Detailed information for compound 542932

Basic information

Technical information
  • TDR Targets ID: 542932
  • Name: 2-acetoxybenzoic acid; methyl 2-hydroxybenzoa te; propyl 2-hydroxybenzoate
  • MW: 512.505 | Formula: C27H28O10
  • H donors: 3 H acceptors: 7 LogP: 6.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)Oc1ccccc1C(=O)O.COC(=O)c1ccccc1O.CCCOC(=O)c1ccccc1O
  • InChi: 1S/C10H12O3.C9H8O4.C8H8O3/c1-2-7-13-10(12)8-5-3-4-6-9(8)11;1-6(10)13-8-5-3-2-4-7(8)9(11)12;1-11-8(10)6-4-2-3-5-7(6)9/h3-6,11H,2,7H2,1H3;2-5H,1H3,(H,11,12);2-5,9H,1H3
  • InChiKey: DDJRJGYGWMZCLH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-acetoxybenzoic acid; 2-hydroxybenzoic acid methyl ester; 2-hydroxybenzoic acid propyl ester
  • 2-acetyloxybenzoic acid; methyl 2-hydroxybenzoate; propyl 2-hydroxybenzoate
  • pharodoran
  • 138230-31-6
  • Benzoic acid, 2-(acetyloxy)-, mixt. with methyl hydroxybenzoate and propyl hydroxybenzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0298 0.0665
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.0582 0.0501
Toxoplasma gondii facilitative glucose transporter GT1 0.0123 0.2241 0.3229
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0584 0.0968
Leishmania major importin beta-1 subunit, putative 0.0023 0.0298 0.0589
Schistosoma mansoni hypothetical protein 0.0166 0.3085 0.5308
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0327 0.017
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0383 0.1528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2566 0.4396
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0383 0.0227
Echinococcus granulosus pyruvate kinase 0.0033 0.049 0.0748
Giardia lamblia Pyruvate kinase 0.0017 0.0178 0.045
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0257 0.0241
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0582 0.0911
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0186 0.0161
Loa Loa (eye worm) hypothetical protein 0.0034 0.0503 0.0411
Plasmodium vivax proline--tRNA ligase, putative 0.0043 0.0686 0.0535
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0403 0.1606
Toxoplasma gondii sugar transporter ST2 0.0017 0.0186 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0582 0.2028
Giardia lamblia Pyruvate kinase 0.0033 0.049 0.8097
Loa Loa (eye worm) pyruvate kinase 0.0033 0.049 0.0395
Plasmodium falciparum protein kinase 7 0.0347 0.6607 0.6551
Schistosoma mansoni glucose transport protein 0.0123 0.2241 0.3826
Echinococcus granulosus GPCR family 2 0.0016 0.0152 0.0156
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0186 0.1722
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Plasmodium vivax glutathione reductase, putative 0.0046 0.0745 0.0594
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0745 0.1197
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0686 0.224
Brugia malayi Sugar transporter family protein 0.0017 0.0186 0.0161
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0745 0.249
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0186 0.0111
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0327 0.0711
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0186 0.0125
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0584 0.0914
Loa Loa (eye worm) glutathione reductase 0.0046 0.0745 0.0687
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1065 0.1759
Echinococcus granulosus General substrate transporter 0.0105 0.1905 0.3235
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.2509 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0152 0.0156
Echinococcus multilocularis solute carrier family 22 0.0017 0.0186 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0591 0.2073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0567 0.0593
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.0582 0.0609
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0383 0.7253
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.0582 0.0429
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0136 0.2509 0.2789
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0257 0.0339
Brugia malayi hypothetical protein 0.0017 0.0186 0.0161
Echinococcus multilocularis Protein lozenge 0.0058 0.0983 0.1615
Schistosoma mansoni sugar transporter 0.0017 0.0186 0.0215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0806 0.0757
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0257 0.0129
Brugia malayi RNA, U transporter 1 0.0081 0.1423 0.156
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0303 0.0327
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2566 0.4396
Echinococcus multilocularis pyruvate kinase 0.0017 0.0178 0.0201
Echinococcus granulosus pyruvate kinase 0.0017 0.0178 0.0201
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1891 0.3952
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0186 0.0741
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.016 0.0637
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0198 0.3714 0.3612
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0686 0.2734
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.049 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0186 0.0125
Trypanosoma brucei glucose transporter 2A 0.0038 0.0591 0.2357
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0136 0.2509 0.4297
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0567 0.0885
Schistosoma mansoni importin beta-1 0.0028 0.0403 0.0596
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.016 0.0132
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.016 0.0637
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.049 0.0512
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0303 0.0327
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0584 0.2327
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0327 0.0259
