Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0125 | 0.4155 | 0.4782 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0134 | 0.4555 | 0.5856 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0142 | 0.4933 | 0.6376 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0134 | 0.4555 | 0.4555 |
Brugia malayi | AMP-binding enzyme family protein | 0.0125 | 0.4155 | 0.4155 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0142 | 0.4933 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.013 | 0.4368 | 0.5599 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0034 | 0 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.013 | 0.4368 | 0.5599 |
Loa Loa (eye worm) | acyl carrier protein | 0.0062 | 0.127 | 0.1462 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0089 | 0.2495 | 0.2941 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0054 | 0.0933 | 0.0864 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0034 | 0 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.02 | 0.7562 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0042 | 0.0384 | 0.0108 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0112 | 0.3541 | 0.4459 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.02 | 0.7562 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0142 | 0.4933 | 0.6376 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0108 | 0.3367 | 0.4155 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0134 | 0.4555 | 0.5856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0108 | 0.3367 | 0.4452 |
Mycobacterium ulcerans | thioesterase TesA | 0.0112 | 0.3541 | 0.4682 |
Mycobacterium ulcerans | polyketide synthase | 0.0134 | 0.4555 | 0.6023 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0242 | 0.9436 | 1 |
Schistosoma mansoni | methyltransferase-related | 0.004 | 0.0306 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0034 | 0 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0142 | 0.4933 | 0.6522 |
Brugia malayi | AMP-binding enzyme family protein | 0.0041 | 0.0343 | 0.0343 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0142 | 0.4933 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0134 | 0.4555 | 0.6023 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0068 | 0.1547 | 0.3136 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0112 | 0.3541 | 0.4398 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0041 | 0.0343 | 0.0052 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0134 | 0.4555 | 0.6023 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0142 | 0.4933 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0132 | 0.4474 | 0.5149 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0142 | 0.4933 | 0.6522 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.02 | 0.7562 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0042 | 0.0384 | 0.0508 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0095 | 0.2802 | 0.5682 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0046 | 0.0564 | 0.0356 |
Mycobacterium ulcerans | thioesterase | 0.0112 | 0.3541 | 0.4682 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0134 | 0.4555 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0108 | 0.3367 | 0.4452 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0087 | 0.2419 | 0.4903 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0034 | 0 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0134 | 0.4555 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.02 | 0.7562 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.011 | 0.3447 | 0.4329 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0089 | 0.2495 | 0.3299 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0034 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0306 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0134 | 0.4555 | 0.5856 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0125 | 0.4155 | 0.5305 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0034 | 0 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0142 | 0.4933 | 0.6376 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0089 | 0.2495 | 0.3299 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0034 | 0 | 0.5 |
Brugia malayi | Methyltransferase-like protein 4 | 0.004 | 0.0306 | 0.0306 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0134 | 0.4555 | 0.6023 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0076 | 0.1931 | 0.224 |
Onchocerca volvulus | 0.0233 | 0.9058 | 0.9285 | |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0306 | 0.5 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0041 | 0.0343 | 0.0454 |
Giardia lamblia | Methyltransferase like 2 | 0.004 | 0.0306 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1881 | 0.2164 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0096 | 0.2842 | 0.3495 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0134 | 0.4555 | 0.6023 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0142 | 0.4933 | 0.6337 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0034 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0142 | 0.4933 | 0.6522 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.869 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 56.3 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
IC50 (binding) | = 56.3 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
IC50 (binding) | = 75 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
IC50 (binding) | = 75 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
Inhibition (binding) | = 72 % | Inhibition of PTP1B at 100 uM | ChEMBL. | 17095232 |
Inhibition (binding) | = 72 % | Inhibition of PTP1B at 100 uM | ChEMBL. | 17095232 |
Ki (binding) | = 54 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
Ki (binding) | = 54 uM | Inhibition of PTP1B in presence of 0.01% Triton X-100 | ChEMBL. | 17095232 |
Ki (binding) | = 64 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
Ki (binding) | = 64 uM | Inhibition of PTP1B | ChEMBL. | 17095232 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.