Detailed information for compound 44555

Basic information

Technical information
  • TDR Targets ID: 44555
  • Name: 2-[4-(diethoxyphosphorylmethyl)phenyl]-6,7-di methoxy-4-prop-2-enoxyquinazoline
  • MW: 472.471 | Formula: C24H29N2O6P
  • H donors: 0 H acceptors: 3 LogP: 3.87 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1nc(nc2c1cc(OC)c(c2)OC)c1ccc(cc1)CP(=O)(OCC)OCC
  • InChi: 1S/C24H29N2O6P/c1-6-13-30-24-19-14-21(28-4)22(29-5)15-20(19)25-23(26-24)18-11-9-17(10-12-18)16-33(27,31-7-2)32-8-3/h6,9-12,14-15H,1,7-8,13,16H2,2-5H3
  • InChiKey: HUGKGXGBMAPBER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-allyloxy-2-[4-(diethoxyphosphorylmethyl)phenyl]-6,7-dimethoxy-quinazoline
  • 4-allyloxy-2-[4-(diethoxyphosphorylmethyl)phenyl]-6,7-dimethoxyquinazoline
  • 2-[4-(diethoxyphosphorylmethyl)phenyl]-6,7-dimethoxy-4-prop-2-enoxy-quinazoline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni integrin alpha 0.0312 0.2196 0.2196
Schistosoma mansoni hypothetical protein 0.0067 0.0301 0.0301
Trichomonas vaginalis cyclins, putative 0.0045 0.0134 0.031
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0103 0.0581 1
Brugia malayi hypothetical protein 0.0049 0.0158 0.0259
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0035 0.0052 0.0052
Loa Loa (eye worm) integrin beta-2 0.0319 0.2254 0.3702
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.0147
Trypanosoma brucei unspecified product 0.0033 0.004 0.0465
Trichomonas vaginalis cyclins, putative 0.0045 0.0134 0.031
Plasmodium falciparum plasmepsin II 0.0103 0.0581 1
Trypanosoma cruzi trypanothione synthetase 0.007 0.0324 0.1067
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0103 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0103 0.0581 0.0954
Leishmania major cyclin 0.0045 0.0134 0.3032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0021 0.0014
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0089 1
Plasmodium falciparum plasmepsin I 0.0103 0.0581 1
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.0299 0.049
Giardia lamblia Furin precursor putative serine protease 0.0158 0.1002 0.4358
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0069 0.0116
Trichomonas vaginalis cyclin A, putative 0.0045 0.0134 0.031
Trichomonas vaginalis cyclin B, putative 0.0045 0.0134 0.031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0035
Plasmodium vivax aspartyl proteinase, putative 0.0103 0.0581 1
Leishmania major trypanothione synthetase, putative 0.007 0.0324 1
Trypanosoma brucei trypanothione synthetase, putative 0.007 0.0324 0.5684
Echinococcus granulosus glutamate receptor 2 0.0042 0.0108 0.0156
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0035 0.0052 0.0052
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0299 0.0589
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.1272 0.3476
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0049 0.0158 0.0259
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0021 0.0035
Schistosoma mansoni integrin beta subunit 0.0188 0.1238 0.1238
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0299 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Trypanosoma cruzi cyclin 6, putative 0.0045 0.0134 0.0324
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0021
Brugia malayi Cyclin, N-terminal domain containing protein 0.0045 0.0134 0.022
Loa Loa (eye worm) hypothetical protein 0.0073 0.0346 0.0567
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.0299 0.049
Brugia malayi proprotein convertase 2 0.0512 0.3745 0.6151
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0035 0.0052 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0035 0.0052 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.0147
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.0147
Loa Loa (eye worm) hypothetical protein 0.032 0.2256 0.3705
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0021 0.0035
Brugia malayi Subtilase family protein 0.0035 0.0052 0.0085
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0035 0.0052 0.5
Brugia malayi neuroendocrine convertase 1 precursor 0.0512 0.3745 0.6151
Brugia malayi Integrin alpha pat-2 precursor 0.0312 0.2196 0.3606
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0113
Trichomonas vaginalis cyclins, putative 0.0045 0.0134 0.031
Echinococcus granulosus furin 0.0815 0.6089 1
Trichomonas vaginalis cyclin B, putative 0.0045 0.0134 0.031
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0495 0.3615 0.5929
Onchocerca volvulus 0.0035 0.0052 0.2767
Schistosoma mansoni inhibitor of apoptosis protein 0.0052 0.0187 0.0187
Schistosoma mansoni inositol transporter 0.0145 0.0905 0.0905
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0103 0.0581 0.0954