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0123 0.2241 0.3826
Echinococcus multilocularis General substrate transporter 0.0105 0.1905 0.3235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2566 0.4396
Schistosoma mansoni hypothetical protein 0.0303 0.5755 1
Brugia malayi major facilitator superfamily protein 0.0017 0.0186 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0327 0.017
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0136 0.2509 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.0582 0.0655
Loa Loa (eye worm) hypothetical protein 0.0033 0.049 0.0395
Trypanosoma brucei pyruvate kinase 1 0.0033 0.049 0.1951
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0257 0.0339
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.5755 0.642
Loa Loa (eye worm) hypothetical protein 0.0464 0.8884 1
Plasmodium falciparum hexose transporter 0.0123 0.2241 0.2115
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0123 0.2241 0.3826
Schistosoma mansoni glucose transport protein 0.0123 0.2241 0.3826
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0257 0.0413
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0584 0.1547
Schistosoma mansoni ran 0.0021 0.0257 0.0339
Mycobacterium leprae Probable lipase LipE 0.0038 0.0584 0.1547
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0298 0.0589
Brugia malayi hypothetical protein 0.0017 0.0186 0.0161
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1891 0.3952
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1065 0.1759
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0198 0.3714 0.5513
Loa Loa (eye worm) hypothetical protein 0.0038 0.0584 0.0503
Loa Loa (eye worm) hypothetical protein 0.0037 0.0567 0.0484
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0537 0.0831
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0383 0.0952
Brugia malayi RNA binding protein 0.0062 0.1065 0.1156
Loa Loa (eye worm) hypothetical protein 0.0038 0.0584 0.0503
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0582 0.0429
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0186 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0186 0.0125
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0152 0.0156
Onchocerca volvulus 0.0038 0.0584 0.0458
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.0582 0.0429
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0567 0.0593
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1891 0.3952
Plasmodium falciparum mitogen-activated protein kinase 2 0.0198 0.3714 0.3612
Toxoplasma gondii sugar transporter ST3 0.0017 0.0186 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0584 0.2038
Schistosoma mansoni hypothetical protein 0.0016 0.0152 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.049 0.0753
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0186 0.0215
Loa Loa (eye worm) beta-lactamase 0.0038 0.0584 0.0503
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1891 0.3952
Giardia lamblia Hexose transporter 0.0017 0.0186 0.0641
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0745 0.0687
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0178 0.0019
Treponema pallidum NADH oxidase 0.0016 0.016 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0584 0.0503
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0686 0.224
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0383 0.1074
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0745 0.0594
Trypanosoma brucei sugar transporter, putative 0.0017 0.0186 0.0741
Brugia malayi Sugar transporter family protein 0.0017 0.0186 0.0161
Mycobacterium ulcerans lipase LipD 0.0038 0.0584 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0745 0.1335
Schistosoma mansoni glucose transporter 0.0017 0.0186 0.0215
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0186 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0582 0.0911
Onchocerca volvulus 0.0038 0.0584 0.0458
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0298 0.0665
Echinococcus granulosus pyruvate kinase 0.0033 0.049 0.0748
Leishmania major trypanothione reductase 0.0046 0.0745 0.249
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0584 0.0968
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0584 0.0914
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0327 0.017
Brugia malayi hypothetical protein 0.0024 0.0327 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0186 0.0125
Plasmodium vivax pyruvate kinase, putative 0.0033 0.049 0.0335
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0123 0.2241 0.3826
Entamoeba histolytica protein kinase, putative 0.0038 0.0582 0.1444
Chlamydia trachomatis pyruvate kinase 0.0033 0.049 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.1891 0.3952
Plasmodium vivax sugar transporter, putative 0.0017 0.0186 0.0027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0257 0.0413
Entamoeba histolytica hypothetical protein 0.0023 0.0298 0.0184
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.0582 0.0501
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0152 0.0009
Plasmodium falciparum thioredoxin reductase 0.0046 0.0745 0.0594
Echinococcus granulosus pyruvate kinase 0.0017 0.0178 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.049 0.0349
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.0582 0.0429
Echinococcus granulosus solute carrier family 22 0.0017 0.0186 0.0215
Brugia malayi Cam kinase protein 1 0.0038 0.0582 0.0609
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0186 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0178 0.0201
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0584 0.0968
Trichomonas vaginalis esterase, putative 0.0038 0.0584 0.2038
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0152 0.0156
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0567 0.1378
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0584 0.2038
