Detailed information for compound 551210

Basic information

Technical information
  • TDR Targets ID: 551210
  • Name: 5-(2,5-dioxo-4-phenyl-imidazolidin-4-yl)-5-ph enyl-imidazolidine-2,4-dione
  • MW: 350.328 | Formula: C18H14N4O4
  • H donors: 4 H acceptors: 4 LogP: 0.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)NC1(c1ccccc1)C1(NC(=O)NC1=O)c1ccccc1
  • InChi: 1S/C18H14N4O4/c23-13-17(21-15(25)19-13,11-7-3-1-4-8-11)18(12-9-5-2-6-10-12)14(24)20-16(26)22-18/h1-10H,(H2,19,21,23,25)(H2,20,22,24,26)
  • InChiKey: ZRUGFCSNTLNZEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(2,5-dioxo-4-phenyl-4-imidazolidinyl)-5-phenylimidazolidine-2,4-dione
  • 5-(2,5-diketo-4-phenyl-imidazolidin-4-yl)-5-phenyl-hydantoin
  • 5-(2,5-dioxo-4-phenylimidazolidin-4-yl)-5-phenylimidazolidine-2,4-dione
  • diphenylhydantil
  • 18749-95-6
  • (4,4'-Biimidazolidine)-2,2',5,5'-tetrone, 4,4'-diphenyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0247 0.0894
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0047 0.0204
Leishmania major glucose transporter, lmgt2 0.0032 0.065 0.868
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0165 0.2978
Trypanosoma brucei glucose transporter 1E 0.0032 0.065 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Brugia malayi Sugar transporter family protein 0.0014 0.0247 0.0894
Schistosoma mansoni apoferritin-2 0.0009 0.0124 0.0478
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0641 0.2798
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Brugia malayi CXXC zinc finger family protein 0.0031 0.0629 0.2594
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni glucose transporter 0.0014 0.0247 0.1018
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0247 0.0201
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0641 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0641 0.2648
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.229 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0247 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0247 0.0894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0075 0.0328
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0378 0.1651
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0641 0.0925
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Entamoeba histolytica protein kinase, putative 0.0031 0.0641 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0641 0.2648
Trichomonas vaginalis helicase, putative 0.0007 0.0075 0.0328
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0443 0.1937
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0443 0.6932
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0075 0.0328
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0047 0.0377
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0443 0.0399
Echinococcus granulosus solute carrier family 22 0.0014 0.0247 0.0894
Loa Loa (eye worm) hypothetical protein 0.0031 0.0626 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0247 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0032 0.065 0.2839
Toxoplasma gondii sugar transporter ST2 0.0014 0.0247 0.0327
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0091 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0247 0.0894
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0124 0.2801
Echinococcus multilocularis ferritin 0.0009 0.0124 0.0346
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0247 0.5239
Loa Loa (eye worm) hypothetical protein 0.0023 0.0443 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0206 0.0709
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.065 0.2839
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0247 0.0894
Schistosoma mansoni sugar transporter 0.0014 0.0247 0.1018
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0626 0.2684
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0443 0.1881
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0134 0.0391
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0247 0.108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.229 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.065 0.868
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0075 0.0328
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0629 0.2594
Trichomonas vaginalis glucose transporter, putative 0.0032 0.065 0.2839
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0247 0.6499
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0596 0.2448
Trichomonas vaginalis glucose transporter, putative 0.0032 0.065 0.2839
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni ferritin light chain 0.0009 0.0124 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0247 0.108
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0641 0.2648
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0247 0.0894
Leishmania major protein kinase, putative 0.0031 0.0641 0.855
Leishmania major glucose transporter, lmgt1 0.0032 0.065 0.868
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0443 0.1769
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0047 0.0218
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0443 0.1769
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Schistosoma mansoni ferritin 0.0009 0.0124 0.0478
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0744 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Echinococcus granulosus ferritin 0.0009 0.0124 0.0346
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0626 0.9752
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0641 0.0925
Onchocerca volvulus 0.0031 0.0629 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0744 1
Leishmania major glucose transporter, lmgt3 0.0032 0.065 0.868
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0626 0.2684
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0626 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0641 0.0925
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0047 0.0377
