Detailed information for compound 542895

Basic information

Technical information
  • TDR Targets ID: 542895
  • Name: (2R)-2-[[(2S)-2-amino-5-guanidino-pentanoyl]- iodo-amino]-5-(2,5-dioxopyrrol-1-yl)-2-[(4-hy droxyphenyl)methyl]-3-oxo-pentanoic acid
  • MW: 614.39 | Formula: C22H27IN6O7
  • H donors: 5 H acceptors: 7 LogP: -3.43 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=NCCC[C@@H](C(=O)N([C@](C(=O)CCN1C(=O)C=CC1=O)(C(=O)O)Cc1ccc(cc1)O)I)N)N
  • InChi: 1S/C22H27IN6O7/c23-29(19(34)15(24)2-1-10-27-21(25)26)22(20(35)36,12-13-3-5-14(30)6-4-13)16(31)9-11-28-17(32)7-8-18(28)33/h3-8,15,30H,1-2,9-12,24H2,(H,35,36)(H4,25,26,27)/t15-,22+/m0/s1
  • InChiKey: AFNHYMBYOPDLFG-OYHNWAKOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-2-[[(2S)-2-amino-5-guanidino-1-oxopentyl]-iodoamino]-5-(2,5-dioxo-1-pyrrolyl)-2-[(4-hydroxyphenyl)methyl]-3-oxopentanoic acid
  • (2R)-2-[[(2S)-2-azanyl-5-[bis(azanyl)methylideneamino]pentanoyl]-iodo-amino]-5-(2,5-dioxopyrrol-1-yl)-2-[(4-hydroxyphenyl)methyl]-3-oxo-pentanoic acid
  • (2R)-2-[[(2S)-2-amino-5-guanidino-pentanoyl]-iodo-amino]-2-(4-hydroxybenzyl)-3-keto-5-maleimido-valeric acid
  • (2R)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]-iodoamino]-5-(2,5-dioxopyrrol-1-yl)-2-[(4-hydroxyphenyl)methyl]-3-oxopentanoic acid
  • 3-maleimidopropionylarginylmonoiodotyrosine
  • (2R)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]-iodo-amino]-5-(2,5-dioxopyrrol-1-yl)-2-[(4-hydroxyphenyl)methyl]-3-oxo-pentanoic acid
  • 138191-82-9
  • 3-Mpait
  • L-Tyrosine, N-(N2-(3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl)-2-arginyl)-3-(ido-125I)-
  • 3-Maleimidopropionyl-arg-I-tyr

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.3489 0.3489
Loa Loa (eye worm) RNA binding protein 0.0066 0.1081 0.1224
Schistosoma mansoni ran 0.0022 0.0208 0.0208
Leishmania major importin beta-1 subunit, putative 0.0024 0.0253 0.0431
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0206 0.0252
Schistosoma mansoni hypothetical protein 0.0014 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0014 0.0056 0.0056
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0202 0.3809 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0475 0.0503
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0283 0.5182
Echinococcus multilocularis importin subunit beta 1 0.003 0.0366 0.0366
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.046 0.1855
Onchocerca volvulus 0.0016 0.0093 0.0044
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0284 0.0309
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0186 0.3489 0.5495
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.3489 0.3489
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0093 0.0044
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0251 0.0232
Trypanosoma cruzi hexose transporter, putative 0.002 0.0159 0.0179
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0425 0.168
Echinococcus multilocularis pyruvate kinase 0.0035 0.046 0.046
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0283 0.0201
Echinococcus granulosus pyruvate kinase 0.0035 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Entamoeba histolytica hypothetical protein 0.0026 0.0283 0.0207
Mycobacterium tuberculosis Conserved protein 0.0035 0.0475 0.0853
Echinococcus multilocularis pyruvate kinase 0.0027 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0028 0.033 0.0331
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0574 0.051
Loa Loa (eye worm) pyruvate kinase 0.0035 0.046 0.0485
Onchocerca volvulus 0.0016 0.0093 0.0044
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0931 1
Onchocerca volvulus 0.0016 0.0093 0.0044
Brugia malayi Thioredoxin reductase 0.0095 0.1663 0.1914
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.3489 0.3489
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.046 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0283 0.0512
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.046 0.0481
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0475 0.1027
Onchocerca volvulus 0.0016 0.0093 0.0044
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.1663 0.1661
Giardia lamblia Pyruvate kinase 0.0018 0.0124 0.0838
Trichomonas vaginalis esterase, putative 0.0035 0.0475 0.1929
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0283 0.0308
Trypanosoma brucei trypanothione reductase 0.0095 0.1663 0.4224
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0208 0.0181
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Echinococcus multilocularis General substrate transporter 0.0099 0.1748 0.1748
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0283 0.0512
Onchocerca volvulus 0.0016 0.0093 0.0044
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0202 0.3809 1
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0483 0.105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0096 0.0051
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0474 0.0502
Onchocerca volvulus 0.0016 0.0093 0.0044
Onchocerca volvulus 0.0434 0.8448 1
Brugia malayi Sugar transporter family protein 0.0016 0.0093 0.0044
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0475 0.0503
Loa Loa (eye worm) hypothetical protein 0.0026 0.0284 0.0276
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0208 0.3151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0475 0.0475
Leishmania major hypothetical protein, conserved 0.0026 0.0284 0.0514
