TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 587.577 | Formula: C27H27F6N3O3S
H donors: 2 H acceptors: 4 LogP: 5.29 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: N#CC(C1CC1)(C1CC1)NC(=O)[C@H](CC(F)(F)F)N[C@H](C(F)(F)F)c1ccc(cc1)c1ccc(cc1)S(=O)(=O)C
InChi: 1S/C27H27F6N3O3S/c1-40(38,39)21-12-6-17(7-13-21)16-2-4-18(5-3-16)23(27(31,32)33)35-22(14-26(28,29)30)24(37)36-25(15-34,19-8-9-19)20-10-11-20/h2-7,12-13,19-20,22-23,35H,8-11,14H2,1H3,(H,36,37)/t22-,23-/m0/s1
InChiKey: MRFFFLZDQYKPHZ-GOTSBHOMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0813	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.065	0.3241
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.028	0.1396
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.028	0.0572
Onchocerca volvulus		0.0086	0.2004	0.2004
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0813	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0328	0.1637
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1192	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2004	0.2004
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2004	0.41
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.1512	0.3093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0247	0.1231
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.065	0.3241
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0813	0.0813
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1192	0.2438
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1145	0.1145
Plasmodium vivax	vivapain-1	0.0047	0.0813	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0328	0.1637
Echinococcus granulosus	cathepsin l1	0.0086	0.2004	0.41
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2004	0.41
Onchocerca volvulus		0.0086	0.2004	0.2004
Loa Loa (eye worm)	cysteine protease	0.0086	0.2004	0.2004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2004	0.41
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0208	0.0208
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0245	0.1225
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2004	0.2004
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2004	0.41
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0208	0.0208
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0208	0.0425
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0338	0.1684
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1192	0.5946
Onchocerca volvulus		0.0059	0.1192	0.1192
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0568	0.2835
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0813	0.1662
Plasmodium vivax	vivapain-2	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0338	0.1684
Echinococcus granulosus	cathepsin l1	0.0059	0.1192	0.2438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0025	0.0141	0.0465
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2004	0.2004
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2004	0.2004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0041	0.0651	0.2152
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1192	0.1192
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.2004	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2004	0.2004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0568	0.2835
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0591	0.0591
Echinococcus multilocularis	cysteine protease	0.0086	0.2004	0.41
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2004	0.2004
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.2004	0.2004
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.2004	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0742	0.37
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0813	0.4054
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0052	0.0972	0.4015
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2004	0.41
Giardia lamblia	GTOR	0.0052	0.0972	0.643
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.1192	0.1192
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2004	0.41
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1192	0.1192
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0813	0.1662
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0813	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0813	0.4054
Toxoplasma gondii	cathepsin CPL	0.0086	0.2004	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0813	0.1662
Entamoeba histolytica	cysteine protease, putative	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0568	0.2835
Loa Loa (eye worm)	fibroinase	0.0086	0.2004	0.2004
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.1512	0.7145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.028	0.1396
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.2004	0.41
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2004	0.2004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0972	0.4851
Loa Loa (eye worm)	hypothetical protein	0.0349	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0813	0.1662
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.2004	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.028	0.1396
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.028	0.1396
Onchocerca volvulus		0.0349	1	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0591	0.1209
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2004	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0027	0.0208	0.0208
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0813	0.1662
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0419	0.209
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1192	0.5946
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0813	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.1512	0.748
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2004	0.2004
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0052	0.0972	0.1989
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2004	0.41
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2004	1
Brugia malayi	cathepsin L-like precursor	0.0059	0.1192	0.1192
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0052	0.0972	0.1989
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0813	0.3901
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0208	0.0208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0052	0.0972	0.4718
Loa Loa (eye worm)	hypothetical protein	0.0181	0.4888	0.4888
Echinococcus granulosus	cathepsin b	0.0181	0.4888	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0972	0.4851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2004	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1192	0.1192
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0813	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0338	0.1684
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0568	0.2835
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0052	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1192	0.1192
