Detailed information for compound 539672

Basic information

Technical information
  • TDR Targets ID: 539672
  • Name: (2R,3S,4R,5S)-3,4-dihydroxy-2-(hydroxymethyl) -1-oxa-6,8-diazaspiro[4.4]nonane-7,9-dione
  • MW: 218.164 | Formula: C7H10N2O6
  • H donors: 5 H acceptors: 5 LogP: -2.77 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@]2([C@@H]([C@@H]1O)O)NC(=O)NC2=O
  • InChi: 1S/C7H10N2O6/c10-1-2-3(11)4(12)7(15-2)5(13)8-6(14)9-7/h2-4,10-12H,1H2,(H2,8,9,13,14)/t2-,3-,4-,7+/m1/s1
  • InChiKey: RFZZKBWDDKMWNM-GTBMBKLPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3S,4R,5S)-3,4-dihydroxy-2-methylol-1-oxa-6,8-diazaspiro[4.4]nonane-7,9-quinone
  • hydantocidin
  • 130607-26-0
  • 6-Oxa-1,3-diazaspiro(4.4)nonane-2,4-dione, 8,9-dihydroxy-7-(hydroxymethyl)-, (5S-(5alpha,7alpha,8beta,9beta))-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0121 0.0925 0.4607
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0261 0.2765
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0261 0.0254
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Brugia malayi metallopeptidase family M24 containing protein 0.0121 0.0925 0.0918
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0976 1 1
Plasmodium vivax peptidase, putative 0.0121 0.0925 0.0918
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.01 0.01
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0121 0.0925 0.0918
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0461 0.0461
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0121 0.0925 1
Echinococcus granulosus methionyl aminopeptidase 2 0.0976 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Loa Loa (eye worm) initiation factor 2-associated protein 0.0976 1 1
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0135 0.0127
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0121 0.0925 0.0918
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0121 0.0925 0.0918
Schistosoma mansoni tar DNA-binding protein 0.007 0.0387 0.0379
Leishmania major hypothetical protein, conserved 0.0121 0.0925 0.0918
Brugia malayi metallopeptidase family M24 containing protein 0.0121 0.0925 0.0918
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Giardia lamblia Methionine aminopeptidase 0.0976 1 1
Echinococcus multilocularis tar DNA binding protein 0.007 0.0387 0.0379
Mycobacterium ulcerans methionine aminopeptidase 0.0121 0.0925 1
Echinococcus granulosus FACT complex subunit SPT16 0.0121 0.0925 0.0918
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0121 0.0925 0.4607
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Echinococcus multilocularis xaa Pro dipeptidase 0.0121 0.0925 0.0918
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0121 0.0925 0.0918
Trypanosoma cruzi aminopeptidase P, putative 0.0121 0.0925 0.0918
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0121 0.0925 0.0918
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0261 0.2765
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0121 0.0925 0.0925
Echinococcus granulosus tar DNA binding protein 0.007 0.0387 0.0379
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0135 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0108 0.01
Onchocerca volvulus Dipeptidase C homolog 0.0121 0.0925 0.0925
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Echinococcus multilocularis FACT complex subunit SPT16 0.0121 0.0925 0.0918
Loa Loa (eye worm) hypothetical protein 0.0121 0.0925 0.0925
Entamoeba histolytica methionine aminopeptidase, putative 0.0976 1 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0121 0.0925 0.0918
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0121 0.0925 0.0918
Plasmodium vivax FACT complex subunit SPT16, putative 0.0121 0.0925 0.0918
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0121 0.0925 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0976 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0121 0.0925 0.0918
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0121 0.0925 0.0918
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1998 1
Echinococcus granulosus methionine aminopeptidase type I 0.0121 0.0925 0.0918
Chlamydia trachomatis aminopeptidase P 0.0121 0.0925 0.5
Loa Loa (eye worm) DNA-binding protein 0.0121 0.0925 0.0925
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0121 0.0925 0.0918
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0121 0.0925 0.0918
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0121 0.0925 0.0918
Toxoplasma gondii creatinase domain-containing protein 0.0121 0.0925 0.0918
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0976 1 1
Trypanosoma cruzi aminopeptidase P1, putative 0.0121 0.0925 0.0918
Echinococcus granulosus xaa pro aminopeptidase 0.0121 0.0925 0.0918
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0121 0.0925 0.0918
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.01 0.0092
Schistosoma mansoni tar DNA-binding protein 0.007 0.0387 0.0379
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0121 0.0925 0.5
Plasmodium vivax methionine aminopeptidase 2, putative 0.0976 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0108 0.01
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0121 0.0925 0.0918
Echinococcus multilocularis Proliferation associated protein 2G4 0.0121 0.0925 0.0918
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Echinococcus multilocularis xaa Pro dipeptidase 0.0121 0.0925 0.0918
Loa Loa (eye worm) hypothetical protein 0.0121 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0121 0.0925 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0261 0.0254
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Plasmodium falciparum methionine aminopeptidase 2 0.0976 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Trypanosoma brucei Metallopeptidase family M24, putative 0.0121 0.0925 0.0918
Echinococcus granulosus xaa Pro dipeptidase 0.0121 0.0925 0.0918
Leishmania major methionine aminopeptidase 2, putative 0.0976 1 1
Echinococcus granulosus chromobox protein 1 0.0078 0.0461 0.0454
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0121 0.0925 1
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0121 0.0925 0.0918
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0121 0.0925 0.0918
Echinococcus multilocularis chromobox protein 1 0.0078 0.0461 0.0454
