Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Mycobacterium leprae | Possible secreted protease | 0.0067 | 0.0803 | 0.5 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0067 | 0.0803 | 0.0803 |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0067 | 0.0803 | 0.5 |
Echinococcus granulosus | geminin | 0.0334 | 0.7153 | 0.7078 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0363 | 0.0363 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0256 | 0.0256 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.0067 | 0.0803 | 0.0561 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0373 | 0.0373 |
Leishmania major | subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trypanosoma brucei | serine peptidase, clan SB, family S8-like protein | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0067 | 0.0803 | 0.0803 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0373 | 0.0373 |
Schistosoma mansoni | site-1 peptidase (S08 family) | 0.0067 | 0.0803 | 0.0803 |
Mycobacterium ulcerans | membrane-anchored serine protease (mycosin), MycP4 | 0.0067 | 0.0803 | 0.5 |
Brugia malayi | Hypothetical subtilase-type proteinase F21H12.6 in chromosome II | 0.0067 | 0.0803 | 0.0803 |
Plasmodium vivax | subtilisin-like serine protease, putative | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.27 | 0.27 |
Toxoplasma gondii | subtilisin SUB9 | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0067 | 0.0803 | 0.5 |
Brugia malayi | celfurPC protein | 0.0067 | 0.0803 | 0.0803 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.7153 | 0.7153 |
Toxoplasma gondii | subtilisin SUB12 | 0.0067 | 0.0803 | 0.5 |
Brugia malayi | proprotein convertase 2 | 0.0067 | 0.0803 | 0.0803 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.0067 | 0.0803 | 0.0561 |
Plasmodium falciparum | subtilisin-like protease 1 | 0.0067 | 0.0803 | 0.5 |
Brugia malayi | hypothetical protein | 0.0147 | 0.27 | 0.27 |
Toxoplasma gondii | subtilisin SUB6 | 0.0067 | 0.0803 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0256 | 0.0256 |
Mycobacterium tuberculosis | Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | subtilase | 0.0067 | 0.0803 | 0.0803 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0256 | 0.0256 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0067 | 0.0803 | 0.0803 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Mycobacterium ulcerans | proline rich membrane-anchored mycosin MycP5 | 0.0067 | 0.0803 | 0.5 |
Toxoplasma gondii | subtilisin SUB2 | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0067 | 0.0803 | 0.5 |
Onchocerca volvulus | 0.0147 | 0.27 | 0.2425 | |
Mycobacterium ulcerans | membrane-anchored mycosin MycP3 | 0.0067 | 0.0803 | 0.5 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0067 | 0.0803 | 0.0803 |
Mycobacterium tuberculosis | Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) | 0.0067 | 0.0803 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0373 | 0.0373 |
Toxoplasma gondii | subtilisin SUB5 | 0.0067 | 0.0803 | 0.5 |
Plasmodium falciparum | subtilisin-like protease 3 | 0.0067 | 0.0803 | 0.5 |
Brugia malayi | Subtilase family protein | 0.0067 | 0.0803 | 0.0803 |
Toxoplasma gondii | subtilisin SUB4 | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Toxoplasma gondii | subtilisin SUB1 | 0.0067 | 0.0803 | 0.5 |
Echinococcus multilocularis | 0.0067 | 0.0803 | 0.0561 | |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0067 | 0.0803 | 0.0561 |
Mycobacterium leprae | PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) | 0.0067 | 0.0803 | 0.5 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0067 | 0.0803 | 0.0561 |
Mycobacterium tuberculosis | Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) | 0.0067 | 0.0803 | 0.5 |
Trypanosoma cruzi | subtilisin peptidase | 0.0067 | 0.0803 | 0.5 |
Toxoplasma gondii | subtilisin SUB8 | 0.0067 | 0.0803 | 0.5 |
Echinococcus multilocularis | Furin 1 | 0.0067 | 0.0803 | 0.0561 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0256 | 0.0256 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Plasmodium vivax | subtilisin-like protease 1 | 0.0067 | 0.0803 | 0.5 |
Mycobacterium leprae | PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) | 0.0067 | 0.0803 | 0.5 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0067 | 0.0803 | 0.0803 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0067 | 0.0803 | 0.0561 |
Toxoplasma gondii | subtilisin SUB11 | 0.0067 | 0.0803 | 0.5 |
Brugia malayi | endoprotease bli-4 precursor | 0.0067 | 0.0803 | 0.0803 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0067 | 0.0803 | 0.0561 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0067 | 0.0803 | 0.0803 |
Echinococcus multilocularis | tumor protein p63 | 0.0335 | 0.7178 | 0.7104 |
Plasmodium vivax | subtilisin-like protease 2, putative | 0.0067 | 0.0803 | 0.5 |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Mycobacterium tuberculosis | Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Toxoplasma gondii | subtilisin SUB7 | 0.0067 | 0.0803 | 0.5 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0067 | 0.0803 | 0.0803 |
Trypanosoma cruzi | serine peptidase, clan SB, family S8-like protein | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Plasmodium falciparum | subtilisin-like protease 2 | 0.0067 | 0.0803 | 0.5 |
Schistosoma mansoni | site-1 peptidase (S08 family) | 0.0453 | 1 | 1 |
Trypanosoma brucei | subtilisin peptidase | 0.0067 | 0.0803 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0335 | 0.7178 | 0.7104 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Echinococcus multilocularis | membrane bound transcription factor site 1 | 0.0453 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0373 | 0.0373 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0256 | 0.0256 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0067 | 0.0803 | 0.5 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0067 | 0.0803 | 0.0803 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0803 | 0.0803 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0363 | 0.0363 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0067 | 0.0803 | 0.5 |
Toxoplasma gondii | subtilisin SUB10 | 0.0067 | 0.0803 | 0.5 |
Echinococcus multilocularis | geminin | 0.0334 | 0.7153 | 0.7078 |
Echinococcus granulosus | Furin 1 | 0.0067 | 0.0803 | 0.0561 |
Onchocerca volvulus | 0.0453 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 1 | 1 |
Echinococcus granulosus | furin | 0.0067 | 0.0803 | 0.0561 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.7153 | 0.7153 |
Echinococcus granulosus | membrane bound transcription factor site 1 | 0.0453 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 25.5 mg Kg-1 | Anticonvulsant activity against MES-induced seizure in ip dosed C57B/6 mouse by MES test | ChEMBL. | 17761423 |
ED50 (functional) | = 25.5 mg Kg-1 | Anticonvulsant activity against MES-induced seizure in ip dosed C57B/6 mouse by MES test | ChEMBL. | 17761423 |
Ratio TD50/ED50 (functional) | = 4 | Protective index, ratio of TD50 for C57B/6 mouse by rotarod test to ED50 for C57B/6 mouse by MES test | ChEMBL. | 17761423 |
TD50 (ADMET) | = 101 mg Kg-1 | Neurotoxicity in ip dosed C57B/6 mouse after 30 mins by rotarod test | ChEMBL. | 17761423 |
TD50 (ADMET) | = 101 mg Kg-1 | Neurotoxicity in ip dosed C57B/6 mouse after 30 mins by rotarod test | ChEMBL. | 17761423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.