Detailed information for compound 511383

Basic information

Technical information
  • TDR Targets ID: 511383
  • Name: (4Z)-4-[[4-(diethylaminomethyl)anilino]methyl idene]-6-(4-methylanilino)isoquinoline-1,3-di one
  • MW: 454.563 | Formula: C28H30N4O2
  • H donors: 3 H acceptors: 2 LogP: 4.95 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(Cc1ccc(cc1)N/C=C/1\C(=O)NC(=O)c2c1cc(cc2)Nc1ccc(cc1)C)CC
  • InChi: 1S/C28H30N4O2/c1-4-32(5-2)18-20-8-12-21(13-9-20)29-17-26-25-16-23(30-22-10-6-19(3)7-11-22)14-15-24(25)27(33)31-28(26)34/h6-17,29-30H,4-5,18H2,1-3H3,(H,31,33,34)/b26-17-
  • InChiKey: KOLQCOSRJKVBAQ-ONUIUJJFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4Z)-4-[[4-(diethylaminomethyl)anilino]methylene]-6-(4-methylanilino)isoquinoline-1,3-dione
  • (4Z)-4-[[[4-(diethylaminomethyl)phenyl]amino]methylidene]-6-[(4-methylphenyl)amino]isoquinoline-1,3-dione
  • (4Z)-4-[[4-(diethylaminomethyl)anilino]methylene]-6-(p-toluidino)isoquinoline-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni opsin-like receptor 0.014 0.0843 0.3157
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.014 0.0843 0.0843
Brugia malayi G protein-coupled receptor 0.014 0.0843 0.0843
Schistosoma mansoni hypothetical protein 0.0035 0.0047 0.0175
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0677 1
Echinococcus multilocularis neuropeptides capa receptor 0.014 0.0843 0.1531
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.0843 0.1531
Schistosoma mansoni neuropeptide f receptor 76f 0.014 0.0843 0.3157
Brugia malayi G-protein coupled receptor 0.014 0.0843 0.0843
Brugia malayi secreted modular calcium-binding protein 1 0.0057 0.0215 0.0215
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0079 0.0144
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0079 0.0079
Echinococcus multilocularis musashi 0.0031 0.0021 0.0038
Echinococcus granulosus intermediate filament protein 0.0031 0.0021 0.0024
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0118 0.0677 0.0677
Onchocerca volvulus 0.0173 0.1096 0.1077
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Echinococcus granulosus neuropeptides capa receptor 0.014 0.0843 0.0953
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Echinococcus multilocularis neuropeptide Y receptor 0.014 0.0843 0.1531
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0079 0.0089
Echinococcus granulosus g protein coupled receptor 0.014 0.0843 0.0953
Onchocerca volvulus 0.014 0.0843 0.0824
Onchocerca volvulus 0.0057 0.0215 0.0194
Brugia malayi hypothetical protein 0.044 0.3119 0.3119
Brugia malayi hypothetical protein 0.0173 0.1096 0.1096
Onchocerca volvulus 0.014 0.0843 0.0824
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0192 0.0718
Schistosoma mansoni hypothetical protein 0.0172 0.1086 0.4067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0192 0.0192
Echinococcus multilocularis tachykinin peptides receptor 99D 0.014 0.0843 0.1531
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0079 0.0144
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.014 0.0843 0.1531
Loa Loa (eye worm) hypothetical protein 0.135 1 1
Echinococcus granulosus neuropeptide receptor A26 0.014 0.0843 0.0953
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0843 0.0953
Echinococcus multilocularis mitogen activated protein kinase 0.0118 0.0677 0.123
Echinococcus multilocularis sex peptide receptor 0.014 0.0843 0.1531
Onchocerca volvulus 0.014 0.0843 0.0824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0054 0.0192 0.0192
Echinococcus granulosus neuropeptide receptor 0.014 0.0843 0.0953
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0079 0.0296
Echinococcus granulosus neuropeptide Y receptor 0.014 0.0843 0.0953
Onchocerca volvulus Neuropeptide F receptor homolog 0.014 0.0843 0.0824
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0192 0.0718
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus Solute carrier organic anion transporter family 0.0173 0.1096 0.1238
Schistosoma mansoni neuropeptide receptor 0.014 0.0843 0.3157
Echinococcus multilocularis lamin dm0 0.0031 0.0021 0.0038
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.014 0.0843 0.1531
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis orexin receptor type 2 0.014 0.0843 0.1531
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0192 0.0217
Echinococcus multilocularis fmrfamide receptor 0.014 0.0843 0.1531
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0192 0.0217
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Onchocerca volvulus 0.0173 0.1096 0.1077
Onchocerca volvulus 0.044 0.3119 0.3105
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.014 0.0843 0.3157
Echinococcus multilocularis neuropeptide FF receptor 2 0.014 0.0843 0.1531
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0079 0.0089
