TDR Targets

Basic information

Technical information

TDR Targets ID: 447696
Name: 1-(2-chloro-2-phenylethyl)-N-[(2-chlorophenyl )methyl]-6-methylsulfanylpyrazolo[3,4-d]pyrim idin-4-amine
MW: 444.38 | Formula: C21H19Cl2N5S
H donors: 1 H acceptors: 3 LogP: 5.52 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CSc1nc(NCc2ccccc2Cl)c2c(n1)n(nc2)CC(c1ccccc1)Cl
InChi: 1S/C21H19Cl2N5S/c1-29-21-26-19(24-11-15-9-5-6-10-17(15)22)16-12-25-28(20(16)27-21)13-18(23)14-7-3-2-4-8-14/h2-10,12,18H,11,13H2,1H3,(H,24,26,27)
InChiKey: XNWHPCMDUYIUSL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-chloro-2-phenyl-ethyl)-N-[(2-chlorophenyl)methyl]-6-methylsulfanyl-pyrazolo[3,4-d]pyrimidin-4-amine
1-(2-chloro-2-phenylethyl)-N-[(2-chlorophenyl)methyl]-6-(methylthio)-4-pyrazolo[3,4-d]pyrimidinamine
(2-chlorobenzyl)-[1-(2-chloro-2-phenyl-ethyl)-6-(methylthio)pyrazolo[3,4-d]pyrimidin-4-yl]amine
1-(2-chloro-2-phenylethyl)-N-[(2-chlorophenyl)methyl]-6-methylsulfanylpyrazolo[4,5-e]pyrimidin-4-amine
1-(2-chloro-2-phenyl-ethyl)-N-[(2-chlorophenyl)methyl]-6-methylsulfanyl-pyrazolo[4,5-e]pyrimidin-4-amine
1-(2-chloro-2-phenylethyl)-N-[(2-chlorophenyl)methyl]-6-(methylthio)-4-pyrazolo[4,5-e]pyrimidinamine
(2-chlorobenzyl)-[1-(2-chloro-2-phenyl-ethyl)-6-(methylthio)pyrazolo[4,5-e]pyrimidin-4-yl]amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0178	0.2246	0.1996
Brugia malayi	fibroinase precursor	0.0062	0.0312	0.0275
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0124	0.134	0.316
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0257	0.3564	0.3539
Brugia malayi	Papain family cysteine protease containing protein	0.0257	0.3564	0.3539
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0312	0.0275
Onchocerca volvulus		0.0124	0.134	0.316
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0124	0.134	0.134
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0124	0.134	0.1306
Echinococcus multilocularis	dro:myosuppressin receptor	0.0124	0.134	0.134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0124	0.134	0.134
Echinococcus granulosus	cathepsin b	0.0643	1	1
Schistosoma mansoni	cathepsin s	0.0079	0.0595	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.163	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0643	1	1
Schistosoma mansoni	histamine h1 receptor	0.0124	0.134	0.1189
Schistosoma mansoni	cathepsin F (C01 family)	0.0257	0.3564	0.3452
Echinococcus granulosus	hypothetical protein	0.0124	0.134	0.134
Trypanosoma cruzi	cysteine peptidase, putative	0.0257	0.3564	0.3357
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0312	0.0275
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0124	0.134	0.1189
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0257	0.3564	0.3564
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0124	0.134	0.1306
Entamoeba histolytica	cysteine proteinase, putative	0.0257	0.3564	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0257	0.3564	0.3564
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	cathepsin B	0.0242	0.3308	0.3283
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0124	0.134	0.1189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0257	0.3564	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0124	0.134	0.134
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.0312	0.0275
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0124	0.134	0.134
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0171	0.0171
Schistosoma mansoni	hypothetical protein	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Brugia malayi	Cathepsin L-like precursor	0.0257	0.3564	0.3539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0054	0.0171	0.0171
Schistosoma mansoni	adenoreceptor	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2246	0.2216
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0046	0.0038	0.0038
Brugia malayi	RE15519p	0.0124	0.134	0.1306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Schistosoma mansoni	amine GPCR	0.0124	0.134	0.1189
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.0595	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Brugia malayi	cathepsin F-like cysteine proteinase	0.0062	0.0312	0.0275
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0054	0.0171	0.0171
Onchocerca volvulus	Cathepsin F homolog	0.0257	0.3564	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0054	0.0171	0.0171
Giardia lamblia	Cathepsin B precursor	0.0242	0.3308	1
Schistosoma mansoni	myosin xvIII	0.0124	0.134	0.1189
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0257	0.3564	0.3539
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0124	0.134	0.134
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0062	0.0312	0.0143
