TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 447.573 | Formula: C26H33N5O2
H donors: 3 H acceptors: 2 LogP: 2.82 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2)N1CCN(CC1)c1ccccc1C
InChi: 1S/C26H33N5O2/c1-18-8-4-7-11-23(18)30-12-14-31(15-13-30)24(32)22(29-25(33)26(2,3)27)16-19-17-28-21-10-6-5-9-20(19)21/h4-11,17,22,28H,12-16,27H2,1-3H3,(H,29,33)/t22-/m1/s1
InChiKey: QQAGKFNEBOHJEO-JOCHJYFZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0474	0.6461
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.2074	0.6875
Schistosoma mansoni	nuclear receptor	0.0011	0.0056	0.0056
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0453	0.1502
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0453	0.1502
Schistosoma mansoni	rab6-interacting	0.002	0.0368	0.0368
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2074	0.2074
Loa Loa (eye worm)	nuclear hormone receptor	0.0011	0.0056	0.0056
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0734	0.0734
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0474	0.6461
Brugia malayi	ecdysteroid receptor	0.0022	0.0453	0.1502
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0453	0.1966
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1192	0.1192
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0368	0.0368
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0368	0.1008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0453	0.0453
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0453	0.0453
Onchocerca volvulus		0.0031	0.0734	0.3183
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0734	0.0734
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1192	0.1192
Mycobacterium tuberculosis	Probable oxidoreductase	0.0031	0.0734	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0453	0.0453
Brugia malayi	steroid hormone receptor	0.0022	0.0453	0.1502
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0474	0.6461
Echinococcus multilocularis	jun protein	0.0099	0.3017	0.3017
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.1192	0.3952
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0474	0.0474
Schistosoma mansoni	lipoxygenase	0.0119	0.3694	0.3694
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0031	0.0734	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0474	0.0474
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0234	0.319
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0474	0.0474
Loa Loa (eye worm)	DR-78	0.0011	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0483	0.6587
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0056	0.0185
Brugia malayi	ecdysone receptor	0.0011	0.0056	0.0185
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0483	0.6587
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0368	0.0368
Onchocerca volvulus		0.0077	0.2305	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0098	0.0098
Plasmodium falciparum	MO15-related protein kinase	0.0118	0.3654	1
Onchocerca volvulus		0.0031	0.0734	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0734	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1192	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.0056	0.0185
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0453	0.0453
Plasmodium falciparum	importin beta, putative	0.0029	0.0666	0.1822
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0474	0.1571
Onchocerca volvulus		0.002	0.0368	0.1599
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0483	0.6587
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0453	0.1966
Echinococcus multilocularis	RUN	0.002	0.0368	0.0368
Schistosoma mansoni	jun-related protein	0.008	0.2395	0.2395
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0474	0.6461
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0453	0.1502
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0099	0.3017	0.3017
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0098	0.0326
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0474	0.0474
Leishmania major	aldo-keto reductase-like protein	0.0031	0.0734	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0453	0.0453
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0483	0.6587
Trichomonas vaginalis	ran, putative	0.0021	0.0411	0.5602
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0453	0.1502
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0474	0.6461
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0453	0.1502
Toxoplasma gondii	cell-cycle-associated protein kinase, putative	0.011	0.3394	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0098	0.0098
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0474	0.6461
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.1192	0.1192
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2074	0.2074
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0098	0.0098
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0011	0.0056	0.0056
Echinococcus granulosus	jun protein	0.0099	0.3017	0.3017
Brugia malayi	hypothetical protein	0.0011	0.0056	0.0185
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0453	0.0453
Echinococcus granulosus	aldehyde reductase	0.0022	0.0434	0.0434
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0734	0.0734
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0474	0.1952
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0453	0.0453
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0011	0.0056	0.0185
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0734	1
Leishmania major	DNA polymerase eta, putative	0.0023	0.0474	0.6461
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.2074	0.2074
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0453	0.1502
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0453	0.0453
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0453	0.0453
Schistosoma mansoni	hypothetical protein	0.0306	1	1
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0734	0.0734
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0474	0.6461
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0734	0.0734
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0453	0.0453
Mycobacterium ulcerans	oxidoreductase	0.0031	0.0734	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0056	0.0056
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Schistosoma mansoni	hypothetical protein	0.002	0.0368	0.0368
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0453	0.0453
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0734	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0453	0.0453
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1192	0.1192
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0011	0.0056	0.0056
Schistosoma mansoni	lipoxygenase	0.0083	0.2492	0.2492
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0056	0.0056
