TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.743 | Formula: C33H36N6O2S
H donors: 4 H acceptors: 2 LogP: 4.77 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(ccc1NC(=O)c1cc2c(n1C)cccc2)c1csc2c1c(N)ncc2/C=C/CN[C@@H]1CC[C@H](CC1)N
InChi: 1S/C33H36N6O2S/c1-39-27-8-4-3-6-21(27)16-28(39)33(40)38-26-14-9-20(17-29(26)41-2)25-19-42-31-22(18-37-32(35)30(25)31)7-5-15-36-24-12-10-23(34)11-13-24/h3-9,14,16-19,23-24,36H,10-13,15,34H2,1-2H3,(H2,35,37)(H,38,40)/b7-5+/t23-,24-
InChiKey: FRQGIFZNGIECRT-LSKJDRFGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	LYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	FGR proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	TEK tyrosine kinase, endothelial	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.0703	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0038	0.0247	0.0417
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0625	0.2063
Onchocerca volvulus		0.0026	0.0097	0.0493
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0114	0.1185	0.1185
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0114	0.1185	0.3914
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0018	0.0006	0.0028
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0018	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0032	0.0172	0.0289
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0097	0.032
Onchocerca volvulus		0.0167	0.1839	0.9355
Onchocerca volvulus	Putative nachr subunit	0.0038	0.0247	0.1258
Loa Loa (eye worm)	DOMON domain-containing protein	0.005	0.0403	0.133
Onchocerca volvulus		0.0038	0.0247	0.1258
Echinococcus granulosus	c src tyrosine kinase	0.0043	0.0316	0.1043
Schistosoma mansoni	hypothetical protein	0.0032	0.0172	0.0289
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0018	0.0006	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus granulosus	tyrosine protein kinase Srms	0.0026	0.0097	0.032
Schistosoma mansoni	adapter molecule crk	0.0036	0.0224	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Entamoeba histolytica	hypothetical protein	0.0075	0.0703	0.9477
Brugia malayi	SH2 domain containing protein	0.0018	0.0006	0.0018
Echinococcus granulosus	nAChR subunit	0.002	0.0032	0.0106
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0032	0.0106
Onchocerca volvulus		0.0026	0.0097	0.0493
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0247	0.0817
Loa Loa (eye worm)	TK protein kinase	0.0096	0.0966	0.3191
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Schistosoma mansoni	tensin-related	0.0018	0.0006	0.0009
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0114	0.1185	0.3914
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.0247	0.0817
Loa Loa (eye worm)	GABA receptor subunit	0.002	0.0032	0.0106
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0096	0.0966	0.0966
Loa Loa (eye worm)	STAT protein	0.0018	0.0006	0.0018
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0089	0.0875	0.0875
Echinococcus granulosus	tyrosine protein kinase HCK	0.0078	0.0742	0.245
Brugia malayi	Cation transporter family protein	0.0038	0.0247	0.0817
Brugia malayi	RhoGAP domain containing protein	0.0018	0.0006	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0019	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0114	0.1185	0.1185
Echinococcus granulosus	SH2 domain containing protein 7	0.0018	0.0006	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0263	0.3028	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0018	0.0006	0.0018
Echinococcus multilocularis		0.0018	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.032
Brugia malayi	SH2 domain containing protein	0.0026	0.0097	0.032
Loa Loa (eye worm)	hypothetical protein	0.0263	0.3028	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0189	0.2114	0.6982
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0018	0.0006	0.0018
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0247	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0006	0.0018
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0114	0.1185	0.3914
Schistosoma mansoni	tensin	0.0018	0.0006	0.0009
Schistosoma mansoni	tensin	0.0018	0.0006	0.0009
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0018	0.0006	0.0018
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.002	0.0032	0.0106
Brugia malayi	hypothetical protein	0.0018	0.0006	0.0018
Brugia malayi	SH2 domain containing protein	0.0018	0.0006	0.0018
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0018	0.0006	0.0009
Entamoeba histolytica	SH2 domain containing protein	0.0018	0.0006	0.0075
Brugia malayi	hypothetical protein	0.0075	0.0703	0.2322
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0038	0.0247	0.0817
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0114	0.1185	0.1185
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0247	0.0817