Brugia malayi intermediate filament protein 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0057 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0192 0.0192
Schistosoma mansoni retinoic acid receptor RXR 0.0054 0.0192 0.0718
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0192 0.0718
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0192 0.0348
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0079
Onchocerca volvulus Putative organic anion transporter 0.0173 0.1096 0.1077
Loa Loa (eye worm) hypothetical protein 0.0173 0.1096 0.1096
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.014 0.0843 0.0843
Brugia malayi MAP kinase sur-1 0.0118 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0047
Brugia malayi gonadotropin-releasing hormone receptor 2 0.014 0.0843 0.0843
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.0843 0.1531
Brugia malayi ORL1-like opioid receptor 0.014 0.0843 0.0843
Toxoplasma gondii transporter, major facilitator family protein 0.0173 0.1096 1
Schistosoma mansoni hypothetical protein 0.014 0.0843 0.3157
Onchocerca volvulus 0.014 0.0843 0.0824
Brugia malayi Tachykinin-like peptides receptor 99D 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis neuropeptide receptor 0.014 0.0843 0.1531
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0079 0.0079
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.014 0.0843 0.0824
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0079 0.0144
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0079 0.0296
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0192 0.0192
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Entamoeba histolytica hypothetical protein 0.0039 0.0079 0.5
Brugia malayi neuropeptide F receptor 0.014 0.0843 0.0843
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0192 0.0718
Echinococcus multilocularis neuropeptides capa receptor 0.014 0.0843 0.1531
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0843 0.0953
Brugia malayi G-protein coupled receptor 0.014 0.0843 0.0843
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0087 0.0087
Brugia malayi putative neuropeptide receptor NPR1 0.014 0.0843 0.0843
Schistosoma mansoni neuropeptide F-like receptor 0.014 0.0843 0.3157
Echinococcus granulosus tachykinin peptides receptor 99D 0.014 0.0843 0.0953
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0079 0.0296
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0192 0.0348
Schistosoma mansoni organic anion transporter 0.0173 0.1096 0.4102
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0708 0.08
Loa Loa (eye worm) neuropeptide F receptor 0.014 0.0843 0.0843
Schistosoma mansoni hypothetical protein 0.014 0.0843 0.3157
Onchocerca volvulus 0.014 0.0843 0.0824
Brugia malayi putative neuropeptide receptor 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0057 0.0215 0.0215
Schistosoma mansoni opsin-like receptor 0.014 0.0843 0.3157
Echinococcus multilocularis g protein coupled receptor 0.014 0.0843 0.1531
Echinococcus multilocularis allatostatin A receptor 0.014 0.0843 0.1531
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0079 0.0296
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Trypanosoma cruzi MFS transporter, putative 0.0173 0.1096 1
Loa Loa (eye worm) TYRA-2 protein 0.014 0.0843 0.0843
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0708 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0079 0.0079
Brugia malayi hypoxia-induced factor 1 0.0174 0.1103 0.1103
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0079 0.0144
Echinococcus granulosus geminin 0.0172 0.1086 0.1227
Schistosoma mansoni biogenic amine receptor 0.014 0.0843 0.3157
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.014 0.0843 0.0843
Brugia malayi hypothetical protein 0.0173 0.1096 0.1096
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0079 0.0296
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.0843 0.0953
Brugia malayi AKH receptor 0.014 0.0843 0.0843
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0192 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.0843 0.0953
Brugia malayi Serotonin receptor 0.014 0.0843 0.0843
Echinococcus granulosus mitogen activated protein kinase 0.0118 0.0677 0.0765
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0215 0.0215
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0079 0.0144
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.01 0.0182
Brugia malayi Melatonin receptor type 1A 0.014 0.0843 0.0843
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0054 0.0192 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Brugia malayi PXA domain containing protein 0.0039 0.0079 0.0079
Echinococcus multilocularis serotonin receptor 0.014 0.0843 0.1531
Onchocerca volvulus Putative organic anion transporter 0.135 1 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0192 0.0718