Echinococcus granulosus	cysteine protease	0.0141	0.163	0.163
Brugia malayi	G protein-coupled receptor F59B2.13	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0595	0.0559
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0141	0.163	0.1361
Plasmodium vivax	vivapain-1	0.0141	0.163	0.4054
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0171	0.0171
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0054	0.0171	0.0171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.2246	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0257	0.3564	0.3539
Schistosoma mansoni	neuropeptide F-like receptor	0.0124	0.134	0.1189
Echinococcus multilocularis	neuropeptide receptor A26	0.0124	0.134	0.134
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0062	0.0312	0.0275
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	neuropeptide s receptor	0.0124	0.134	0.134
Schistosoma mansoni	biogenic amine receptor	0.0124	0.134	0.1189
Echinococcus granulosus	neuropeptide FF receptor 2	0.0124	0.134	0.134
Echinococcus multilocularis	fmrfamide receptor	0.0124	0.134	0.134
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0257	0.3564	0.3564
Brugia malayi	Dopamine receptor	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	rhodopsin orphan GPCR	0.0124	0.134	0.134
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Brugia malayi	G protein-coupled receptor	0.0124	0.134	0.1306
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0124	0.134	0.134
Brugia malayi	Cathepsin L-like precursor	0.0178	0.2246	0.2216
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0312	0.0143
Brugia malayi	G-protein coupled receptor	0.0124	0.134	0.1306
Brugia malayi	Melatonin receptor type 1A	0.0124	0.134	0.1306
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.0312	0.0143
Echinococcus granulosus	fmrfamide receptor	0.0124	0.134	0.134
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0171	0.0171
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0124	0.134	0.1189
Brugia malayi	cathepsin L precursor	0.0062	0.0312	0.0275
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Brugia malayi	Cathepsin L-like precursor	0.0178	0.2246	0.2216
Brugia malayi	follicle stimulating hormone receptor	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Echinococcus multilocularis	neuropeptide receptor	0.0124	0.134	0.134
Loa Loa (eye worm)	fibroinase	0.0257	0.3564	0.3539
Echinococcus granulosus	rhodopsin orphan GPCR	0.0124	0.134	0.134
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0312	0.0143
Echinococcus multilocularis	g protein coupled receptor	0.0124	0.134	0.134
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0124	0.134	0.316
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0054	0.0171	0.0171
Echinococcus granulosus	orexin receptor type 2	0.0124	0.134	0.134
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Trypanosoma cruzi	cysteine protease, putative	0.0141	0.163	0.1361
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0046	0.0038	0.0038
Echinococcus granulosus	cathepsin L	0.0062	0.0312	0.0312
Echinococcus multilocularis	cysteine protease	0.0257	0.3564	0.3564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Schistosoma mansoni	neuropeptide receptor	0.0124	0.134	0.1189
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0257	0.3564	1
Echinococcus multilocularis	allatostatin A receptor	0.0124	0.134	0.134
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0114	0.1172	0.1172
Echinococcus granulosus	7TM GPCR rhodopsin	0.0124	0.134	0.134
Echinococcus multilocularis	cathepsin L	0.0062	0.0312	0.0312
Brugia malayi	larval opioid receptor	0.0124	0.134	0.1306
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Onchocerca volvulus		0.0257	0.3564	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0595	0.0292
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0124	0.134	0.1189
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0124	0.134	0.1306
Schistosoma mansoni	growth hormone secretagogue receptor	0.0124	0.134	0.1189
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0124	0.134	0.134
Brugia malayi	GnHR receptor homolog	0.0124	0.134	0.1306
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0643	1	1
Brugia malayi	neuropeptide F receptor	0.0124	0.134	0.1306
Brugia malayi	Serotonin receptor	0.0124	0.134	0.1306
Brugia malayi	Cathepsin L-like precursor	0.0257	0.3564	0.3539
Trypanosoma cruzi	cysteine proteinase, putative	0.0141	0.163	0.1361
Echinococcus granulosus	rhodopsin orphan GPCR	0.0124	0.134	0.134
Echinococcus granulosus	tm gpcr rhodopsin	0.0124	0.134	0.134
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0124	0.134	0.1189
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0257	0.3564	1
