Detailed information for compound 511680

Basic information

Technical information
  • TDR Targets ID: 511680
  • Name: (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-1 7-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,1 5,16-decahydro-1H-cyclopenta[a]phenanthren-3- one
  • MW: 324.457 | Formula: C22H28O2
  • H donors: 1 H acceptors: 2 LogP: 2.67 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#C[C@]1(O)CC[C@@H]2[C@]1(CC)CC(=C)[C@H]1[C@H]2CCC2=CC(=O)CC[C@H]12
  • InChi: 1S/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
  • InChiKey: GCKFUYQCUCGESZ-BPIQYHPVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • 3-keto-desogestrel
  • ETONOGESTREL
  • Org-3236
  • D04104
  • Etonogestrel (USAN/INN)
  • Implanon (TN)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens sex hormone-binding globulin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0593 0.0548
Loa Loa (eye worm) RNA binding protein 0.0061 0.0349 0.0348
Mycobacterium tuberculosis Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) 0.0106 0.0902 0.1634
Onchocerca volvulus Hexokinase homolog 0.0532 0.6124 0.6104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0073 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0486 0.0441
Brugia malayi hypothetical protein 0.0167 0.1645 0.1605
Echinococcus granulosus jun protein 0.0081 0.0593 0.0548
Leishmania major cathepsin L-like protease 0.0068 0.043 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0194 0.1975 0.1936
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0073 0.0025
Onchocerca volvulus 0.0064 0.038 0.0332
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0067 0.0416 0.037
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0061 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Entamoeba histolytica hexokinase 1 0.0847 1 1
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0202 0.2074 0.608
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0088 0.0675 0.0674
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0068 0.0434 0.0738
Echinococcus granulosus lysine specific demethylase 5A 0.0119 0.1053 0.101
Trichomonas vaginalis esterase, putative 0.0072 0.0486 0.1423
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0073 0.0025
Loa Loa (eye worm) beta-lactamase 0.0072 0.0486 0.0485
Schistosoma mansoni single-minded 0.005 0.0208 0.0161
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0081 0.0588 0.0542
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0349 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0073 0.0072
Giardia lamblia Prenyltransferase 0.006 0.0331 0.0844
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Onchocerca volvulus 0.0067 0.0416 0.0369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0073 0.0072
Brugia malayi nuclear receptor NHR-88 0.0039 0.0073 0.0025
Brugia malayi glutaminase DH11.1 0.0264 0.2839 0.2805
Entamoeba histolytica hypothetical protein 0.007 0.0461 0.046
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.006 0.0331 0.097
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0088 0.0675 0.063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0073 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0175 0.0128
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0194 0.1975 0.1936
Toxoplasma gondii ABC1 family protein 0.0072 0.0486 0.0441
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0039 0.007 0.0043
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0095 0.0765 0.2694
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0486 0.0441
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0073 0.0025
Trypanosoma cruzi squalene synthase, putative 0.0242 0.257 0.2534
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.786 0.785
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0252 0.0205
Brugia malayi Hexokinase family protein 0.0532 0.6124 0.6105
Loa Loa (eye worm) hypothetical protein 0.0072 0.0486 0.0485
Brugia malayi jmjC domain containing protein 0.0078 0.0551 0.0506
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0349 0.0302
Leishmania major hypothetical protein, conserved 0.0075 0.0524 0.0479
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0073 0.0072
Leishmania major cathepsin L-like protease 0.0068 0.043 0.0384
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0088 0.0675 0.063
Trypanosoma brucei hexokinase 0.0847 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0073 0.0072
Mycobacterium ulcerans beta-lactamase 0.0072 0.0486 0.1712
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.786 0.785
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0067 0.0416 0.0415
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0073 0.0025
Brugia malayi Hexokinase family protein 0.0847 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0073 0.0024
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0139 0.1303 0.1261
Trypanosoma brucei squalene synthase, putative 0.0242 0.257 0.2565
Schistosoma mansoni porphobilinogen synthase 0.0209 0.2159 0.2122
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0486 0.0839
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0486 0.0441
Leishmania major hypothetical protein, conserved 0.0045 0.0147 0.01
Brugia malayi jmjC domain containing protein 0.0045 0.0147 0.01
