Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | nM | Inhibition of [3H]-PSB-11 binding to adenosine A3 receptor; ND denotes 'Not determined' | ChEMBL. | 15771453 |
Ki (binding) | = 10 nM | Inhibition of [3H]-ZM-241,385 binding to human adenosine A2B receptor | ChEMBL. | 11906291 |
Ki (binding) | = 10 nM | Inhibition of [3H]-ZM-241,385 binding to human adenosine A2B receptor | ChEMBL. | 11906291 |
Ki (binding) | = 10 nM | Inhibition of [3H]-ZM-241,380 binding to adenosine A2b receptor | ChEMBL. | 15771453 |
Ki (binding) | = 24 nM | Inhibition of [3H]-CCPA binding to rat adenosine A1 receptor | ChEMBL. | 11906291 |
Ki (binding) | = 24 nM | Inhibition of [3H]-CCPA binding to rat adenosine A1 receptor | ChEMBL. | 11906291 |
Ki (binding) | = 24 nM | Inhibition of [3H]-CCPA binding to adenosine A1 receptor | ChEMBL. | 15771453 |
Ki (binding) | = 365 nM | Inhibition of [3H]-MSX-2 binding to rat adenosine A2A receptor | ChEMBL. | 11906291 |
Ki (binding) | = 365 nM | Inhibition of [3H]-MSX-2 binding to rat adenosine A2A receptor | ChEMBL. | 11906291 |
Ki (binding) | = 365 nM | Inhibition of [3H]-MSX-2 binding to adenosine A2a receptor | ChEMBL. | 15771453 |
ND (binding) | 0 | Selectivity ratio against adenosine A3 and A2B receptors; Not determined | ChEMBL. | 11906291 |
Ratio (binding) | = 37 | Selectivity ratio of the compound( A2A/A2B) | ChEMBL. | 11906291 |
Ratio (binding) | = 2 | Selectivity ratio of the compound (A1/A2B) | ChEMBL. | 11906291 |
Ratio (binding) | = 37 | Selectivity ratio of the compound( A2A/A2B) | ChEMBL. | 11906291 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.