Detailed information for compound 442264

Basic information

Technical information
  • TDR Targets ID: 442264
  • Name: N-[4-[4-amino-7-[(E)-3-(4-phenylpiperazin-1-y l)prop-1-enyl]thieno[3,2-c]pyridin-3-yl]-2-me thoxyphenyl]-1-methylindole-2-carboxamide
  • MW: 628.786 | Formula: C37H36N6O2S
  • H donors: 2 H acceptors: 2 LogP: 6.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1NC(=O)c1cc2c(n1C)cccc2)c1csc2c1c(N)ncc2/C=C/CN1CCN(CC1)c1ccccc1
  • InChi: 1S/C37H36N6O2S/c1-41-31-13-7-6-9-26(31)21-32(41)37(44)40-30-15-14-25(22-33(30)45-2)29-24-46-35-27(23-39-36(38)34(29)35)10-8-16-42-17-19-43(20-18-42)28-11-4-3-5-12-28/h3-15,21-24H,16-20H2,1-2H3,(H2,38,39)(H,40,44)/b10-8+
  • InChiKey: MUWSIXAPOWUMQR-CSKARUKUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[4-amino-7-[(E)-3-(4-phenylpiperazin-1-yl)prop-1-enyl]thieno[3,2-c]pyridin-3-yl]-2-methoxy-phenyl]-1-methyl-indole-2-carboxamide
  • N-[4-[4-amino-7-[(E)-3-(4-phenyl-1-piperazinyl)prop-1-enyl]-3-thieno[3,2-c]pyridinyl]-2-methoxyphenyl]-1-methyl-2-indolecarboxamide
  • N-[4-[4-azanyl-7-[(E)-3-(4-phenylpiperazin-1-yl)prop-1-enyl]thieno[3,2-c]pyridin-3-yl]-2-methoxy-phenyl]-1-methyl-indole-2-carboxamide
  • N-[4-[4-amino-7-[(E)-3-(4-phenylpiperazino)prop-1-enyl]thieno[3,2-c]pyridin-3-yl]-2-methoxy-phenyl]-1-methyl-indole-2-carboxamide
  • N-[4-[4-amino-7-[(E)-3-(4-phenylpiperazin-1-yl)prop-1-enyl]thieno[4,5-c]pyridin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide
  • N-[4-[4-amino-7-[(E)-3-(4-phenylpiperazin-1-yl)prop-1-enyl]thieno[4,5-c]pyridin-3-yl]-2-methoxy-phenyl]-1-methyl-indole-2-carboxamide
  • N-[4-[4-amino-7-[(E)-3-(4-phenyl-1-piperazinyl)prop-1-enyl]-3-thieno[4,5-c]pyridinyl]-2-methoxyphenyl]-1-methyl-2-indolecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0502 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0502 0.3358
Entamoeba histolytica hypothetical protein 0.0025 0.0092 0.2646
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0113 0.0113
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0113 0.2262
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0025 0.0092 0.2646
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0057 0.0502 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0025 0.0092 0.0092
Mycobacterium ulcerans DNA-3-methyladenine glycosylase I TagA 0.018 0.2077 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0057 0.0502 0.3358
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0113 0.076
Onchocerca volvulus 0.0026 0.0098 0.1943
Schistosoma mansoni hypothetical protein 0.0031 0.0163 0.0177
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0616
Brugia malayi DOMON domain containing protein 0.0026 0.0098 0.0653
Schistosoma mansoni RAR-like nuclear receptor 0.0057 0.0502 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0057 0.0502 0.3358
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0057 0.0502 0.3358
Brugia malayi hypothetical protein 0.003 0.0155 0.1038
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0135 0.1494 0.1494
Loa Loa (eye worm) DOMON domain-containing protein 0.0026 0.0098 0.0653
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.018 0.2077 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0057 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0163 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0057 0.0502 0.3358
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Entamoeba histolytica hypothetical protein 0.0035 0.0221 0.7258
Onchocerca volvulus Protein ultraspiracle homolog 0.0057 0.0502 1
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0135 0.1494 0.1617
Schistosoma mansoni steroid hormone receptor ad4bp 0.0057 0.0502 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0057 0.0502 0.3358
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0155 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0502 0.3358
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0025 0.0092 0.0092
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0297 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0057 0.0502 0.3358
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0041 0.0297 0.199
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0041 0.0297 0.0297
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0113 0.076
Brugia malayi DOMON domain containing protein 0.0026 0.0098 0.0653
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0163 0.0163
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0113 0.2262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0057 0.0502 0.3358
Brugia malayi hypothetical protein 0.0027 0.0113 0.076
Brugia malayi nuclear receptor NHR-67 0.0027 0.0113 0.076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0057 0.0502 0.0543
Onchocerca volvulus Bile acid receptor homolog 0.0057 0.0502 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0057 0.0502 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0057 0.0502 0.3358
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0163 0.1091
Schistosoma mansoni coup transcription factor 0.0057 0.0502 0.0543
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0502 0.0543
Loa Loa (eye worm) hypothetical protein 0.0135 0.1494 1
Loa Loa (eye worm) steroid hormone receptor 0.0057 0.0502 0.3358
Schistosoma mansoni hypothetical protein 0.0067 0.0623 0.0674
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0163 0.1091
Schistosoma mansoni dopamine-beta-monooxygenase 0.0255 0.3037 0.3288
Brugia malayi steroid hormone receptor 0.0057 0.0502 0.3358