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0734	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0411	0.1125
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0483	0.6587
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0411	0.0411
Brugia malayi	hypothetical protein	0.0012	0.0098	0.0326
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0011	0.0056	0.0056
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Brugia malayi	Doublecortin family protein	0.002	0.0368	0.1221
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0368	0.1008
Schistosoma mansoni	pol-related	0.0031	0.0734	0.0734
Echinococcus multilocularis	nuclear receptor nhr 48	0.0011	0.0056	0.0056
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0453	0.1502
Loa Loa (eye worm)	hypothetical protein	0.002	0.0368	0.0368
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0411	0.1362
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0098	0.0098
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0011	0.0056	0.0056
Brugia malayi	TAR-binding protein	0.0071	0.2074	0.6875
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0098	0.0326
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0474	0.0474
Schistosoma mansoni	rab6-interacting	0.002	0.0368	0.0368
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0031	0.0734	1
Schistosoma mansoni	coup transcription factor	0.0022	0.0453	0.0453
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0368	0.0368
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0119	0.3694	0.3694
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0453	0.1502
Brugia malayi	hypothetical protein	0.002	0.0368	0.1221
Echinococcus multilocularis	snurportin 1	0.0306	1	1
Echinococcus granulosus	aldo keto reductase	0.0031	0.0734	0.0734
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0734	0.2432
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0666	0.0666
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0474	0.6461
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0118	0.3654	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0453	0.0453
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0453	0.1502
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0734	0.0734
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2074	0.2074
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0474	0.6461
Entamoeba histolytica	hypothetical protein	0.0023	0.0483	0.6587
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1192	0.1192
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0011	0.0056	0.0242
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0734	1
Brugia malayi	hypothetical protein	0.0012	0.0098	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Echinococcus granulosus	dna polymerase eta	0.0023	0.0474	0.0474
Brugia malayi	nuclear hormone receptor	0.0022	0.0453	0.1502
Onchocerca volvulus		0.002	0.0368	0.1599
Giardia lamblia	Aldose reductase	0.0031	0.0734	1
Trypanosoma cruzi	aldo-keto reductase	0.0031	0.0734	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0453	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0011	0.0056	0.0056
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0453	0.1502
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0098	0.0098
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0031	0.0734	1
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0666	0.1822
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0453	0.0453
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0453	0.0453
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0734	0.2432
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0734	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Onchocerca volvulus		0.0031	0.0734	0.3183
Trypanosoma brucei	unspecified product	0.0016	0.0234	0.319
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0234	0.319
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1192	0.1192
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0734	0.0734
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Loa Loa (eye worm)	RNA binding protein	0.0071	0.2074	0.2074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0453	0.0453
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0098	0.0098
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0368	0.0368
Echinococcus granulosus	nuclear receptor nhr 48	0.0011	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0666	0.0666
Onchocerca volvulus		0.0011	0.0056	0.0242
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.0056	0.0056
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0453	0.0453
Brugia malayi	RNA, U transporter 1	0.0082	0.2444	0.8103
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0734	0.0734
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0453	0.0453
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0056	0.0185
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0411	0.5602
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Schistosoma mansoni	nuclear receptor	0.0011	0.0056	0.0056
Brugia malayi	hypothetical protein	0.0077	0.2305	0.764
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0011	0.0056	0.0185
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0453	0.0453
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.008	0.2395	0.2395
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0734	0.2432
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0011	0.0056	0.0242
Echinococcus multilocularis	aldehyde reductase	0.0022	0.0434	0.0434
Brugia malayi	hypothetical protein	0.0011	0.0056	0.0185
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0234	0.319
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0368	0.0368
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0474	0.1571
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0011	0.0056	0.0056
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0453	0.0453
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0368	0.0368
Schistosoma mansoni	importin beta-1	0.0029	0.0666	0.0666
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0453	0.0453
Echinococcus granulosus	RUN	0.002	0.0368	0.0368
Brugia malayi	hypothetical protein	0.002	0.0368	0.1221
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0453	0.0453
Trypanosoma brucei	unspecified product	0.0023	0.0474	0.6461
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0098	0.0098
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0734	1
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0453	0.1966
Echinococcus granulosus	hypothetical protein	0.0031	0.0734	0.0734
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Onchocerca volvulus		0.0022	0.0453	0.1966
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0474	0.0474
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0119	0.3694	0.3694
