Detailed information for compound 536720

Basic information

Technical information
  • TDR Targets ID: 536720
  • Name: (3S,8S,9S,10R,13R,14S)-10,13-dimethyl-2,3,4,7 ,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]ph enanthren-3-ol
  • MW: 272.425 | Formula: C19H28O
  • H donors: 1 H acceptors: 1 LogP: 4.52 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC=C2)C)C1)C
  • InChi: 1S/C19H28O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h3,5,9,14-17,20H,4,6-8,10-12H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
  • InChiKey: QVHPTAJAHUONLV-DYKIIFRCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • androsta-5,16-dien-3 beta-ol
  • 1224-94-8
  • Androsta-5,16-dien-3-ol, (3beta)-
  • Androsta-5,16-dien-3beta-ol
  • Androstadienol
  • 5,16-Androstadien-3beta-ol
  • Andien-beta

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.002 0.0149 0.6886
Onchocerca volvulus 0.002 0.0149 0.1233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0979 0.0979
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0979 0.0979
Onchocerca volvulus 0.0033 0.0303 0.2563
Echinococcus multilocularis transmembrane protease serine 3 0.002 0.0149 0.0149
Toxoplasma gondii PAN domain-containing protein 0.0306 0.3498 1
Echinococcus granulosus transmembrane protease serine 3 0.002 0.0149 0.0324
Schistosoma mansoni hypothetical protein 0.0043 0.0425 0.0928
Leishmania major GTP-binding protein, putative 0.0021 0.0169 0.2298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0213 1
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Onchocerca volvulus 0.0033 0.0303 0.2563
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0169 0.2298
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0016 0.0031
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0041 0.1722
Schistosoma mansoni patched 1 0.0045 0.0444 0.0969
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0444 0.1238
Toxoplasma gondii PAN domain-containing protein 0.0306 0.3498 1
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0405
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.002 0.0149 0.0149
Toxoplasma gondii microneme protein MIC17B 0.0033 0.0303 0.0853
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0139 1
Schistosoma mansoni topbp1 0.001 0.0041 0.009
Onchocerca volvulus 0.0033 0.0303 0.2563
Echinococcus multilocularis glycoprotein Antigen 5 0.002 0.0149 0.0149
Loa Loa (eye worm) Smad1 0.0008 0.0016 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0213 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.1143 0.8447
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 0.1215
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0101
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0588
Loa Loa (eye worm) hypothetical protein 0.0029 0.0259 0.0715
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0979 0.7234
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0169 0.2298
Echinococcus multilocularis nibrin 0.001 0.0041 0.0041
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0979 0.275
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0041 0.0817
Echinococcus granulosus glycoprotein Antigen 5 0.002 0.0149 0.0324
Treponema pallidum DNA ligase (lig) 0.001 0.0041 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0213 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0139 0.0377
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0139 0.1877
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.0044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0213 1
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0841
Schistosoma mansoni hypothetical protein 0.0043 0.0425 0.0928
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.0303 0.0853
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Plasmodium falciparum cysteine repeat modular protein 1 0.0068 0.0717 1
Brugia malayi DKFZp564C0469 protein 0.001 0.0041 0.0266
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.1143 0.2495
Trichomonas vaginalis ran, putative 0.0021 0.0169 0.373
Brugia malayi Trypsin-like protease protein 5 0.002 0.0149 0.1065
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 0.0462
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0036
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0194 0.431
Toxoplasma gondii kringle domain-containing protein 0.0068 0.0717 0.2039
Brugia malayi MH2 domain containing protein 0.0008 0.0016 0.0082
Onchocerca volvulus 0.0052 0.0534 0.4543
Onchocerca volvulus 0.0033 0.0303 0.2563
Brugia malayi Smad1 0.0008 0.0016 0.0082
Brugia malayi Importin beta-1 subunit 0.0029 0.0259 0.1882
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0016 0.0036
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Echinococcus multilocularis expressed conserved protein 0.0098 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0841
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0139 0.6421
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0366 0.0799
Schistosoma mansoni hypothetical protein 0.0068 0.0717 0.1566
Toxoplasma gondii microneme protein MIC17C 0.0033 0.0303 0.0853
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0169 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0817
Entamoeba histolytica hypothetical protein 0.0038 0.0366 0.3171
Echinococcus granulosus replication factor c subunit 1 0.001 0.0041 0.009
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0534 0.1165
Echinococcus multilocularis tumor protein p63 0.0359 0.4119 0.4119
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Mycobacterium ulcerans hypothetical protein 0.0025 0.0213 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0259 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0366 0.0799
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0213 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0213 1
Toxoplasma gondii microneme protein MIC17A 0.0033 0.0303 0.0853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0127 0.5844
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0139 0.6421
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.1162 0.2536
Loa Loa (eye worm) TK/ROR protein kinase 0.0068 0.0717 0.2011
Plasmodium vivax importin-beta 2, putative 0.0029 0.0259 0.3558
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0041 0.0503
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0127 0.5844
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.458 0.458
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0041 0.0503
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.3548 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0139 0.1877
Loa Loa (eye worm) hypothetical protein 0.0055 0.0562 0.1572
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0303 0.0853