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.043 0.0384
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0073 0.0025
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0067 0.0416 0.037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0073 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0073 0.0025
Trypanosoma cruzi hexokinase, putative 0.0847 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0486 0.0839
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0095 0.0765 0.1372
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0486 0.0441
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.341 0.341
Echinococcus multilocularis jumonji domain containing 1A 0.0045 0.0147 0.01
Echinococcus granulosus protein farnesyltransferase subunit beta 0.006 0.0331 0.0285
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0073 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0048 0.0047
Leishmania major farnesyltransferase beta subunit 0.006 0.0331 0.0285
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Echinococcus granulosus hexokinase 0.0847 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0486 0.0485
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.006 0.0331 0.0331
Mycobacterium ulcerans lipase LipD 0.0072 0.0486 0.1712
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0073 0.0025
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0067 0.0416 0.041
Loa Loa (eye worm) hypothetical protein 0.0078 0.0551 0.055
Trypanosoma cruzi lanosterol synthase, putative 0.0066 0.0403 0.0357
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0067 0.0416 0.037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0486 0.0485
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0202 0.2074 0.608
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0139 0.1303 0.1261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Onchocerca volvulus 0.0072 0.0486 0.0439
Loa Loa (eye worm) hypothetical protein 0.0247 0.2625 0.2624
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.006 0.0331 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0461 0.0415
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0088 0.0675 0.063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0045 0.0147 0.01
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0103 0.0056
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0103 0.03
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.0675 0.063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0073 0.0025
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0369 0.0323
Echinococcus granulosus tar DNA binding protein 0.0061 0.0349 0.0302
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0048 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0084 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0073 0.0025
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0073 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0147 0.0147
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0067 0.0416 0.1217
Loa Loa (eye worm) hypothetical protein 0.0578 0.6693 0.6692
Brugia malayi fructose-bisphosphate aldolase 1 0.0088 0.0675 0.063
Echinococcus multilocularis lysine specific demethylase 6a 0.0078 0.0551 0.0506
Wolbachia endosymbiont of Brugia malayi delta-aminolevulinic acid dehydratase 0.0209 0.2159 1
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0088 0.0675 0.063
Brugia malayi jmjC domain containing protein 0.006 0.0331 0.0285
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0147 0.01
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0357 0.0311
Trypanosoma brucei lanosterol synthase 0.0066 0.0403 0.0397
Loa Loa (eye worm) hypothetical protein 0.0079 0.0566 0.0565
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0068 0.0434 0.1527
Echinococcus granulosus lysine specific demethylase 6a 0.0078 0.0551 0.0506
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0463 0.5275 1
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0068 0.0434 0.1527
Trypanosoma cruzi protein farnesyltransferase, putative 0.006 0.0331 0.0285
Brugia malayi Hexokinase family protein 0.0262 0.2816 0.2782
Brugia malayi PAS domain containing protein 0.005 0.0208 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0486 0.0441
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0486 0.0839
Schistosoma mansoni phd/f-box containing protein 0.0045 0.0147 0.01
Onchocerca volvulus 0.0847 1 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0194 0.1975 0.5789
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0067 0.0416 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Echinococcus multilocularis jun protein 0.0081 0.0593 0.0548
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0486 0.1423
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0194 0.1975 0.1974
Entamoeba histolytica hexokinase 2 0.0847 1 1
Echinococcus granulosus dna polymerase kappa 0.004 0.0084 0.0037
Brugia malayi hypothetical protein 0.007 0.0461 0.0415
Brugia malayi hypoxia-induced factor 1 0.0154 0.1486 0.1445
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0486 0.0485
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0593 0.0548
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0039 0.007 0.0247
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0175 0.0174