Plasmodium falciparum protein kinase 6 0.0489 0.9541 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0096 0.0047
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0425 0.0895
Brugia malayi beta-lactamase 0.0035 0.0475 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0483 0.1973
Brugia malayi hypothetical protein 0.0016 0.0093 0.0044
Plasmodium vivax importin-beta 2, putative 0.003 0.0366 0.0289
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0366 0.0735
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0474 0.0617
Echinococcus multilocularis solute carrier family 22 0.0016 0.0093 0.0093
Trypanosoma brucei glucose transporter 1E 0.0036 0.0483 0.105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0051
Plasmodium falciparum hexose transporter 0.0115 0.2071 0.2094
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Echinococcus multilocularis pyruvate kinase 0.0018 0.0124 0.0124
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0425 0.9058
Leishmania major pyruvate kinase 0.0035 0.046 0.0987
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.2071 0.2071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0056 0.0056
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0014 0.0056 0.0004
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0474 0.0404
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.046 0.0481
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0483 0.105
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0425 0.0352
Echinococcus multilocularis snurportin 1 0.0319 0.6142 0.6142
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.046 0.1854
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0475 0.0853
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0425 1
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0425 0.168
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0014 0.0056 0.0004
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0474 0.0404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.3489 0.3489
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.046 0.0819
Brugia malayi hypothetical protein 0.0016 0.0093 0.0044
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0283 0.027
Schistosoma mansoni glucose transport protein 0.0115 0.2071 0.2071
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0475 0.0475
Mycobacterium tuberculosis Conserved protein 0.0035 0.0475 0.0853
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.2071 0.2071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0014 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0202 0.3809 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0425 0.0538
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0283 0.294
Plasmodium falciparum thioredoxin reductase 0.0033 0.0425 0.0352
Onchocerca volvulus 0.0016 0.0093 0.0044
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0425 0.0895
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0475 0.1929
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0202 0.3809 0.3809
Schistosoma mansoni glucose transporter 0.0016 0.0093 0.0093
Brugia malayi RNA binding protein 0.0066 0.1081 0.1221
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1081 0.1081
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.457 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0475 0.0503
Onchocerca volvulus 0.0016 0.0093 0.0044
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Mycobacterium ulcerans hypothetical protein 0.0035 0.0475 0.5026
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0251 0.0232
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0093 0.0869
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0474 0.0404
Schistosoma mansoni sugar transporter 0.0016 0.0093 0.0093
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0284 0.0514
Echinococcus granulosus basement membrane specific heparan sulfate 0.0014 0.0056 0.0056
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.4088 0.8924
Loa Loa (eye worm) hypothetical protein 0.0052 0.0801 0.0892
Plasmodium vivax glutathione reductase, putative 0.0095 0.1663 0.1661
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1081 0.1224
Schistosoma mansoni protein kinase 0.0035 0.0474 0.0474
Brugia malayi hypothetical protein 0.0434 0.8448 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0093 0.0048
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0425 0.0895
Schistosoma mansoni hypothetical protein 0.0115 0.2071 0.2071
Schistosoma mansoni pyruvate kinase 0.0035 0.046 0.046
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0253 0.0431
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0284 0.0514
Onchocerca volvulus 0.0016 0.0093 0.0044
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0093 0.0093
Plasmodium falciparum thioredoxin reductase 0.0095 0.1663 0.1661
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0483 0.1973
Schistosoma mansoni sugar transporter 0.0016 0.0093 0.0093
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0208 0.0186
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.4088 0.8924
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0283 0.0961
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0093 0.0869
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0425 0.0352
Brugia malayi hypothetical protein 0.0026 0.0284 0.0271
Plasmodium vivax pyruvate kinase, putative 0.0035 0.046 0.0388