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0041 0.0503
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0534 0.1491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0979 0.2138
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0041 0.0817
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0213 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0213 0.2923
Loa Loa (eye worm) trypsin family protein 0.002 0.0149 0.0405
Onchocerca volvulus 0.002 0.0149 0.1233
Brugia malayi CXXC zinc finger family protein 0.0028 0.0246 0.1788
Schistosoma mansoni DNA ligase IV 0.001 0.0041 0.009
Echinococcus multilocularis tissue type plasminogen activator 0.0068 0.0717 0.0717
Toxoplasma gondii microneme protein MIC4 0.0033 0.0303 0.0853
Leishmania major hypothetical protein, conserved 0.0068 0.0717 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0405
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0259 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0127 0.5844
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.1143 0.1143
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0213 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0444 1
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0303 0.0853
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1352 0.3801
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.0303 0.0853
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0613 0.1338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0979 0.2138
Onchocerca volvulus 0.002 0.0149 0.1233
Onchocerca volvulus 0.002 0.0149 0.1233
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0041 0.0266
Echinococcus granulosus dnaJ subfamily B 0.0398 0.458 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0149 0.0324
Brugia malayi hypothetical protein 0.001 0.0041 0.0266
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0041 0.0817
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0107 0.1168 0.2551
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0005 0.0011
Onchocerca volvulus 0.001 0.0041 0.0308
Onchocerca volvulus 0.0028 0.0246 0.207
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0101
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0169 0.0169
Brugia malayi Trypsin family protein 0.002 0.0149 0.1065
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0101
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.002 0.0149 0.0324
Toxoplasma gondii microneme protein, putative 0.0033 0.0303 0.0853
Echinococcus granulosus importin subunit beta 1 0.0029 0.0259 0.0565
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0405
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0041 0.0041
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 0.2298
Loa Loa (eye worm) hypothetical protein 0.0107 0.1168 0.3283
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0841
Entamoeba histolytica hypothetical protein 0.0024 0.0194 0.1663
Entamoeba histolytica hypothetical protein 0.0038 0.0366 0.3171
Onchocerca volvulus 0.0033 0.0303 0.2563
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0041 0.0503
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0041 0.1415
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0169 0.2298
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0107 0.1168 0.2551
Echinococcus granulosus Mastin 0.002 0.0149 0.0324
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0405
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.1143 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0041 0.0817
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.1668 0.1668
Toxoplasma gondii hypothetical protein 0.0033 0.0303 0.0853
Toxoplasma gondii subtilisin SUB12 0.0033 0.0303 0.0853
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0588
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0194 0.431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0127 0.5844
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0036
Echinococcus multilocularis Smad4 0.0008 0.0016 0.0016
Echinococcus granulosus snurportin 1 0.031 0.3548 0.7746
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Loa Loa (eye worm) hypothetical protein 0.0107 0.1168 0.3283
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Brugia malayi MH2 domain containing protein 0.0008 0.0016 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0366 0.0366
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0194 0.431
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0841
Brugia malayi Kringle domain containing protein 0.0068 0.0717 0.5289
Schistosoma mansoni cpg binding protein 0.003 0.0265 0.0578
Onchocerca volvulus 0.0033 0.0303 0.2563
Echinococcus granulosus smad 0.0008 0.0016 0.0036
Brugia malayi MH2 domain containing protein 0.0122 0.1352 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0259 0.0259
Onchocerca volvulus 0.0025 0.0213 0.179
Schistosoma mansoni Smad4 0.0008 0.0016 0.0036
Brugia malayi MH1 domain containing protein 0.0008 0.0016 0.0082
Loa Loa (eye worm) hypothetical protein 0.0068 0.0717 0.2011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0979 0.2138
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0588
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0213 0.2923
Schistosoma mansoni smad 0.0008 0.0016 0.0036
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0101
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0101
Plasmodium falciparum importin beta, putative 0.0029 0.0259 0.3558
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.1668 0.3642
Echinococcus multilocularis protein patched 0.0045 0.0444 0.0444
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0041 0.0103
Schistosoma mansoni hypothetical protein 0.002 0.0149 0.0324
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0303 0.0841
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0036
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0041 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0213 0.183
Schistosoma mansoni hypothetical protein 0.0398 0.458 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0817
Echinococcus multilocularis cpg binding protein 0.003 0.0265 0.0265
Schistosoma mansoni topbp1 0.001 0.0041 0.009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0246 0.068
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0444 0.0444
Onchocerca volvulus 0.0068 0.0717 0.6124
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0213 1
Entamoeba histolytica hypothetical protein 0.001 0.0041 0.0315
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0303 0.0841
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0213 0.183
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0817
