TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 427.459 | Formula: C23H21N7O2
H donors: 2 H acceptors: 4 LogP: 2.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1NC(=O)c1cc2c(n1C)cccc2)c1nn(c2c1c(N)ncn2)C
InChi: 1S/C23H21N7O2/c1-29-16-7-5-4-6-13(16)10-17(29)23(31)27-15-9-8-14(11-18(15)32-3)20-19-21(24)25-12-26-22(19)30(2)28-20/h4-12H,1-3H3,(H,27,31)(H2,24,25,26)
InChiKey: HGLHTBMFKAIGGR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit	0.0034	0.0015	0.0017
Echinococcus multilocularis	insulin receptor	0.0048	0.0175	0.0175
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.005	0.0206	0.4354
Loa Loa (eye worm)	hypothetical protein	0.005	0.0206	0.0469
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0075	0.0501	0.1141
Schistosoma mansoni	nAChR subunit	0.0075	0.0501	0.0578
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.005	0.0206	0.0469
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0259	0.0589
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.005	0.0206	0.4354
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.021	0.2147	0.4887
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0075	0.0501	0.1141
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0146	0.137	0.3119
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.021	0.2147	0.4887
Mycobacterium ulcerans	DNA-3-methyladenine glycosylase I TagA	0.0194	0.1955	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0075	0.0501	0.0501
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.005	0.0206	0.0469
Onchocerca volvulus		0.0075	0.0501	0.2281
Onchocerca volvulus		0.021	0.2147	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0054	0.0259	0.2767
Echinococcus multilocularis		0.0054	0.0259	0.0259
Schistosoma mansoni	tyrosine kinase	0.0079	0.0558	0.0643
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0075	0.0501	0.0501
Schistosoma mansoni	nAChR subunit	0.0075	0.0501	0.0578
Onchocerca volvulus		0.0075	0.0501	0.2281
Mycobacterium tuberculosis	Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g	0.0096	0.0767	0.5
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0066	0.0396	0.1086
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0075	0.0501	0.0578
Brugia malayi	Cation transporter family protein	0.0075	0.0501	0.1141
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.005	0.0206	0.0238
Brugia malayi	excitatory GABA receptor EXP-1A	0.0075	0.0501	0.1141
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.021	0.2147	0.4887
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0034	0.0015	0.0034
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0066	0.0396	0.0902
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0066	0.0396	0.1086
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0075	0.0501	0.1141
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.005	0.0206	0.1296
Onchocerca volvulus		0.0075	0.0501	0.2281
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0074	0.0491	1
Echinococcus multilocularis	nAChR subunit	0.0075	0.0501	0.0501
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.004	0.0085	0.0193
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Brugia malayi	DOMON domain containing protein	0.0076	0.0516	0.1175
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.005	0.0206	0.4354
Schistosoma mansoni	tyrosine kinase	0.0048	0.0175	0.0202
Schistosoma mansoni	neurotransmitter gated ion channel	0.004	0.0085	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Onchocerca volvulus		0.0076	0.0516	0.2352
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.0501	0.1141
Schistosoma mansoni	nAChR subunit	0.0075	0.0501	0.0578
Loa Loa (eye worm)	TK/INSR protein kinase	0.0048	0.0175	0.0399
Brugia malayi	Furin-like cysteine rich region family protein	0.0146	0.137	0.3119
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0054	0.0259	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.0501	0.1141
Schistosoma mansoni	neurotransmitter gated ion channel	0.0034	0.0015	0.0017
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0054	0.0259	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.004	0.0085	0.0193
Echinococcus granulosus	glycine receptor subunit beta	0.0075	0.0501	0.1141
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0034	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0066	0.0396	0.0396
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0054	0.0259	0.0298
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0079	0.0558	0.1269
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0075	0.0501	0.1141
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.005	0.0206	0.4354
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0075	0.0501	0.0501
Onchocerca volvulus		0.004	0.0085	0.0328
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0075	0.0501	0.1141
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0075	0.0501	0.1141
Brugia malayi	hypothetical protein	0.0038	0.006	0.0136
Onchocerca volvulus		0.0075	0.0501	0.2281
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0034	0.0015	0.0015
Schistosoma mansoni	nAChR subunit	0.0075	0.0501	0.0578
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0066	0.0396	0.0902
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0048	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0075	0.0501	0.1141
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.004	0.0085	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.0501	0.1141
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0066	0.0396	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.005	0.0206	0.0206