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Echinococcus granulosus lamin 0.0031 0.0021 0.0024
Schistosoma mansoni myosin xvIII 0.014 0.0843 0.3157
Schistosoma mansoni neuropeptide receptor 0.014 0.0843 0.3157
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.014 0.0843 0.1531
Echinococcus multilocularis G protein coupled receptor 139 0.014 0.0843 0.1531
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Brugia malayi hypothetical protein 0.0189 0.1213 0.1213
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis Protein lozenge 0.0055 0.0203 0.0369
Schistosoma mansoni amine GPCR 0.014 0.0843 0.3157
Brugia malayi Dopamine receptor protein 2 0.014 0.0843 0.0843
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0118 0.0677 0.5
Brugia malayi follicle stimulating hormone receptor 0.0672 0.4871 0.4871
Schistosoma mansoni single-minded 0.0056 0.0211 0.0789
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0192 0.0217
Echinococcus granulosus g-protein coupled receptor 0.014 0.0843 0.0953
Brugia malayi Dopamine receptor 0.014 0.0843 0.0843
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0192 0.0192
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0079 0.0144
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0079 0.0079
Onchocerca volvulus 0.014 0.0843 0.0824
Echinococcus multilocularis follistatin 0.0057 0.0215 0.039
Schistosoma mansoni hypothetical protein 0.0172 0.1086 0.4067
Onchocerca volvulus 0.0054 0.0192 0.0171
Trypanosoma brucei protein kinase, putative 0.0118 0.0677 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0192 0.0217
Loa Loa (eye worm) hypothetical protein 0.044 0.3119 0.3119
Schistosoma mansoni organic anion transporter 0.0173 0.1096 0.4102
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.014 0.0843 0.0843
Echinococcus granulosus sex peptide receptor 0.014 0.0843 0.0953
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.0843 0.0953
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus lamin dm0 0.0031 0.0021 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0192 0.0192
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0079 0.0079
Entamoeba histolytica hypothetical protein 0.0039 0.0079 0.5
Echinococcus granulosus agrin 0.0057 0.0215 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0192 0.0171
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.014 0.0843 0.0953
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0079 0.0079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0054 0.0192 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0192 0.0192
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0079 0.0089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.0843 0.3157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0192 0.0192
Onchocerca volvulus 0.014 0.0843 0.0824
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0677 1
Brugia malayi sulfakinin receptor protein 0.014 0.0843 0.0843
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni lozenge 0.0055 0.0203 0.0761
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.014 0.0843 0.0953
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Brugia malayi neuropeptide F receptor 0.014 0.0843 0.0843
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0192 0.0171
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0168 0.0168
Echinococcus granulosus neuropeptides capa receptor 0.014 0.0843 0.0953
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0079 0.0144
Echinococcus multilocularis lamin 0.0031 0.0021 0.0038
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0079
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.014 0.0843 0.0843
Echinococcus granulosus Solute carrier family 22 5 0.1198 0.8852 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.1096 0.1096
Schistosoma mansoni agrin 0.0057 0.0215 0.0805
Echinococcus multilocularis G-protein coupled receptor, putative 0.014 0.0843 0.1531
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0192 0.0718
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0192 0.0718
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Schistosoma mansoni growth hormone secretagogue receptor 0.014 0.0843 0.3157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0192 0.0348
Brugia malayi sodium-independent organic anion transporter family protein 0.0173 0.1096 0.1096
Echinococcus granulosus g protein coupled receptor 0.014 0.0843 0.0953
Echinococcus multilocularis dro:myosuppressin receptor 0.014 0.0843 0.1531
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0708 0.2652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0192 0.0192
Brugia malayi G protein-coupled receptor F59B2.13 0.014 0.0843 0.0843
Onchocerca volvulus Putative organic anion transporter 0.0173 0.1096 0.1077
