Detailed information for compound 423172

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 830.996 | Formula: C42H70O16
  • H donors: 10 H acceptors: 11 LogP: 2.29 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@@H](O[C@H]2CC[C@]3([C@H](C2(C)C)CC[C@@]2([C@@H]3CC[C@H]3[C@@]2(C)CC[C@@H]3[C@@]2(C[C@H](O)[C@@H](C(O2)(C)C)O)C(=O)O)C)C)[C@@H]([C@H]([C@@H]1O)O)O[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O
  • InChi: 1S/C42H70O16/c1-37(2)24-11-15-41(7)25(9-8-19-20(10-14-40(19,41)6)42(36(52)53)16-21(45)33(51)38(3,4)58-42)39(24,5)13-12-26(37)56-35-32(30(49)28(47)23(18-44)55-35)57-34-31(50)29(48)27(46)22(17-43)54-34/h19-35,43-51H,8-18H2,1-7H3,(H,52,53)/t19-,20+,21+,22-,23-,24+,25-,26+,27-,28-,29+,30+,31-,32-,33+,34+,35+,39+,40-,41-,42+/m1/s1
  • InChiKey: VRJXPIOFTJEYMJ-BQFHCAHQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Echinococcus multilocularis transfer RNA-Gly 0.0059 0.0454 0.0454
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0699 0.9546 0.9546
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0032 0.0062 0.0062
Leishmania major hypothetical protein, conserved 0.0038 0.0154 0.1034
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0154 0.1034
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0047 0.0277 0.1541
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0028 0.001 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0055 0.0368
Echinococcus multilocularis voltage gated potassium channel 0.0059 0.0454 0.0454
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0059 0.0454 0.0454
Schistosoma mansoni voltage-gated potassium channel 0.0731 1 1
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0418 0.0418
Brugia malayi K+ channel tetramerisation domain containing protein 0.0032 0.0062 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0277 0.1541
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0454 0.0454
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0154 0.0154
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0454 0.0454
Schistosoma mansoni edp1-related 0.0032 0.0062 0.0062
Echinococcus granulosus potassium voltage gated channel protein 0.0059 0.0454 0.0454
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0133 0.1494 0.4824
Schistosoma mansoni isoleucine--tRNA ligase 0.0133 0.1494 0.1494
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0047 0.0277 0.0416
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0057 0.0418 0.0418
Brugia malayi K+ channel tetramerisation domain containing protein 0.0032 0.0062 0.0062
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0086 0.0826 0.228
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0133 0.1494 1
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0028 0.001 0.0065
Brugia malayi RNA binding protein 0.0057 0.0418 0.0418
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0032 0.0062 0.0062
Loa Loa (eye worm) RNA binding protein 0.0057 0.0418 0.0418
Trypanosoma brucei btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0154 0.1034
Mycobacterium ulcerans hypothetical protein 0.0038 0.0154 0.047
Loa Loa (eye worm) hypothetical protein 0.0038 0.0154 0.0154
Toxoplasma gondii valyl-tRNA synthetase 0.0047 0.0277 0.1853
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0133 0.1494 0.4332
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0047 0.0277 0.1541
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0032 0.0062 0.0417
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0454 0.0454
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0059 0.0454 0.0454
Brugia malayi leucyl-tRNA synthetase 0.0047 0.0277 0.0277
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0245 0.3087 1
Echinococcus multilocularis transcription factor btf3 0.0031 0.0055 0.0055
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0133 0.1494 1
Schistosoma mansoni hypothetical protein 0.0033 0.0084 0.0084
Echinococcus granulosus leucyl tRNA synthetase 0.0047 0.0277 0.0277
Brugia malayi K+ channel tetramerisation domain containing protein 0.0032 0.0062 0.0062
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0245 0.3087 1
Schistosoma mansoni isoleucine--tRNA ligase 0.0133 0.1494 0.1494
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0055 0.0368
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0154 0.0691
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0032 0.0062 0.0062
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0028 0.001 0.0065
Echinococcus granulosus valyl tRNA synthetase 0.0047 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0104 0.1093 0.1093
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0133 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0133 0.1494 0.1494
Brugia malayi beta-lactamase family protein 0.0038 0.0154 0.0154
Schistosoma mansoni methionine-tRNA synthetase 0.0028 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0418 0.0418
Brugia malayi K+ channel tetramerisation domain containing protein 0.0032 0.0062 0.0062
Trypanosoma brucei btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Toxoplasma gondii ABC1 family protein 0.0038 0.0154 0.1034
Schistosoma mansoni transcription factor btf3 0.0031 0.0055 0.0055
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0133 0.1494 1
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0133 0.1494 1
Trypanosoma brucei potassium voltage-gated channel, putative 0.0032 0.0062 0.0417
Echinococcus multilocularis shaker cognate 0.0059 0.0454 0.0454
Echinococcus granulosus tar DNA binding protein 0.0057 0.0418 0.0418
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0245 0.3087 1
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0028 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0154 0.0154