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0172	0.0172
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0172	0.0567
Schistosoma mansoni	nAChR subunit	0.0038	0.0247	0.0417
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0247	0.0417
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0114	0.1185	0.1185
Onchocerca volvulus		0.0026	0.0097	0.0493
Echinococcus granulosus	tensin	0.0018	0.0006	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Loa Loa (eye worm)	TK protein kinase	0.0078	0.0742	0.245
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0018	0.0006	0.0006
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0114	0.1185	0.3914
Echinococcus multilocularis	nAChR subunit	0.0038	0.0247	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Schistosoma mansoni	suppressor of cytokine signaling	0.0018	0.0006	0.0009
Mycobacterium ulcerans	DNA-3-methyladenine glycosylase I TagA	0.0187	0.2092	0.5
Brugia malayi	SH2 domain containing protein	0.0018	0.0006	0.0018
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0172	0.0567
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0026	0.0097	0.032
Schistosoma mansoni	growth factor receptor-bound protein	0.0036	0.0224	0.0379
Brugia malayi	SH2 domain containing protein	0.0018	0.0006	0.0018
Schistosoma mansoni	tyrosine kinase	0.0043	0.0316	0.0533
Schistosoma mansoni	peptidylglycine monooxygenase	0.0263	0.3028	0.5107
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0032	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0032	0.0106
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0006	0.0018
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0247	0.0817
Echinococcus granulosus	signal transduction protein lnk realted	0.0018	0.0006	0.0018
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0114	0.1185	0.3914
Brugia malayi	SH2 domain containing protein	0.0026	0.0097	0.032
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0038	0.0247	0.0817
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0247	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0006	0.0006
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0038	0.0247	0.0417
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0038	0.0247	0.0417
Loa Loa (eye worm)	SH2 domain-containing protein	0.0018	0.0006	0.0018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0114	0.1185	0.1185
Schistosoma mansoni	vav2	0.0018	0.0006	0.0009
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0247	0.0247
Echinococcus granulosus	NCK adaptor protein	0.0036	0.0224	0.0741
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0247	0.0817
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0	0.5
Onchocerca volvulus		0.0038	0.0247	0.1258
Entamoeba histolytica	protein kinase, putative	0.0078	0.0742	1
Schistosoma mansoni	nAChR subunit	0.0038	0.0247	0.0417
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0075	0.0703	0.2322
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0247	0.0817
Schistosoma mansoni	nAChR subunit	0.0038	0.0247	0.0417
Echinococcus multilocularis	SH2 motif	0.0018	0.0006	0.0006
Echinococcus granulosus	SH2 motif	0.0018	0.0006	0.0018
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0018	0.0006	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0018	0	0.0002
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0097	0.032
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0043	0.0316	0.0533
Schistosoma mansoni	nAChR subunit	0.0038	0.0247	0.0417
Brugia malayi	excitatory GABA receptor EXP-1A	0.0038	0.0247	0.0817
Schistosoma mansoni	signal transduction protein lnk-related	0.0018	0.0006	0.0009
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0091	0.0154
Onchocerca volvulus		0.0018	0.0006	0.0028
Mycobacterium tuberculosis	Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g	0.0093	0.0927	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0247	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Brugia malayi	Sex muscle abnormal protein 5	0.0036	0.0224	0.0741
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0018	0.0006	0.0018
Schistosoma mansoni	tensin-related	0.0018	0.0006	0.0009
Echinococcus multilocularis	c src tyrosine kinase	0.0043	0.0316	0.0316
Echinococcus multilocularis	tensin	0.0018	0.0006	0.0006
Schistosoma mansoni	tyrosine kinase	0.0043	0.0316	0.0533
Loa Loa (eye worm)	hypothetical protein	0.01	0.1015	0.3353
Echinococcus multilocularis	SH2 motif	0.0018	0.0006	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0018	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0043	0.0316	0.0316
Schistosoma mansoni	tyrosine kinase	0.0114	0.1185	0.1999
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0038	0.0247	0.0817
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0114	0.1185	0.3914
Onchocerca volvulus		0.005	0.0403	0.2049