Brugia malayi Sugar transporter family protein 0.0014 0.0247 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0744 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0091 0.033
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0247 0.303
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0247 0.0327
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0364 0.5587
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.229 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0641 0.0597
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0641 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0641 0.2648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.229 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0091 0.0196
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0047 0.0218
Brugia malayi Sugar transporter family protein 0.0102 0.229 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0031 0.0136
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0626 0.2734
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0247 0.108
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0047 0.0262
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0443 0.1769
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0641 0.2648
Brugia malayi major facilitator superfamily protein 0.0014 0.0247 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0247 0.0894
Schistosoma mansoni ferritin light chain 0.0009 0.0124 0.0478
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0247 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0124 0.2258
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0641 0.0597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.065 0.868
Plasmodium falciparum hexose transporter 0.0102 0.229 0.2253
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0165 1
Plasmodium vivax hexose transporter 0.0102 0.229 0.2253
Loa Loa (eye worm) hypothetical protein 0.0031 0.0626 0.2583
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.065 0.868
Trypanosoma brucei sugar transporter, putative 0.0014 0.0247 0.303
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0247 0.0894
Schistosoma mansoni protein kinase 0.0031 0.0641 0.2749
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0596 0.2448
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0247 0.0894
Plasmodium vivax sugar transporter, putative 0.0014 0.0247 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0364 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.229 1
Toxoplasma gondii sugar transporter ST1 0.0014 0.0247 0.0327
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0247 0.303
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0626 0.2583
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0443 0.0625
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0626 0.2583
Trypanosoma cruzi hexose transporter 0.0032 0.065 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.229 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0626 0.2583
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.065 0.2839
Echinococcus multilocularis solute carrier family 22 0.0014 0.0247 0.0894
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0132 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0031 0.0136
Echinococcus multilocularis expressed protein 0.0009 0.0124 0.0346
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0247 0.1018
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0744 0.0701
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0443 0.6849
Loa Loa (eye worm) histone methyltransferase 0.001 0.0134 0.0391
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0165 0.3243
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0247 0.303
Schistosoma mansoni cpg binding protein 0.0033 0.0669 0.2875
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0047 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.229 1
Schistosoma mansoni glucose transport protein 0.0102 0.229 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.065 0.2839
Trichomonas vaginalis sugar transporter, putative 0.0032 0.065 0.2839
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0047 0.0468
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.065 0.868
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Toxoplasma gondii protein kinase, putative 0.0289 0.6628 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.229 1
Entamoeba histolytica hypothetical protein 0.0023 0.0443 0.6679
Echinococcus granulosus solute carrier family 22 0.0014 0.0247 0.0894
Entamoeba histolytica protein kinase, putative 0.0031 0.0641 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0031 0.0136
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0091 0.0196
Echinococcus multilocularis solute carrier family 22 0.0014 0.0247 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0032 0.065 0.868
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0247 0.303
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0247 0.108
Leishmania major hypothetical protein, conserved 0.0014 0.0247 0.303
Echinococcus granulosus solute carrier family 22 0.0014 0.0247 0.0894
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0443 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0641 0.2648
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0641 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0075 0.0328
Mycobacterium ulcerans sugar transporter 0.0014 0.0247 0.5239
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0641 0.2648
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0641 0.855
Loa Loa (eye worm) hypothetical protein 0.0031 0.0641 0.2648
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0641 0.2648
Brugia malayi hypothetical protein 0.0014 0.0247 0.0894
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0443 0.5783
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1269 0.1876
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0641 0.2648
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0124 0.1565
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1431 0.6224
