TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 304.389 | Formula: C19H20N4
H donors: 0 H acceptors: 3 LogP: 4.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ncc2c(n1)n(CC(C)(C)C)c(c2)Cc1ccccc1
InChi: 1S/C19H20N4/c1-19(2,3)13-23-16(9-14-7-5-4-6-8-14)10-15-12-21-17(11-20)22-18(15)23/h4-8,10,12H,9,13H2,1-3H3
InChiKey: MTWFVGHXLPKAPY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0378	0.2664
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1291	0.1776
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0378	0.077
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.1773	1
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0378	0.0521
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1291	0.2503
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1291	0.2503
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.1291	0.125
Brugia malayi	hypothetical protein	0.005	0.1143	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0669	0.0914
Entamoeba histolytica	cysteine protease, putative	0.0054	0.1291	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1291	0.188
Echinococcus granulosus	cysteine protease	0.0028	0.0378	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Onchocerca volvulus		0.0054	0.1291	0.3235
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0834	0.4564
Onchocerca volvulus		0.0054	0.1291	0.3235
Echinococcus granulosus	chromobox protein 1	0.0068	0.1773	0.3437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Schistosoma mansoni	dihydrofolate reductase	0.0043	0.0895	0.1304
Echinococcus granulosus	thymidylate synthase	0.0104	0.3054	0.5922
Trypanosoma cruzi	cysteine protease, putative	0.0028	0.0378	0.077
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0066	0.1709	0.2488
Echinococcus granulosus	dihydrofolate reductase	0.0043	0.0895	0.1736
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0031	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0669	0.3603
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0834	0.1484
Echinococcus multilocularis	geminin	0.0165	0.5158	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1709	0.2346
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.0031	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0104	0.3054	0.4447
Leishmania major	methionine synthase, putative	0.0112	0.3311	0.7263
Loa Loa (eye worm)	fibroinase	0.0054	0.1291	0.1771
Schistosoma mansoni	hypothetical protein	0.0165	0.5158	0.751
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1291	0.2503
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0047	0.5
Echinococcus granulosus	cathepsin L	0.0028	0.0378	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0734	0.3981
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0669	0.0914
Brugia malayi	Carboxylesterase family protein	0.0066	0.1709	0.2351
Onchocerca volvulus		0.0054	0.1291	0.3235
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0669	0.0974
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1291	0.3235
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0087	0.2437	0.4725
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.1143	0.6352
Echinococcus granulosus	cathepsin l1	0.0054	0.1291	0.2503
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Echinococcus granulosus	cathepsin l1	0.0036	0.0669	0.1296
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0017	0.0005	0.0007
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768
Brugia malayi	Fli-1 protein	0.0214	0.6868	0.9451
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0047	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0669	0.0914
Brugia malayi	chromobox protein homolog 3	0.0038	0.0734	0.101
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Echinococcus granulosus	geminin	0.0165	0.5158	1
Brugia malayi	Dihydrofolate reductase	0.0043	0.0895	0.1232
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.007	0.1866	0.2562
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1291	0.3235
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0378	0.0551
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0378	0.077
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0669	0.092
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.005	0.1143	0.2466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Brugia malayi	Heterochromatin protein 1	0.0068	0.1773	0.2439
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0036	0.0669	0.1414
Mycobacterium leprae	PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2)	0.0112	0.3311	0.2653
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.1291	0.1771
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0028	0.0378	0.0333
Plasmodium vivax	vivapain-2	0.0054	0.1291	0.1264
Loa Loa (eye worm)	fli-1 protein	0.0214	0.6868	0.9451
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0378	0.0738
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0147	0.4541	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0147	0.4541	0.4524
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1291	0.2794
Schistosoma mansoni	chromobox protein	0.0068	0.1773	0.2581
Echinococcus multilocularis	carboxylesterase 5A	0.0066	0.1709	0.3313