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus neuropeptide FF receptor 2 0.014 0.0843 0.0953
Onchocerca volvulus 0.014 0.0843 0.0824
Brugia malayi PXA domain containing protein 0.0039 0.0079 0.0079
Onchocerca volvulus 0.014 0.0843 0.0824
Echinococcus multilocularis g protein coupled receptor 0.014 0.0843 0.1531
Onchocerca volvulus 0.0173 0.1096 0.1077
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0173 0.1096 0.1096
Echinococcus granulosus orexin receptor type 2 0.014 0.0843 0.0953
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.014 0.0843 0.3157
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0021 0.0021
Echinococcus granulosus serotonin receptor 0.014 0.0843 0.0953
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0192 0.0192
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0054 0.0192 0.0348
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.014 0.0843 0.3157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0708 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0708 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0087 0.0098
Brugia malayi SPARC precursor 0.0057 0.0215 0.0215
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0173 0.1096 0.1989
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0192 0.0171
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0708 0.2652
Echinococcus granulosus follistatin 0.0057 0.0215 0.0243
Loa Loa (eye worm) hypothetical protein 0.0057 0.0215 0.0215
Brugia malayi steroid hormone receptor 0.0054 0.0192 0.0192
Echinococcus multilocularis neuropeptide receptor 0.014 0.0843 0.1531
Echinococcus multilocularis neuropeptide receptor A26 0.014 0.0843 0.1531
Echinococcus granulosus alpha 1A adrenergic receptor 0.014 0.0843 0.0953
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0079 0.0079
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0079 0.0089
Brugia malayi bHLH-PAS transcription factor 0.0042 0.01 0.01
Echinococcus multilocularis expressed protein 0.0756 0.5509 1
Onchocerca volvulus 0.014 0.0843 0.0824
Brugia malayi Serotonin/octopamine receptor family protein 7 0.014 0.0843 0.0843
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0672 0.4871 0.4871
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.014 0.0843 0.1531
Loa Loa (eye worm) runx1 0.0055 0.0203 0.0203
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0192 0.0348
Loa Loa (eye worm) neuropeptide F receptor 0.014 0.0843 0.0843
Brugia malayi PAS domain containing protein 0.0056 0.0211 0.0211
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.044 0.3119 0.3119
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0087 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0192 0.0192
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0168 0.0168
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.0843 0.3157
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0843 0.0953
Echinococcus multilocularis thyroid hormone receptor alpha 0.0054 0.0192 0.0348
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0057 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0079 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0843 0.0953
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0192 0.0217
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0021 0.0021
Echinococcus granulosus single minded 2 0.0042 0.01 0.0113
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0173 0.1096 0.1989
Onchocerca volvulus 0.0042 0.01 0.0079
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0079 0.0144
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0192 0.0718
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0079
Echinococcus granulosus peptide allatostatin:somatostatin 0.014 0.0843 0.0953
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0192 0.0192
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.014 0.0843 0.0953
Echinococcus granulosus g protein coupled receptor 0.014 0.0843 0.0953
Schistosoma mansoni amine GPCR 0.014 0.0843 0.3157
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0843 0.0953
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0173 0.1096 0.1096
Schistosoma mansoni opsin-like receptor 0.014 0.0843 0.3157
Echinococcus multilocularis mitogen activated protein kinase 3 0.0118 0.0677 0.123
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0079 0.0089
Echinococcus multilocularis geminin 0.0172 0.1086 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0087 0.0326
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0192 0.0718
Echinococcus granulosus thyrotropin releasing hormone receptor 0.014 0.0843 0.0953
Onchocerca volvulus 0.014 0.0843 0.0824
Echinococcus granulosus 7tm_1 domain containing protein 0.014 0.0843 0.0953
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0192 0.0217
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0079 0.0079
