Detailed information for compound 421071
Basic information
Technical information
- TDR Targets ID: 421071
- Name: N-[4-[[[2-(4-chloroanilino)pyridine-3-carbony l]amino]sulfamoyl]phenyl]acetamide
- MW: 459.906 | Formula: C20H18ClN5O4S
-
H donors: 4
H acceptors: 5
LogP: 3.22
Rotable bonds: 9
Rule of 5 violations (Lipinski): 1 - SMILES: CC(=O)Nc1ccc(cc1)S(=O)(=O)NNC(=O)c1cccnc1Nc1ccc(cc1)Cl
- InChi: 1S/C20H18ClN5O4S/c1-13(27)23-15-8-10-17(11-9-15)31(29,30)26-25-20(28)18-3-2-12-22-19(18)24-16-6-4-14(21)5-7-16/h2-12,26H,1H3,(H,22,24)(H,23,27)(H,25,28)
- InChiKey: OTNYYPVKFLDBDD-UHFFFAOYSA-N
Network
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Synonyms
- N-[4-[[[[2-(4-chloroanilino)-3-pyridyl]-oxomethyl]amino]sulfamoyl]phenyl]acetamide
- N-[4-[[[2-[(4-chlorophenyl)amino]pyridin-3-yl]carbonylamino]sulfamoyl]phenyl]ethanamide
- N-[4-[[[2-(4-chloroanilino)nicotinoyl]amino]sulfamoyl]phenyl]acetamide
- N-[4-[[[2-[(4-chlorophenyl)amino]pyridine-3-carbonyl]amino]sulfamoyl]phenyl]acetamide
- N-[4-[[[[2-[(4-chlorophenyl)amino]-3-pyridyl]-oxomethyl]amino]sulfamoyl]phenyl]acetamide
- 2-(4-Chloroanilino)-N'-[(4-acetylaminophenyl)sulphonyl]nicotino hydrazide
- NSC737147
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Leishmania major | farnesyltransferase beta subunit | 0.011 | 0.1586 | 1 |
| Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.011 | 0.1586 | 1 |
| Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.0048 | 0.015 | 0.015 |
| Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.011 | 0.1586 | 1 |
| Leishmania major | lanosterol synthase, putative | 0.0091 | 0.1143 | 0.6912 |
| Toxoplasma gondii | metallo-beta-lactamase domain-containing protein | 0.0048 | 0.015 | 0.0948 |
| Plasmodium vivax | unspecified product | 0.0048 | 0.015 | 0.0948 |
| Echinococcus granulosus | zinc phosphodiesterase | 0.0048 | 0.015 | 0.015 |
| Trypanosoma cruzi | protein farnesyltransferase, putative | 0.011 | 0.1586 | 0.853 |
| Trichomonas vaginalis | A-type flavoprotein | 0.0048 | 0.015 | 0.0948 |
| Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.2304 | 0.2186 |
| Mycobacterium ulcerans | hydrolase | 0.0048 | 0.015 | 0.5 |
| Chlamydia trachomatis | ribonuclease Z | 0.0048 | 0.015 | 0.5 |
| Mycobacterium ulcerans | beta lactamase-like protein | 0.0048 | 0.015 | 0.5 |
| Trypanosoma cruzi | lanosterol synthase, putative | 0.012 | 0.1833 | 1 |
| Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.2304 | 0.2186 |
| Mycobacterium ulcerans | hydrolase | 0.0048 | 0.015 | 0.5 |
| Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0048 | 0.015 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.015 | 0.0948 |
| Giardia lamblia | Prenyltransferase | 0.011 | 0.1586 | 1 |
| Echinococcus granulosus | ETHE1 protein | 0.0048 | 0.015 | 0.015 |
| Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.011 | 0.1586 | 1 |
| Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.011 | 0.1586 | 0.1458 |
| Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0472 | 1 | 1 |
| Trichomonas vaginalis | beta lactamase domain, putative | 0.0048 | 0.015 | 0.0948 |
| Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0048 | 0.015 | 0.0948 |
| Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.2212 | 0.2212 |
| Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.011 | 0.1586 | 1 |
| Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.0048 | 0.015 | 0.5 |
| Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.011 | 0.1586 | 0.853 |
| Mycobacterium leprae | conserved hypothetical protein | 0.0048 | 0.015 | 0.5 |
| Mycobacterium leprae | conserved hypothetical protein | 0.0048 | 0.015 | 0.5 |
| Mycobacterium leprae | Beta-lactamase-like protein | 0.0048 | 0.015 | 0.5 |
| Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.008 | 0.0895 | 0.5646 |
| Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.011 | 0.1586 | 0.1458 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.015 | 0.0948 |
| Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.012 | 0.1833 | 1 |
| Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0251 | 0.4861 | 0.4783 |
| Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0048 | 0.015 | 0.0948 |
| Trypanosoma cruzi | protein farnesyltransferase, putative | 0.011 | 0.1586 | 0.853 |
| Trichomonas vaginalis | beta lactamase domain, putative | 0.0048 | 0.015 | 0.0948 |
| Trichomonas vaginalis | beta lactamase domain, putative | 0.0048 | 0.015 | 0.0948 |
| Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.011 | 0.1586 | 0.1458 |
| Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.011 | 0.1586 | 1 |
| Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.015 | 0.5 |
| Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0251 | 0.4861 | 0.4783 |
| Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0124 | 0.1907 | 0.1784 |
| Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.011 | 0.1586 | 1 |
| Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0048 | 0.015 | 0.0948 |
| Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.011 | 0.1586 | 0.1586 |
| Trichomonas vaginalis | beta lactamase domain, putative | 0.0048 | 0.015 | 0.0948 |
| Trypanosoma brucei | lanosterol synthase | 0.012 | 0.1833 | 1 |
| Trypanosoma cruzi | lanosterol synthase, putative | 0.012 | 0.1833 | 1 |
| Onchocerca volvulus | 0.0048 | 0.015 | 0.5 | |
| Mycobacterium ulcerans | hydrolase | 0.0048 | 0.015 | 0.5 |
| Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.015 | 0.5 |
| Mycobacterium ulcerans | Zn-dependent glyoxylase | 0.0048 | 0.015 | 0.5 |
| Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.015 | 0.5 |
| Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0048 | 0.015 | 0.015 |
| Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0127 | 0.1994 | 0.1872 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.015 | 0.0948 |
| Schistosoma mansoni | peptidylglycine monooxygenase | 0.0251 | 0.4861 | 0.4783 |
| Trichomonas vaginalis | beta lactamase domain, putative | 0.0048 | 0.015 | 0.0948 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.015 | 0.0948 |
| Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.011 | 0.1586 | 1 |
| Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.011 | 0.1586 | 1 |
| Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0048 | 0.015 | 0.015 |
| Loa Loa (eye worm) | hypothetical protein | 0.0472 | 1 | 1 |
| Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.011 | 0.1586 | 0.1458 |
| Treponema pallidum | ribonuclease Z | 0.0048 | 0.015 | 0.5 |
| Onchocerca volvulus | 0.0048 | 0.015 | 0.5 | |
| Mycobacterium ulcerans | glyoxalase II, GloB | 0.0048 | 0.015 | 0.5 |
| Trichomonas vaginalis | beta lactamase domain, putative | 0.0048 | 0.015 | 0.0948 |
| Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.4861 | 0.4783 |
| Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0472 | 1 | 1 |
| Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.011 | 0.1586 | 1 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.015 | 0.0948 |
| Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.011 | 0.1586 | 1 |
| Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.2304 | 0.2186 |
| Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.2304 | 0.2186 |
| Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.015 | 0.5 |
| Mycobacterium leprae | POSSIBLE HYDROLASE | 0.0048 | 0.015 | 0.5 |
| Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0048 | 0.015 | 0.0948 |
| Onchocerca volvulus | Putative hydrolase PNKD | 0.0048 | 0.015 | 0.5 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.015 | 0.0948 |
| Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0472 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| GI50 (functional) | < 4 | Antitumor activity against HOP62 cells | ChEMBL. | 17097292 |
| GI50 (functional) | < 4 | Antitumor activity against HOP92 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.04 | Antitumor activity against UO31 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.05 | Antitumor activity against UACC257 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.23 | Antitumor activity against SN12C cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.24 | Antitumor activity against SKOV3 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.28 | Antitumor activity against ACHN cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.3 | Antitumor activity against MOLT4 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.31 | Antitumor activity against EKVX cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.32 | Antitumor activity against 786-0 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.35 | Antitumor activity against OVCAR4 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.37 | Antitumor activity against NCI-H226 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.38 | Antitumor activity against MDA-MB-231 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.43 | Antitumor activity against RXF393 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.44 | Antitumor activity against OVCAR8 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.46 | Antitumor activity against DU145 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.49 | Antitumor activity against A549 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.53 | Antitumor activity against PC3 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.54 | Antitumor activity against RPMI-8226 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.56 | Antitumor activity against IGROV1 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.6 | Antitumor activity against TK10 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.6 | Antitumor activity against BT549 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.62 | Antitumor activity against U251 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.62 | Antitumor activity against HS578T cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.63 | Antitumor activity against SK-MEL-28 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.66 | Antotumor activity against SF268 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.67 | Antitumor activity against CCRF-CEM cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.73 | Antitumor activity against A498 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.81 | Antitumor activity against SF539 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.85 | Antitumor activity against SNB19 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.86 | Antitumor activity against HCT15 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.94 | Antitumor activity against M14 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 4.99 | Antitumor activity against COLO205 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.04 | Antitumor activity against CAKI1 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.05 | Antitumor activity against UACC62 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.07 | Antitumor activity against K562 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.08 | Antitumor activity against HCC2998 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.12 | Antitumor activity against SW620 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.14 | Antitumor activity against HCT116 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.19 | Antitumor activity against NCI-H522 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.2 | Antitumor activity against SR cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.2 | Antitumor activity against T47D cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.25 | Antitumor activity against SK-MEL-5 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.26 | Antitumor activity against SNB75 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.33 | Antitumor activity against NCI-H460 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.36 | Antitumor activity against MCF7 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.38 | Antitumor activity against KM12 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.4 | Antitumor activity against HT29 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.43 | Antitumor activity against OVCAR3 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.46 | Antitumor activity against SF295 cells | ChEMBL. | 17097292 |
| GI50 (functional) | = 5.49 | Antitumor activity against MDA-MB-435 cells | ChEMBL. | 17097292 |
| Inhibition (functional) | = 31 % | Growth inhibition of NCI-H460 at 10 uM | ChEMBL. | 17097292 |
| Inhibition (functional) | = 31 % | Growth inhibition of NCI-H460 at 10 uM | ChEMBL. | 17097292 |
| Inhibition (functional) | = 52 % | Growth inhibition of MCF7 cells at 10 uM | ChEMBL. | 17097292 |
| Inhibition (functional) | = 52 % | Growth inhibition of MCF7 cells at 10 uM | ChEMBL. | 17097292 |
| Inhibition (functional) | = 60 % | Growth inhibition of SF268 cells at 10 uM | ChEMBL. | 17097292 |
