Detailed information for compound 516586

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.383 | Formula: C20H18N4O2
  • H donors: 2 H acceptors: 3 LogP: 0.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1ccccn1
  • InChi: 1S/C20H18N4O2/c21-9-5-11-24-12-14(13-6-1-2-8-16(13)24)17-18(20(26)23-19(17)25)15-7-3-4-10-22-15/h1-4,6-8,10,12H,5,9,11,21H2,(H,23,25,26)
  • InChiKey: UXOFRVJXABAVMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Protein kinase C brain isozyme 0.0188 0.1935 0.5412
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0054 0.0379 0.1493
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0064 0.049 0.049
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1208 0.3319
Echinococcus multilocularis peregrin 0.0034 0.0141 0.0141
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.039 0.1289
Onchocerca volvulus 0.0091 0.0802 0.2705
Schistosoma mansoni rab6-interacting 0.0023 0.0014 0.004
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0144 0.8892
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0025 0.0038 0.0106
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0478 0.1338
Echinococcus granulosus dnaJ subfamily C 6 0.0071 0.0571 0.1598
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.039 0.109
Schistosoma mansoni hypothetical protein 0.0335 0.3638 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.015 0.0413
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.039 0.109
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0232 0.065
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0232 0.0639
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.039 0.1071
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0029 0.0092 0.0092
Loa Loa (eye worm) AGC/NDR protein kinase 0.0029 0.0092 0.036
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0144 0.9521
Entamoeba histolytica hypothetical protein 0.0042 0.0232 0.1779
Loa Loa (eye worm) hypothetical protein 0.0058 0.042 0.1654
Schistosoma mansoni unc-13 (munc13) 0.0025 0.0038 0.0104
Schistosoma mansoni hypothetical protein 0.0128 0.1242 0.3413
Brugia malayi Matrixin family protein 0.0091 0.0802 0.3156
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0217 0.2271 0.2271
Echinococcus granulosus serine:threonine protein kinase N2 0.0029 0.0092 0.0256
Loa Loa (eye worm) AGC/AKT protein kinase 0.0029 0.0092 0.036
Plasmodium vivax SET domain protein, putative 0.0034 0.015 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.103 0.103
Echinococcus granulosus RNA directed DNA polymerase 0.0134 0.1305 0.3651
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1208 0.3962
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0141 0.0555
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0133 0.1298 0.5108
Schistosoma mansoni hypothetical protein 0.0071 0.0571 0.1571
Plasmodium falciparum phd finger protein, putative 0.0034 0.0141 0.978
Brugia malayi Hemopexin family protein 0.0128 0.1242 0.4887
Brugia malayi 6-phosphofructokinase 0.0126 0.1208 0.4753
Brugia malayi Protein kinase domain containing protein 0.0029 0.0092 0.036
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0092 0.0252
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.015 0.015
Loa Loa (eye worm) matrixin family protein 0.0219 0.2294 0.9027
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0144 0.8892
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Onchocerca volvulus 0.0025 0.0038 0.0081
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0329 0.3575 0.3575
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.015 0.042
Brugia malayi Pre-SET motif family protein 0.024 0.2541 1
Brugia malayi 6-phosphofructokinase 0.0126 0.1208 0.4753
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0328 0.1292
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.039 0.1534
Loa Loa (eye worm) phosphofructokinase 0.0126 0.1208 0.4753
Schistosoma mansoni serine/threonine kinase 0.0029 0.0092 0.0252
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.1208 0.3378
Brugia malayi mbt repeat family protein 0.0055 0.039 0.1534
Schistosoma mansoni protein kinase 0.0152 0.152 0.4177
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0144 1
Echinococcus granulosus NDR protein kinase 0.0029 0.0092 0.0256
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0057
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0096 0.086 0.2365
Schistosoma mansoni polycystin 1-related 0.0023 0.0014 0.004
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0144 0.9521
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0014 0.0014
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0478 0.1314
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1208 0.3319
Loa Loa (eye worm) hypothetical protein 0.0034 0.0141 0.0555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.015 0.0413
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.1208 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0029 0.0092 0.036
Entamoeba histolytica hypothetical protein 0.0042 0.0232 0.1779
Brugia malayi Pre-SET motif family protein 0.0034 0.015 0.0592
Brugia malayi hypothetical protein 0.0023 0.0014 0.0057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.015 1
Loa Loa (eye worm) matrixin family protein 0.0201 0.2083 0.8199
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.1208 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0519 0.0519
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.039 0.039
Onchocerca volvulus 0.0128 0.1242 0.4214
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0519 0.1427
Echinococcus granulosus unc 13 munc13 0.0025 0.0038 0.0106
Brugia malayi p70 ribosomal S6 kinase beta 0.0029 0.0092 0.036
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0294 0.0823
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0144 0.0224
Brugia malayi Protein kinase domain containing protein 0.0029 0.0092 0.036