Echinococcus granulosus BTB:POZ domain containing protein 0.0032 0.0062 0.0062
Brugia malayi isoleucyl-tRNA synthetase 0.0133 0.1494 0.1494
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0731 1 1
Loa Loa (eye worm) beta-lactamase 0.0038 0.0154 0.0154
Plasmodium vivax kelch protein K13, putative 0.0032 0.0062 0.005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0038 0.0154 0.0154
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0154 0.0154
Chlamydia trachomatis valine--tRNA ligase 0.0047 0.0277 0.18
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0154 0.0154
Brugia malayi valyl-tRNA synthetase family protein 0.0047 0.0277 0.0277
Leishmania major hypothetical protein, conserved 0.0032 0.0062 0.0417
Echinococcus granulosus valyl tRNA synthetase 0.0047 0.0277 0.0277
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0304 0.0304
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0032 0.0062 0.0062
Echinococcus granulosus potassium voltage gated channel protein 0.0059 0.0454 0.0454
Echinococcus multilocularis potassium voltage gated channel protein 0.0731 1 1
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0104 0.1093 0.1093
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0133 0.1494 0.1494
Loa Loa (eye worm) TAR-binding protein 0.0057 0.0418 0.0418
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0032 0.0062 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0154 0.1034
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0059 0.0454 0.0454
Schistosoma mansoni voltage-gated potassium channel 0.0731 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0059 0.0454 0.0454
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0292 0.3755 1
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Loa Loa (eye worm) hypothetical protein 0.0038 0.0154 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0454 0.0454
Leishmania major potassium voltage-gated channel, putative 0.0032 0.0062 0.0417
Brugia malayi beta-lactamase 0.0038 0.0154 0.0154
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0731 1 1
Onchocerca volvulus 0.0032 0.0062 0.057
Echinococcus multilocularis valyl tRNA synthetase 0.0047 0.0277 0.0277
Mycobacterium tuberculosis Possible DNA glycosylase 0.0245 0.3087 0.9964
Schistosoma mansoni leucyl-tRNA synthetase 0.0047 0.0277 0.0277
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0304 0.0304
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0154 0.047
Echinococcus multilocularis potassium voltage gated channel protein 0.0059 0.0454 0.0454
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0032 0.0062 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0154 0.1034
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Onchocerca volvulus 0.0104 0.1093 1
Brugia malayi TAR-binding protein 0.0057 0.0418 0.0418
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0032 0.0062 0.0062
Trypanosoma cruzi transcription factor btf3, putative 0.0031 0.0055 0.0368
Brugia malayi mKIAA0176 protein 0.0032 0.0062 0.0062
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0059 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.001
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0133 0.1494 1
Echinococcus granulosus geminin 0.0152 0.1773 0.1773
Loa Loa (eye worm) hypothetical protein 0.0032 0.0062 0.0062
Leishmania major basic transcription factor 3a, putative 0.0031 0.0055 0.0368
Onchocerca volvulus 0.0038 0.0154 0.1413
Onchocerca volvulus 0.0047 0.0277 0.2533
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0454 0.0454
Echinococcus multilocularis potassium voltage gated channel protein 0.0059 0.0454 0.0454
Onchocerca volvulus 0.0038 0.0154 0.1413
Schistosoma mansoni hypothetical protein 0.0152 0.1773 0.1773
Schistosoma mansoni valine-tRNA ligase 0.0047 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0049 0.0304 0.0304
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0133 0.1494 1
Entamoeba histolytica valyl tRNA synthetase, putative 0.0047 0.0277 0.1541
Mycobacterium ulcerans beta-lactamase 0.0038 0.0154 0.047
Schistosoma mansoni vesicular amine transporter 0.0059 0.0454 0.0454
Leishmania major leucyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Brugia malayi Valyl-tRNA synthetase 0.0047 0.0277 0.0277
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0133 0.1494 0.4568
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0418 0.0418
Leishmania major valyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0032 0.0062 0.0062
Echinococcus multilocularis geminin 0.0152 0.1773 0.1773
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0032 0.0062 0.0062
Echinococcus multilocularis BTB:POZ domain containing protein 0.0032 0.0062 0.0062
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0277
Mycobacterium ulcerans lipase LipD 0.0038 0.0154 0.047
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Echinococcus multilocularis valyl tRNA synthetase 0.0047 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.001
Schistosoma mansoni valine-tRNA ligase 0.0047 0.0277 0.0277
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.3097 1
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Echinococcus multilocularis leucyl tRNA synthetase 0.0047 0.0277 0.0277
Onchocerca volvulus 0.0028 0.001 0.0089
Onchocerca volvulus 0.0032 0.0062 0.057
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0028 0.001 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0062 0.0417
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0154 0.047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0084
Plasmodium falciparum kelch protein K13 0.0032 0.0062 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0154 0.1034