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0067 0.0416 0.037
Leishmania major hexokinase, putative 0.0847 1 1
Mycobacterium leprae PROBABLE DELTA-AMINOLEVULINIC ACID DEHYDRATASE HEMB (PORPHOBILINOGEN SYNTHASE) (ALAD) (ALADH) 0.0209 0.2159 1
Onchocerca volvulus 0.0081 0.0593 0.0547
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0084 0.0037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0049 0.0199 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0073 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0073 0.0025
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0194 0.1975 0.1936
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0416 0.037
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.006 0.0331 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Schistosoma mansoni thyroid hormone receptor 0.0162 0.158 0.154
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Onchocerca volvulus 0.0072 0.0486 0.0439
Trypanosoma cruzi phytoene synthase, putative 0.0075 0.0524 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0175 0.0128
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0194 0.1975 0.1974
Loa Loa (eye worm) hypothetical protein 0.0072 0.0486 0.0485
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0084 0.0297
Plasmodium falciparum porphobilinogen synthase 0.0209 0.2159 0.2122
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0084 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0073 0.0072
Schistosoma mansoni phosphatidylserine receptor 0.0045 0.0147 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0073 0.0025
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.006 0.0331 0.0331
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0349 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0084 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.043 0.0384
Brugia malayi jmjC domain containing protein 0.0045 0.0147 0.01
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.006 0.0331 0.0285
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0049 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0165 0.0164
Toxoplasma gondii PLU-1 family protein 0.0042 0.0119 0.0072
Onchocerca volvulus 0.0847 1 1
Entamoeba histolytica hypothetical protein 0.007 0.0461 0.046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0084 0.0245
Plasmodium vivax delta-aminolevulinic acid dehydratase, putative 0.0209 0.2159 0.2122
Trypanosoma cruzi protein farnesyltransferase, putative 0.006 0.0331 0.0285
Brugia malayi jmjC domain containing protein 0.0045 0.0147 0.01
Echinococcus granulosus delta aminolevulinic acid dehydratase 0.0209 0.2159 0.2122
Loa Loa (eye worm) hexokinase 0.0262 0.2816 0.2816
Mycobacterium tuberculosis Conserved protein 0.0072 0.0486 0.0839
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.006 0.0331 0.097
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0175 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Brugia malayi fructose-bisphosphate aldolase 2 0.0088 0.0675 0.063
Echinococcus multilocularis hexokinase 0.0847 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0073 0.0025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0349 0.0348
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0073 0.0025
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1316 0.1275
Brugia malayi hexokinase type II 0.0269 0.2905 0.2871
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0349 0.0302
Chlamydia trachomatis delta-aminolevulinic acid dehydratase 0.0209 0.2159 0.5
Schistosoma mansoni thyroid hormone receptor 0.0162 0.158 0.154
Brugia malayi jmjC domain containing protein 0.0063 0.0369 0.0323
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0194 0.1975 0.1936
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0073 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0416 0.037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0461 0.0415
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0075 0.0524 0.0477
Loa Loa (eye worm) hypoxia-induced factor 1 0.0154 0.1486 0.1485
Loa Loa (eye worm) acetyltransferase 0.014 0.1316 0.1316
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0486 0.0839
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.341 0.341
Schistosoma mansoni hexokinase 0.0847 1 1
Echinococcus multilocularis dna polymerase kappa 0.004 0.0084 0.0037
Trypanosoma cruzi lanosterol synthase, putative 0.0066 0.0403 0.0357
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0073 0.0025
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0194 0.1975 0.1936
Loa Loa (eye worm) hypothetical protein 0.0194 0.1975 0.1974
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.0675 0.0669
Echinococcus multilocularis phd:f box containing protein 0.0045 0.0147 0.01
Toxoplasma gondii hexokinase 0.0847 1 1
Echinococcus granulosus cpg binding protein 0.0054 0.0265 0.0218
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0088 0.0675 0.063
Entamoeba histolytica hypothetical protein 0.007 0.0461 0.046
Brugia malayi beta-lactamase 0.0072 0.0486 0.0441
Toxoplasma gondii hypothetical protein 0.0127 0.1156 0.1114
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.006 0.0331 0.097
Brugia malayi steroid hormone receptor 0.0039 0.0073 0.0025
