Detailed information for compound 510038

Basic information

Technical information
  • TDR Targets ID: 510038
  • Name: 2,2-diphenylcyclopropan-1-amine
  • MW: 209.286 | Formula: C15H15N
  • H donors: 1 H acceptors: 0 LogP: 2.9 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC1CC1(c1ccccc1)c1ccccc1
  • InChi: 1S/C15H15N/c16-14-11-15(14,12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14H,11,16H2
  • InChiKey: WVRNJJILWVMIRA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2-diphenylcyclopropanamine
  • (2,2-diphenylcyclopropyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0018 0.0149 0.0892
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.015 0.043
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0029 0.0449 0.0805
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0449 0.9223
Brugia malayi hypothetical protein 0.0027 0.0392 0.0697
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Brugia malayi Cell death protein 3 precursor 0.0029 0.0449 0.0805
Trypanosoma brucei metacaspase 0.0029 0.0449 0.2731
Loa Loa (eye worm) hypothetical protein 0.0029 0.0449 0.0806
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Brugia malayi BRM protein 0.0075 0.1675 0.3143
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Loa Loa (eye worm) hypothetical protein 0.0027 0.0392 0.0697
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0186 0.0248
Echinococcus granulosus caspase 8 0.0029 0.0449 0.268
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0392 0.7927
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0208 0.5233 0.5143
Schistosoma mansoni lamin 0.0029 0.0461 0.2753
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0094 0.013
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0449 0.8976
Brugia malayi Isocitrate dehydrogenase 0.0018 0.015 0.0236
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.015 0.0897
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.0026 0.0157
Leishmania major hypothetical protein, conserved 0.0064 0.1393 1
Plasmodium falciparum metacaspase-like protein 0.0029 0.0449 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0186 0.0175
Brugia malayi cytochrome P450 0.0015 0.0094 0.0129
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.381 0.7231
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Loa Loa (eye worm) hypothetical protein 0.0029 0.0447 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Onchocerca volvulus 0.0029 0.0461 0.0022
Onchocerca volvulus 0.0238 0.6042 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 0.5233 0.6414
Echinococcus granulosus caspase 2 0.0029 0.0449 0.268
Echinococcus granulosus lamin dm0 0.0029 0.0461 0.2753
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.015 0.2411
Echinococcus multilocularis caspase 2 0.0029 0.0449 0.268
Echinococcus granulosus GPCR family 2 0.0018 0.0149 0.0892
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0749 0.4473
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.015 0.043
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0099 0.0138
Trypanosoma brucei metacaspase MCA3 0.0029 0.0449 0.2731
Brugia malayi intermediate filament protein 0.0029 0.0461 0.0829
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Onchocerca volvulus 0.003 0.0483 0.0061
Schistosoma mansoni hypothetical protein 0.004 0.0749 0.4473
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0149 0.0892
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Leishmania major hypothetical protein, conserved 0.0027 0.0392 0.2293
Echinococcus multilocularis musashi 0.0029 0.0461 0.2753
Echinococcus granulosus global transcription activator snf2l2 0.0075 0.1675 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.015 0.0236
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0186 0.0305
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0029 0.0449 0.268
Plasmodium vivax metacaspase 1, putative 0.0029 0.0449 0.8976
Plasmodium vivax SET domain protein, putative 0.003 0.0483 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0483 0.2883
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0453 0.2707
Loa Loa (eye worm) hypothetical protein 0.0018 0.0149 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Schistosoma mansoni hypothetical protein 0.0015 0.0094 0.0563
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0392 0.7268
Brugia malayi hypothetical protein 0.004 0.0749 0.1378
Brugia malayi Pre-SET motif family protein 0.003 0.0483 0.087
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0149 0.0235
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0461 0.0829
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1161 0.2164
Trichomonas vaginalis set domain proteins, putative 0.0238 0.6042 0.7415
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0186 0.0709
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.015 0.0897
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 0.5233 0.6414
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0149 0.0892
Trypanosoma brucei metacaspase MCA2 0.0029 0.0449 0.2731
Trypanosoma brucei Metacaspase-4 0.0029 0.0449 0.2731
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0094 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Brugia malayi Pre-SET motif family protein 0.0209 0.527 1
Echinococcus granulosus Chromo domain 0.0013 0.0027 0.0158
Trypanosoma brucei metacaspase 5, putative 0.0029 0.0449 0.2731
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.015 0.0897
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0749 0.4473
Brugia malayi isocitrate dehydrogenase 0.0018 0.015 0.0236
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0392 0.8097
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0058 0.0344
Loa Loa (eye worm) hypothetical protein 0.0014 0.0058 0.006
Plasmodium falciparum metacaspase 1 0.0029 0.0449 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0392 0.2293
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.381 1
Echinococcus multilocularis caspase 0.0029 0.0449 0.268
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Brugia malayi hypothetical protein 0.0017 0.014 0.0217
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0749 0.4473
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0483 1
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Loa Loa (eye worm) hypothetical protein 0.0055 0.1161 0.2164
Echinococcus multilocularis global transcription activator snf2l2 0.0075 0.1675 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0483 0.0871
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0449 0.268
Echinococcus granulosus intermediate filament protein 0.0029 0.0461 0.2753
Schistosoma mansoni ap endonuclease 0.0019 0.0186 0.1112
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0392 0.2293
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0483 0.2883
Echinococcus granulosus BRK domain containing protein 0.0013 0.0026 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.1393 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0186 0.3235
Schistosoma mansoni cytochrome P450 0.0015 0.0094 0.0563
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 0.5233 0.5143
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0392 0.8097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1161 0.2163