Leishmania major glucose transporter, lmgt2 0.0038 0.0591 0.1837
Trypanosoma brucei trypanothione reductase 0.0046 0.0745 0.2968
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0383 0.0952
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0383 0.5491
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0567 0.0484
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0582 0.0911
Loa Loa (eye worm) runx1 0.0058 0.0983 0.096
Schistosoma mansoni hypothetical protein 0.0016 0.0152 0.0156
Echinococcus granulosus geminin 0.0166 0.3085 0.5308
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1065 0.1156
Echinococcus multilocularis GPCR, family 2 0.0016 0.0152 0.0156
Plasmodium vivax importin-beta 2, putative 0.0028 0.0403 0.0247
Schistosoma mansoni hypothetical protein 0.0034 0.0503 0.0773
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0257 0.0099
Loa Loa (eye worm) pyruvate kinase 0.0033 0.049 0.0395
Loa Loa (eye worm) sugar transporter 0.0123 0.2241 0.2399
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0584 0.0968
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0584 0.0968
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0591 0.1837
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1891 0.8746
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.0582 0.0429
Echinococcus multilocularis transcription factor Dp 1 0.0079 0.1389 0.2329
Schistosoma mansoni protein kinase 0.0038 0.0582 0.0911
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.049 0.1404
Mycobacterium tuberculosis Conserved protein 0.0038 0.0584 0.0968
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0383 0.0562
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0257 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0327 0.0711
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0186 0.0215
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0584 0.0968
Echinococcus multilocularis pyruvate kinase 0.0033 0.049 0.0748
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0136 0.2509 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.016 0.0637
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Plasmodium falciparum importin beta, putative 0.0028 0.0403 0.0247
Schistosoma mansoni sugar transporter 0.0017 0.0186 0.0215
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0383 0.0443
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.0582 0.0429
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0077 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0591 0.2073
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0567 0.0885
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0123 0.2241 0.3826
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.049 0.1951
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0123 0.2241 0.3826
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.049 0.0349
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.049 0.1585
Trypanosoma brucei glucose transporter 1E 0.0038 0.0591 0.2357
Loa Loa (eye worm) hypothetical protein 0.003 0.0433 0.033
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.0582 0.0429
Schistosoma mansoni hypothetical protein 0.0016 0.0152 0.0156
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.016 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0152 0.0009
Schistosoma mansoni ran 0.0021 0.0257 0.0339
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.0582 0.0911
Leishmania major glucose transporter, lmgt3 0.0038 0.0591 0.1837
Schistosoma mansoni pyruvate kinase 0.0033 0.049 0.0748
Schistosoma mansoni protein kinase 0.0038 0.0582 0.0911
Loa Loa (eye worm) hypothetical protein 0.0038 0.0582 0.0501
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1065 0.1054
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0567 0.1957
Leishmania major hypothetical protein, conserved 0.0038 0.0584 0.1805
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.0582 0.2319
Brugia malayi Sugar transporter family protein 0.0123 0.2241 0.2486
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0318 0.0758
Plasmodium falciparum proline--tRNA ligase 0.0043 0.0686 0.0535
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0123 0.2241 0.3826
Schistosoma mansoni glucose transport protein 0.0123 0.2241 0.3826
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.2566 0.2771
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2241 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0123 0.2241 0.3826
Loa Loa (eye worm) RNA binding protein 0.0062 0.1065 0.1054
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Leishmania major GTP-binding protein, putative 0.0021 0.0257 0.0413
Loa Loa (eye worm) hypothetical protein 0.0464 0.8884 1
Giardia lamblia Sugar-proton symporter 0.0017 0.0186 0.0641
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1065 0.1759
Mycobacterium ulcerans beta-lactamase 0.0038 0.0584 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Plasmodium falciparum pyruvate kinase 0.0033 0.049 0.0335
Brugia malayi beta-lactamase family protein 0.0038 0.0584 0.0612
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.016 0.118
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1065 0.1759
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0152 0.0156
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0403 0.0377
Echinococcus granulosus importin subunit beta 1 0.0028 0.0403 0.0596
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0255 0.0405
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Echinococcus multilocularis pyruvate kinase 0.0017 0.0178 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0591 0.2073
Brugia malayi Importin beta-1 subunit 0.0028 0.0403 0.0407
Mycobacterium ulcerans sugar transporter 0.0017 0.0186 0.1722
Echinococcus multilocularis geminin 0.0166 0.3085 0.5308