Echinococcus multilocularis	g protein coupled receptor	0.0124	0.134	0.134
Schistosoma mansoni	hypothetical protein	0.0124	0.134	0.1189
Giardia lamblia	Cathepsin B precursor	0.0242	0.3308	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0124	0.134	0.134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Schistosoma mansoni	tyrosine kinase	0.0251	0.3468	0.3354
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0124	0.134	0.1306
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0124	0.134	0.1306
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.0312	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0312	0.0275
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	neuropeptide receptor	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	biogenic amine receptor	0.0124	0.134	0.1189
Onchocerca volvulus		0.0124	0.134	0.316
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0124	0.134	0.134
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0062	0.0312	0.0275
Echinococcus granulosus	rhodopsin orphan GPCR	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0124	0.134	0.134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0046	0.0038	0.0038
Brugia malayi	cathepsin L-like precursor	0.0178	0.2246	0.2216
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Echinococcus multilocularis	G protein coupled receptor 139	0.0124	0.134	0.134
Entamoeba histolytica	cysteine proteinase 2	0.0141	0.163	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0124	0.134	0.1189
Brugia malayi	Tyrosine-protein kinase abl-1	0.0114	0.1172	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0124	0.134	0.134
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0124	0.134	0.1189
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0171	0.0171
Echinococcus granulosus	biogenic amine 5HT receptor	0.0124	0.134	0.134
Echinococcus granulosus	g protein coupled receptor	0.0124	0.134	0.134
Brugia malayi	SRC-1	0.0054	0.0171	0.0134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Onchocerca volvulus		0.0124	0.134	0.316
Schistosoma mansoni	opsin-like receptor	0.0124	0.134	0.1189
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.0312	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0903	0.0868
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0054	0.0171	0.0171
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0312	0.0143
Echinococcus granulosus	G protein coupled receptor 139	0.0124	0.134	0.134
Onchocerca volvulus	Cathepsin L homolog	0.0257	0.3564	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0242	0.3308	0.8677
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0312	0.0275
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.1842	0.181
Onchocerca volvulus		0.0124	0.134	0.316
Trypanosoma cruzi	cysteine proteinase, putative	0.0141	0.163	0.1361
Loa Loa (eye worm)	TK/ABL protein kinase	0.026	0.3605	0.358
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Giardia lamblia	Cathepsin B precursor	0.0242	0.3308	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0257	0.3564	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.026	0.3605	0.3605
Trypanosoma cruzi	cysteine peptidase, putative	0.0257	0.3564	0.3357
Schistosoma mansoni	biogenic amine receptor	0.0124	0.134	0.1189
Echinococcus granulosus	rhodopsin orphan GPCR	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0595	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0178	0.2246	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus multilocularis	cathepsin L cysteine protease	0.0257	0.3564	0.3564
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0124	0.134	0.1189
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Onchocerca volvulus		0.0124	0.134	0.316
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0595	0.0559
Brugia malayi	Cathepsin L-like precursor	0.0257	0.3564	0.3539
Schistosoma mansoni	amine GPCR	0.0124	0.134	0.1189
Brugia malayi	AKH receptor	0.0124	0.134	0.1306
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0124	0.134	0.1189
Echinococcus granulosus	g protein coupled receptor	0.0124	0.134	0.134
Brugia malayi	sulfakinin receptor protein	0.0124	0.134	0.1306
Echinococcus granulosus	serotonin receptor	0.0124	0.134	0.134
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0124	0.134	0.134
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Echinococcus granulosus	tm gpcr rhodopsin	0.0124	0.134	0.134
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Onchocerca volvulus		0.0124	0.134	0.316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0124	0.134	0.1189
Echinococcus granulosus	neuropeptides capa receptor	0.0124	0.134	0.134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0312	0.0143