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0014 0.0056 0.0056
Schistosoma mansoni pyruvate kinase 0.0035 0.046 0.046
Onchocerca volvulus 0.0016 0.0093 0.0044
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.046 0.0485
Onchocerca volvulus 0.0035 0.0475 0.0499
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.043 0.043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Schistosoma mansoni hypothetical protein 0.0014 0.0056 0.0056
Schistosoma mansoni protein kinase 0.0035 0.0474 0.0474
Schistosoma mansoni lozenge 0.0054 0.0858 0.0858
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0425 0.4489
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0475 0.5026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0208 0.0311
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0425 0.0895
Echinococcus multilocularis Protein lozenge 0.0054 0.0858 0.0858
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0283 0.294
Plasmodium falciparum mitogen-activated protein kinase 2 0.0186 0.3489 0.3595
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0474 0.1026
Brugia malayi major facilitator superfamily protein 0.0016 0.0093 0.0044
Echinococcus multilocularis GPCR, family 2 0.0016 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Echinococcus granulosus importin subunit beta 1 0.003 0.0366 0.0366
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0931 0.0931
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.6142 0.7253
Loa Loa (eye worm) hypothetical protein 0.0434 0.8448 1
Onchocerca volvulus 0.0016 0.0093 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0284 0.0514
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.046 0.0582
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0931 0.1043
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0208 0.0311
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0483 0.105
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0574 0.1296
Trypanosoma brucei glucose transporter 2A 0.0036 0.0483 0.105
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.046 0.0594
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0093 0.0869
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0202 0.3809 0.3809
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0124 0.0033
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0425 0.0538
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0283 0.0283
Toxoplasma gondii facilitative glucose transporter GT1 0.0115 0.2071 0.3201
Schistosoma mansoni importin beta-1 0.003 0.0366 0.0366
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.2071 0.2071
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0366 0.0735
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0801 0.0888
Echinococcus multilocularis solute carrier family 22 0.0016 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0574 0.1296
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0284 0.0202
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1081 0.1081
Mycobacterium ulcerans beta-lactamase 0.0035 0.0475 0.5026
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0283 0.6043
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0474 0.0404
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Brugia malayi beta-lactamase family protein 0.0035 0.0475 0.0499
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0014 0.0056 0.0056
Leishmania major protein kinase, putative 0.0035 0.0474 0.1026
Brugia malayi glutathione reductase 0.0095 0.1663 0.1914
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0931 0.2256
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Schistosoma mansoni sugar transporter 0.0016 0.0093 0.0093
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0014 0.0056 0.0004
Entamoeba histolytica hypothetical protein 0.0024 0.0253 0.0124
Echinococcus granulosus pyruvate kinase 0.0018 0.0124 0.0124
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.046 0.0481
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0014 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Plasmodium falciparum proline--tRNA ligase 0.004 0.0574 0.051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0475 0.0503
Echinococcus granulosus low density lipoprotein receptor ldl 0.0014 0.0056 0.0056
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0574 0.1296
Brugia malayi Sugar transporter family protein 0.0016 0.0093 0.0044
Plasmodium falciparum importin beta, putative 0.003 0.0366 0.0289
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0425 0.0425
Schistosoma mansoni hypothetical protein 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0475 0.0475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.3489 0.3489
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0202 0.3809 0.4474
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0251 0.0117
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0093 0.0093
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0474 0.0474
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0093 0.0044
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0425 0.0895
Toxoplasma gondii protein kinase, putative 0.0325 0.6274 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0425 0.0352
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0014 0.0056 0.0056
Leishmania major GTP-binding protein, putative 0.0022 0.0208 0.0311
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.046 0.0481