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0502 0.3358
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0041 0.0297 0.199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0057 0.0502 0.0543
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0502 0.3358
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0025 0.0092 0.0616
Schistosoma mansoni hypothetical protein 0.0031 0.0163 0.0177
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0113 0.076
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0113 0.076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0502 0.0502
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0092 0.2646
Schistosoma mansoni hypothetical protein 0.0031 0.0163 0.0177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0057 0.0502 0.3358
Onchocerca volvulus 0.0057 0.0502 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0057 0.0502 0.0543
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0135 0.1494 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0092 0.2646
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0113 0.076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0502 0.3358
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0092 0.2646
Schistosoma mansoni nuclear receptor 0.0027 0.0113 0.0123
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0025 0.0092 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1019 0.6821
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0113 0.0123
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.1091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0057 0.0502 0.3358
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0057 0.0502 0.3358
Onchocerca volvulus 0.0027 0.0113 0.2262
Schistosoma mansoni hypothetical protein 0.0035 0.0221 0.0239
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0113 0.0113
Brugia malayi nuclear receptor RXR 0.0027 0.0113 0.076
Brugia malayi ecdysone receptor 0.0027 0.0113 0.076
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0089 0.0913 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0221 0.7258
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0092 0.2646
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0025 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0041 0.0297 0.0322
Loa Loa (eye worm) hypothetical protein 0.0098 0.1019 0.6821
Loa Loa (eye worm) hypothetical protein 0.003 0.0155 0.1038
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0221 0.0239
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0041 0.0297 0.1035
Echinococcus granulosus GPCR family 2 0.0031 0.0163 0.1091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0155 0.0168
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0163 0.0163
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0113 0.076
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0113 0.076
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0041 0.0297 0.199
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0113 0.076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0502 0.3358
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0113 0.0123
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Echinococcus granulosus ecdysone induced protein 78C 0.0057 0.0502 0.3358
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0113 0.0113
Brugia malayi nuclear receptor NHR-88 0.0057 0.0502 0.3358
Schistosoma mansoni zinc finger protein 0.0027 0.0113 0.0123
Loa Loa (eye worm) DOMON domain-containing protein 0.0026 0.0098 0.0653
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0221 0.1478
Brugia malayi hypothetical protein 0.0027 0.0113 0.076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1019 0.6821
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0025 0.0092 0.0616
Echinococcus multilocularis FTZ F1 alpha 0.0057 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358
Loa Loa (eye worm) hypothetical protein 0.003 0.0155 0.1038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0057 0.0502 0.0502
Schistosoma mansoni retinoic acid receptor RXR 0.0057 0.0502 0.0543
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0057 0.0502 0.0543
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0057 0.0502 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0057 0.0502 0.3358
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0092 0.0616
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0092 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0113 0.076
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0502 0.3358
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0155 0.1038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Schistosoma mansoni nuclear receptor 0.0027 0.0113 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0623 0.4169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0057 0.0502 0.3358
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0092 0.0616
Brugia malayi nuclear receptor NHR-88 0.0027 0.0113 0.076
Brugia malayi tailless protein 0.0027 0.0113 0.076
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0041 0.0297 0.1035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0057 0.0502 0.3358
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0113 0.076
Loa Loa (eye worm) hypothetical protein 0.003 0.0155 0.1038
Echinococcus multilocularis ecdysone induced protein 78C 0.0057 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358
Onchocerca volvulus 0.0027 0.0113 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0057 0.0502 0.3358
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0057 0.0502 0.3358