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Onchocerca volvulus		0.0124	0.134	0.316
Schistosoma mansoni	opsin-like receptor	0.0124	0.134	0.1189
Echinococcus multilocularis	cathepsin b	0.0643	1	1
Echinococcus granulosus	neuropeptide receptor A26	0.0124	0.134	0.134
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0124	0.134	0.134
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0643	1	1
Onchocerca volvulus		0.0257	0.3564	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0141	0.163	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0312	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	tyrosine kinase	0.0046	0.0038	0.0038
Schistosoma mansoni	amine GPCR	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.163	0.1598
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0054	0.0171	0.0171
Echinococcus granulosus	somatostatin receptor	0.0124	0.134	0.134
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0141	0.163	0.4054
Onchocerca volvulus		0.0178	0.2246	0.5946
Brugia malayi	neuropeptide F receptor	0.0124	0.134	0.1306
Echinococcus multilocularis	serotonin receptor	0.0124	0.134	0.134
Echinococcus granulosus	neuropeptide receptor	0.0124	0.134	0.134
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0171	0.0171
Schistosoma mansoni	cathepsin S (C01 family)	0.0062	0.0312	0.0143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.2246	0.5946
Brugia malayi	putative neuropeptide receptor	0.0124	0.134	0.1306
Loa Loa (eye worm)	ctsf protein	0.0257	0.3564	0.3539
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Plasmodium vivax	unspecified product	0.0141	0.163	0.4054
Echinococcus multilocularis	neuropeptides capa receptor	0.0124	0.134	0.134
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0124	0.134	0.134
Onchocerca volvulus		0.0124	0.134	0.316
Onchocerca volvulus		0.0257	0.3564	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Echinococcus multilocularis	neuropeptide receptor	0.0124	0.134	0.134
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0171	0.0171
Brugia malayi	Serotonin receptor	0.0124	0.134	0.1306
Toxoplasma gondii	cathepsin CPL	0.0257	0.3564	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0124	0.134	0.134
Schistosoma mansoni	neuropeptide f receptor 76f	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0312	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0124	0.134	0.1189
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0124	0.134	0.1306
Plasmodium vivax	vivapain-2	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2246	0.2216
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0124	0.134	0.134
Schistosoma mansoni	cathepsin F (C01 family)	0.0178	0.2246	0.211
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0124	0.134	0.134
Brugia malayi	Dopamine receptor protein 2	0.0124	0.134	0.1306
Echinococcus multilocularis	neuropeptides capa receptor	0.0124	0.134	0.134
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	hypothetical protein	0.0124	0.134	0.1189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0124	0.134	0.1306
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0062	0.0312	0.0143
Leishmania major	cysteine peptidase A (CPA)	0.0257	0.3564	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0257	0.3564	0.3357
Entamoeba histolytica	cysteine protease, putative	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Onchocerca volvulus		0.0124	0.134	0.316
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0257	0.3564	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0124	0.134	0.134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0124	0.134	0.134
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0312	0.0275
Loa Loa (eye worm)	melatonin receptor type 1A	0.0124	0.134	0.1306
Echinococcus multilocularis	g-protein coupled receptor	0.0124	0.134	0.134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0054	0.0171	0.0171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Echinococcus granulosus	cathepsin L cysteine protease	0.0141	0.163	0.163
Echinococcus multilocularis	cathepsin L	0.0141	0.163	0.163
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0124	0.134	0.1189
Onchocerca volvulus		0.0257	0.3564	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.0312	0.0275
Brugia malayi	cathepsin F-like cysteine proteinase	0.0079	0.0595	0.0559
Onchocerca volvulus	Cathepsin L homolog	0.0257	0.3564	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0054	0.0171	0.0171
Echinococcus granulosus	cathepsin l1	0.0257	0.3564	0.3564
Echinococcus multilocularis	cathepsin L cysteine protease	0.0257	0.3564	0.3564
Schistosoma mansoni	cathepsin F (C01 family)	0.0257	0.3564	0.3452
Echinococcus multilocularis	g protein coupled receptor	0.0124	0.134	0.134