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.457 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0124 0.0124
Mycobacterium tuberculosis Conserved protein 0.0035 0.0475 0.0853
Entamoeba histolytica protein kinase, putative 0.0035 0.0474 0.0738
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1081 0.1224
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.046 0.046
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Echinococcus multilocularis solute carrier family 22 0.0016 0.0093 0.0093
Mycobacterium tuberculosis Probable reductase 0.0216 0.4088 0.8924
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0202 0.3809 1
Loa Loa (eye worm) pyruvate kinase 0.0035 0.046 0.0485
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.046 0.0987
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0483 0.1973
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0206 0.0252
Brugia malayi hypothetical protein 0.0016 0.0093 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Brugia malayi beta-lactamase family protein 0.0035 0.0475 0.0499
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.043 0.043
Treponema pallidum NADH oxidase 0.0033 0.0425 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0483 0.1973
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0124 0.0033
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0425 0.0425
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0475 0.0853
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.046 0.0987
Echinococcus multilocularis pyruvate kinase 0.0018 0.0124 0.0124
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.1663 0.1663
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.2071 0.2071
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.2071 0.2071
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.003 0.0366 0.0373
Loa Loa (eye worm) hypothetical protein 0.0035 0.0475 0.0503
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0474 0.0502
Schistosoma mansoni protein kinase 0.0035 0.0474 0.0474
Echinococcus multilocularis pyruvate kinase 0.0018 0.0124 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0475 0.1929
Brugia malayi TAR-binding protein 0.0066 0.1081 0.1221
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0475 0.0404
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0115 0.2071 0.2071
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0483 0.105
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0425 0.0895
Echinococcus granulosus basement membrane specific heparan sulfate 0.0014 0.0056 0.0056
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0483 0.1973
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0475 0.0475
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0283 0.0283
Plasmodium falciparum pyruvate kinase 0.0035 0.046 0.0388
Onchocerca volvulus 0.0035 0.0475 0.0499
Echinococcus granulosus solute carrier family 22 0.0016 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.3489 0.3489
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0014 0.0056 0.0004
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0474 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.022 0.0641
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.2071 0.2071
Onchocerca volvulus 0.0016 0.0093 0.0044
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0474 0.0474
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0283 0.0274
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.046 0.0481
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0093 0.0093
Chlamydia trachomatis pyruvate kinase 0.0035 0.046 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0425 0.0352
Brugia malayi Importin beta-1 subunit 0.003 0.0366 0.0369
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.2071 0.2071
Trypanosoma cruzi hexose transporter 0.0036 0.0483 0.105
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0253 0.081
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0208 0.0311
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0474 0.0498
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.4088 0.8924
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0474 0.0404
Plasmodium falciparum glutathione reductase 0.0033 0.0425 0.0352
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0574 0.1296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Onchocerca volvulus 0.0035 0.0475 0.0499
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0425 0.4489
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0425 0.4489
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0425 0.0742
Schistosoma mansoni ran 0.0022 0.0208 0.0208
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0202 0.3809 0.4472
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0474 0.0404
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0475 0.1929
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0574 0.1296
Leishmania major glucose transporter, lmgt2 0.0036 0.0483 0.105
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0474 0.0474
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0474 0.0617
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0208 0.0122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Echinococcus granulosus GPCR family 2 0.0016 0.0096 0.0096
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0202 0.3809 0.3809
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0284 0.0202
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0253 0.081