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0121 0.0925 0.0918
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0261 0.1274
Onchocerca volvulus 0.0035 0.0008 0.0008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0261 0.0254
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0108 0.01
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Echinococcus multilocularis xaa pro aminopeptidase 0.0121 0.0925 0.0918
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0135 0.0135
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0108 0.01
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0121 0.0925 0.0918
Brugia malayi chromobox protein homolog 3 0.0043 0.01 0.0092
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0976 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0261 0.2765
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0121 0.0925 0.0918
Echinococcus granulosus Proliferation associated protein 2G4 0.0121 0.0925 0.0918
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0121 0.0925 0.0918
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Schistosoma mansoni tar DNA-binding protein 0.007 0.0387 0.0379
Treponema pallidum methionine aminopeptidase (map) 0.0121 0.0925 0.5
Chlamydia trachomatis methionine aminopeptidase 0.0121 0.0925 0.5
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0121 0.0925 1
Loa Loa (eye worm) TAR-binding protein 0.007 0.0387 0.0387
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0121 0.0925 0.0918
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0108 0.01
Echinococcus multilocularis microtubule associated protein 2 0.0768 0.7791 0.7789
Brugia malayi RNA binding protein 0.007 0.0387 0.0379
Echinococcus multilocularis chromobox protein 1 0.0078 0.0461 0.0454
Loa Loa (eye worm) beta-lactamase 0.0035 0.0008 0.0008
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0121 0.0925 0.0918
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0108 0.01
Mycobacterium tuberculosis Dipeptidase PepE 0.0121 0.0925 0.4607
Schistosoma mansoni tar DNA-binding protein 0.007 0.0387 0.0379
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Brugia malayi metallopeptidase family M24 containing protein 0.0121 0.0925 0.0918
Schistosoma mansoni tar DNA-binding protein 0.007 0.0387 0.0379
Loa Loa (eye worm) methionine aminopeptidase type I 0.0121 0.0925 0.0925
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0976 1 1
Echinococcus multilocularis methionyl aminopeptidase 2 0.0976 1 1
Mycobacterium ulcerans aminopeptidase 0.0121 0.0925 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0121 0.0925 0.4607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0108 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.01 0.0092
Echinococcus multilocularis methionine aminopeptidase, type I 0.0121 0.0925 0.0918
Schistosoma mansoni peptidase 0.0121 0.0925 0.0918
Onchocerca volvulus 0.0035 0.0008 0.0008
Loa Loa (eye worm) RNA binding protein 0.007 0.0387 0.0387
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0121 0.0925 0.0918
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0008 0.0008
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Echinococcus granulosus microtubule associated protein 2 0.0768 0.7791 0.7789
Brugia malayi TAR-binding protein 0.007 0.0387 0.0379
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0121 0.0925 0.0918
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0461 0.0454
Brugia malayi Methionine aminopeptidase protein type I 0.0121 0.0925 0.0918
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0261 0.0254
Echinococcus granulosus xaa Pro dipeptidase 0.0121 0.0925 0.0918
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0261 0.0254
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0976 1 1
Toxoplasma gondii peptidase D, putative 0.0121 0.0925 0.0918
Loa Loa (eye worm) hypothetical protein 0.0121 0.0925 0.0925
Onchocerca volvulus 0.0035 0.0008 0.0008
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0121 0.0925 0.0918
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0976 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Toxoplasma gondii transcriptional elongation factor FACT140 0.0121 0.0925 0.0918
Brugia malayi Heterochromatin protein 1 0.0078 0.0461 0.0454
Onchocerca volvulus 0.0121 0.0925 0.0925
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0976 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0976 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Trypanosoma brucei methionine aminopeptidase, putative 0.0121 0.0925 0.0918
Schistosoma mansoni chromobox protein 0.0078 0.0461 0.0454
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0121 0.0925 0.0918
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0387 0.0379
Mycobacterium ulcerans dipeptidase 0.0121 0.0925 1
Toxoplasma gondii methionine aminopeptidase 0.0121 0.0925 0.0918
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0461 0.0454
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0387 0.0387
Mycobacterium ulcerans dipeptidase PepE 0.0121 0.0925 1
Toxoplasma gondii methionine aminopeptidase 0.0121 0.0925 0.0918
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0976 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0121 0.0925 0.0918
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Leishmania major transcription factor-like protein 0.0121 0.0925 0.0918
Schistosoma mansoni microtubule-associated protein tau 0.0768 0.7791 0.7789
Echinococcus granulosus chromobox protein 1 0.0078 0.0461 0.0454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0108 0.01
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0121 0.0925 0.0918
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0121 0.0925 0.0918
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0976 1 1
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0121 0.0925 0.0925
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0261 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.01 0.01
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0121 0.0925 0.5
Schistosoma mansoni chromobox protein 0.0078 0.0461 0.0454
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0121 0.0925 0.0918
Treponema pallidum aminopeptidase P 0.0121 0.0925 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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