Echinococcus multilocularis lysine specific demethylase 5A 0.0113 0.0987 0.0944
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0073 0.0025
Plasmodium vivax farnesyltransferase beta subunit, putative 0.006 0.0331 0.0285
Giardia lamblia Rab geranylgeranyltransferase 0.0194 0.1975 0.5731
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0486 0.0839
Loa Loa (eye worm) glutaminase 0.0264 0.2839 0.2839
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0349 0.0302
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0067 0.0416 0.037
Leishmania major hexokinase, putative 0.0847 1 1
Brugia malayi RNA binding protein 0.0061 0.0349 0.0302
Trypanosoma cruzi hexokinase, putative 0.0847 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.043 0.0384
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0486 0.048
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.0675 0.063
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0095 0.0765 0.2694
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0073 0.0025
Mycobacterium ulcerans hypothetical protein 0.0072 0.0486 0.1712
Echinococcus granulosus single minded 2 0.0037 0.0049 0.0001
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0088 0.0675 0.063
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0486 0.0839
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.146 0.5142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0073 0.0025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0486 0.1712
Giardia lamblia Fructose-bisphosphate aldolase 0.0311 0.341 1
Schistosoma mansoni cpg binding protein 0.0049 0.0199 0.0152
Echinococcus granulosus Squalene phytoene synthase 0.0075 0.0524 0.0479
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0073 0.0025
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0067 0.0416 0.037
Trypanosoma brucei protein farnesyltransferase beta subunit 0.006 0.0331 0.0325
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0073 0.0025
Onchocerca volvulus 0.0039 0.0073 0.0024
Loa Loa (eye worm) glutaminase 2 0.0264 0.2839 0.2839
Loa Loa (eye worm) hexokinase 0.0532 0.6124 0.6123
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.0675 0.063
Loa Loa (eye worm) jmjC domain-containing protein 0.0161 0.1574 0.1574
Trypanosoma brucei hexokinase, putative 0.0847 1 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0194 0.1975 0.5789
Trichomonas vaginalis aldehyde oxidase, putative 0.0202 0.2074 0.608
Plasmodium falciparum protein farnesyltransferase subunit beta 0.006 0.0331 0.0285
Brugia malayi jmjC domain containing protein 0.0161 0.1574 0.1534
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.1053 0.101
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0067 0.0416 0.037
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0194 0.1975 0.5789
Schistosoma mansoni porphobilinogen synthase 0.0209 0.2159 0.2122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0073 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Brugia malayi ecdysteroid receptor 0.0039 0.0073 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0486 0.0441
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1105 0.1062
Loa Loa (eye worm) hypothetical protein 0.0045 0.0147 0.0147
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0067 0.0416 0.037
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.006 0.0331 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0073 0.0025
Leishmania major hypothetical protein, conserved 0.0072 0.0486 0.0441
Trypanosoma cruzi squalene synthase, putative 0.0242 0.257 0.2534
Echinococcus multilocularis hexokinase 0.0847 1 1
Schistosoma mansoni hypothetical protein 0.0315 0.3459 0.3427
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.146 0.582
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0061 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0175 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0147 0.0147
Echinococcus multilocularis hexokinase type 2 0.0847 1 1
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0088 0.0675 0.063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0073 0.0025
Plasmodium vivax hexokinase, putative 0.0847 1 1
Echinococcus granulosus hexokinase 0.0847 1 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0088 0.0675 0.063
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0486 0.1423
Brugia malayi CXXC zinc finger family protein 0.0049 0.0199 0.0152
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1316 0.1275
Leishmania major squalene synthase, putative 0.0242 0.257 0.2534
Echinococcus granulosus microtubule associated protein 2 0.0673 0.786 0.785
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0084 0.0037
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.006 0.0332 0.1168
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0088 0.0675 0.063
Loa Loa (eye worm) hypothetical protein 0.0269 0.2905 0.2904
Schistosoma mansoni protein phosphatase 2C 0.0045 0.0147 0.01
Echinococcus multilocularis delta aminolevulinic acid dehydratase 0.0209 0.2159 0.2122
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Plasmodium vivax JmjC domain containing protein 0.0066 0.0412 0.0366
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0486 0.0839
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.158 0.154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0349 0.0302