Echinococcus granulosus	neuropeptide receptor	0.0124	0.134	0.134
Echinococcus multilocularis	serotonin receptor	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Echinococcus granulosus	cathepsin l1	0.0178	0.2246	0.2246
Echinococcus granulosus	tm gpcr rhodopsin	0.0124	0.134	0.134
Echinococcus multilocularis	orexin receptor type 2	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	allatostatin A receptor	0.0124	0.134	0.134
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.3308	0.3192
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0257	0.3564	0.3564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.163	0.1598
Brugia malayi	Cathepsin L-like precursor	0.0257	0.3564	0.3539
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	neuropeptide F-like receptor	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2246	0.2216
Schistosoma mansoni	amine GPCR	0.0124	0.134	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	G-protein coupled receptor	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0643	1	1
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.163	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.163	0.4054
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0124	0.134	0.134
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0124	0.134	0.1189
Schistosoma mansoni	neuropeptide receptor	0.0124	0.134	0.1189
Schistosoma mansoni	hypothetical protein	0.0124	0.134	0.1189
Echinococcus granulosus	sex peptide receptor	0.0124	0.134	0.134
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0643	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.163	0.4054
Echinococcus granulosus	tyrosine protein kinase Blk	0.0046	0.0038	0.0038
Echinococcus multilocularis	sex peptide receptor	0.0124	0.134	0.134
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0124	0.134	0.134
Echinococcus multilocularis	cathepsin b	0.0643	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0141	0.163	0.1484
Echinococcus multilocularis	somatostatin receptor	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	dro:myosuppressin receptor	0.0124	0.134	0.134
Brugia malayi	putative neuropeptide receptor NPR1	0.0124	0.134	0.1306
Loa Loa (eye worm)	neuropeptide F receptor	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Onchocerca volvulus		0.0124	0.134	0.316
Loa Loa (eye worm)	hypothetical protein	0.0257	0.3564	0.3539
Echinococcus granulosus	g protein coupled receptor	0.0124	0.134	0.134
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0124	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0038	0.0038
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0124	0.134	0.1306
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.163	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	biogenic amine 5HT receptor	0.0124	0.134	0.134
Schistosoma mansoni	neuropeptide receptor	0.0124	0.134	0.1189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0312	0.0275
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.163	0.4054
Brugia malayi	G-protein coupled receptor	0.0124	0.134	0.1306
Echinococcus granulosus	neuropeptides capa receptor	0.0124	0.134	0.134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0257	0.3564	0.3357
Loa Loa (eye worm)	G-protein coupled receptor	0.0124	0.134	0.1306
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0124	0.134	0.134
Brugia malayi	Dopamine receptor protein 1	0.0124	0.134	0.1306
Trypanosoma cruzi	cruzipain precursor, putative	0.0079	0.0595	0.0292
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0124	0.134	0.1189
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Plasmodium vivax	vivapain-2	0.0257	0.3564	1
Echinococcus granulosus	cathepsin L	0.0141	0.163	0.163
Echinococcus granulosus	g-protein coupled receptor	0.0124	0.134	0.134
Schistosoma mansoni	cathepsin B (C01 family)	0.0062	0.0312	0.0143
Schistosoma mansoni	amine GPCR	0.0124	0.134	0.1189
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0643	1	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0124	0.134	0.1189
Brugia malayi	cathepsin L-like cysteine proteinase	0.0062	0.0312	0.0275
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.0312	0.0275
Echinococcus granulosus	neuropeptide Y receptor	0.0124	0.134	0.134
Brugia malayi	Cathepsin L-like precursor	0.0257	0.3564	0.3539
Onchocerca volvulus		0.0257	0.3564	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Schistosoma mansoni	opsin-like receptor	0.0124	0.134	0.1189
Onchocerca volvulus		0.0124	0.134	0.316
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Onchocerca volvulus		0.0124	0.134	0.316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0312	0.0143
Plasmodium vivax	vivapain-3	0.0141	0.163	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0257	0.3564	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.026	0.3605	0.3605