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0483 0.2883
Onchocerca volvulus 0.0208 0.5233 0.8553
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0186 0.0305
Giardia lamblia DNA repair protein RAD52 0.0387 1 1
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0449 0.2731
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 0.5233 0.6414
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 0.5233 0.6414
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0064 0.1393 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0094 0.013
Schistosoma mansoni helicase 0.0075 0.1675 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0483 0.2883
Echinococcus multilocularis BRK domain 0.0013 0.0026 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0449 0.9223
Echinococcus multilocularis lamin 0.0029 0.0461 0.2753
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0149 0.0892
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0186 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0483 0.2883
Schistosoma mansoni caspase-7 (C14 family) 0.0029 0.0449 0.268
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Loa Loa (eye worm) hypothetical protein 0.0038 0.0693 0.1271
Loa Loa (eye worm) BRM protein 0.0039 0.0712 0.1308
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0094 0.1136
Schistosoma mansoni lamin 0.0029 0.0461 0.2753
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0186 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0483 0.2883
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0033
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0149 0.0234
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0461 0.0829
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0029 0.0449 0.9223
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0144 0.3522 0.9223
Echinococcus multilocularis Chromo domain 0.0013 0.0027 0.0158
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0058 0.0344
Schistosoma mansoni caspase-3 (C14 family) 0.0029 0.0449 0.268
Echinococcus granulosus caspase 0.0029 0.0449 0.268
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0208 0.5233 0.6414
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.015 0.043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0461 0.0829
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.1393 0.1667
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0483 0.2883
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.015 0.2411
Onchocerca volvulus 0.0029 0.0461 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Entamoeba histolytica hypothetical protein 0.011 0.2617 0.2477
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.8134 0.8099
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0064 0.1393 0.1667
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Schistosoma mansoni hypothetical protein 0.0038 0.0693 0.4136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.015 0.043
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.381 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0186 0.5
Trypanosoma cruzi metacaspase 5, putative 0.0029 0.0449 0.2731
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0186 0.1112
Entamoeba histolytica hypothetical protein 0.004 0.0749 0.0573
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.1393 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.011 0.2617 0.2477
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0029 0.0449 0.05
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0208 0.5233 0.6414
Echinococcus multilocularis 0.0015 0.0094 0.0563
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0186 0.0709
Treponema pallidum fructose-bisphosphate aldolase 0.0317 0.8134 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0693 0.127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.8134 0.8099
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0392 0.2293
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0461 0.0829
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0099 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0449 0.05
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 0.8134 0.8099
Echinococcus multilocularis lamin dm0 0.0029 0.0461 0.2753
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0029 0.0449 0.268
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.527 1
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0094 0.0563
Schistosoma mansoni ap endonuclease 0.0019 0.0186 0.1112
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0208 0.5233 0.9929
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0149 0.0892
Loa Loa (eye worm) BRM protein 0.0048 0.0954 0.177
Loa Loa (eye worm) cytochrome P450 0.0015 0.0094 0.013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0186 0.0709
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0186 0.0709
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.015 0.015
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.015 0.043
Schistosoma mansoni hypothetical protein 0.0013 0.0026 0.0157
Leishmania major metacaspase, putative 0.0029 0.0449 0.2731
Schistosoma mansoni hypothetical protein 0.0018 0.0149 0.0892
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0094 0.013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0149 0.0234
Brugia malayi Cytochrome P450 family protein 0.0015 0.0094 0.0129
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0186 0.1209
Loa Loa (eye worm) hypothetical protein 0.0029 0.0449 0.0806
Schistosoma mansoni intermediate filament proteins 0.0029 0.0461 0.2753
Trypanosoma cruzi metacaspase, putative 0.0029 0.0449 0.2731
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0186 0.1112
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0208 0.5233 0.5143
Echinococcus granulosus lamin 0.0029 0.0461 0.2753
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1161 0.2163
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0029 0.0449 0.268
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.8134 1
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0208 0.5233 0.9929
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157
Echinococcus multilocularis caspase 8 0.0029 0.0449 0.268
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.015 0.0897
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0208 0.5233 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0186 0.1085
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0026 0.0157

Activities

Activity type Activity value Assay description Source Reference
Kinact (binding) 0 Inhibition of human MAOA ChEMBL. 18242989
Kinact (binding) 0 Inhibition of human MAOB ChEMBL. 18242989
Kinact (binding) 0 Inhibition of human LSD1 ChEMBL. 18242989
Ratio (binding) < 1 /M/s Ratio of Kinact to KI of human LSD1 ChEMBL. 18242989
Ratio (binding) < 1 /M/s Ratio of Kinact to KI of human LSD1 ChEMBL. 18242989
Ratio (binding) < 1.5 /M/s Ratio of Kinact to KI of human MAOA ChEMBL. 18242989
Ratio (binding) < 1.5 /M/s Ratio of Kinact to KI of human MAOA ChEMBL. 18242989
Ratio (binding) < 14 /M/s Ratio of Kinact to KI of human MAOB ChEMBL. 18242989
Ratio (binding) < 14 /M/s Ratio of Kinact to KI of human MAOB ChEMBL. 18242989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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