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Echinococcus multilocularis integrin alpha ps 0.014 0.0864 0.1754
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0035 0.0052 0.0081
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0158 0.1002 0.2726
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0662 0.4908 0.806
Onchocerca volvulus 0.0037 0.0069 0.3681
Schistosoma mansoni glutamate receptor NMDA 0.0067 0.0299 0.0299
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0069 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0089 0.0147
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0052 0.0187 0.0359
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0052 0.0187 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0113
Echinococcus multilocularis solute carrier family 5 0.0145 0.0905 0.1839
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Echinococcus multilocularis epidermal growth factor receptor 0.0057 0.022 0.0427
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Loa Loa (eye worm) integrin alpha pat-2 0.0481 0.3503 0.5753
Loa Loa (eye worm) hypothetical protein 0.0236 0.1608 0.264
Plasmodium vivax plasmepsin IV, putative 0.0103 0.0581 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.1272 0.3476
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0089 0.1373
Brugia malayi endoprotease bli-4 precursor 0.0815 0.6089 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0145 0.0905 0.1839
Brugia malayi Kelch motif family protein 0.0049 0.0158 0.0259
Echinococcus granulosus integrin alpha ps 0.0067 0.0301 0.0475
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Loa Loa (eye worm) hypothetical protein 0.0245 0.1677 0.2754
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0085
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0103 0.0581 0.1554
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0052 0.0187 0.0307
Loa Loa (eye worm) hypothetical protein 0.0052 0.0187 0.0307
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0089 0.0185
Echinococcus multilocularis GPCR, family 2 0.0031 0.0021 0.0018
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0067 0.0299 0.0589
Echinococcus multilocularis integrin beta 2 0.0237 0.1613 0.3296
Echinococcus multilocularis integrin alpha 3 0.0239 0.1632 0.3335
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0158 0.1002 0.2726
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0299 0.0589
Echinococcus granulosus glutamate receptor 2 0.0067 0.0299 0.0471
Echinococcus granulosus neuroendocrine convertase 2 0.0512 0.3745 0.6143
Trypanosoma brucei mitotic cyclin 6 0.0045 0.0134 0.22
Onchocerca volvulus Deterin homolog 0.0052 0.0187 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0195 0.2705
Brugia malayi Integrin beta pat-3 precursor 0.0319 0.2254 0.3702
Trypanosoma cruzi CYC2-like cyclin, putative 0.0045 0.0134 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.008
Schistosoma mansoni cpg binding protein 0.003 0.0012 0.0012
Schistosoma mansoni cathepsin D (A01 family) 0.0304 0.2138 0.2138
Echinococcus granulosus sodium:glucose cotransporter 2 0.0145 0.0905 0.147
Loa Loa (eye worm) endoprotease bli-4 0.0815 0.6089 1
Plasmodium falciparum plasmepsin IV 0.0103 0.0581 1
Brugia malayi polk-prov protein 0.003 0.0015 0.0024
Echinococcus granulosus high affinity choline transporter 1 0.0037 0.0069 0.0093
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0299 0.0299
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0364 0.2599 1
Echinococcus multilocularis dna polymerase kappa 0.004 0.0089 0.0158
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0067 0.0299 0.0471
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Schistosoma mansoni glutamate receptor NMDA 0.0067 0.0299 0.0299
Echinococcus multilocularis inhibitor of apoptosis protein 0.0052 0.0187 0.0359
Echinococcus granulosus sodium:myo inositol cotransporter 0.0145 0.0905 0.147
Trichomonas vaginalis cyclin B, putative 0.0045 0.0134 0.031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0815 0.6089 0.6089
Plasmodium falciparum plasmepsin VI 0.0103 0.0581 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0299 0.0589
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0035 0.0052 0.5
Trichomonas vaginalis cyclin B, putative 0.0045 0.0134 0.031
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0236 0.1608 0.264
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.0299 0.049
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0299 0.0299
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Chlamydia trachomatis outer membrane protein PmpC 0.0073 0.0347 0.5
Brugia malayi GH02984p 0.0037 0.0069 0.0113
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0298 0.049
Trypanosoma cruzi trypanothione synthetase 0.007 0.0324 0.1067