Echinococcus granulosus dro:myosuppressin receptor 0.014 0.0843 0.0953
Echinococcus granulosus biogenic amine 5HT receptor 0.014 0.0843 0.0953
Onchocerca volvulus 0.014 0.0843 0.0824
Echinococcus multilocularis somatostatin receptor 0.014 0.0843 0.1531
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.014 0.0843 0.3157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.0843 0.1531
Schistosoma mansoni follistatin 0.0057 0.0215 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0192 0.0192
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0079 0.0296
Brugia malayi GnHR receptor homolog 0.014 0.0843 0.0843
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.014 0.0843 0.0843
Loa Loa (eye worm) hypoxia-induced factor 1 0.0174 0.1103 0.1103
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0843 0.0953
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0021
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.014 0.0843 0.0843
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.014 0.0843 0.1531
Schistosoma mansoni lamin 0.0031 0.0021 0.0079
Schistosoma mansoni biogenic amine (5HT) receptor 0.014 0.0843 0.3157
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0192 0.0192
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0021 0.0021
Brugia malayi hypothetical protein 0.0039 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus neuropeptide receptor 0.014 0.0843 0.0953
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0079 0.0089
Schistosoma mansoni neuropeptide F-like receptor 0.014 0.0843 0.3157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Loa Loa (eye worm) hypothetical protein 0.0173 0.1096 0.1096
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0173 0.1096 0.1238
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.014 0.0843 0.3157
Schistosoma mansoni peptide (allatostatin)-like receptor 0.014 0.0843 0.3157
Schistosoma mansoni amine GPCR 0.014 0.0843 0.3157
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.014 0.0843 0.3157
Brugia malayi RE15519p 0.014 0.0843 0.0843
Onchocerca volvulus 0.014 0.0843 0.0824
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0192 0.0718
Onchocerca volvulus 0.014 0.0843 0.0824
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.014 0.0843 0.3157
Echinococcus granulosus neuropeptide Y receptor 0.014 0.0843 0.0953
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.014 0.0843 0.1531
Schistosoma mansoni lamin 0.0031 0.0021 0.0079
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0079 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0054 0.0192 0.0192
Schistosoma mansoni amine GPCR 0.014 0.0843 0.3157
Echinococcus multilocularis neuropeptide Y receptor 0.014 0.0843 0.1531
Loa Loa (eye worm) hypothetical protein 0.0051 0.0168 0.0168
Schistosoma mansoni biogenic amine receptor 0.014 0.0843 0.3157
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0079 0.0089
Loa Loa (eye worm) agrin synaptic family protein 0.0057 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0079
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni neuropeptide receptor 0.014 0.0843 0.3157
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0677 0.2536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Echinococcus multilocularis g-protein coupled receptor 0.014 0.0843 0.1531
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0192 0.0217
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0708 0.1286
Loa Loa (eye worm) melatonin receptor type 1A 0.014 0.0843 0.0843
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0677 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni hypothetical protein 0.014 0.0843 0.3157
Onchocerca volvulus 0.014 0.0843 0.0824
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0708 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0843 0.3157
Loa Loa (eye worm) hypothetical protein 0.0173 0.1096 0.1096
Brugia malayi sodium-independent organic anion transporter family protein 0.0173 0.1096 0.1096
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni histamine h1 receptor 0.014 0.0843 0.3157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Schistosoma mansoni biogenic amine (5HT) receptor 0.014 0.0843 0.3157
Onchocerca volvulus 0.0173 0.1096 0.1077
Echinococcus multilocularis expressed protein 0.0057 0.0215 0.039
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0381 0.2671 1
Echinococcus granulosus fmrfamide receptor 0.014 0.0843 0.0953
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0079 0.0144
Echinococcus multilocularis g protein coupled receptor 0.014 0.0843 0.1531
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.014 0.0843 0.3157
Schistosoma mansoni adenoreceptor 0.014 0.0843 0.3157
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.0211 0.0789
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0843 0.0953