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1208 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0141 0.0387
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0478 0.0478
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0478 0.1882
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0092 0.0252
Loa Loa (eye worm) AGC/PKN protein kinase 0.0029 0.0092 0.036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.015 0.015
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0139 0.1366 0.5378
Echinococcus multilocularis protein kinase c epsilon type 0.0054 0.0379 0.0379
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0029 0.0092 0.0256
Loa Loa (eye worm) hypothetical protein 0.0134 0.1305 0.5137
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0144 0.0224
Loa Loa (eye worm) hypothetical protein 0.0034 0.015 0.0592
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0144 0.5
Schistosoma mansoni lipoxygenase 0.0064 0.049 0.1348
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0217 0.2271 0.6351
Loa Loa (eye worm) hypothetical protein 0.0091 0.0802 0.3156
Echinococcus granulosus peregrin 0.0034 0.0141 0.0394
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1208 0.5
Brugia malayi Hr1 repeat family protein 0.0029 0.0092 0.036
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0141 0.8409
Echinococcus multilocularis RUN 0.0023 0.0014 0.0014
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0144 0.0224
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0329 0.3575 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0144 1
Echinococcus granulosus protein kinase C gamma type 0.0168 0.1696 0.4745
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.015 0.0413
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0188 0.1935 0.1935
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0141 0.9312
Entamoeba histolytica protein kinase, putative 0.0029 0.0092 0.0591
Loa Loa (eye worm) hypothetical protein 0.0055 0.039 0.1534
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1208 0.3962
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0223 0.0223
Schistosoma mansoni atypical protein kinase C 0.005 0.033 0.0907
Schistosoma mansoni unc-13 (munc13) 0.0025 0.0038 0.0104
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0144 0.1032
Onchocerca volvulus Alhambra homolog 0.0034 0.0141 0.0435
Entamoeba histolytica hypothetical protein 0.0042 0.0232 0.1779
Brugia malayi Matrixin family protein 0.0219 0.2294 0.9027
Loa Loa (eye worm) hypothetical protein 0.0155 0.1544 0.6076
Brugia malayi Matrixin family protein 0.0091 0.0802 0.3156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.015 0.0413
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0144 0.8892
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0144 0.0224
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0092 0.0092
Trichomonas vaginalis set domain proteins, putative 0.0274 0.2926 1
Onchocerca volvulus 0.0034 0.015 0.0467
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0091 0.0802 0.3156
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0144 0.0224
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0025 0.0038 0.0038
Brugia malayi Matrixin family protein 0.0091 0.0802 0.3156
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0136 0.0379
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0478 0.1338
Brugia malayi PHD-finger family protein 0.0034 0.0141 0.0555
Echinococcus multilocularis conserved hypothetical protein 0.0276 0.295 0.295
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0092 0.0252
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0141 0.0394
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0134 0.1305 0.1305
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0223 0.0613
Brugia malayi mbt repeat family protein 0.0055 0.039 0.1534
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0014 0.0014
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0029 0.0092 0.0256
Echinococcus granulosus RUN 0.0023 0.0014 0.004
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0014 0.004
Schistosoma mansoni hypothetical protein 0.0034 0.0141 0.0387
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0014 0.0014
Trichomonas vaginalis protein kinase inhibitor, putative 0.0071 0.0571 0.1727
Schistosoma mansoni jumonji domain containing protein 0.0088 0.0767 0.2109
Schistosoma mansoni hypothetical protein 0.0042 0.0232 0.0639
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.1935 0.5318
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0328 0.1292
Entamoeba histolytica protein kinase, putative 0.0029 0.0092 0.0591
Trypanosoma brucei RNA helicase, putative 0.012 0.1138 0.9377
Loa Loa (eye worm) matrix metalloproteinase 0.0091 0.0802 0.3156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.036
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0144 0.0224
Brugia malayi hypothetical protein 0.0042 0.0232 0.0915
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0141 0.8409
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0223 0.0624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0328 0.0902
Brugia malayi Protein kinase domain containing protein 0.0029 0.0092 0.036
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0519 0.1453
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0092 0.0252
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0092 0.0092
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0519 0.2044
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0152 0.152 0.4251
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0133 0.1298 0.5108
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0141 0.0141
Schistosoma mansoni protein kinase 0.0152 0.152 0.4177
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0029 0.0092 0.036
Echinococcus multilocularis unc 13 (munc13) 0.0025 0.0038 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0557 0.2193
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1208 0.4753