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0124	0.134	0.1306
Onchocerca volvulus		0.0124	0.134	0.316
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0124	0.134	0.134
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0124	0.134	0.1306
Onchocerca volvulus		0.0257	0.3564	1
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0242	0.3308	0.9214
Brugia malayi	ORL1-like opioid receptor	0.0124	0.134	0.1306
Echinococcus multilocularis	neuropeptide s receptor	0.0124	0.134	0.134
Echinococcus granulosus	neuropeptide Y receptor	0.0124	0.134	0.134
Echinococcus multilocularis	fmrfamide receptor	0.0124	0.134	0.134
Onchocerca volvulus		0.0124	0.134	0.316
Trypanosoma cruzi	cysteine peptidase, putative	0.0257	0.3564	0.3357
Plasmodium vivax	unspecified product	0.0079	0.0595	0.087
Echinococcus granulosus	rhodopsin orphan GPCR	0.0124	0.134	0.134
Toxoplasma gondii	cathepsin B	0.0242	0.3308	0.9214
Schistosoma mansoni	cathepsin C	0.0062	0.0312	0.0143
Entamoeba histolytica	cysteine protease, putative	0.0141	0.163	0.4054
Onchocerca volvulus		0.0124	0.134	0.316
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	TYRA-2 protein	0.0124	0.134	0.1306
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0141	0.163	0.1484
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0054	0.0171	0.0171
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0242	0.3308	0.3093
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0054	0.0171	0.0171
Onchocerca volvulus		0.0124	0.134	0.316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.163	0.4054
Echinococcus multilocularis	cysteine protease	0.0257	0.3564	0.3564
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Entamoeba histolytica	cysteine proteinase, putative	0.0178	0.2246	0.5946
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0124	0.134	0.134
Echinococcus granulosus	cathepsin b	0.0643	1	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0595	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Echinococcus granulosus	7tm_1 domain containing protein	0.0124	0.134	0.134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Loa Loa (eye worm)	cysteine protease	0.0257	0.3564	0.3539
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Onchocerca volvulus		0.0124	0.134	0.316
Loa Loa (eye worm)	SRC-1	0.0054	0.0171	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0312	0.0275
Leishmania major	cathepsin L-like protease	0.0257	0.3564	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0257	0.3564	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0079	0.0595	0.0559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0257	0.3564	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0141	0.163	0.1484
Brugia malayi	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0124	0.134	0.1306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0257	0.3564	1
Onchocerca volvulus		0.0257	0.3564	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 101.7 %	Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 24 hrs by MTT assay	ChEMBL.	17929792
Activity (functional)	= 101.7 %	Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 24 hrs by MTT assay	ChEMBL.	17929792
Activity (functional)	= 101.7 %	Antiproliferative activity against human Saos2 cells assessed as cell viability at 12.5 uM after 24 hrs by MTT assay relative to control	ChEMBL.	19410338
Activity (functional)	= 102.1 %	Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 48 hrs by MTT assay	ChEMBL.	17929792
Activity (functional)	= 102.1 %	Antiproliferative activity against human SaOS2 cells assessed as cellular viability at 12.5 uM after 48 hrs by MTT assay	ChEMBL.	17929792
Inhibition (binding)		Inhibition human recombinant cSRC using KVEKIGEGTYGVVYK peptide substrate at 100 uM in presence of [gamma-32P]-ATP	ChEMBL.	21856155
Inhibition (ADMET)	= 85 %	Inhibition of human osteoblast growth at 25 uM after 48 hrs by MTT assay	ChEMBL.	17929792
Ki (binding)	= 0.089 uM	Inhibition human recombinant Abl using Abtide peptide substrate in presence of [gamma-32P]-ATP	ChEMBL.	21856155
Ki (binding)	= 0.09 uM	Inhibition of human recombinant Abl	ChEMBL.	19410338
Ki (binding)	= 3.1 uM	Inhibition of human recombinant Src	ChEMBL.	17929792
Ki (binding)	= 3.1 uM	Inhibition of human recombinant Src	ChEMBL.	17929792
Ki (binding)	= 3.1 uM	Inhibition of human recombinant Src	ChEMBL.	19410338

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL236375
PubChem: 23655679

Bibliographic References

3 literature references were collected for this gene.

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Detailed information for compound 447696