Schistosoma mansoni jumonji domain containing protein 0.0045 0.0147 0.01
Loa Loa (eye worm) hexokinase 0.0847 1 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0103 0.0056
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0073 0.0025
Schistosoma mansoni hypothetical protein 0.0075 0.0524 0.0479
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0349 0.0302
Toxoplasma gondii parasite porphobilinogen synthase PBGS 0.0209 0.2159 0.2122
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0194 0.1975 0.1936
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.043 0.0424
Echinococcus granulosus JmjC domain containing protein 4 0.0045 0.0147 0.01
Leishmania major fructose-1,6-bisphosphate aldolase 0.0088 0.0675 0.063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0175 0.0128
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1105 0.1062
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0048 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0134 0.1238 0.4359
Echinococcus multilocularis snurportin 1 0.0315 0.3459 0.3427
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0593 0.0548
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1316 0.1275
Schistosoma mansoni protein farnesyltransferase subunit beta 0.006 0.0331 0.0285
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.043 0.0384
Brugia malayi Cytochrome P450 family protein 0.0046 0.0165 0.0118
Brugia malayi jmjC domain containing protein 0.006 0.0331 0.0285
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0073 0.0024
Onchocerca volvulus 0.0049 0.0199 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0486 0.0441
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0049 0.0001
Echinococcus granulosus phd:f box containing protein 0.0045 0.0147 0.01
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.006 0.0331 0.097
Mycobacterium ulcerans delta-aminolevulinic acid dehydratase 0.0209 0.2159 0.7605
Brugia malayi beta-lactamase family protein 0.0072 0.0486 0.0441
Schistosoma mansoni cpg binding protein 0.0054 0.0265 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0349 0.0302
Treponema pallidum hexokinase (hxk) 0.0847 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0175 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0073 0.0025
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.006 0.0331 0.097
Echinococcus granulosus hexokinase type 2 0.0847 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0084 0.0245
Loa Loa (eye worm) hypothetical protein 0.0167 0.1645 0.1644
Plasmodium falciparum JmjC domain-containing protein, putative 0.0066 0.0412 0.0366
Brugia malayi TAR-binding protein 0.0061 0.0349 0.0302
Plasmodium falciparum hexokinase 0.0847 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0048 0.0168
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0045 0.0147 0.0141
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0073 0.0025
Leishmania major lanosterol synthase, putative 0.0049 0.0204 0.0157
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0049 0.0173
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0061 0.0013
Schistosoma mansoni cpg binding protein 0.0054 0.0265 0.0218
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.007 0.0451 0.0405
Brugia malayi hypothetical protein 0.0064 0.038 0.0333
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0078 0.0551 0.0506
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0073 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0073 0.0024
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0127 0.1156 0.3389
Schistosoma mansoni jun-related protein 0.0066 0.0407 0.0361
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0084 0.0297
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0461 0.0415
Loa Loa (eye worm) hypothetical protein 0.0105 0.0881 0.088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0073 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0147 0.0147
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0048 0.0137
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0073 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Schistosoma mansoni hypothetical protein 0.0062 0.0364 0.0318
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0088 0.0675 0.063
Onchocerca volvulus 0.0532 0.6124 0.6104
Mycobacterium ulcerans glutaminase 0.0264 0.2839 1
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0088 0.0675 0.063
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0039 0.007 0.0247
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0103 0.03
Mycobacterium ulcerans phytoene synthase, CrtB 0.0075 0.0524 0.1845
Trichomonas vaginalis glutaminase, putative 0.0264 0.2839 0.8326
Echinococcus multilocularis cpg binding protein 0.0054 0.0265 0.0218
Echinococcus multilocularis JmjC domain containing protein 4 0.0045 0.0147 0.01
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0067 0.0416 0.041
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0073 0.0072
Toxoplasma gondii hypothetical protein 0.0067 0.0416 0.037
Onchocerca volvulus 0.0072 0.0486 0.0439
Brugia malayi nuclear hormone receptor 0.0039 0.0073 0.0025
Brugia malayi bZIP transcription factor family protein 0.0081 0.0593 0.0548
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0486 0.1423