| Inhibition (functional) | = 60 % | Growth inhibition of SF268 cells at 10 uM | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against CCRF-CEM cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against K562 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against MOLT4 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against RPMI-8226 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SR cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against A549 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against EKVX cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against HOP62 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against HOP92 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against NCI-H226 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against NCI-H460 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against NCI-H522 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against COLO205 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against HCC2998 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against HCT116 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against HCT15 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against HT29 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against KM12 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SW620 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antotumor activity against SF268 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SF295 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SF539 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SNB19 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SNB75 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against U251 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against M14 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SK-MEL-28 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SK-MEL-5 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against UACC257 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against UACC62 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against IGROV1 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against OVCAR3 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against OVCAR4 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against OVCAR8 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SKOV3 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against 786-0 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against A498 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against ACHN cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against CAKI1 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against RXF393 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against SN12C cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against TK10 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against UO31 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against PC3 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against DU145 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against MCF7 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against MDA-MB-231 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against HS578T cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against MDA-MB-435 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against BT549 cells | ChEMBL. | 17097292 |
| LC50 (functional) | > -4 | Antitumor activity against T47D cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | 0 | Antitumor activity against NCI-H23 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | 0 | Antitumor activity against SK-MEL-2 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | 0 | Antitumor activity against OVCAR5 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | 0 | Antitumor activity against NCI/ADR-RES cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against CCRF-CEM cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HL60 (TB) cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against K562 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against MOLT4 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against RPMI-8226 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SR cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against A549 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against EKVX cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HOP62 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HOP92 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against NCI-H226 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against NCI-H322 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against NCI-H460 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against NCI-H522 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against COLO205 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HCC2998 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HCT116 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HCT15 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HT29 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against KM12 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SW620 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antotumor activity against SF268 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SF295 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SF539 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SNB19 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SNB75 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against U251 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against LOX IMV1 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against MALME 3M cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against M14 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SK-MEL-28 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SK-MEL-5 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against UACC257 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against UACC62 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against IGROV1 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against OVCAR3 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against OVCAR4 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against OVCAR8 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SKOV3 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against 786-0 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against A498 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against ACHN cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against CAKI1 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against RXF393 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against SN12C cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against TK10 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against UO31 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against PC3 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against DU145 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against MCF7 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against MDA-MB-231 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against HS578T cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against MDA-MB-435 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against BT549 cells | ChEMBL. | 17097292 |
| Log LC50 (functional) | > 4 | Antitumor activity against T47D cells | ChEMBL. | 17097292 |
