Detailed information for compound 510038

Basic information

Technical information
  • TDR Targets ID: 510038
  • Name: 2,2-diphenylcyclopropan-1-amine
  • MW: 209.286 | Formula: C15H15N
  • H donors: 1 H acceptors: 0 LogP: 2.9 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1CC1(c1ccccc1)c1ccccc1
  • InChi: 1S/C15H15N/c16-14-11-15(14,12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14H,11,16H2
  • InChiKey: WVRNJJILWVMIRA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2-diphenylcyclopropanamine
  • (2,2-diphenylcyclopropyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Echinococcus multilocularis global transcription activator snf2l2 0.0075 0.1675 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0094 0.013
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0392 0.8097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0149 0.0234
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0483 0.2883
Schistosoma mansoni lamin 0.0029 0.0461 0.2753
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.015 0.2411
Echinococcus multilocularis 0.0015 0.0094 0.0563
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0186 0.0305
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 0.5233 0.5143
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0392 0.7927
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Brugia malayi BRM protein 0.0075 0.1675 0.3143
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Echinococcus granulosus caspase 2 0.0029 0.0449 0.268
Loa Loa (eye worm) hypothetical protein 0.0027 0.0392 0.0697
Echinococcus granulosus lamin dm0 0.0029 0.0461 0.2753
Loa Loa (eye worm) BRM protein 0.0048 0.0954 0.177
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 0.8134 0.8099
Brugia malayi Pre-SET motif family protein 0.0209 0.527 1
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0449 0.2731
Brugia malayi hypothetical protein 0.004 0.0749 0.1378
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.1393 0.1667
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.015 0.043
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.015 0.2411
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 0.5233 0.6414
Toxoplasma gondii exonuclease III APE 0.0019 0.0186 0.3235
Echinococcus granulosus caspase 8 0.0029 0.0449 0.268
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 0.5233 0.6414
Brugia malayi Pre-SET motif family protein 0.003 0.0483 0.087
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0483 1
Leishmania major hypothetical protein, conserved 0.0064 0.1393 1
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0449 0.2731
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0483 0.2883
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0208 0.5233 0.5143
Schistosoma mansoni hypothetical protein 0.0038 0.0693 0.4136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0186 0.0709
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 0.5233 0.6414
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0392 0.2293
Echinococcus multilocularis lamin 0.0029 0.0461 0.2753
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.015 0.043
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0094 0.013
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0094 0.1136
Echinococcus multilocularis BRK domain 0.0013 0.0026 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0483 0.2883
Leishmania major metacaspase, putative 0.0029 0.0449 0.2731
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0392 0.8097
Echinococcus granulosus lamin 0.0029 0.0461 0.2753
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.015 0.043
Schistosoma mansoni ap endonuclease 0.0019 0.0186 0.1112
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.527 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0186 0.0305
Schistosoma mansoni hypothetical protein 0.0013 0.0026 0.0157
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0461 0.0829
Brugia malayi cytochrome P450 0.0015 0.0094 0.0129
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0186 0.0179
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0064 0.1393 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.015 0.0236
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Echinococcus multilocularis caspase 8 0.0029 0.0449 0.268
Schistosoma mansoni helicase 0.0075 0.1675 1
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0208 0.5233 0.9929
Loa Loa (eye worm) cytochrome P450 0.0015 0.0094 0.013
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 0.5233 0.5143
Trypanosoma brucei Metacaspase-4 0.0029 0.0449 0.2731
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0461 0.0829
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0099 0.0138
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.015 0.015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0453 0.2707
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0149 0.0235
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0208 0.5233 0.9929
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0483 0.2883
Trypanosoma brucei metacaspase MCA3 0.0029 0.0449 0.2731
Trypanosoma brucei metacaspase MCA2 0.0029 0.0449 0.2731
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 0.5233 0.6414
Brugia malayi hypothetical protein 0.0017 0.014 0.0217
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 0.5233 0.6414
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0029 0.0449 0.268
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0144 0.3522 0.9223
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0392 0.2293
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.015 0.0897
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0392 0.7268
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Schistosoma mansoni caspase-3 (C14 family) 0.0029 0.0449 0.268
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0029 0.0449 0.268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0483 0.2883
Plasmodium vivax metacaspase 1, putative 0.0029 0.0449 0.8976
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0449 0.268
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Loa Loa (eye worm) hypothetical protein 0.0018 0.0149 0.0235
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Brugia malayi Cell death protein 3 precursor 0.0029 0.0449 0.0805
Loa Loa (eye worm) hypothetical protein 0.0055 0.1161 0.2164
Schistosoma mansoni hypothetical protein 0.0015 0.0094 0.0563
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0186 0.1112
Giardia lamblia DNA repair protein RAD52 0.0387 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0094 0.013
Treponema pallidum fructose-bisphosphate aldolase 0.0317 0.8134 1
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0094 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1161 0.2163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0058 0.0344
Loa Loa (eye worm) hypothetical protein 0.0029 0.0447 0.0802
