TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 353.821 | Formula: C17H22ClN2O4-
H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1cc2c(CN)ncc(c2cc1OC)C(=O)OCC.[Cl-]
InChi: 1S/C17H22N2O4.ClH/c1-4-6-23-16-8-12-11(7-15(16)21-3)13(17(20)22-5-2)10-19-14(12)9-18;/h7-8,10H,4-6,9,18H2,1-3H3;1H/p-1
InChiKey: VCNAYXDUNJWXBZ-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	calcium activated potassium channel variant	0.0145	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Schistosoma mansoni	serine-rich repeat protein	0.0604	0.1693	0.1693
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0145	0.0324	0.2209
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0209	0.0515	0.0515
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0052	0.0662
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0054	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0145	0.0324	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus multilocularis	potassium channel subfamily K 8	0.0145	0.0324	0.0324
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.009	0.0159	0.0147
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0145	0.0324	0.2209
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0145	0.0324	0.2209
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0145	0.0324	0.0324
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0145	0.0324	0.2209
Brugia malayi	Bromodomain containing protein	0.0041	0.0012	0.0023
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0145	0.0324	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.007	0.0101	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Onchocerca volvulus		0.0145	0.0324	0.1693
Plasmodium falciparum	telomerase reverse transcriptase	0.017	0.0399	1
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.009	0.0159	0.4342
Plasmodium falciparum	potassium channel	0.0145	0.0324	0.7955
Onchocerca volvulus		0.0145	0.0324	0.1693
Schistosoma mansoni	calcium-activated potassium channel	0.0145	0.0324	0.0324
Schistosoma mansoni	calcium-activated potassium channel	0.0145	0.0324	0.0324
Loa Loa (eye worm)	TWK-28 protein	0.0145	0.0324	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Trypanosoma brucei	telomerase reverse transcriptase	0.017	0.0399	1
Echinococcus multilocularis	twik family of potassium channels	0.0145	0.0324	0.0324
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0052	0.0052
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0145	0.0324	0.2209
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0145	0.0324	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus granulosus	geminin	0.018	0.0428	0.0428
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Echinococcus granulosus	potassium channel subfamily K 8	0.0145	0.0324	0.0324
Schistosoma mansoni	hypothetical protein	0.0048	0.0033	0.0033
Echinococcus multilocularis	potassium channel subfamily K	0.0145	0.0324	0.0324
Treponema pallidum	hypothetical protein	0.0048	0.0033	0.5
Loa Loa (eye worm)	CUTiclin family member	0.0048	0.0033	0.0021
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0052	0.0052
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0324	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0324	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0052	0.004
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0145	0.0324	0.0312
Loa Loa (eye worm)	CUTiclin-Like family member	0.0048	0.0033	0.0021
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.257	0.7562	0.7562
Brugia malayi	Cache domain containing protein	0.0517	0.1435	1
Brugia malayi	von Willebrand Factor	0.0048	0.0033	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0052	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.007	0.0101	0.0101
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0145	0.0324	0.2209
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0623	0.1751	1
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.007	0.0101	0.0101
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.017	0.0399	1
Schistosoma mansoni	hypothetical protein	0.0145	0.0324	0.0324
Echinococcus multilocularis	potassium channel subfamily K 8	0.0145	0.0324	0.0324
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0145	0.0324	0.0312
Toxoplasma gondii	ion channel protein	0.0145	0.0324	0.7955
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0145	0.0324	0.2209
Leishmania major	telomerase reverse transcriptase, putative	0.017	0.0399	1
Leishmania major	calcium/potassium channel (CAKC), putative	0.0145	0.0324	0.7841
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0209	0.0515	0.2806
Leishmania major	hypothetical protein, conserved	0.0145	0.0324	0.7841
Mycobacterium ulcerans	transmembrane cation transporter	0.0145	0.0324	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0145	0.0324	0.2209
Onchocerca volvulus		0.0145	0.0324	0.1693
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus multilocularis	collagen alpha 1(VII) chain	0.0048	0.0033	0.0033
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.007	0.0101	0.1392
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0052	0.0527
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0145	0.0324	0.0312
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0048	0.0033	0.0169
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0145	0.0324	0.7841
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Echinococcus granulosus	voltage dependent calcium channel subunit	0.1169	0.3379	0.3379
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus multilocularis	twik family of potassium channels	0.0145	0.0324	0.0324
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0044	0.0021	0.0086
Echinococcus granulosus	potassium channel subfamily K 8	0.0145	0.0324	0.0324
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.007	0.0101	0.1392
Brugia malayi	prolyl oligopeptidase family protein	0.007	0.0101	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0051	0.0039
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0145	0.0324	0.2209
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0052	0.0662
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0145	0.0324	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.007	0.0101	0.1392
Onchocerca volvulus		0.0145	0.0324	0.1693
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0026	0.0014
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0145	0.0324	0.5
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.1121	0.3237	0.3237
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0115	0.0103
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0054	0.0051	0.0051
Loa Loa (eye worm)	uncoordinated protein 58	0.0145	0.0324	0.0312
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0324	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus multilocularis	geminin	0.018	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Plasmodium vivax	potassium channel, putative	0.0145	0.0324	0.7955
Schistosoma mansoni	hypothetical protein	0.0604	0.1693	0.1693
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.0515	0.3549
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Loa Loa (eye worm)	glutamate receptor	0.0044	0.0021	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Loa Loa (eye worm)	hypothetical protein	0.134	0.389	0.3883