Brugia malayi	cathepsin F-like cysteine proteinase	0.0027	0.0208	0.0208
Onchocerca volvulus		0.0086	0.2004	0.2004
Giardia lamblia	Cathepsin B precursor	0.007	0.1512	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.4888	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2004	0.41
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Toxoplasma gondii	cathepsin B	0.007	0.1512	0.7543
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2004	0.2004
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2004	0.41
Onchocerca volvulus		0.0086	0.2004	0.2004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0245	0.1225
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0813	0.1662
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0039	0.0568	0.2835
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0568	0.2835
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2004	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.2004	0.41
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0052	0.0972	0.1989
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.4888	0.4888
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0052	0.0972	0.1989
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0813	0.4054
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.4888	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0813	0.1662
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.065	0.3241
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0813	0.0813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0568	0.2835
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Onchocerca volvulus		0.0086	0.2004	0.2004
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Echinococcus multilocularis	cathepsin L	0.0047	0.0813	0.1662
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.1192	0.2438
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1145	0.1145
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.4888	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0052	0.0972	0.1989
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.1512	0.3093
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.028	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1145	0.1145
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2004	0.41
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0568	0.2835
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Giardia lamblia	Cathepsin B precursor	0.007	0.1512	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.1512	0.7543
Echinococcus granulosus	cysteine protease	0.0047	0.0813	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0029	0.028	0.028
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.2004	0.2004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0247	0.1231
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0208	0.0208
Echinococcus granulosus	cathepsin L	0.0047	0.0813	0.1662
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.2004	0.2004
Schistosoma mansoni	cathepsin s	0.0027	0.0208	0.0425
Onchocerca volvulus		0.0086	0.2004	0.2004
Leishmania major	cathepsin L-like protease	0.0086	0.2004	1
Onchocerca volvulus		0.0086	0.2004	0.2004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.065	0.3241
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0813	0.3901
Giardia lamblia	Cathepsin B precursor	0.007	0.1512	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0041	0.0651	0.3074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0247	0.1231
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.2004	0.2004
Loa Loa (eye worm)	cathepsin B	0.007	0.1512	0.1512
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0052	0.0972	0.4015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0972	0.4851
Echinococcus multilocularis	cysteine protease	0.0086	0.2004	0.41
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0813	0.1662
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.028	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0591	0.0591
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0041	0.0651	0.1331
Loa Loa (eye worm)	ctsf protein	0.0086	0.2004	0.2004
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.2004	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Echinococcus granulosus	cathepsin b	0.0181	0.4888	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.065	0.3241
Plasmodium vivax	vivapain-2	0.0086	0.2004	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0052	0.0972	0.4851
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0453	0.226
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0052	0.0972	0.4851
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1145	0.1145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2004	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0813	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0247	0.1231
Echinococcus multilocularis	cathepsin b	0.0181	0.4888	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1192	0.5946
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0245	0.1225
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.2004	0.41
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0052	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0208	0.0208
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2004	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0208	0.0425
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0813	0.1662
Plasmodium vivax	vivapain-3	0.0047	0.0813	0.4054
Plasmodium vivax	unspecified product	0.0047	0.0813	0.4054
Plasmodium vivax	unspecified product	0.0027	0.0208	0.1037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Brugia malayi	hypothetical protein	0.0029	0.028	0.028
Echinococcus multilocularis	cathepsin b	0.0181	0.4888	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2004	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0052	0.0972	0.4718
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.4888	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.4888	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0813	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 nM	Inhibition of humanized rabbit cathepsin K	ChEMBL.	18226527
IC50 (binding)	= 1.5 nM	Inhibition of humanized rabbit cathepsin K	ChEMBL.	18226527
IC50 (binding)	= 89 nM	Inhibition of cathepsin S (unknown origin)	ChEMBL.	18226527
IC50 (binding)	= 89 nM	Inhibition of cathepsin S (unknown origin)	ChEMBL.	18226527
IC50 (binding)	= 434 nM	Inhibition of cathepsin B (unknown origin)	ChEMBL.	18226527
IC50 (binding)	= 434 nM	Inhibition of cathepsin B (unknown origin)	ChEMBL.	18226527
IC50 (binding)	= 750 nM	Inhibition of cathepsin L (unknown origin)	ChEMBL.	18226527
IC50 (binding)	= 750 nM	Inhibition of cathepsin L (unknown origin)	ChEMBL.	18226527

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL252784

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 507276