Schistosoma mansoni ATP-binding cassette transporter 0.0067 0.0299 0.0299
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0021
Chlamydia trachomatis outer membrane protein PmpF 0.0073 0.0347 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.0134 0.022
Trypanosoma brucei RNA helicase, putative 0.01 0.0558 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0045 0.0134 0.022
Echinococcus multilocularis high affinity choline transporter 1 0.0037 0.0069 0.0116
Schistosoma mansoni tyrosine kinase 0.0057 0.022 0.022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0244 0.0244
Echinococcus granulosus dna polymerase kappa 0.004 0.0089 0.0126
Schistosoma mansoni cpg binding protein 0.003 0.0012 0.0012
Chlamydia trachomatis outer membrane protein PmpD 0.0073 0.0347 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0024
Echinococcus granulosus membrane bound transcription factor site 1 0.0035 0.0052 0.0065
Onchocerca volvulus 0.0052 0.0187 1
Schistosoma mansoni integrin alpha-ps 0.014 0.0864 0.0864
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0103 0.0581 0.0936
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0495 0.3615 0.7418
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.008
Echinococcus granulosus Furin 1 0.0192 0.1272 0.2072
Loa Loa (eye worm) hypothetical protein 0.0049 0.0158 0.0259
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Brugia malayi Furin-like cysteine rich region family protein 0.0057 0.022 0.0361
Chlamydia trachomatis outer membrane protein PmpB 0.0073 0.0347 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0089 0.0185
Echinococcus multilocularis glutamate receptor 2 0.0042 0.0108 0.0196
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0035 0.0052 0.0085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0021 0.0035
Loa Loa (eye worm) hypothetical protein 0.0067 0.0301 0.0494
Loa Loa (eye worm) glutamate receptor 2 0.0067 0.0299 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.008
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0069 0.0113
Echinococcus granulosus integrin alpha 3 0.0239 0.1632 0.2666
Schistosoma mansoni site-1 peptidase (S08 family) 0.0035 0.0052 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Schistosoma mansoni site-1 peptidase (S08 family) 0.0035 0.0052 0.0052
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0299 0.0471
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.1272 0.3476
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0089 1
Trypanosoma cruzi cyclin, putative 0.0045 0.0134 0.0324
Schistosoma mansoni hypothetical protein 0.0158 0.1002 0.1002
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Echinococcus granulosus solute carrier family 5 0.0145 0.0905 0.147
Echinococcus granulosus glutamate NMDA receptor subunit 0.0067 0.0299 0.0471
Echinococcus granulosus inhibitor of apoptosis protein 0.0052 0.0187 0.0287
Loa Loa (eye worm) hypothetical protein 0.0052 0.0187 0.0307
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0299 0.0299
Loa Loa (eye worm) TK/EGFR protein kinase 0.0057 0.022 0.0361
Schistosoma mansoni sodium/solute symporter 0.0037 0.0069 0.0069
Echinococcus multilocularis integrin alpha ps 0.014 0.0864 0.1754
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Echinococcus granulosus cyclin B 0.0045 0.0134 0.02
Loa Loa (eye worm) hypothetical protein 0.0172 0.1114 0.1829
Trypanosoma brucei trypanothione synthetase 0.007 0.0324 0.5684
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.1272 0.3476
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0331 0.2344 0.4801
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0035 0.0052 0.0085
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0089 0.1373
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0021
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0035 0.0052 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Trichomonas vaginalis cyclins, putative 0.0045 0.0134 0.031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Echinococcus multilocularis integrin alpha ps 0.0067 0.0301 0.0594
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trypanosoma cruzi cyclin, putative 0.0045 0.0134 0.0324
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Onchocerca volvulus 0.0045 0.0134 0.718
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0035 0.0052 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Brugia malayi Angiotensin-converting enzyme family protein 0.0662 0.4908 0.806
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0192 0.1272 0.1272
Chlamydia trachomatis outer membrane protein PmpE 0.0073 0.0347 0.5
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0052 0.0187 0.0187
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.1272 0.3476
Loa Loa (eye worm) hypothetical protein 0.0067 0.0298 0.049