Brugia malayi	Cation transporter family protein	0.0038	0.0247	0.0817
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0018	0.0006	0.0006
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0247	0.0817
Schistosoma mansoni	tyrosine kinase	0.0026	0.0097	0.0164
Loa Loa (eye worm)	SH2 domain-containing protein	0.0018	0.0006	0.0018
Brugia malayi	DOMON domain containing protein	0.005	0.0403	0.133
Brugia malayi	DOMON domain containing protein	0.005	0.0403	0.133
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Mycobacterium leprae	PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g	0.0093	0.0927	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0114	0.1185	0.1185
Brugia malayi	SH2 domain containing protein	0.0018	0.0006	0.0018
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.0187	0.2092	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0038	0.0247	0.0247
Entamoeba histolytica	hypothetical protein	0.002	0.0032	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Schistosoma mansoni	nAChR subunit	0.0038	0.0247	0.0417
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Schistosoma mansoni	SH2A	0.0018	0.0006	0.0009
Brugia malayi	Variant SH3 domain containing protein	0.0036	0.0224	0.0741
Schistosoma mansoni	nck2/grb4	0.0036	0.0224	0.0379
Brugia malayi	SH2 domain containing protein	0.0018	0.0006	0.0018
Brugia malayi	hypothetical protein	0.0026	0.0097	0.032
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0043	0.0316	0.1043
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0038	0.0247	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus multilocularis	nAChR subunit	0.002	0.0032	0.0032
Schistosoma mansoni	GTPase activating protein	0.0018	0.0006	0.0009
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0247	0.0817
Schistosoma mansoni	tensin	0.0018	0.0006	0.0009
Onchocerca volvulus		0.0026	0.0097	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0097	0.032
Onchocerca volvulus		0.0018	0.0006	0.0028
Brugia malayi	Variant SH3 domain containing protein	0.0036	0.0224	0.0741
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0247	0.0417
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0018	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus granulosus	tyrosine kinase	0.0026	0.0097	0.032
Schistosoma mansoni	hypothetical protein	0.0032	0.0172	0.0289
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0018	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0097	0.032
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0247	0.0817
Schistosoma mansoni	hypothetical protein	0.0018	0.0006	0.0009
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.0247	0.0247
Brugia malayi	Cation transporter family protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Entamoeba histolytica	hypothetical protein	0.0075	0.0703	0.9477
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0114	0.1185	0.1185
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0026	0.0097	0.0097
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0036	0.0224	0.0741
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0172	0.0567
Schistosoma mansoni	hypothetical protein	0.0068	0.0625	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.1015	0.3353
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0026	0.0097	0.1307
Brugia malayi	DOMON domain containing protein	0.005	0.0403	0.133
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0247	0.0817
Echinococcus granulosus	tyrosine protein kinase shark	0.0026	0.0097	0.032
Loa Loa (eye worm)	hypothetical protein	0.0018	0	0.0002
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0247	0.0417
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0114	0.1185	0.1185
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0247	0.0817
Schistosoma mansoni	tyrosine kinase	0.0114	0.1185	0.1999
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0038	0.0247	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0006	0.0018
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0018	0.0006	0.0018
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0038	0.0247	0.0817
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0247	0.0247
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0036	0.0224	0.0741
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.1015	0.3353
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0026	0.0097	0.032
Schistosoma mansoni	hypothetical protein	0.0032	0.0172	0.0289
Onchocerca volvulus		0.0018	0.0006	0.0028
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0038	0.0247	0.0817
Trypanosoma brucei	conserved protein	0.0018	0	0.5
Schistosoma mansoni	nephrin	0.0018	0.0009	0.0015
Entamoeba histolytica	protein kinase, putative	0.0018	0.0006	0.0075
Onchocerca volvulus		0.005	0.0403	0.2049
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0038	0.0247	0.0817