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1208 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0029 0.0092 0.0092
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1208 1
Brugia malayi Doublecortin family protein 0.0023 0.0014 0.0057
Onchocerca volvulus Matrix metalloproteinase homolog 0.0201 0.2083 0.7105
Echinococcus multilocularis conserved hypothetical protein 0.0276 0.295 0.295
Schistosoma mansoni rab6-interacting 0.0023 0.0014 0.004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0149
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0014 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0379 0.1043
Schistosoma mansoni hypothetical protein 0.012 0.1138 0.3128
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0144 0.0224
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0152 0.152 0.152
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0467 0.184
Schistosoma mansoni glucose-6-phosphatase 0.0277 0.2971 0.8165
Onchocerca volvulus Matrilysin homolog 0.0201 0.2083 0.7105
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.1208 1
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.1208 0.1208
Loa Loa (eye worm) hypothetical protein 0.011 0.1031 0.4059
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0029 0.0092 0.036
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0029 0.0092 0.036
Entamoeba histolytica protein kinase, putative 0.0029 0.0092 0.0591
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0294 0.0294
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.1208 1
Brugia malayi protein kinase C II. 0.0054 0.0379 0.1493
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0223 0.0878
Echinococcus multilocularis serine threonine protein kinase 0.0168 0.1696 0.1696
Brugia malayi jmjC domain containing protein 0.011 0.103 0.4055
Brugia malayi Protein kinase c protein 2 0.016 0.1605 0.6316
Loa Loa (eye worm) MBCTL1 0.0063 0.0478 0.1882
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.1935 0.5318
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Echinococcus granulosus protein kinase c epsilon type 0.0054 0.0379 0.1061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0328 0.0328
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1208 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0029 0.0092 0.0092
Echinococcus granulosus protein kinase c iota type 0.005 0.033 0.0923
Echinococcus multilocularis RNA directed DNA polymerase 0.0134 0.1305 0.1305
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.039 0.1071
Schistosoma mansoni lipoxygenase 0.0023 0.0014 0.004
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.103 0.2882
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0328 0.0902
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1208 0.3962
Loa Loa (eye worm) hypothetical protein 0.0091 0.0802 0.3156
Onchocerca volvulus Matrilysin homolog 0.0091 0.0802 0.2705
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0144 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0328 0.0918
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0064 0.049 0.1372
Brugia malayi Matrixin family protein 0.0091 0.0802 0.3156
Brugia malayi phosphofructokinase 0.0126 0.1208 0.4753
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.011 0.1031 0.7439
Schistosoma mansoni loxhd1 0.0023 0.0014 0.004
Brugia malayi Bromodomain containing protein 0.0034 0.0141 0.0555
Loa Loa (eye worm) hypothetical protein 0.0063 0.0478 0.1882
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1208 0.4753
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.039 0.1071
Schistosoma mansoni protein kinase 0.0152 0.152 0.4177
Echinococcus multilocularis protein kinase c iota type 0.005 0.033 0.033
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0144 0.5
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0014 0.0057
Mycobacterium ulcerans hydrolase 0.011 0.1031 0.7439
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0029 0.0092 0.0092
Onchocerca volvulus 0.0055 0.039 0.1289
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0029 0.0092 0.0256
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1208 0.3962
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.039 0.039
Echinococcus multilocularis dnaJ subfamily C 6 0.0071 0.0571 0.0571
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0014 0.004
Loa Loa (eye worm) DnaJ domain-containing protein 0.0071 0.0571 0.2249
Brugia malayi hypothetical protein 0.0023 0.0014 0.0057
Brugia malayi DnaJ domain containing protein 0.0071 0.0571 0.2249
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0478 0.0478
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.011 0.1031 0.4059
Schistosoma mansoni hypothetical protein 0.0023 0.0014 0.004
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.1208 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0223 0.0613
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.2541 1
Onchocerca volvulus 0.0274 0.2926 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0328 0.0918
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0328 0.0328
Schistosoma mansoni protein kinase C 0.0025 0.0038 0.0104
Entamoeba histolytica hypothetical protein 0.0042 0.0232 0.1779
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0091 0.0802 0.2204
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Entamoeba histolytica protein kinase, putative 0.0029 0.0092 0.0591
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0092 0.0041
Brugia malayi jmjC domain containing protein 0.0041 0.0223 0.0878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0328 0.0902

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.58 uM Inhibition of CaMK2delta (unknown origin) ChEMBL. 18334294
IC50 (binding) = 1.58 uM Inhibition of CaMK2delta (unknown origin) ChEMBL. 18334294

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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