Trypanosoma cruzi	ion transport protein, putative	0.0145	0.0324	0.7841
Brugia malayi	hypothetical protein	0.0145	0.0324	0.2209
Schistosoma mansoni	hypothetical protein	0.0048	0.0033	0.0033
Leishmania major	potassium channel subunit-like protein	0.0145	0.0324	0.7841
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0565	0.1578	0.1578
Loa Loa (eye worm)	hypothetical protein	0.3387	1	1
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Loa Loa (eye worm)	von Willebrand factor domain-containing protein	0.0048	0.0033	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.1493	0.4347	0.434
Schistosoma mansoni	hypothetical protein	0.3387	1	1
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0145	0.0324	0.7841
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.005	0.0039	0.0039
Schistosoma mansoni	hypothetical protein	0.018	0.0428	0.0428
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Onchocerca volvulus		0.0145	0.0324	0.1693
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0324	1
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0145	0.0324	0.7841
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0328
Echinococcus multilocularis	small conductance calcium activated potassium	0.3387	1	1
Toxoplasma gondii	RNA-directed DNA polymerase	0.017	0.0399	1
Onchocerca volvulus		0.0145	0.0324	0.1693
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0209	0.0515	0.0515
Onchocerca volvulus		0.0145	0.0324	0.1693
Echinococcus multilocularis	serotonin receptor	0.0151	0.034	0.034
Schistosoma mansoni	calcium-activated potassium channel	0.2833	0.8347	0.8347
Giardia lamblia	Telomerase catalytic subunit	0.017	0.0399	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0209	0.0515	0.0515
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.1169	0.3379	0.3379
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0145	0.0324	0.2209
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0052	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Trypanosoma cruzi	hypothetical protein, conserved	0.0145	0.0324	0.7841
Loa Loa (eye worm)	hypothetical protein	0.0517	0.1435	0.1424
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0145	0.0324	0.0324
Onchocerca volvulus		0.0145	0.0324	0.1693
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1111	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Mycobacterium ulcerans	ion transport protein	0.0145	0.0324	0.5
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0052	0.0052
Echinococcus granulosus	collagen alpha 1VII chain	0.0048	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.007	0.0101	0.1392
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.009	0.0159	0.4342
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0145	0.0324	0.2209
Trypanosoma cruzi	hypothetical protein, conserved	0.0145	0.0324	0.7841
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0052	0.0052
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.0515	0.0503
Treponema pallidum	76K protein	0.0048	0.0033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Plasmodium falciparum	potassium channel	0.0145	0.0324	0.7955
Echinococcus granulosus	potassium channel subfamily K	0.0145	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0051	0.0039
Brugia malayi	MAP kinase sur-1	0.0054	0.0052	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Brugia malayi	Zona pellucida-like domain containing protein	0.0048	0.0033	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0145	0.0324	0.7841
Loa Loa (eye worm)	TWK-7 protein	0.0145	0.0324	0.0312
Giardia lamblia	Hypothetical protein	0.0145	0.0324	0.7841
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0324	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Echinococcus granulosus	voltage dependent calcium channel subunit	0.257	0.7562	0.7562
Brugia malayi	hypothetical protein	0.0145	0.0324	0.2209
Plasmodium vivax	potassium channel, putative	0.0145	0.0324	0.7955
Echinococcus granulosus	Dipeptidyl peptidase 9	0.007	0.0101	0.0101
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0145	0.0324	0.2209
Leishmania major	ion transport protein-like protein	0.0145	0.0324	0.7841
Brugia malayi	hypothetical protein	0.0048	0.0033	0.0169
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0145	0.0324	0.7841
Schistosoma mansoni	calcium-activated potassium channel	0.3387	1	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0145	0.0324	0.2209
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0264	0.0678	0.0666
Schistosoma mansoni	amine GPCR	0.0377	0.1016	0.1016
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0048	0.0033	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0151	0.034	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.017	0.0399	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus granulosus	twik family of potassium channels	0.0145	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0145	0.0324	0.7841
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	0.034	0.034
Brugia malayi	Telomerase reverse transcriptase	0.0453	0.1243	0.8653
Leishmania major	hypothetical protein, conserved	0.0145	0.0324	0.7841
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	0.034	0.034
Brugia malayi	follicle stimulating hormone receptor	0.0264	0.0678	0.469
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus multilocularis	serotonin receptor	0.0151	0.034	0.034
Echinococcus multilocularis	calcium activated potassium channel variant	0.0145	0.0324	0.0324
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.007	0.0101	0.1846
Brugia malayi	hypothetical protein	0.0054	0.0051	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0145	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Brugia malayi	Bromodomain containing protein	0.008	0.0129	0.084
Schistosoma mansoni	hypothetical protein	0.018	0.0428	0.0428
Trypanosoma cruzi	ion transport protein, putative	0.0145	0.0324	0.7841
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0324	0.0312
Plasmodium vivax	telomerase reverse transcriptase, putative	0.017	0.0399	1
Toxoplasma gondii	ion channel protein	0.0145	0.0324	0.7955
Echinococcus granulosus	twik family of potassium channels	0.0145	0.0324	0.0324
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0145	0.0324	0.0324
Brugia malayi	von Willebrand factor type A domain containing protein	0.0048	0.0033	0.0169
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0145	0.0324	1
Loa Loa (eye worm)	von Willebrand factor type A domain-containing protein	0.0048	0.0033	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0033	0.0021
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0052	0.0052
Brugia malayi	Zona pellucida-like domain containing protein	0.0048	0.0033	0.0169
Schistosoma mansoni	twik family of potassium channels-related	0.0145	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0043	0.002	0.0008

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.4 uM	In vitro inhibition of Dipeptidylpeptidase IV from Caco-2 (human colon carcinoma) cells.	ChEMBL.	10915049

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 158103

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 54868