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0038	0.0247	0.0817
Onchocerca volvulus		0.0038	0.0247	0.1258
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0263	0.3028	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0133	0.1429	0.4719
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0043	0.0316	0.0316
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0006	0.0018
Echinococcus multilocularis	tyrosine kinase	0.0026	0.0097	0.0097
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0038	0.0247	0.0817
Echinococcus granulosus	N chimaerin	0.0018	0.0006	0.0018
Schistosoma mansoni	nAChR subunit	0.0038	0.0247	0.0417
Echinococcus multilocularis	roundabout 2	0.0022	0.0054	0.0054
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0172	0.0172
Schistosoma mansoni	suppressor of cytokine signaling	0.0018	0.0006	0.0009
Loa Loa (eye worm)	LGC-31 protein	0.0038	0.0247	0.0817
Echinococcus multilocularis	N chimaerin	0.0018	0.0006	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0114	0.1185	0.1185
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0247	0.0247
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0018	0.0006	0.0018
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0096	0.0966	0.0966
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Echinococcus granulosus	tyrosine protein kinase Blk	0.0096	0.0966	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0498	0.5929	1
Loa Loa (eye worm)	DOMON domain-containing protein	0.005	0.0403	0.133
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0036	0.0224	0.0224
Echinococcus granulosus	nAChR subunit	0.0038	0.0247	0.0817
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0036	0.0224	0.0379
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0247	0.0247
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0018	0.0006	0.0006
Brugia malayi	SRC-1	0.0114	0.1185	0.3914
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0247	0.0817
Schistosoma mansoni	hypothetical protein	0.0018	0.0006	0.0009
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0263	0.3028	0.3028
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.1015	0.3353
Onchocerca volvulus		0.0026	0.0097	0.0493
Brugia malayi	SH2 domain containing protein	0.0018	0.0006	0.0018
Brugia malayi	Tyrosine-protein kinase abl-1	0.0043	0.0316	0.1043
Onchocerca volvulus		0.002	0.0032	0.0164
Schistosoma mansoni	neurotransmitter gated ion channel	0.002	0.0032	0.0054
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.002	0.0032	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0224	0.0741
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0026	0.0097	0.0097
Echinococcus granulosus	SHC transforming protein 3	0.0018	0.0006	0.0018
Echinococcus multilocularis	NCK adaptor protein	0.0036	0.0224	0.0224
Onchocerca volvulus		0.0018	0.0006	0.0028
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0038	0.0247	0.0817
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0038	0.0247	0.0817
Loa Loa (eye worm)	TK/ABL protein kinase	0.0026	0.0097	0.032
Leishmania major	hypothetical protein, conserved	0.0018	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Echinococcus multilocularis	signal transduction protein lnk realted	0.0018	0.0006	0.0006
Entamoeba histolytica	hypothetical protein	0.0075	0.0703	0.9477
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0018	0.0006	0.0018
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0114	0.1185	0.3914
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0018	0.0006	0.0018
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0263	0.3028	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0172	0.0567
Schistosoma mansoni	tyrosine kinase	0.0026	0.0097	0.0164
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0018	0.0006	0.0075
Echinococcus granulosus	expressed conserved protein	0.0018	0.0006	0.0018
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0032	0.0054
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0096	0.0966	0.0966
Echinococcus multilocularis	SH2 domain containing protein 7	0.0018	0.0006	0.0006
Echinococcus granulosus	SH2 motif	0.0018	0.0006	0.0018
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0114	0.1185	0.3914
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Onchocerca volvulus		0.0018	0.0006	0.0028
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0247	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0172	0.0567
Schistosoma mansoni	shc transforming protein	0.0018	0.0006	0.0009
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0247	0.0247
Schistosoma mansoni	hypothetical protein	0.0075	0.0703	0.1186
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0	0.5
Echinococcus granulosus	GPCR family 2	0.0032	0.0172	0.0567
Echinococcus granulosus	hypothetical protein	0.0018	0.0006	0.0018