Loa Loa (eye worm) hypothetical protein 0.0398 0.2861 0.4698
Echinococcus granulosus GPCR family 2 0.0031 0.0021 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.004 0.0465
Schistosoma mansoni furin-1 (S08 family) 0.0354 0.2526 0.2526
Loa Loa (eye worm) subtilase 0.0035 0.0052 0.0085
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0045 0.0134 0.3032
Echinococcus multilocularis membrane bound transcription factor site 1 0.0035 0.0052 0.0081
Brugia malayi Probable ATP-dependent helicase DHX35 0.0071 0.0332 0.0545
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0299 0.0589
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0299 0.0299
Mycobacterium leprae Possible secreted protease 0.0035 0.0052 0.5
Echinococcus multilocularis cyclin B 0.0045 0.0134 0.0251
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0021
Giardia lamblia High cysteine membrane protein Group 2 0.0303 0.2126 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0103 0.0581 0.1171
Toxoplasma gondii aspartyl protease ASP1 0.0103 0.0581 1
Echinococcus granulosus sodium:glucose cotransporter 0.0145 0.0905 0.147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0331 0.2344 0.3837
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0537 0.0882
Loa Loa (eye worm) hypothetical protein 0.0071 0.0332 0.0545
Schistosoma mansoni hypothetical protein 0.01 0.0558 0.0558
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0299 0.0471
Echinococcus granulosus integrin alpha ps 0.014 0.0864 0.1402
Schistosoma mansoni integrin alpha-ps 0.0073 0.0346 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Schistosoma mansoni cathepsin D (A01 family) 0.0304 0.2138 0.2138
Loa Loa (eye worm) proprotein convertase 2 0.0192 0.1272 0.2088
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0398 0.2861 0.4698
Echinococcus multilocularis 0.0657 0.4869 1
Entamoeba histolytica cyclin, putative 0.0045 0.0134 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Echinococcus granulosus integrin beta 2 0.0237 0.1613 0.2634
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.008
Loa Loa (eye worm) hypothetical protein 0.0815 0.6089 1
Brugia malayi celfurPC protein 0.0657 0.4869 0.7996
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.1272 0.3476
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Echinococcus multilocularis Furin 1 0.0192 0.1272 0.2593
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0158 0.1002 0.2726
Echinococcus multilocularis neuroendocrine convertase 2 0.0512 0.3745 0.7686
Loa Loa (eye worm) DEAH box polypeptide 35 0.0071 0.0332 0.0545
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0035 0.0052 0.5
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0067 0.0299 0.0589
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.024 0.164 0.164
Schistosoma mansoni high-affinity choline transporter 0.0037 0.0069 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Loa Loa (eye worm) hypothetical protein 0.0045 0.0134 0.022
Schistosoma mansoni hypothetical protein 0.0067 0.0298 0.0298
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0035 0.0052 0.0684
Schistosoma mansoni cyclin B 0.0045 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0495 0.3615 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0299 0.0589
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0052 0.008
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0052 0.0187 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1002 0.2726
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0537 0.0882
Trichomonas vaginalis hypothetical protein 0.0158 0.1002 0.2726
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0145 0.0905 0.1839
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0495 0.3615 1
Schistosoma mansoni hypothetical protein 0.0052 0.0187 0.0187
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0069 0.0093
Trypanosoma brucei subtilisin peptidase 0.0035 0.0052 0.0684
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0299 0.0471
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0021 0.0018
Schistosoma mansoni inositol transporter 0.0145 0.0905 0.0905
Echinococcus granulosus epidermal growth factor receptor 0.0057 0.022 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0089 0.1373

Activities

Activity type Activity value Assay description Source Reference
Change (functional) < -71 % Effect on change in plasma triglycerides (TG) in triton-induced hyperlipedimic rats after peroral administration of 100 mg/kg. ChEMBL. 8691473
Change (functional) < -35 % Effect on change in total cholesterol (TC) in triton-induced hyperlipedimic rats after peroral administration of 100 mg/kg. ChEMBL. 8691473

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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