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0383 0.583
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.2509 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.016 0.0637
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.2509 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2119 0.4472
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0257 0.0099
Echinococcus multilocularis solute carrier family 22 0.0017 0.0186 0.0215
Echinococcus granulosus solute carrier family 22 0.0017 0.0186 0.0215
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0582 0.0911
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Leishmania major pyruvate kinase 0.0033 0.049 0.1404
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0136 0.2509 0.2706
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0403 0.0596
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0186 0.0048
Brugia malayi Thioredoxin reductase 0.0046 0.0745 0.0793
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0584 0.2038
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0584 0.0914
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0584 0.1805
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0186 0.006
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0186 0.0125
Entamoeba histolytica hypothetical protein 0.0027 0.0383 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trypanosoma cruzi hexose transporter 0.0038 0.0591 0.1837
Schistosoma mansoni sugar transporter 0.0017 0.0186 0.0215
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0186 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0584 0.2038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Mycobacterium tuberculosis Conserved protein 0.0038 0.0584 0.0968
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2566 0.4396
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0383 0.0562
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0582 0.0911
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.0582 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0186 0.0215
Schistosoma mansoni protein kinase 0.0038 0.0582 0.0911
Brugia malayi hypothetical protein 0.0017 0.0186 0.0161
Loa Loa (eye worm) hypothetical protein 0.0038 0.0584 0.0503
Echinococcus granulosus snurportin 1 0.0303 0.5755 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0591 0.1837
Loa Loa (eye worm) hypothetical protein 0.0038 0.0584 0.0503
Loa Loa (eye worm) hypothetical protein 0.0038 0.0584 0.0503
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0296 0.0174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.2566 0.2853
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0591 0.2357
Leishmania major pyruvate kinase 0.0033 0.049 0.1404
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0136 0.2509 0.4297
Echinococcus granulosus transcription factor Dp 1 0.0079 0.1389 0.2329
Brugia malayi hypothetical protein 0.0464 0.8884 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0383 0.0562
Brugia malayi glutathione reductase 0.0046 0.0745 0.0793
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.016 0.118
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0186 0.0111
Onchocerca volvulus 0.0464 0.8884 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0257 0.2381
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1065 0.1054
Echinococcus multilocularis pyruvate kinase 0.0033 0.049 0.0748
Schistosoma mansoni hypothetical protein 0.0016 0.0152 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0591 0.2073
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.0582 0.0429
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0123 0.2241 0.3826
Brugia malayi TAR-binding protein 0.0062 0.1065 0.1156
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0257 0.1023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0152 0.0123
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0186 0.0161
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0591 0.2073
Schistosoma mansoni pyruvate kinase 0.0033 0.049 0.0748
Echinococcus multilocularis solute carrier family 22 0.0017 0.0186 0.0215
Loa Loa (eye worm) hypothetical protein 0.0024 0.0327 0.0209
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0686 0.224
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0806 0.0863
Schistosoma mansoni lozenge 0.0058 0.0983 0.1615
Entamoeba histolytica protein kinase, putative 0.0038 0.0582 0.1444
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0383 0.0227
Toxoplasma gondii sugar transporter ST1 0.0017 0.0186 0.004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0077 0.0039
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0591 0.2357
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0745 0.1197
Echinococcus granulosus solute carrier family 22 0.0017 0.0186 0.0215
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2566 0.4396
Schistosoma mansoni sugar transporter 0.0017 0.0186 0.0215
Trypanosoma brucei glucose transporter, putative 0.0038 0.0591 0.2357
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0582 0.0911
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1065 0.1759
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0591 0.1837
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.049 0.0505
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.049 0.1404
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0584 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2566 0.4396
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0403 0.1606
Echinococcus multilocularis solute carrier family 22 0.0017 0.0186 0.0215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0806 0.0757
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.0582 0.0655
Loa Loa (eye worm) hypothetical protein 0.0023 0.0296 0.0174
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0584 0.0968