Echinococcus granulosus expressed protein 0.0009 0.0124 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0247 0.108
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0641 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0247 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0364 1
Schistosoma mansoni sugar transporter 0.0014 0.0247 0.1018
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3753 0.3724
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Brugia malayi major facilitator superfamily protein 0.0014 0.0247 0.0894
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0247 0.108
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0047 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0247 0.108
Schistosoma mansoni sugar transporter 0.0014 0.0247 0.1018
Toxoplasma gondii sugar transporter ST3 0.0014 0.0247 0.0327
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0047 0.0218
Schistosoma mansoni hypothetical protein 0.0102 0.229 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0047 0.0137
Trypanosoma cruzi hexose transporter, putative 0.0032 0.065 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni cpg binding protein 0.0031 0.0629 0.2696
Schistosoma mansoni ferritin 0.0009 0.0124 0.0478
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0626 0.2583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0075 0.0328
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0075 0.0328
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0641 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Echinococcus granulosus General substrate transporter 0.0088 0.1955 0.851
Trypanosoma brucei glucose transporter, putative 0.0032 0.065 0.868
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0247 0.303
Plasmodium vivax CDK-related protein kinase 6, putative 0.0435 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0744 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni glucose transport protein 0.0102 0.229 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0247 0.0894
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0091 0.0196
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0443 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0626 1
Schistosoma mansoni sugar transporter 0.0014 0.0247 0.1018
Brugia malayi hypothetical protein 0.0014 0.0247 0.0894
Schistosoma mansoni ferritin 0.0009 0.0124 0.0478
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0134 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Loa Loa (eye worm) sugar transporter 0.0102 0.229 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.065 0.868
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0744 0.0701
Echinococcus multilocularis cpg binding protein 0.0033 0.0669 0.2776
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0443 0.5783
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Loa Loa (eye worm) hypothetical protein 0.0025 0.0492 0.1987
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0443 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0641 0.2648
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0124 0.2801
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0744 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0124 0.2258
Giardia lamblia Sugar-proton symporter 0.0014 0.0247 0.346
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3753 0.3724
Brugia malayi hypothetical protein 0.0014 0.0247 0.0894
Trypanosoma brucei glucose transporter 2A 0.0032 0.065 0.868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0641 0.2648
Schistosoma mansoni cpg binding protein 0.0033 0.0669 0.2875
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0443 0.1881
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0641 0.0597
Schistosoma mansoni apoferritin-2 0.0009 0.0124 0.0478
Trichomonas vaginalis ferritin, putative 0.0009 0.0124 0.0543
Schistosoma mansoni protein kinase 0.0031 0.0641 0.2749
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni glucose transport protein 0.0102 0.229 1
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0124 0.6563
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Schistosoma mansoni protein kinase 0.0031 0.0641 0.2749
Plasmodium falciparum protein kinase 7 0.0289 0.6628 0.6612
Echinococcus granulosus cpg binding protein 0.0033 0.0669 0.2776
Loa Loa (eye worm) hypothetical protein 0.0014 0.0247 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0316 0.3994
Giardia lamblia Hexose transporter 0.0014 0.0247 0.346
Schistosoma mansoni ferritin 0.0009 0.0124 0.0478
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0641 0.2749
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0047 0.0024
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.229 0.3424
Loa Loa (eye worm) sugar transporter 0.0014 0.0247 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0075 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0443 0.5783
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0443 0.0399
Echinococcus multilocularis solute carrier family 22 0.0014 0.0247 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0075 0.0328
Echinococcus multilocularis General substrate transporter 0.0088 0.1955 0.851
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0047 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0247 0.108
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.229 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0247 0.0894
Brugia malayi Cam kinase protein 1 0.0031 0.0641 0.2648
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0744 0.1081
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3753 0.5643
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0641 0.0597
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0075 0.0328
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0124 0.3868
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0247 0.6499

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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