| Log TGI (functional) | 0 | Antitumor activity against NCI-H23 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | 0 | Antitumor activity against SK-MEL-2 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | 0 | Antitumor activity against OVCAR5 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | 0 | Antitumor activity against NCI/ADR-RES cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against CCRF-CEM cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HL60 (TB) cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against K562 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against MOLT4 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against RPMI-8226 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SR cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against A549 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against EKVX cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HOP62 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HOP92 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against NCI-H226 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against NCI-H322 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against NCI-H460 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against NCI-H522 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HCC2998 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HCT116 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HCT15 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HT29 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against KM12 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SW620 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antotumor activity against SF268 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SF295 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SNB19 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SNB75 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against U251 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against LOX IMV1 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against MALME 3M cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against M14 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SK-MEL-28 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SK-MEL-5 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against UACC257 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against UACC62 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against IGROV1 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against OVCAR3 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against OVCAR4 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against OVCAR8 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SKOV3 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against 786-0 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against A498 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against CAKI1 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against RXF393 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against SN12C cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against TK10 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against UO31 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against PC3 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against DU145 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against MCF7 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against MDA-MB-231 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against HS578T cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against MDA-MB-435 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against BT549 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | > 4 | Antitumor activity against T47D cells | ChEMBL. | 17097292 |
| Log TGI (functional) | = 4.12 | Antitumor activity against SF539 cells | ChEMBL. | 17097292 |
| Log TGI (functional) | = 4.12 | Antitumor activity against ACHN cells | ChEMBL. | 17097292 |
| Log TGI (functional) | = 4.24 | Antitumor activity against COLO205 cells | ChEMBL. | 17097292 |
| MIC (functional) | = 17 ug ml-1 | Antibacterial activity against Bacillus subtilis MTCC 441 after 18 hrs | ChEMBL. | 17097292 |
| MIC (functional) | = 18 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 448 after 18 hrs | ChEMBL. | 17097292 |
| MIC (functional) | = 18 ug ml-1 | Antibacterial activity against Vibrio species after 18 hrs | ChEMBL. | 17097292 |
| MIC (functional) | = 18 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 448 after 18 hrs | ChEMBL. | 17097292 |
| MIC (functional) | = 22 ug ml-1 | Antibacterial activity against Staphylococcus epidermidis MTCC 435 after 18 hrs | ChEMBL. | 17097292 |
| MIC (functional) | > 25 ug ml-1 | Antibacterial activity against Psesudomonas aeruginosa MTCC 424 after 18 hrs | ChEMBL. | 17097292 |
| pGI50 (functional) | 0 | Antitumor activity against NCI-H23 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | 0 | Antitumor activity against SK-MEL-2 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | 0 | Antitumor activity against OVCAR5 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | 0 | Antitumor activity against NCI/ADR-RES cells | ChEMBL. | 17097292 |
| pGI50 (functional) | > 4 | Antitumor activity against HOP62 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | > 4 | Antitumor activity against HOP92 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | > 4 | Antitumor activity against NCI-H322 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | > 4 | Antitumor activity against MALME 3M cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.04 | Antitumor activity against UO31 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.05 | Antitumor activity against UACC257 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.23 | Antitumor activity against SN12C cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.24 | Antitumor activity against SKOV3 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.28 | Antitumor activity against ACHN cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.3 | Antitumor activity against MOLT4 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.31 | Antitumor activity against EKVX cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.32 | Antitumor activity against 786-0 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.35 | Antitumor activity against OVCAR4 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.37 | Antitumor activity against NCI-H226 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.38 | Antitumor activity against MDA-MB-231 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.43 | Antitumor activity against RXF393 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.44 | Antitumor activity against OVCAR8 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.46 | Antitumor activity against DU145 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.49 | Antitumor activity against A549 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.53 | Antitumor activity against PC3 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.54 | Antitumor activity against RPMI-8226 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.56 | Antitumor activity against IGROV1 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.6 | Antitumor activity against TK10 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.6 | Antitumor activity against BT549 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.62 | Antitumor activity against U251 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.62 | Antitumor activity against LOX IMV1 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.62 | Antitumor activity against HS578T cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.63 | Antitumor activity against SK-MEL-28 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.66 | Antotumor activity against SF268 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.67 | Antitumor activity against CCRF-CEM cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.73 | Antitumor activity against A498 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.81 | Antitumor activity against SF539 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.85 | Antitumor activity against SNB19 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.86 | Antitumor activity against HCT15 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.94 | Antitumor activity against M14 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 4.99 | Antitumor activity against COLO205 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.01 | Antitumor activity against HL60 (TB) cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.04 | Antitumor activity against CAKI1 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.05 | Antitumor activity against UACC62 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.07 | Antitumor activity against K562 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.08 | Antitumor activity against HCC2998 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.12 | Antitumor activity against SW620 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.14 | Antitumor activity against HCT116 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.19 | Antitumor activity against NCI-H522 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.2 | Antitumor activity against SR cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.2 | Antitumor activity against T47D cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.25 | Antitumor activity against SK-MEL-5 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.26 | Antitumor activity against SNB75 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.33 | Antitumor activity against NCI-H460 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.36 | Antitumor activity against MCF7 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.38 | Antitumor activity against KM12 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.4 | Antitumor activity against HT29 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.43 | Antitumor activity against OVCAR3 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.46 | Antitumor activity against SF295 cells | ChEMBL. | 17097292 |
| pGI50 (functional) | = 5.49 | Antitumor activity against MDA-MB-435 cells | ChEMBL. | 17097292 |
| TGI (functional) | = -4.24 | Antitumor activity against COLO205 cells | ChEMBL. | 17097292 |
| TGI (functional) | = -4.12 | Antitumor activity against SF539 cells | ChEMBL. | 17097292 |
| TGI (functional) | = -4.12 | Antitumor activity against ACHN cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against CCRF-CEM cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against K562 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against MOLT4 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against RPMI-8226 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SR cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against A549 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against EKVX cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against HOP62 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against HOP92 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against NCI-H226 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against NCI-H460 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against NCI-H522 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against HCC2998 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against HCT116 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against HCT15 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against HT29 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against KM12 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SW620 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antotumor activity against SF268 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SF295 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SNB19 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SNB75 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against U251 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against M14 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SK-MEL-28 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SK-MEL-5 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against UACC257 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against UACC62 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against IGROV1 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against OVCAR3 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against OVCAR4 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against OVCAR8 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SKOV3 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against 786-0 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against A498 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against CAKI1 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against RXF393 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against SN12C cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against TK10 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against UO31 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against PC3 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against DU145 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against MCF7 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against MDA-MB-231 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against HS578T cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against MDA-MB-435 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against BT549 cells | ChEMBL. | 17097292 |
| TGI (functional) | > -4 | Antitumor activity against T47D cells | ChEMBL. | 17097292 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL228208
- PubChem: 16126694
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.