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0015	0.0034
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0066	0.0396	1
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0749	0.8677	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.021	0.2147	0.4887
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.004	0.0085	0.0098
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0075	0.0501	0.1141
Onchocerca volvulus		0.0076	0.0516	0.2352
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0201	0.2032	0.4624
Onchocerca volvulus	Putative nachr subunit	0.0075	0.0501	0.2281
Schistosoma mansoni	tyrosine kinase	0.0048	0.0175	0.0202
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.006	0.0069
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.021	0.2147	0.2147
Loa Loa (eye worm)	phosphatidylinositol 3	0.021	0.2147	0.4887
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Loa Loa (eye worm)	phosphatidylinositol kinase	0.021	0.2147	0.4887
Loa Loa (eye worm)	DOMON domain-containing protein	0.0076	0.0516	0.1175
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0075	0.0501	0.0501
Echinococcus multilocularis	nAChR subunit	0.004	0.0085	0.0085
Entamoeba histolytica	hypothetical protein	0.005	0.0206	0.4354
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.005	0.0206	0.4354
Brugia malayi	DOMON domain containing protein	0.0076	0.0516	0.1175
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0066	0.0396	0.0902
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0066	0.0396	1
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.0194	0.1955	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.005	0.0206	0.0238
Loa Loa (eye worm)	ACC-1 protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	acetylcholine receptor protein	0.0034	0.0015	0.0034
Onchocerca volvulus		0.0075	0.0501	0.2281
Brugia malayi	hypothetical protein	0.0034	0.0015	0.0034
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Onchocerca volvulus		0.004	0.0085	0.0328
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0054	0.0259	0.2767
Schistosoma mansoni	hypothetical protein	0.0072	0.0466	0.0537
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0075	0.0501	0.1141
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0075	0.0501	0.1141
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0054	0.0259	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.0501	0.1141
Brugia malayi	hypothetical protein	0.0034	0.0015	0.0034
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.005	0.0206	0.0469
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0075	0.0501	0.1141
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0075	0.0501	0.1141
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0075	0.0501	0.0501
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0075	0.0501	0.1141
Schistosoma mansoni	nAChR subunit	0.0075	0.0501	0.0578
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0175	0.0399
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0034	0.0015	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Loa Loa (eye worm)	phosphatidylinositol 3	0.005	0.0206	0.0469
Echinococcus multilocularis	glycine receptor subunit beta	0.0075	0.0501	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Schistosoma mansoni	neurotransmitter gated ion channel	0.0034	0.0015	0.0017
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0075	0.0501	0.1141
Echinococcus multilocularis		0.0045	0.0142	0.0142
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0075	0.0501	0.0501
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.006	0.006
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0075	0.0501	0.0501
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0466	0.1061
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0075	0.0501	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	DOMON domain-containing protein	0.0076	0.0516	0.1175
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Brugia malayi	Cation transporter family protein	0.0075	0.0501	0.1141
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.0194	0.1955	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.005	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	LGC-31 protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0034	0.0015	0.0034
Echinococcus granulosus	epidermal growth factor receptor	0.0079	0.0558	0.1269
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.0868	0.1975
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0034	0.0015	0.0034
Schistosoma mansoni	nAChR subunit	0.0075	0.0501	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0075	0.0501	0.0501
Brugia malayi	DOMON domain containing protein	0.0076	0.0516	0.1175
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0075	0.0501	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Onchocerca volvulus		0.021	0.2147	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0048	0.0175	0.0399
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0396	0.4393	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Loa Loa (eye worm)	DOMON domain-containing protein	0.0076	0.0516	0.1175
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.005	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.004	0.0085	0.0193
Onchocerca volvulus		0.0075	0.0501	0.2281
Loa Loa (eye worm)	hypothetical protein	0.021	0.2147	0.4887
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.005	0.0206	0.0469
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0075	0.0501	0.0501