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0686 0.224
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0567 0.0885
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0178 0.0019
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0186 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0584 0.0503
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Echinococcus multilocularis pyruvate kinase 0.0017 0.0178 0.0201
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0186 0.0027
Plasmodium vivax hexose transporter 0.0123 0.2241 0.2115
Mycobacterium ulcerans hypothetical protein 0.0038 0.0584 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0383 0.0562
Schistosoma mansoni hypothetical protein 0.0123 0.2241 0.3826
Loa Loa (eye worm) sugar transporter 0.0017 0.0186 0.0048
Mycobacterium tuberculosis Conserved protein 0.0038 0.0584 0.0968
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0591 0.2073
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2119 1
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0591 0.1837
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0383 0.0385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0584 0.0914
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1891 0.3952
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0186 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0584 0.1805
Brugia malayi major facilitator superfamily protein 0.0017 0.0186 0.0161
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0584 0.0612
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0582 0.0911
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0383 0.0347
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0806 0.0863
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0043 0.0686 0.0816
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.016 0.1468
Leishmania major glucose transporter, lmgt1 0.0038 0.0591 0.1837
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0186 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2566 0.4396
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2119 0.4472
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.016 0.0169
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0383 0.583
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0567 0.0885
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0186 0.0161
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.4541 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0503 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0186 0.0125
Toxoplasma gondii ABC1 family protein 0.0038 0.0584 0.0658
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0136 0.2509 0.4297
Leishmania major protein kinase, putative 0.0038 0.0582 0.1797
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0591 0.2073
Plasmodium vivax CDK-related protein kinase 6, putative 0.0521 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0152 0.0123
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.016 0.0169
Echinococcus granulosus solute carrier family 22 0.0017 0.0186 0.0215
Plasmodium falciparum glutathione reductase 0.0046 0.0745 0.0594
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0591 0.2357
Brugia malayi hypothetical protein 0.0016 0.0158 0.0129
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0186 0.0111
Echinococcus multilocularis snurportin 1 0.0303 0.5755 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0186 0.1722
Loa Loa (eye worm) pyruvate kinase 0.0033 0.049 0.0395
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.049 0.1028
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0186 0.0125
Brugia malayi beta-lactamase 0.0038 0.0584 0.0612
Mycobacterium ulcerans pyruvate kinase 0.0033 0.049 0.8038
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.049 0.0349
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0567 0.1454
Toxoplasma gondii protein kinase, putative 0.0347 0.6607 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.016 0.118
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0584 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0567 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0178 0.0201
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.0582 0.0429
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0186 0.0215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0186 0.0048
Trichomonas vaginalis ran, putative 0.0021 0.0257 0.0466
Leishmania major hypothetical protein, conserved 0.0024 0.0327 0.0711
Onchocerca volvulus 0.0038 0.0584 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0584 0.2038
Brugia malayi beta-lactamase family protein 0.0038 0.0584 0.0612
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0186 0.0125
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0296 0.0174
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0584 1
Schistosoma mansoni hypothetical protein 0.0166 0.3085 0.5308
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0298 0.0665
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0537 0.0831
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0582 0.0911
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1065 0.1759
Echinococcus multilocularis pyruvate kinase 0.0026 0.0355 0.0512
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0327 0.1302
Loa Loa (eye worm) hypothetical protein 0.0028 0.0403 0.0296
Toxoplasma gondii thioredoxin reductase 0.0046 0.0745 0.0907
Echinococcus granulosus tar DNA binding protein 0.0062 0.1065 0.1759
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0186 0.1722
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2119 0.4472
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.049 0.1585
Leishmania major hypothetical protein, conserved 0.0017 0.0186 0.0111
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0178 0.0028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.