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0708 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0118 0.0677 0.0765
Schistosoma mansoni biogenic amine receptor 0.014 0.0843 0.3157
Entamoeba histolytica hypothetical protein 0.0039 0.0079 0.5
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0087 0.0158
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0843 0.1531
Echinococcus granulosus neuropeptide s receptor 0.014 0.0843 0.0953
Echinococcus granulosus biogenic amine 5HT receptor 0.014 0.0843 0.0953
Echinococcus multilocularis biogenic amine (5HT) receptor 0.014 0.0843 0.1531
Onchocerca volvulus 0.014 0.0843 0.0824
Schistosoma mansoni alpha-1 adrenergic receptor 0.014 0.0843 0.3157
Schistosoma mansoni amine GPCR 0.014 0.0843 0.3157
Echinococcus multilocularis fmrfamide receptor 0.014 0.0843 0.1531
Brugia malayi sodium-independent organic anion transporter family protein 0.0173 0.1096 0.1096
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.014 0.0843 0.3157
Echinococcus granulosus 7TM GPCR rhodopsin 0.014 0.0843 0.0953
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0079 0.0296
Brugia malayi ecdysteroid receptor 0.0054 0.0192 0.0192
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0118 0.0677 0.5251
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Brugia malayi Dopamine receptor protein 1 0.014 0.0843 0.0843
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0192 0.0348
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.014 0.0843 0.1531
Loa Loa (eye worm) G-protein coupled receptor 0.014 0.0843 0.0843
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0192 0.0192
Echinococcus granulosus allatostatin A receptor 0.014 0.0843 0.0953
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.014 0.0843 0.0953
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0192 0.0348
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0677 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0192 0.0192
Brugia malayi hypothetical protein 0.0039 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0173 0.1096 0.1096
Brugia malayi nuclear hormone receptor 0.0054 0.0192 0.0192
Schistosoma mansoni coup transcription factor 0.0054 0.0192 0.0718
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.014 0.0843 0.3157
Echinococcus multilocularis serotonin receptor 0.014 0.0843 0.1531
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0192 0.0718
Echinococcus granulosus G protein coupled receptor 139 0.014 0.0843 0.0953
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0087 0.0087
Brugia malayi Serotonin receptor 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Brugia malayi nuclear receptor NHR-88 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0057 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.014 0.0843 0.1531
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.014 0.0843 0.0953
Giardia lamblia Kinase, CMGC MAPK 0.0118 0.0677 0.5
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0215 0.0215
Brugia malayi larval opioid receptor 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis alpha 1A adrenergic receptor 0.014 0.0843 0.1531
Echinococcus multilocularis neuropeptide s receptor 0.014 0.0843 0.1531
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Echinococcus granulosus expressed protein 0.0756 0.5509 0.6223
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.0843 0.3157
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0087 0.0326
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0057 0.0215 0.0215
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0079 0.0296
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.014 0.0843 0.0843
Echinococcus granulosus hypothetical protein 0.014 0.0843 0.0953
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0079 0.0296
Onchocerca volvulus 0.014 0.0843 0.0824
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0087 0.0326
Onchocerca volvulus 0.0173 0.1096 0.1077
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0192 0.0348
Schistosoma mansoni intermediate filament proteins 0.0031 0.0021 0.0079
Loa Loa (eye worm) hypothetical protein 0.0189 0.1213 0.1213
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0708 0.5603
Echinococcus granulosus somatostatin receptor 0.014 0.0843 0.0953
Schistosoma mansoni neuropeptide receptor 0.014 0.0843 0.3157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0192 0.0192
Brugia malayi hypothetical protein 0.014 0.0843 0.0843
Echinococcus multilocularis agrin 0.0057 0.0215 0.039

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.16 uM Inhibition of IGFR (unknown origin) ChEMBL. 18501599
Ratio IC50 (binding) = 0.64 Ratio of IC50 for IR (unknown origin) to IC50 for IGFR (unknown origin) ChEMBL. 18501599

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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