Loa Loa (eye worm) hypothetical protein 0.0072 0.0486 0.0485
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0073 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0073 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0175 0.0128
Brugia malayi beta-lactamase family protein 0.0072 0.0486 0.0441
Loa Loa (eye worm) hypothetical protein 0.0072 0.0486 0.0485
Leishmania major cathepsin L-like protease 0.0068 0.043 0.0384
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0416 0.041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0073 0.0025
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0067 0.0416 0.041
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0486 0.1423
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0048 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0486 0.0441
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0103 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Echinococcus granulosus jumonji domain containing 1A 0.0045 0.0147 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0084 0.0078
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0208 0.0161
Loa Loa (eye worm) hexokinase 0.0847 1 1
Schistosoma mansoni hypothetical protein 0.0066 0.0407 0.0361
Plasmodium falciparum fructose-bisphosphate aldolase 0.0088 0.0675 0.063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0369 0.0323
Treponema pallidum fructose-bisphosphate aldolase 0.0311 0.341 0.341
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0073 0.0025
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.146 0.2702
Onchocerca volvulus 0.0847 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1268 0.1226
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3459 0.3458
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0088 0.0675 0.063
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0593 0.0548
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0486 0.1712
Loa Loa (eye worm) hypothetical protein 0.0081 0.0593 0.0592
Schistosoma mansoni hypothetical protein 0.0123 0.1105 0.1062
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0073 0.0025
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0073 0.0025
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0044 0.0132 0.0085
Schistosoma mansoni coup transcription factor 0.0039 0.0073 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0486 0.1423
Loa Loa (eye worm) hypothetical protein 0.0269 0.2905 0.2904
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0175 0.0128
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0088 0.0675 0.063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.341 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0486 0.0839
Echinococcus granulosus snurportin 1 0.0315 0.3459 0.3427
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0073 0.0025
Loa Loa (eye worm) hypothetical protein 0.0075 0.0524 0.0523
Entamoeba histolytica hypothetical protein 0.007 0.0461 0.046
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0103 0.0056
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0369 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0084 0.0078
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0067 0.0416 0.037
Schistosoma mansoni hypothetical protein 0.007 0.0461 0.0415
Trypanosoma brucei hexokinase 0.0847 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0073 0.0025
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0066 0.0403 0.0679
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0593 0.0548
Echinococcus multilocularis hexokinase 0.0847 1 1
Echinococcus granulosus hexokinase 0.0847 1 1
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0067 0.0416 0.0415
Loa Loa (eye worm) hexokinase type II 0.0847 1 1
Echinococcus multilocularis Squalene phytoene synthase 0.0075 0.0524 0.0479
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0067 0.0416 0.037
Giardia lamblia Rab geranylgeranyltransferase 0.0067 0.0416 0.1095
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0073 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.1053 0.101
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0075 0.0524 0.0911
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0048 0.0047
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0088 0.0675 0.063
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0088 0.0675 0.063
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0073 0.0025
Mycobacterium tuberculosis Conserved protein 0.0072 0.0486 0.0839
Brugia malayi RNA, U transporter 1 0.0084 0.0626 0.0581
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0088 0.0675 0.0674
Schistosoma mansoni glutaminase 0.0264 0.2839 0.2805
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0593 0.0548
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0147 0.01

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 8.23 Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin ChEMBL. 18330978
pKd (binding) = 8.23 Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin ChEMBL. 18330978
Potency (functional) 0.0076 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0422 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.1132 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9856 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.