Brugia malayi	tailless protein	0.0011	0.0056	0.0185
Schistosoma mansoni	hypothetical protein	0.0202	0.6488	0.6488
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0666	0.1961
Brugia malayi	Importin beta-1 subunit	0.0029	0.0666	0.2207
Schistosoma mansoni	zinc finger protein	0.0011	0.0056	0.0056
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0734	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Brugia malayi	orphan nuclear receptor NR2E1	0.0011	0.0056	0.0185
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0411	0.5602
Entamoeba histolytica	Ran family GTPase	0.0021	0.0411	0.5602
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0453	0.1502
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1192	0.1192
Brugia malayi	nuclear hormone receptor family member odr-7	0.0011	0.0056	0.0185
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0474	0.6461
Trypanosoma brucei	prostaglandin f synthase	0.0031	0.0734	1
Echinococcus granulosus	aldo keto reductase	0.0031	0.0734	0.0734
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0734	0.0734
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.2074	0.2074
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0411	0.1211
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0453	0.1502
Schistosoma mansoni	nuclear receptor nhr-48	0.0011	0.0056	0.0056
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0666	0.9075
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2074	0.2074
Schistosoma mansoni	loxhd1	0.002	0.0368	0.0368
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0056	0.0056
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0453	0.0453
Onchocerca volvulus		0.0031	0.0734	0.3183
Onchocerca volvulus		0.0031	0.0734	0.3183
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0453	0.0453
Echinococcus granulosus	tar DNA binding protein	0.0071	0.2074	0.2074
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0474	0.6461
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0666	0.0666
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0474	0.0474
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0453	0.1502
Leishmania major	prostaglandin f synthase, putative	0.0031	0.0734	1
Toxoplasma gondii	aldose reductase, putative	0.0031	0.0734	0.2161
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Brugia malayi	nuclear receptor NHR-67	0.0011	0.0056	0.0185
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0453	0.0453
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0474	0.6461
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0666	0.9075
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0474	0.0474
Schistosoma mansoni	polycystin 1-related	0.002	0.0368	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0096	0.2926	0.2926
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0734	0.0734
Trypanosoma cruzi	aldo/keto reductase, putative	0.0031	0.0734	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0368	0.0368
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Schistosoma mansoni	ran	0.0021	0.0411	0.0411
Brugia malayi	RNA binding protein	0.0071	0.2074	0.6875
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0474	0.0474
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0453	0.1502
Trypanosoma brucei	unspecified product	0.0016	0.0234	0.319
Leishmania major	GTP-binding protein, putative	0.0021	0.0411	0.5602
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0411	0.1125
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0011	0.0056	0.0056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0453	0.0453
Echinococcus multilocularis	geminin	0.0202	0.6488	0.6488
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0453	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0056	0.0056
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0734	0.0734
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0474	0.0474
Trypanosoma brucei	aldo-keto reductase, putative	0.0031	0.0734	1
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0453	0.0453
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0453	0.0453
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0474	0.6461
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.0434	0.5922
Brugia malayi	nuclear receptor RXR	0.0012	0.0098	0.0326
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0056	0.0056
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0734	1
Brugia malayi	bZIP transcription factor family protein	0.0099	0.3017	1
Echinococcus granulosus	geminin	0.0202	0.6488	0.6488
Giardia lamblia	Aldose reductase	0.0031	0.0734	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0453	0.0453
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0453	0.0453
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0734	0.0734
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.2074	0.2074
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0734	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0368	0.0368
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.0056	0.0056
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0453	0.0453
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0453	0.0453
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0734	0.0734
Schistosoma mansoni	ran	0.0021	0.0411	0.0411
Schistosoma mansoni	hypothetical protein	0.0202	0.6488	0.6488
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0099	0.3017	0.3017
Brugia malayi	conserved hypotetical protein	0.0011	0.0056	0.0185
Brugia malayi	nuclear receptor RXR	0.0011	0.0056	0.0185
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0411	0.5602
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0098	0.0098
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0734	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0011	0.0056	0.0056
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0453	0.0453
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0453	0.0453
Brugia malayi	nuclear hormone receptor	0.0011	0.0056	0.0185
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0098	0.0098
Echinococcus granulosus	aldo keto reductase	0.0031	0.0734	0.0734
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0453	0.0453
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.2074	0.2074
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0474	0.6461
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0453	0.1502
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0734	0.2432
Onchocerca volvulus		0.0031	0.0734	0.3183
Onchocerca volvulus		0.0011	0.0056	0.0242

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 150 nM	Concentration required for GH-releasing activity in the rat pituitary cell assay was determined in vitro	ChEMBL.	9871779

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 44480