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Brugia malayi	dihydrofolate reductase family protein	0.0043	0.0895	0.1232
Onchocerca volvulus		0.0054	0.1291	0.3235
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0047	0.0035
Brugia malayi	cathepsin L-like precursor	0.0036	0.0669	0.092
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1709	0.2346
Echinococcus multilocularis	cysteine protease	0.0054	0.1291	0.2503
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Plasmodium vivax	unspecified product	0.0028	0.0378	0.0348
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0043	0.0895	0.0852
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0028	0.0378	0.077
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Plasmodium vivax	vivapain-3	0.0028	0.0378	0.0348
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.1291	0.2794
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1291	0.1776
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0378	0.077
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Schistosoma mansoni	gabp alpha	0.007	0.1866	0.2717
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0669	0.092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1291	0.7209
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0378	0.0521
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0047	0.5
Plasmodium falciparum	hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase	0.0303	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Mycobacterium ulcerans	B12-dependent methionine synthase	0.0112	0.3311	0.3279
Echinococcus granulosus	cathepsin L cysteine protease	0.0028	0.0378	0.0733
Mycobacterium ulcerans	dihydropteroate synthase 2 FolP2	0.0112	0.3311	0.3279
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.1773	0.2434
Loa Loa (eye worm)	hypothetical protein	0.006	0.1509	0.2072
Loa Loa (eye worm)	carboxylesterase	0.0066	0.1709	0.2346
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0378	0.2664
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1291	0.188
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1291	0.1776
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0734	0.1004
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0047	0.5
Brugia malayi	thymidylate synthase	0.0104	0.3054	0.4203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768
Schistosoma mansoni	chromobox protein	0.0068	0.1773	0.2581
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1291	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0347	0.1739
Echinococcus multilocularis	cathepsin L	0.0028	0.0378	0.0733
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0147	0.4541	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0225	0.7267	1
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0378	0.0551
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0378	0.2664
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0734	0.3981
Echinococcus granulosus	chromobox protein 1	0.0068	0.1773	0.3437
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.1291	0.3235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1291	0.1776
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.1291	0.1771
Brugia malayi	Ets-domain containing protein	0.007	0.1866	0.2567
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.1291	0.2503
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.1291	0.1776
Schistosoma mansoni	cathepsin s	0.0018	0.0031	0.0045
Onchocerca volvulus		0.0036	0.0669	0.0848
Toxoplasma gondii	cathepsin CPL	0.0054	0.1291	0.125
Onchocerca volvulus		0.0054	0.1291	0.3235
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0087	0.2437	0.4725
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Schistosoma mansoni	hypothetical protein	0.0165	0.5158	0.751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0669	0.3603
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.1291	0.125
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.1291	0.2503
Loa Loa (eye worm)	cysteine protease	0.0054	0.1291	0.1771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1291	0.7209
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0036
Entamoeba histolytica	cysteine proteinase 1, putative	0.0028	0.0378	0.2664
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1291	0.1776
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.1291	0.125
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1291	0.2794
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0378	0.2664
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0734	0.1098
Echinococcus multilocularis	Ankyrin	0.0017	0.0005	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0347	0.1739
Plasmodium vivax	vivapain-2	0.0054	0.1291	0.1264
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1291	0.1776
Onchocerca volvulus		0.0054	0.1291	0.3235
Echinococcus multilocularis	chromobox protein 1	0.0068	0.1773	0.3437
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1291	1
Mycobacterium tuberculosis	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)	0.0112	0.3311	0.3279
Loa Loa (eye worm)	hypothetical protein	0.003	0.0448	0.0609
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1291	0.2503
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.0378	0.1921