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0075	0.0501	0.0578
Schistosoma mansoni	nAChR subunit	0.0075	0.0501	0.0578
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0015	0.0034
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.005	0.0206	0.0469
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0075	0.0501	0.0578
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0075	0.0501	0.1141
Mycobacterium leprae	PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g	0.0096	0.0767	0.5
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.005	0.0206	0.0469
Echinococcus granulosus	nAChR subunit	0.004	0.0085	0.0193
Echinococcus granulosus	epidermal growth factor receptor	0.0146	0.137	0.3119
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0259	0.0589
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0075	0.0501	0.1141
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.0868	0.1975
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0034	0.0015	0.0015
Entamoeba histolytica	hypothetical protein	0.004	0.0085	0.074
Schistosoma mansoni	nAChR subunit	0.0034	0.0015	0.0017
Brugia malayi	Cation transporter family protein	0.0075	0.0501	0.1141
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0075	0.0501	0.1141
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0075	0.0501	0.1141
Echinococcus granulosus	nAChR subunit	0.0075	0.0501	0.1141
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0034	0.0015	0.0015
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0396	0.4393	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0034	0.0015	0.0034
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0075	0.0501	0.0578
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0075	0.0501	0.1141
Schistosoma mansoni	tyrosine kinase	0.0079	0.0558	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.021	0.2147	0.2147
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.004	0.0085	0.0193
Echinococcus multilocularis	epidermal growth factor receptor	0.0079	0.0558	0.0558
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0075	0.0501	0.1141
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0075	0.0501	0.1141
Schistosoma mansoni	tyrosine kinase	0.0077	0.0532	0.0613
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0259	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.021	0.2147	0.2474
Loa Loa (eye worm)	GABA receptor subunit	0.004	0.0085	0.0193
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0466	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Schistosoma mansoni	tyrosine kinase	0.0146	0.137	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0054	0.0259	0.0589
Echinococcus multilocularis	glycine receptor subunit beta	0.0075	0.0501	0.0501
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0066	0.0396	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0075	0.0501	0.1141
Brugia malayi	hypothetical protein	0.0034	0.0015	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0054	0.0259	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0075	0.0501	0.0578
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0075	0.0501	0.0578
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.004	0.0085	0.0098
Schistosoma mansoni	acetylcholine receptor-related	0.0034	0.0015	0.0017
Brugia malayi	hypothetical protein	0.0034	0.0015	0.0034
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.005	0.0206	0.0238
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.005	0.0206	0.4354
Schistosoma mansoni	hypothetical protein	0.0038	0.006	0.0069
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0075	0.0501	0.1141
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0034	0.0015	0.0034
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0396	0.4393	0.5063
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0501	0.1141
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0034	0.0015	0.0034
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0066	0.0396	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.021	0.2147	0.4887
Brugia malayi	hypothetical protein	0.0034	0.0015	0.0034
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0396	0.4393	0.4393
Loa Loa (eye worm)	hypothetical protein	0.0396	0.4393	1
Echinococcus granulosus	glycine receptor subunit beta	0.0075	0.0501	0.1141
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0396	0.4393	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0034	0.0015	0.0034
Echinococcus granulosus	insulin receptor	0.0048	0.0175	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0034
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0066	0.0396	0.0456
Echinococcus multilocularis	epidermal growth factor receptor	0.0146	0.137	0.137
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0396	0.4393	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0195	0.196	0.4461
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.0868	0.1975
Schistosoma mansoni	tyrosine kinase	0.0077	0.0532	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0868	0.1975
Schistosoma mansoni	peptidylglycine monooxygenase	0.0396	0.4393	0.5063
Schistosoma mansoni	tyrosine kinase	0.0077	0.0532	0.0613
Loa Loa (eye worm)	ACC-1 protein	0.0075	0.0501	0.1141
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.006	0.0136

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.031 uM	Inhibition of Lck	ChEMBL.	17234410
IC50 (binding)	= 0.031 uM	Inhibition of Lck	ChEMBL.	17234410

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 442274