptidase 0.0136 0.0743 0.3216
Onchocerca volvulus 0.0066 0.0299 0.0872
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0066 0.0299 0.1071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0299 0.0249
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0422
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0299 0.0903
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0299 0.0903
Echinococcus granulosus protein jagged 2 0.0028 0.0061 0.0034
Echinococcus multilocularis Glycosyl transferase, family 35 0.046 0.2789 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0066 0.0299 0.0903
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0066 0.0299 0.1071
Onchocerca volvulus Prolyl endopeptidase homolog 0.0136 0.0743 0.2502
Echinococcus granulosus neurogenic locus notch protein 4 0.0028 0.0061 0.0034
Brugia malayi Thioredoxin reductase 0.0076 0.0366 0.1311
Schistosoma mansoni notch 0.0028 0.0061 0.0009
Echinococcus multilocularis neurogenic locus notch protein 4 0.0028 0.0061 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0299 0.1071
Onchocerca volvulus 0.0216 0.1246 0.4345
Schistosoma mansoni hypothetical protein 0.0028 0.0061 0.0009
Onchocerca volvulus 0.0066 0.0299 0.0872
Loa Loa (eye worm) blistered cuticle protein 3 0.0216 0.1246 0.4468
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0066 0.0299 0.1071
Onchocerca volvulus 0.0066 0.0299 0.0872
Brugia malayi G-protein coupled receptor 0.0066 0.0299 0.1071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0066 0.0299 0.1071
Schistosoma mansoni histamine h1 receptor 0.0066 0.0299 0.0249
Loa Loa (eye worm) animal heme peroxidase 0.0216 0.1246 0.4468
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.0366 0.1147
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0066 0.0299 0.0872
Brugia malayi EGF-like domain containing protein 0.0028 0.0061 0.0218
Brugia malayi EGF-like domain containing protein 0.0028 0.0061 0.0218
Echinococcus granulosus tachykinin peptides receptor 99D 0.0066 0.0299 0.0903
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0218
Schistosoma mansoni amine GPCR 0.0066 0.0299 0.0249
Schistosoma mansoni glycogen phosphorylase 0.046 0.2789 0.2752
Trypanosoma cruzi oligopeptidase b 0.0054 0.0226 0.3044
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0051 0.0692

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 28 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 3 hrs ChEMBL. 17079148
Activity (functional) = 30 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 30 mins ChEMBL. 17079148
Activity (functional) = 30 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 3 hrs ChEMBL. 17079148
Activity (functional) = 32 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 1 hr ChEMBL. 17079148
Activity (functional) = 33 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 33 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 2 hrs ChEMBL. 17079148
Activity (functional) = 33 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 35 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 35 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 36 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 30 min ChEMBL. 17079148
Activity (functional) = 39 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 39 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 39 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 1 hr ChEMBL. 17079148
Activity (functional) = 39 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 39 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 40 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 40 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 42 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 2 hrs ChEMBL. 17079148
Activity (functional) = 45 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 45 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 46 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 46 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 48 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 48 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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