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0186 0.1112
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.015 0.0897
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.015 0.043
Onchocerca volvulus 0.0029 0.0461 0.0022
Onchocerca volvulus 0.0029 0.0461 0.0022
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 0.5233 0.6414
Loa Loa (eye worm) hypothetical protein 0.0038 0.0693 0.1271
Brugia malayi hypothetical protein 0.0027 0.0392 0.0697
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0186 0.0175
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0186 0.0709
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0392 0.2293
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Echinococcus multilocularis musashi 0.0029 0.0461 0.2753
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0186 0.1085
Schistosoma mansoni intermediate filament proteins 0.0029 0.0461 0.2753
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0483 0.2883
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0693 0.127
Trypanosoma brucei metacaspase 5, putative 0.0029 0.0449 0.2731
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.381 0.7231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Brugia malayi intermediate filament protein 0.0029 0.0461 0.0829
Schistosoma mansoni hypothetical protein 0.004 0.0749 0.4473
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.1393 1
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1161 0.2163
Entamoeba histolytica hypothetical protein 0.011 0.2617 0.2477
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0099 0.0139
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.381 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0449 0.268
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0749 0.4473
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Plasmodium falciparum metacaspase-like protein 0.0029 0.0449 1
Echinococcus granulosus Chromo domain 0.0013 0.0027 0.0158
Schistosoma mansoni ap endonuclease 0.0019 0.0186 0.1112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0186 0.0709
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.381 1
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Schistosoma mansoni cytochrome P450 0.0015 0.0094 0.0563
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.8134 0.8099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Loa Loa (eye worm) hypothetical protein 0.0029 0.0449 0.0806
Brugia malayi Isocitrate dehydrogenase 0.0018 0.015 0.0236
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0149 0.0892
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Echinococcus multilocularis lamin dm0 0.0029 0.0461 0.2753
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0449 0.9223
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0029 0.0449 0.0805
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0449 0.8976
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0186 0.0248
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0186 0.5
Echinococcus multilocularis caspase 2 0.0029 0.0449 0.268
Loa Loa (eye worm) BRM protein 0.0039 0.0712 0.1308
Trypanosoma brucei metacaspase 0.0029 0.0449 0.2731
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0186 0.0709
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.015 0.0897
Echinococcus multilocularis GPCR, family 2 0.0018 0.0149 0.0892
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0186 0.0175
Loa Loa (eye worm) hypothetical protein 0.0029 0.0461 0.0829
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0208 0.5233 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0149 0.0892
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0149 0.0892
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0749 0.4473
Trichomonas vaginalis set domain proteins, putative 0.0238 0.6042 0.7415
Plasmodium falciparum metacaspase 1 0.0029 0.0449 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.0026 0.0157
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.1393 1
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.1393 0.1667
Echinococcus granulosus caspase 0.0029 0.0449 0.268
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0158
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0449 0.9223
Echinococcus multilocularis Chromo domain 0.0013 0.0027 0.0158
Echinococcus granulosus intermediate filament protein 0.0029 0.0461 0.2753
Echinococcus granulosus GPCR family 2 0.0018 0.0149 0.0892
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0029 0.0449 0.268
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0749 0.4473
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0186 0.1209
Leishmania major hypothetical protein, conserved 0.0027 0.0392 0.2293
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0149 0.0892
Schistosoma mansoni lamin 0.0029 0.0461 0.2753
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0094 0.0563
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.015 0.0236
Onchocerca volvulus 0.0238 0.6042 1
Echinococcus granulosus BRK domain containing protein 0.0013 0.0026 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.011 0.2617 0.2477
Loa Loa (eye worm) hypothetical protein 0.0029 0.0449 0.0806
Plasmodium vivax SET domain protein, putative 0.003 0.0483 1
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0483 0.2883
Echinococcus granulosus global transcription activator snf2l2 0.0075 0.1675 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0483 0.0871
Onchocerca volvulus 0.003 0.0483 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0149 0.0234
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0058 0.0344
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0461 0.0829
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.015 0.043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1161 0.2164
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.8134 0.8099
Echinococcus multilocularis caspase 0.0029 0.0449 0.268
Onchocerca volvulus 0.0208 0.5233 0.8553
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0449 0.9223

Activities

Activity type Activity value Assay description Source Reference
Kinact (binding) 0 Inhibition of human MAOA ChEMBL. 18242989
Kinact (binding) 0 Inhibition of human MAOB ChEMBL. 18242989
Kinact (binding) 0 Inhibition of human LSD1 ChEMBL. 18242989
Ratio (binding) < 1 /M/s Ratio of Kinact to KI of human LSD1 ChEMBL. 18242989
Ratio (binding) < 1 /M/s Ratio of Kinact to KI of human LSD1 ChEMBL. 18242989
Ratio (binding) < 1.5 /M/s Ratio of Kinact to KI of human MAOA ChEMBL. 18242989
Ratio (binding) < 1.5 /M/s Ratio of Kinact to KI of human MAOA ChEMBL. 18242989
Ratio (binding) < 14 /M/s Ratio of Kinact to KI of human MAOB ChEMBL. 18242989
Ratio (binding) < 14 /M/s Ratio of Kinact to KI of human MAOB ChEMBL. 18242989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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