Detailed information for compound 502002

Basic information

Technical information
  • TDR Targets ID: 502002
  • Name: N-ethyl-5-(5-ethyl-2,4-dimethoxyphenyl)-4-[4- (morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-c arboxamide
  • MW: 479.568 | Formula: C27H33N3O5
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)c1noc(c1c1ccc(cc1)CN1CCOCC1)c1cc(CC)c(cc1OC)OC
  • InChi: 1S/C27H33N3O5/c1-5-19-15-21(23(33-4)16-22(19)32-3)26-24(25(29-35-26)27(31)28-6-2)20-9-7-18(8-10-20)17-30-11-13-34-14-12-30/h7-10,15-16H,5-6,11-14,17H2,1-4H3,(H,28,31)
  • InChiKey: QYUJMZDXFKTDAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethyl-5-(5-ethyl-2,4-dimethoxy-phenyl)-4-[4-(morpholinomethyl)phenyl]isoxazole-3-carboxamide
  • N-ethyl-5-(5-ethyl-2,4-dimethoxyphenyl)-4-[4-(morpholinomethyl)phenyl]-3-isoxazolecarboxamide
  • N-ethyl-5-(5-ethyl-2,4-dimethoxy-phenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 90, putative heat shock protein 90kDa alpha (cytosolic), class B member 1 724 aa 725 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Plasmodium vivax conserved Plasmodium protein, unknown function 0.008 0.2653 0.2319
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0215 1 1
Loa Loa (eye worm) POT family protein 0.0082 0.274 0.241
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0124 0.5068 0.5068
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0114 0.4516 0.4516
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0101 0.3784 0.3784
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0126 0.5148 0.4927
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0044 0.0715 0.0292
Loa Loa (eye worm) hypothetical protein 0.0215 1 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0215 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0715 0.0886
Mycobacterium ulcerans heat shock protein 90 0.0031 0 0.5
Treponema pallidum heat shock protein 90 0.0031 0 0.5
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0215 1 1
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0124 0.5068 0.4844
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0101 0.3784 0.3784
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0215 1 1
Giardia lamblia Rab geranylgeranyltransferase 0.0044 0.0715 0.0715
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0101 0.3784 0.3501
Toxoplasma gondii hypothetical protein 0.0101 0.3784 0.7228
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0215 1 1
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0715 0.0367
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0101 0.3784 0.3501
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0715 0.0604
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0101 0.3784 0.3501
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trypanosoma cruzi lanosterol synthase, putative 0.018 0.8066 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0124 0.5068 0.5068
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0715 0.0886
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0044 0.0715 0.0292
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0215 1 1
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0126 0.5148 0.4927
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0124 0.5068 0.4844
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0715 0.0886
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0435 0.0435
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0435 0.0435
Trypanosoma cruzi lanosterol synthase, putative 0.018 0.8066 1
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0126 0.5148 0.4927
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0101 0.3784 0.3501
Toxoplasma gondii hypothetical protein 0.0114 0.4516 0.8809
Echinococcus granulosus heat shock protein 0.0039 0.0435 0.0435
Echinococcus granulosus heat shock protein 90 0.0039 0.0435 0.0435
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0126 0.5148 0.4927
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0435 0.0539
Echinococcus multilocularis heat shock protein 90 0.0039 0.0435 0.0435
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0126 0.5148 0.5148
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0126 0.5148 0.5148
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0435 0.0539
Onchocerca volvulus 0.0101 0.3784 0.5
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0101 0.3784 0.3784
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0101 0.3784 0.3784
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0715 0.0715
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0101 0.3784 0.4389
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0124 0.5068 0.4844
Leishmania major farnesyltransferase beta subunit 0.0124 0.5068 0.8968
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.5068 0.5068
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0215 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0715 0.0292
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0215 1 1
Trypanosoma brucei lanosterol synthase 0.018 0.8066 1
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0715 0.0715
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0435 0.0539
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0715 0.0292
Leishmania major geranylgeranyltransferase, putative 0.0044 0.0715 0.1264
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.5068 0.6283
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0126 0.5148 0.4927
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0101 0.3784 0.4691
Giardia lamblia Rab geranylgeranyltransferase 0.0215 1 1
Giardia lamblia Prenyltransferase 0.0124 0.5068 0.5068
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0101 0.3784 0.3501
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.3784 0.4691
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.018 0.8066 1
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0044 0.0715 0.0715
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0124 0.5068 1
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0124 0.5068 0.6071
Brugia malayi POT family protein 0.0082 0.274 0.241
Giardia lamblia Rab geranylgeranyltransferase 0.0101 0.3784 0.3784
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0101 0.3784 0.4389
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0101 0.3784 0.6695
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.5068 0.5068
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0124 0.5068 0.4844
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.3784 0.4691
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0101 0.3784 0.4691
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0215 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0715 0.0292
Trypanosoma cruzi protein farnesyltransferase, putative 0.0124 0.5068 0.6283
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0124 0.5068 0.5068
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0101 0.3784 0.3501
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0101 0.3784 0.3784
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0044 0.0715 0.0292
Plasmodium falciparum geranylgeranyltransferase, putative 0.0044 0.0715 0.0292
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0101 0.3784 0.4389
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0044 0.0715 0.0604
Plasmodium vivax geranylgeranyltransferase, putative 0.0044 0.0715 0.0292
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0435 0.0539
Leishmania major lanosterol synthase, putative 0.0135 0.5651 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0215 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0124 0.5068 0.5068
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0124 0.5068 0.5068
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0 0.5
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0124 0.5068 0.4844
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0124 0.5068 0.4844
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0126 0.5148 0.5148
Trypanosoma brucei hypothetical protein, conserved 0.0101 0.3784 0.4389
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0435 0.0539
Loa Loa (eye worm) hypothetical protein 0.0044 0.0715 0.0292
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0124 0.5068 0.5068
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0101 0.3784 0.4691
Leishmania major heat shock protein 83-1 0.0039 0.0435 0.0769
Echinococcus multilocularis heat shock protein 0.0039 0.0435 0.0435

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 32 uM Growth inhibition of human HCT116 cells after 24 hrs by SRB assay ChEMBL. 18020435
GI50 (functional) = 32 uM Growth inhibition of human HCT116 cells after 24 hrs by SRB assay ChEMBL. 18020435
IC50 (binding) = 1.56 uM Displacement of fluorescent labelled VER-00051001 from human Hsp90beta by FP assay ChEMBL. 18020435
IC50 (binding) = 1.56 uM Displacement of fluorescent labelled VER-00051001 from human Hsp90beta by FP assay ChEMBL. 18020435

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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