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1291	0.1771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768
Loa Loa (eye worm)	dihydrofolate reductase	0.0043	0.0895	0.1226
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0047	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.0378	0.1921
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.0669	0.092
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0047	0.0091
Echinococcus granulosus	Ankyrin	0.0017	0.0005	0.001
Mycobacterium ulcerans	thymidylate synthase	0.0104	0.3054	0.3022
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0031	0.0036
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0043	0.0895	0.0852
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Schistosoma mansoni	ap endonuclease	0.0018	0.0047	0.0068
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1291	0.7209
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1291	0.2794
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0104	0.3054	0.3022
Loa Loa (eye worm)	thymidylate synthase	0.0104	0.3054	0.4199
Mycobacterium leprae	Probable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS)	0.0112	0.3311	0.2653
Plasmodium vivax	hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative	0.0303	1	1
Echinococcus granulosus	GA binding protein alpha chain	0.007	0.1866	0.3617
Mycobacterium leprae	Probable dihydropteroate synthase 1 FolP1 (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate dipyrophosphorylase 1)	0.0303	1	1
Onchocerca volvulus		0.0104	0.3054	1
Echinococcus multilocularis	chromobox protein 1	0.0068	0.1773	0.3437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1291	0.7209
Plasmodium vivax	vivapain-1	0.0028	0.0378	0.0348
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Echinococcus multilocularis	cysteine protease	0.0054	0.1291	0.2503
Schistosoma mansoni	ets-related	0.0214	0.6868	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0031	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0036
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0147	0.4541	1
Mycobacterium tuberculosis	Hypothetical protein	0.005	0.1143	0.1101
Toxoplasma gondii	dihydropteroate synthase	0.0303	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0225	0.7267	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0047	0.0016
Mycobacterium tuberculosis	Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1)	0.0303	1	1
Echinococcus granulosus	carboxylesterase 5A	0.0066	0.1709	0.3313
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Onchocerca volvulus		0.0054	0.1291	0.3235
Echinococcus multilocularis	thymidylate synthase	0.0104	0.3054	0.5922
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0047	0.0091
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Schistosoma mansoni	ap endonuclease	0.0018	0.0047	0.0068
Loa Loa (eye worm)	ctsf protein	0.0054	0.1291	0.1771
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0669	0.4998
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0378	0.0551
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0834	0.4564
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0104	0.3054	0.2371
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.1709	0.3313
Echinococcus granulosus	acetylcholinesterase	0.0066	0.1709	0.3313
Brugia malayi	Ets-domain containing protein	0.007	0.1866	0.2567
Echinococcus multilocularis	GA binding protein alpha chain	0.007	0.1866	0.3617
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0378	0.2664
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1291	0.2794
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0147	0.4541	0.4515
Echinococcus granulosus	acetylcholinesterase	0.0066	0.1709	0.3313
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1291	0.2768
Entamoeba histolytica	cysteine proteinase 2	0.0028	0.0378	0.2664
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0147	0.4541	0.4515
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.1773	1
Echinococcus multilocularis	dihydrofolate reductase	0.0043	0.0895	0.1736
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.1291	0.2768
Loa Loa (eye worm)	acetylcholinesterase 1	0.0066	0.1709	0.2346
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.1709	0.3313
Brugia malayi	Carboxylesterase family protein	0.0066	0.1709	0.2351
Mycobacterium ulcerans	dihydropteroate synthase 1 FolP1	0.0303	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0378	0.0738
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0047	0.0035
Leishmania major	cathepsin L-like protease	0.0054	0.1291	0.2768

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 nM	Inhibition of cathepsin K by fluorescence assay	ChEMBL.	17911019
IC50 (binding)	= 1.2 nM	Inhibition of cathepsin K by fluorescence assay	ChEMBL.	17911019
IC50 (binding)	= 100 nM	Inhibition of cathepsin S by fluorescence assay	ChEMBL.	17911019
IC50 (binding)	= 100 nM	Inhibition of cathepsin S by fluorescence assay	ChEMBL.	17911019
IC50 (binding)	= 380 nM	Inhibition of cathepsin L by fluorescence assay	ChEMBL.	17911019

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL249979

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 500087