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0038 0.0154 0.0154
Chlamydia trachomatis isoleucine--tRNA ligase 0.0133 0.1494 1
Mycobacterium ulcerans valyl-tRNA synthetase 0.0047 0.0277 0.0868
Echinococcus granulosus voltage gated potassium channel 0.0059 0.0454 0.0454
Trypanosoma brucei btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Echinococcus granulosus transcription factor btf3 0.0031 0.0055 0.0055
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0032 0.0062 0.0417
Schistosoma mansoni voltage-gated potassium channel 0.0059 0.0454 0.0454
Onchocerca volvulus 0.0038 0.0154 0.1413
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0032 0.0062 0.0417
Treponema pallidum valyl-tRNA synthetase 0.0047 0.0277 0.18
Onchocerca volvulus 0.0032 0.0062 0.057
Plasmodium falciparum valine--tRNA ligase, putative 0.0047 0.0277 0.0599
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0047 0.0277 0.1853
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0032 0.0062 0.0062
Trypanosoma brucei btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Toxoplasma gondii tRNA synthetase, putative 0.0047 0.0277 0.1853
Loa Loa (eye worm) hypothetical protein 0.0038 0.0154 0.0154
Plasmodium falciparum valine--tRNA ligase, putative 0.0047 0.0277 0.0599
Giardia lamblia Isoleucyl-tRNA synthetase 0.0133 0.1494 1
Onchocerca volvulus 0.0032 0.0062 0.057
Brugia malayi beta-NAC-like protein 0.0031 0.0055 0.0055
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0133 0.1494 0.3889
Echinococcus multilocularis leucyl tRNA synthetase 0.0047 0.0277 0.0277
Leishmania major hypothetical protein, conserved 0.0032 0.0062 0.0417
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0418 0.0418
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0059 0.0454 0.0454
Treponema pallidum isoleucyl-tRNA synthetase 0.0133 0.1494 1
Trichomonas vaginalis esterase, putative 0.0038 0.0154 0.1034
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0032 0.0062 0.0417
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0032 0.0062 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0304 0.0304
Echinococcus multilocularis tar DNA binding protein 0.0057 0.0418 0.0418
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0245 0.3087 1
Onchocerca volvulus 0.0032 0.0062 0.057
Trypanosoma brucei transcription factor BTF3, putative 0.0031 0.0055 0.0368
Echinococcus granulosus leucyl tRNA synthetase 0.0047 0.0277 0.0277
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0154 0.1034
Trypanosoma cruzi potassium voltage-gated channel 0.0032 0.0062 0.0417
Echinococcus granulosus potassium voltage gated channel protein 0.0731 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0154 0.1034
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0059 0.0454 0.0454
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0245 0.3087 0.9964
Loa Loa (eye worm) hypothetical protein 0.0059 0.0454 0.0454
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0032 0.0062 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0062 0.0062
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0154 0.0154
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0133 0.1494 0.1494
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0059 0.0454 0.0454
Plasmodium falciparum leucine--tRNA ligase, putative 0.0047 0.0277 0.0599
Plasmodium vivax valine--tRNA ligase, putative 0.0047 0.0277 0.1541
Toxoplasma gondii NAC domain-containing protein 0.0031 0.0055 0.0368
Schistosoma mansoni hypothetical protein 0.0152 0.1773 0.1773
Leishmania major isoleucyl-tRNA synthetase, putative 0.0133 0.1494 1
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0032 0.0062 0.0062
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0062 0.0062
Loa Loa (eye worm) voltage-gated potassium channel 0.0059 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0032 0.0062 0.0062
Toxoplasma gondii leucyl-tRNA synthetase 0.0047 0.0277 0.1853
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0055 0.0368
Echinococcus granulosus shaker cognate 0.0059 0.0454 0.0454
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0059 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0032 0.0062 0.0062
Brugia malayi beta-lactamase family protein 0.0038 0.0154 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0154 0.1034
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0028 0.001 0.001
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0032 0.0062 0.0417
Trypanosoma brucei potassium voltage-gated channel, putative 0.0032 0.0062 0.0417
Brugia malayi RNA recognition motif domain containing protein 0.0057 0.0418 0.0418
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0133 0.1494 0.1494
Leishmania major hypothetical protein, conserved 0.0032 0.0062 0.0417
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0062 0.0062
Loa Loa (eye worm) ICD-1 protein 0.0031 0.0055 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0154 0.0154
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0104 0.1093 0.1093
Mycobacterium leprae PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI 0.0047 0.0277 0.0417
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0047 0.0277 0.1853
Trypanosoma cruzi transcription factor btf3, putative 0.0031 0.0055 0.0368

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antifungal activity against Peronophythora litchii at 1 ug/mL by disc diffusion method ChEMBL. 17375953
Activity (functional) 0 Antifungal activity against Glorosprium musarum at 1 ug/mL by disc diffusion method ChEMBL. 17375953
IZ (functional) = 1.4 cm Antifungal activity against Glomerella cingulata at 1 ug/mL by disc diffusion method ChEMBL. 17375953

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.