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1081 0.1081
Leishmania major hypothetical protein, conserved 0.0035 0.0475 0.1027
Loa Loa (eye worm) beta-lactamase 0.0035 0.0475 0.0503
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0475 0.1027
Echinococcus granulosus low density lipoprotein receptor ldl 0.0014 0.0056 0.0056
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0574 0.0779
Brugia malayi RNA, U transporter 1 0.0085 0.1467 0.1681
Mycobacterium leprae Probable lipase LipE 0.0035 0.0475 0.0616
Schistosoma mansoni hypothetical protein 0.0319 0.6142 0.6142
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0014 0.0056 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0475 0.0853
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0425 0.0895
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.2071 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0483 0.105
Leishmania major glucose transporter, lmgt1 0.0036 0.0483 0.105
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0425 0.0895
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.046 0.0583
Trypanosoma brucei glucose transporter, putative 0.0036 0.0483 0.105
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0283 0.0177
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0208 0.0208
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0253 0.081
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.1663 0.1663
Loa Loa (eye worm) hypothetical protein 0.0024 0.0251 0.0236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.3489 0.4091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.1663 0.3506
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0014 0.0056 0.0056
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0475 0.0853
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0283 0.0283
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0483 0.105
Echinococcus multilocularis transcription factor Dp 1 0.0117 0.2107 0.2107
Echinococcus granulosus solute carrier family 22 0.0016 0.0093 0.0093
Giardia lamblia Pyruvate kinase 0.0035 0.046 0.9997
Mycobacterium ulcerans pyruvate kinase 0.0035 0.046 0.4865
Echinococcus granulosus pyruvate kinase 0.0018 0.0124 0.0124
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0093 0.0048
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0014 0.0056 0.0056
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0931 0.1872
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0014 0.0056 0.0056
Onchocerca volvulus 0.0016 0.0093 0.0044
Brugia malayi Sugar transporter family protein 0.0115 0.2071 0.2402
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0093 0.0093
Echinococcus multilocularis solute carrier family 22 0.0016 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.1663 0.1918
Loa Loa (eye worm) hypothetical protein 0.0035 0.0475 0.0503
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0202 0.3809 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0474 0.0474
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.046 0.1854
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0096 0.0047
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0056 0.0004
Echinococcus granulosus pyruvate kinase 0.0035 0.046 0.046
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0475 0.0499
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0475 0.0853
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0801 0.0892
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0425 0.0425
Echinococcus granulosus low density lipoprotein receptor protein 0.0014 0.0056 0.0056
Echinococcus granulosus solute carrier family 22 0.0016 0.0093 0.0093
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0035 0.0475 0.0475
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0093 0.0044
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0475 0.0616
Echinococcus granulosus solute carrier family 22 0.0016 0.0093 0.0093
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0474 0.0617
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Schistosoma mansoni sugar transporter 0.0016 0.0093 0.0093
Plasmodium falciparum protein kinase 7 0.0325 0.6274 0.6542
Echinococcus multilocularis low density lipoprotein receptor protein 0.0014 0.0056 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.3489 0.3489
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0186 0.3489 0.3595
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0483 0.105
Brugia malayi Cam kinase protein 1 0.0035 0.0474 0.0498
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0035 0.0474 0.0502
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0475 0.1929
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.4088 0.8924
Leishmania major pyruvate kinase 0.0035 0.046 0.0987
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0475 0.0499
Plasmodium vivax CDK-related protein kinase 6, putative 0.0489 0.9541 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0284 0.0202
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0483 0.1973
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.3489 0.4094
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0853 0.0953
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0474 0.0474
Mycobacterium ulcerans lipase LipD 0.0035 0.0475 0.5026
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.1663 0.4224
Leishmania major trypanothione reductase 0.0095 0.1663 0.4224