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0247	0.0247
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0006	0.0018
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0018	0.0006	0.0018
Loa Loa (eye worm)	SRC-1	0.0114	0.1185	0.3914
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0189	0.2114	0.6982
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0018	0.0006	0.0018
Brugia malayi	Tensin	0.0018	0.0006	0.0018
Echinococcus granulosus	tyrosine kinase	0.0096	0.0966	0.3191
Loa Loa (eye worm)	TK/FER protein kinase	0.0026	0.0097	0.032
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0075	0.0703	0.0703
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0038	0.0247	0.0817
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0247	0.0817
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0038	0.0247	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0247	0.0817
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0247	0.0817
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0247	0.0817
Echinococcus multilocularis	tensin	0.0018	0.0006	0.0006
Onchocerca volvulus		0.0026	0.0097	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0247	0.0247
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.0187	0.2092	1
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0097	0.032
Onchocerca volvulus		0.0018	0.0006	0.0028
Echinococcus multilocularis	tyrosine protein kinase shark	0.0026	0.0097	0.0097
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0038	0.0247	0.0817
Echinococcus multilocularis	SH2 motif	0.0018	0.0006	0.0006
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0263	0.3028	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0018	0.0006	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0096	0.0966	0.3191
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0263	0.3028	0.5107
Loa Loa (eye worm)	DOMON domain-containing protein	0.005	0.0403	0.133
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0172	0.0567
Echinococcus granulosus	growth factor receptor bound protein 2	0.0036	0.0224	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0625	0.2063
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0018	0.0006	0.0028
Echinococcus granulosus	roundabout 2	0.0022	0.0054	0.0179
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0006	0.0018
Loa Loa (eye worm)	SH2 domain-containing protein	0.0018	0.0006	0.0018
Schistosoma mansoni	nAChR subunit	0.0038	0.0247	0.0417
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0018	0.0006	0.0009
Echinococcus multilocularis	SHC transforming protein 3	0.0018	0.0006	0.0006
Entamoeba histolytica	hypothetical protein	0.0075	0.0703	0.9477
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0247	0.0817
Onchocerca volvulus		0.0038	0.0247	0.1258
Onchocerca volvulus		0.0038	0.0247	0.1258
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0038	0.0247	0.0817
Brugia malayi	protein-tyrosine kinase	0.0096	0.0966	0.3191
Onchocerca volvulus		0.002	0.0032	0.0164
Onchocerca volvulus	Tyrosine kinase homolog	0.0177	0.1966	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0018	0.0006	0.0009
Onchocerca volvulus		0.0038	0.0247	0.1258
Loa Loa (eye worm)	hypothetical protein	0.002	0.0032	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0006	0.0018
Schistosoma mansoni	growth factor receptor-bound protein	0.0036	0.0224	0.0379
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0078	0.0742	0.0742
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0089	0.0875	0.289
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0247	0.0817
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.0247	0.0817
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.013	0.138	0.4559

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.11 uM	Inhibition of Lck	ChEMBL.	17234410
IC50 (binding)	= 0.11 uM	Inhibition of Lck	ChEMBL.	17234410
IC50 (binding)	= 1.9 uM	Inhibition of Tie2	ChEMBL.	17234410
IC50 (binding)	= 1.9 uM	Inhibition of Tie2	ChEMBL.	17234410
IC50 (binding)	= 17.9 uM	Inhibition of Fgr	ChEMBL.	17234410
IC50 (binding)	= 17.9 uM	Inhibition of Fgr	ChEMBL.	17234410
IC50 (binding)	= 18.5 uM	Inhibition of KDR	ChEMBL.	17234410
IC50 (binding)	= 18.5 uM	Inhibition of Lyn	ChEMBL.	17234410
IC50 (binding)	= 18.5 uM	Inhibition of KDR	ChEMBL.	17234410
IC50 (binding)	= 18.5 uM	Inhibition of Lyn	ChEMBL.	17234410
IC50 (binding)	= 19.7 uM	Inhibition of Src	ChEMBL.	17234410
IC50 (binding)	= 19.7 uM	Inhibition of Src	ChEMBL.	17234410
IC50 (binding)	= 24.1 uM	Inhibition of Hck	ChEMBL.	17234410
IC50 (binding)	= 24.1 uM	Inhibition of Hck	ChEMBL.	17234410
IC50 (binding)	= 25.9 uM	Inhibition of Fyn	ChEMBL.	17234410
IC50 (binding)	= 25.9 uM	Inhibition of Fyn	ChEMBL.	17234410

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL395665

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 442268