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0057 0.0502 0.3358
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1019 0.6821
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0135 0.1494 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0057 0.0502 0.3358
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0113 0.0123
Schistosoma mansoni hypothetical protein 0.0031 0.0163 0.0177
Brugia malayi nuclear hormone receptor 0.0057 0.0502 0.3358
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0025 0.0092 0.2646
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0113 0.076
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0113 0.076
Brugia malayi nuclear hormone receptor 0.0027 0.0113 0.076
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0025 0.0092 0.01
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0092 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0502 0.3358
Brugia malayi nuclear receptor RXR 0.003 0.0155 0.1038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0092 0.0616
Brugia malayi conserved hypotetical protein 0.0027 0.0113 0.076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0057 0.0502 0.0543
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0113 0.0113
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0068 0.0643 0.4306
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0297 1
Brugia malayi ecdysteroid receptor 0.0057 0.0502 0.3358
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0155 0.0155
Loa Loa (eye worm) DR-78 0.0027 0.0113 0.076
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0092 0.0616
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.074 0.9238 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0025 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0163 0.1091
Brugia malayi photoreceptor-specific nuclear receptor 0.0057 0.0502 0.3358
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0155 0.1038
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0155 0.1038
Loa Loa (eye worm) hypothetical protein 0.0135 0.1494 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0163 0.0163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0113 0.076
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0113 0.076
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0135 0.1494 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0025 0.0092 0.01
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0025 0.0092 0.2646
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.018 0.2077 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0092 0.2646
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0502 0.0543
Brugia malayi hypothetical protein 0.0035 0.0221 0.1478
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0041 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0155 0.1038
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0066 0.0618 0.4133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0502 0.3358
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0113 0.0113
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0025 0.0092 0.0616
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0025 0.0092 0.01
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0221 0.0221
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0155 0.0168
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0113 0.0113
Brugia malayi DOMON domain containing protein 0.0026 0.0098 0.0653
Echinococcus granulosus FTZ F1 alpha 0.0057 0.0502 0.3358
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0163 0.1091
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0089 0.0913 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0297 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0025 0.0092 0.2646
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0502 0.0502
Onchocerca volvulus 0.0026 0.0098 0.1943
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Loa Loa (eye worm) hypothetical protein 0.0067 0.0623 0.4169
Entamoeba histolytica hypothetical protein 0.0035 0.0221 0.7258
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0018 0.0121
Entamoeba histolytica hypothetical protein 0.0035 0.0221 0.7258
Loa Loa (eye worm) DOMON domain-containing protein 0.0026 0.0098 0.0653
Brugia malayi Steroid receptor seven-up type 2 0.0057 0.0502 0.3358
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0041 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Brugia malayi hypothetical protein 0.003 0.0155 0.1038
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0113 0.0123
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0113 0.076
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0057 0.0502 0.3358
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.076
Schistosoma mansoni peptidylglycine monooxygenase 0.0135 0.1494 0.1617
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0057 0.0502 0.0502
Echinococcus multilocularis Zinc finger, PHD finger 0.0025 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0155 0.1038
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0502 0.0543
Loa Loa (eye worm) hypothetical protein 0.0057 0.0502 0.3358

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.95 uM Inhibition of Lck ChEMBL. 17234410
IC50 (binding) = 2.95 uM Inhibition of Lck ChEMBL. 17234410
IC50 (binding) > 50 uM Inhibition of Hck ChEMBL. 17234410
IC50 (binding) > 50 uM Inhibition of Hck ChEMBL. 17234410

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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