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0931 0.0931
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0208 0.0187
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0014 0.0056 0.0056
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.046 0.0987
Entamoeba histolytica protein kinase, putative 0.0035 0.0474 0.0738
Brugia malayi major facilitator superfamily protein 0.0016 0.0093 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0801 0.0888
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.046 0.0481
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0283 0.0512
Plasmodium falciparum glutathione reductase 0.0095 0.1663 0.1661
Loa Loa (eye worm) hypothetical protein 0.0035 0.0475 0.0503
Echinococcus granulosus snurportin 1 0.0319 0.6142 0.6142
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0474 0.0404
Trypanosoma brucei pyruvate kinase 1 0.0035 0.046 0.0987
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0931 0.0931
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0475 0.5026
Schistosoma mansoni hypothetical protein 0.0512 1 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0425 0.9228
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0216 0.4088 0.8896
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0096 0.0096
Echinococcus granulosus transcription factor Dp 1 0.0117 0.2107 0.2107
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0425 0.044
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.046 0.0485
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0093 0.0093
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.046 0.0481
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.046 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0474 0.1927
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0475 0.0853
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0096 0.0096
Schistosoma mansoni glucose transport protein 0.0115 0.2071 0.2071
Loa Loa (eye worm) sugar transporter 0.0115 0.2071 0.2405
Onchocerca volvulus Putative transporter 0.0016 0.0093 0.0044
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Loa Loa (eye worm) hypothetical protein 0.0434 0.8448 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0425 0.0895
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.046 0.0485
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0014 0.0056 0.0056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0474 0.0474
Schistosoma mansoni glucose transport protein 0.0115 0.2071 0.2071
Echinococcus multilocularis geminin 0.0512 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0366 0.0442
Onchocerca volvulus 0.0016 0.0093 0.0044
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0208 0.0208
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0096 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0425 0.0895
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0474 0.0474
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0474 0.0404
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0283 0.0201
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0251 0.0236
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0124 0.005
Echinococcus granulosus General substrate transporter 0.0099 0.1748 0.1748
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0475 0.1027
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.4088 0.8924
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0425 1
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0483 0.1973
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0475 0.1929
Toxoplasma gondii thioredoxin reductase 0.0095 0.1663 0.254
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.046 0.046
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1081 0.1221
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1081 0.1081
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.457 1
Loa Loa (eye worm) runx1 0.0054 0.0858 0.0959
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Loa Loa (eye worm) glutathione reductase 0.0095 0.1663 0.1918
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1081 0.1081
Toxoplasma gondii ABC1 family protein 0.0035 0.0475 0.0618
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0048
Mycobacterium ulcerans sugar transporter 0.0016 0.0093 0.0869
Echinococcus granulosus tar DNA binding protein 0.0066 0.1081 0.1081
Onchocerca volvulus 0.0016 0.0093 0.0044
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0475 0.0853
Leishmania major glucose transporter, lmgt3 0.0036 0.0483 0.105
Plasmodium vivax hexose transporter 0.0115 0.2071 0.2094
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.4276 0.9343
Brugia malayi hypothetical protein 0.0017 0.0101 0.0054
Loa Loa (eye worm) sugar transporter 0.0016 0.0093 0.0048
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0474 0.0474
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0931 1
Echinococcus multilocularis pyruvate kinase 0.0035 0.046 0.046
Onchocerca volvulus 0.0016 0.0093 0.0044
Trichomonas vaginalis ran, putative 0.0022 0.0208 0.0584
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0208 0.0122
Echinococcus granulosus pyruvate kinase 0.0018 0.0124 0.0124
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.457 1
Loa Loa (eye worm) pyruvate kinase 0.0035 0.046 0.0485
Loa Loa (eye worm) hypothetical protein 0.0035 0.0475 0.0503

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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