Schistosoma mansoni hypothetical protein 0.031 0.3548 0.7746
Entamoeba histolytica Ran family GTPase 0.0021 0.0169 0.1439
Schistosoma mansoni ran 0.0021 0.0169 0.0369
Entamoeba histolytica hypothetical protein 0.0038 0.0366 0.3171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.002
Brugia malayi CHE-14 protein 0.0045 0.0444 0.3258
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0169 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0016 0.0016
Onchocerca volvulus 0.002 0.0149 0.1233
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0016 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0213 0.1546
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0101
Onchocerca volvulus 0.0033 0.0303 0.2563
Echinococcus multilocularis enteropeptidase 0.002 0.0149 0.0149
Brugia malayi Trypsin family protein 0.002 0.0149 0.1065
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0041 0.0103
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.002 0.0149 0.0149
Onchocerca volvulus 0.0107 0.1168 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0213 1
Onchocerca volvulus 0.0033 0.0303 0.2563
Toxoplasma gondii hypothetical protein 0.0033 0.0303 0.0853
Loa Loa (eye worm) hypothetical protein 0.0104 0.1143 0.3211
Brugia malayi RNA, U transporter 1 0.0083 0.0885 0.6536
Loa Loa (eye worm) histone methyltransferase 0.0009 0.002 0.0042
Schistosoma mansoni hypothetical protein 0.0043 0.0425 0.0928
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0016 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0213 0.2923
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0213 0.183
Schistosoma mansoni cpg binding protein 0.0028 0.0246 0.0537
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0213 0.1546
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0169 0.0468
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.002 0.0149 0.0324
Brugia malayi Trypsin family protein 0.0107 0.1168 0.8638
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0259 0.0725
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0539 0.1527
Schistosoma mansoni importin beta-1 0.0029 0.0259 0.0565
Echinococcus multilocularis snurportin 1 0.031 0.3548 0.3548
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0041 0.1722
Schistosoma mansoni cpg binding protein 0.003 0.0265 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0817
Schistosoma mansoni hypothetical protein 0.0043 0.0425 0.0928
Brugia malayi topoisomerase 0.001 0.0041 0.0266
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0016 0.0031
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0041 0.0266
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0405
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0841
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0444 0.0969
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0841
Loa Loa (eye worm) hypothetical protein 0.0019 0.0139 0.0377
Brugia malayi MH1 domain containing protein 0.0008 0.0016 0.0082
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0041 0.0315
Schistosoma mansoni hypothetical protein 0.002 0.0149 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0979 0.2138
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0817
Loa Loa (eye worm) hypothetical protein 0.0045 0.0444 0.1238
Echinococcus granulosus nibrin 0.001 0.0041 0.009
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0303 0.0841
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0194 0.2655
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0041 0.0817
Schistosoma mansoni hypothetical protein 0.0038 0.0366 0.0799
Echinococcus multilocularis smad 0.0008 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0717 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0169 0.6458
Brugia malayi hypothetical protein 0.0038 0.0366 0.2679
Echinococcus granulosus enteropeptidase 0.002 0.0149 0.0324
Echinococcus granulosus tumor protein p63 0.0359 0.4119 0.8994
Entamoeba histolytica hypothetical protein 0.0038 0.0366 0.3171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0139 0.0377
Echinococcus multilocularis protein dispatched 1 0.0051 0.0518 0.0518
Brugia malayi Protein kinase domain containing protein 0.0068 0.0717 0.5289
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0149 0.0324
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0444 0.0969
Echinococcus granulosus Smad4 0.0008 0.0016 0.0036
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0041 0.0503
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0213 1
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.002 0.0149 0.1065
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0041 0.009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0149 0.0324
Loa Loa (eye worm) hypothetical protein 0.0019 0.0139 0.0377
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0303 0.0853
Brugia malayi hypothetical protein 0.001 0.0041 0.0266
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0303 0.0841
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0213 0.1546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0979 0.2138
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0303 0.0841
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0149 0.0324
Onchocerca volvulus 0.0033 0.0303 0.2563
Brugia malayi PAN domain containing protein 0.0033 0.0303 0.2214
Brugia malayi Trypsin family protein 0.002 0.0149 0.1065
Echinococcus granulosus tissue type plasminogen activator 0.0068 0.0717 0.1566
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.002 0.0149 0.0324
Leishmania major importin beta-1 subunit, putative 0.0024 0.0194 0.2655
Onchocerca volvulus 0.0087 0.0938 0.8023
Echinococcus granulosus cpg binding protein 0.003 0.0265 0.0578
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1352 0.3801
Echinococcus multilocularis Mastin 0.002 0.0149 0.0149
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0019 0.01
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.0149 0.0324
Echinococcus granulosus expressed conserved protein 0.0098 0.1068 0.2333
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0068 0.0717 1
Onchocerca volvulus 0.0033 0.0303 0.2563
Onchocerca volvulus 0.0033 0.0303 0.2563
Brugia malayi hypothetical protein 0.002 0.0149 0.1065
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.0149 0.0324
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0041 0.0503
Loa Loa (eye worm) hypothetical protein 0.0019 0.0139 0.0377
Loa Loa (eye worm) hypothetical protein 0.0033 0.0303 0.0841
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0303 0.0853
Schistosoma mansoni ran 0.0021 0.0169 0.0369

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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